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Arthritis Research & Therapy publishes selected collections of research articles, conference proceedings, reviews and reports as supplements, which are free to access online. All articles published in supplements are subject to peer review; meeting abstracts undergo review and selection by the conference. Find out more about publishing a supplement with BioMed Central.

Volume 9 Supplement 3

6th Global Arthritis Research Network (GARN) Meeting

Meeting abstracts

6th Global Arthritis Research Network (GARN) Meeting

Zurich, Switzerland

10-13 May 2007

Edited by Steffen Gay and Peter E Lipsky

Conference website

IL-21 modulates cytokine levels in murine collagen-induced arthritis and contributes to disease pathology

DA Young, M Hegen, H Ma, L Napierata, J Lamothe, M Senices, L Lowe, M Collins, C Nickerson-Nutter Arthritis Research & Therapy 2007, 9(Suppl 3):P1 (19 October 2007)

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Combined anti-inflammatory tritherapy using a novel small interfering RNA lipoplex successfully prevents and cures mice of arthritis

M Khoury, V Escriou, A Galy, R Yao, C Largeau, D Scherman, C Jorgensen, F Apparailly Arthritis Research & Therapy 2007, 9(Suppl 3):P2 (19 October 2007)

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An integrative genomics strategy for the identification of collagen-induced arthritis susceptibility genes

Saleh M Ibrahim Arthritis Research & Therapy 2007, 9(Suppl 3):P3 (19 October 2007)

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Tumour necrosis factor-dependent inflammatory cartilage destruction

A Korb, B Tuerk, F Echtermeyer, T Pap, JS Smolen, K Redlich Arthritis Research & Therapy 2007, 9(Suppl 3):P4 (19 October 2007)

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Histidine deficiency does not protect against aggrecan-induced arthritis

Gyorgy Nagy, Marianna Holub, Karoly Németh, Maria Pasztoi, Mercedesz Mazan, Agnes Koncz, Andras Falus, Edit Buzas Arthritis Research & Therapy 2007, 9(Suppl 3):P5 (19 October 2007)

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Mast cells jump start K/BxN serum transfer arthritis via IL-1

PA Nigrovic, A Johnsen, BA Binstadt, PA Monach, M Gurish, Y Iwakura, D Mathis, C Benoist, DM Lee Arthritis Research & Therapy 2007, 9(Suppl 3):P6 (19 October 2007)

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Disrupting Mer receptor tyrosine kinase expression prevents autoimmune chronic graft-versus-host disease

Wen-Hai Shao, Robert A Eisenberg, Philip L Cohen Arthritis Research & Therapy 2007, 9(Suppl 3):P7 (19 October 2007)

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IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from human marginal zone B cells as well as from circulating peripheral blood B cells from autoimmune patients

Rachel Ettinger, Stefan Kuchen, Gary P Sims, Rachel Robbins, David Withers, Randy T Fischer, Peter E Lipsky Arthritis Research & Therapy 2007, 9(Suppl 3):P8 (19 October 2007)

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IL-33: a novel cytokine with proinflammatory properties

Gaby Palmer, David Moulin, Olivier Donzé, Dominique Talabot-Ayer, Cem Gabay Arthritis Research & Therapy 2007, 9(Suppl 3):P9 (19 October 2007)

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Tolerogenic dendritic cells differentially modulate naïve and memory CD4⁺T cells

Amy E Anderson, Bethan Sayers, Julie Diboll, John D Isaacs, Catharien MU Hilkens Arthritis Research & Therapy 2007, 9(Suppl 3):P10 (19 October 2007)

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Generation of dexamethasone and vitamin D3-treated human monocyte-derived dendritic cells with tolerogenic properties

Bethan Sayers, Muzlifah Haniffa, Julie Diboll, John Isaacs, Catharien Hilkens Arthritis Research & Therapy 2007, 9(Suppl 3):P11 (19 October 2007)

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Arthritis induced by systemic autoimmunity against glucose-6-phosphate isomerase in normal mice

T Kamradt, L Bruns, O Frey, L Morawietz, D Schubert, A Taubner Arthritis Research & Therapy 2007, 9(Suppl 3):P12 (19 October 2007)

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Regulation of eicosanoid production in peripheral blood mononuclear cells from patients with systemic sclerosis

Otylia Kowal-Bielecka, Krzysztof Kowal, Justyna Chwiecko, Stanislaw Sierakowski, Oliver Distler, Sylwia Chwiesko, Izabela Domyslawska, Steffen Gay Arthritis Research & Therapy 2007, 9(Suppl 3):P13 (19 October 2007)

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Characterization of immunoglobulin mutations in humans with activation-induced cytidine deaminase deficiency

Nancy S Longo, Colleen Satorius, Anne Durandy, Peter E Lipsky Arthritis Research & Therapy 2007, 9(Suppl 3):P14 (19 October 2007)

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CXCL13, CCL21 and CXCL12 are upregulated in mucosal-associated lymphoid tissue lymphomas in patients with Sjorgen's syndrome and cooperate in the maintenance of the immune response and malignant cell survival

F Barone, M Bombardieri, J Spencer, P Isaacson, F Humby, P Morgan, S Challacombe, G Valesini, C Pitzalis Arthritis Research & Therapy 2007, 9(Suppl 3):P15 (19 October 2007)

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Fine-specificity of the antibodies against citrullinated protein response is influenced by shared epitope alleles

KN Verpoort, K Cheung, A Ioan-Facsinay, AHM van der Helm-van Mil, RRP de Vries, FC Breedveld, TWJ Huizinga, GJM Pruijn, REM Toes Arthritis Research & Therapy 2007, 9(Suppl 3):P16 (19 October 2007)

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Activation of synovial fibroblasts by laminin-1 and transforming growth factor beta induces expression of stromelysins independently of TNFα, IL-1β or NF-κB

Katrin Warstat, Thomas Pap, Gerd Klein, Steffen Gay, Wilhelm K Aicher Arthritis Research & Therapy 2007, 9(Suppl 3):P17 (19 October 2007)

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Tumor necrosis factor polymorphisms in psoriatic arthritis: association with the promoter polymorphism TNF-857 independent of the PSORS1 risk allele

K Reich, U Hüffmeier, IR König, J Lascorz, J Lohmann, J Wendler, H Traupe, R Mössner, A Reis, H Burkhardt Arthritis Research & Therapy 2007, 9(Suppl 3):P18 (19 October 2007)

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Safety and diagnostic value of medical arthroscopy: retrospective analysis of 100 medical arthroscopies performed by a rheumatologist

Ved Chaturvedi Arthritis Research & Therapy 2007, 9(Suppl 3):P19 (19 October 2007)

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Investigation of the role of the p38 MAPK α and δ isoforms in nonresponse to tumour necrosis factor blockade in the synovium of rheumatoid arthritis patients

LR Coulthard, LD Church, RJ Mathews, S Churchman, L Dickie, M Buch, R Reece, A English, AW Morgan, S Gay, P Emery, MF McDermott Arthritis Research & Therapy 2007, 9(Suppl 3):P20 (19 October 2007)

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The synovial cadherin (cadherin-11) promotes intercellular motility

Hans P Kiener, Christopher S Stipp, Philip G Allen, David M Lee, Michael B Brenner Arthritis Research & Therapy 2007, 9(Suppl 3):P21 (19 October 2007)

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Cadherin-11 regulates synovial fibroblast behavior in health and disease

David M Lee, Hans P Kiener, Sandeep K Agarwal, Erika H Noss, Gerald FM Watts, Osamu Chisaka, Masatoshi Takeichi, Michael B Brenner Arthritis Research & Therapy 2007, 9(Suppl 3):P22 (19 October 2007)

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Toll-like receptor 9 agonists and IL-15 promote activation, proliferation, secretion of proinflammatory cytokines and differentiation of B cells isolated from bone marrow of rheumatoid arthritis patients

W Rudnicka, E Warnawin, T Burakowski, M Bik, E Kontny, M Chorazy-Massalska, A Radzikowska, M Buler, P Maldyk, W Maslinski Arthritis Research & Therapy 2007, 9(Suppl 3):P23 (19 October 2007)

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Class switched memory B cells are enriched in the synovium after rituximab treatment

Burkhard Möller, Istvan Vajtai, Sabine Adler, Stefan Eggli, Hans-Rudolf Ziswiler, Clemens Dahinden, Peter M Villiger Arthritis Research & Therapy 2007, 9(Suppl 3):P24 (19 October 2007)

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Evidence for the role of CD74 in innate immunity, arthritis, and the action of migration inhibitory factor

Eric Morand, Lanie Santos, Pamela Hall, Michael Hickey Arthritis Research & Therapy 2007, 9(Suppl 3):P25 (19 October 2007)

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Nitric oxide differentially regulates T-cell function in rheumatoid arthritis and systemic lupus erythematosus

Gyorgy Nagy, Joanna M Clark, Edit Buzas, Claire L Gorman, Pal Geher, Andras Perl, Andras Falus, Andrew P Cope Arthritis Research & Therapy 2007, 9(Suppl 3):P26 (19 October 2007)

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Circulating levels of IL-7 in rheumatoid arthritis

S Churchman, S Field, C Burgoyne, A Brown, P Emery, F Ponchel Arthritis Research & Therapy 2007, 9(Suppl 3):P27 (19 October 2007)

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The regulation of IL-7 production in synovial stromal cells in rheumatoid arthritis is promiscuous

S Field, E Jones, A English, C Burgoyne, S Churchman, R Reece, P Emery, F Ponchel Arthritis Research & Therapy 2007, 9(Suppl 3):P28 (19 October 2007)

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Mesenchymal stem cell repair capabilities are defective in rheumatoid arthritis in relation with in vivo exposure to inflammation

E Jones, S Field, A English, R Reece, P Emery, D McGonagle, F Ponchel Arthritis Research & Therapy 2007, 9(Suppl 3):P29 (19 October 2007)

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Diagnostic value of anticyclic citrullinated peptide antibodies in Greek patients with rheumatoid arthritis: association with extra-articular manifestations

Ioannis Alexiou, Anastasios Germenis, Athanasios Ziogas, Athanasios Koutroumbas, Katerina Theodoridou, Anastasia Kontogianni, Lazaros I Sakkas Arthritis Research & Therapy 2007, 9(Suppl 3):P30 (19 October 2007)

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Phase 1 study of TRU-015, a CD20-directed small modular immunopharmaceutical (SMIP™) protein therapeutic, in subjects with rheumatoid arthritis

DJ Burge, SA Bookbinder, AJ Kivitz, RM Fleischmann, C Shu, J Bannink, D Barone Arthritis Research & Therapy 2007, 9(Suppl 3):P31 (19 October 2007)

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TRU-015, a small modular immunopharmaceutical (SMIP™) drug candidate directed against CD20, demonstrates clinical improvement in subjects with rheumatoid arthritis

DJ Burge, C Shu, RW Martin, TW Littlejohn, DJ Wallace, J Taborn, WR Palmer, A Kivitz Arthritis Research & Therapy 2007, 9(Suppl 3):P32 (19 October 2007)

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Quantiferon-TB Gold test in screening for latent tuberculosis before and during antitumour necrosis factor treatment

J Vencovský, M Havelková, Š Forejtová, K Jarošová, I Pùtová Arthritis Research & Therapy 2007, 9(Suppl 3):P33 (19 October 2007)

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Peroxisome proliferator-activated receptor gamma 1 expression is diminished in human osteoarthritis cartilage and is downregulated by IL-1β in articular chondrocytes

H Afif, L Mfuna, J Martel-Pelletier, J-P Pelletier, H Fahmi Arthritis Research & Therapy 2007, 9(Suppl 3):P34 (19 October 2007)

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Abnormal collagen type 1 production in subchondral osteoarthritic osteoblasts is responsible in part for altered mineralization in these cells

Denis Chouchourel, Geneviève Bariteau, Aline Delalandre, Daniel Lajeunesse Arthritis Research & Therapy 2007, 9(Suppl 3):P35 (19 October 2007)

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Altered expression and production of leptin is responsible for abnormal cell markers in subchondral osteoblasts from osteoarthritic patients

Daniel Lajeunesse, Marie-Solange Mutabaruka, Mohamed Aoulab-Aissa, Aline Delalandre Arthritis Research & Therapy 2007, 9(Suppl 3):P36 (19 October 2007)

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Molecular mechanisms involved in a differential association of Frzb biology with osteoarthritis and osteoporosis

Rik JU Lories, Jan Schrooten, Inge Derese, Jenny Peeters, Astrid Bakker, Frank P Luyten Arthritis Research & Therapy 2007, 9(Suppl 3):P37 (19 October 2007)

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Matrix remodeling during enchondral ossification and aggrecan cleavage in osteoarthritic cartilage depends on syndecan-4

Frank Echtermeyer, Katja Neugebauer, Ingmar Meinecke, Christine Herzog, Rita Dreier, Thomas Pap Arthritis Research & Therapy 2007, 9(Suppl 3):P38 (19 October 2007)

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Differential Toll-like receptor-dependent collagenase expression in chondrocytes

Qian Zhang, Wang Hui, Rose Davidson, Clare Darrah, Simon T Donell, Ian M Clark, Tim E Cawston, John H Robinson, Andrew D Rowan, David A Young Arthritis Research & Therapy 2007, 9(Suppl 3):P39 (19 October 2007)

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