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 Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus.
Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Ortmann WA, Espe KJ, Shark KB, Grande WJ, Hughes KM, Kapur V, Gregersen PK, Behrens TW
Proc Natl Acad Sci U S A 2003 Mar 4 100(5):2610-5 [abstract on PubMed] [related articles] [request from library]
Selected by | Betty Tsao
Evaluated 21 Mar 2003
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Betty Tsao
University of California, Los Angeles, United States
IMMUNOLOGY

 New Finding
 The authors compared gene expression profiles in peripheral blood mononuclear cells (PBMCs) from 48 systemic lupus erythematosus (SLE) patients to those from 42 normal controls, and found approximately half of the studied patients exhibiting dysregulated expression of genes in the interferon (IFN) pathway. It appears that this IFN gene expression pattern may serve as a biomarker for more severe SLE.

Evaluated 21 Mar 2003
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