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Arthritis Research & Therapy publishes selected collections of research articles, conference proceedings, reviews and reports as supplements, which are free to access online. All articles published in supplements are subject to peer review; meeting abstracts undergo review and selection by the conference. Find out more about publishing a supplement with BioMed Central.

Volume 5 Supplement 3

3rd World Congress of the Global Arthritis Research Network (GARN): International Arthritis Summit

Meeting abstracts

3rd World Congress of the Global Arthritis Research Network (GARN): International Arthritis Summit

Summit Hall at Sheraton Resorts in Miyazaki, Japan

14-17 September 2003

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DNA degradation during apoptotic cell death

S Nagata Arthritis Res Ther 2003, 5(Suppl 3):1 (12 September 2003)

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Paracrine pathways of cartilage destruction in osteoarthritis

S Abramson, M Attur, M Dave, M Leung, J Patel, P Gomez, A Amin Arthritis Res Ther 2003, 5(Suppl 3):2 (12 September 2003)

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Fifty years' experience in resarch for pathogenesis of rheumatoid arthritis.

NJ Zvaifler Arthritis Res Ther 2003, 5(Suppl 3):3 (12 September 2003)

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Interferons and IRF/Stat transcription factors in the regulation of immunity, oncogenesis and bone remodeling

T Taniguchi, A Takaoka, H Takayanagi, K Honda Arthritis Res Ther 2003, 5(Suppl 3):4 (12 September 2003)

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Delineating biologic pathways involved in skeletal growth and homeostasis through the study of rare Mendelian diseases that affect bones and joints

M Warman Arthritis Res Ther 2003, 5(Suppl 3):5 (12 September 2003)

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Assessing the burden of musculoskeletal conditions: a joint World Health Organization–Bone and Joint Decade project

N Khaltaev, B Pfleger, AD Woolf, C Mathers, K Akesson, JM Hazes, D Symmons Arthritis Res Ther 2003, 5(Suppl 3):174 (12 September 2003)

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Fortieth Anniversary of APLAR

P Pispati Arthritis Res Ther 2003, 5(Suppl 3):175 (12 September 2003)

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Premise: traditional disease-modifying antirheumatic drugs are less effective and safe than targeted therapy with biologic response modifiers in rheumatoid arthritis

R Fleischmann Arthritis Res Ther 2003, 5(Suppl 3):6 (12 September 2003)

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The use of animal models to find and understand arthritis genes

R Holmdahl Arthritis Res Ther 2003, 5(Suppl 3):7 (12 September 2003)

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Synovial mast cells require C5a receptor (CD88) for arthritis induction

D Lee, M Brenner, C Gerard, C Benoist, D Mathis, G Watts Arthritis Res Ther 2003, 5(Suppl 3):8 (12 September 2003)

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Albumin-based drug delivery as novel therapeutic approach for rheumatoid arthritis

A Wunder, U Muller-Ladner, E Stelzer, E Neumann, H Sinn, S Gay, C Fiehn Arthritis Res Ther 2003, 5(Suppl 3):9 (12 September 2003)

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SKG mice, a new genetic model of rheumatoid arthritis

S Sakaguchi, T Takahashi, H Hata, T Nomura, N Sakaguchi Arthritis Res Ther 2003, 5(Suppl 3):10 (12 September 2003)

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The role of IL-17 in the development of arthritis in mouse models

Y Iwakura, S Nakae, R Horai, S Saijo Arthritis Res Ther 2003, 5(Suppl 3):11 (12 September 2003)

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Cytokine production by dendritic cells genetically engineered to express IL-4: induction of Th2 responses and differential regulation of IL-12 and IL-23 synthesis

D Fox, Y Morita, R Gupta, K Seidl, K McDonagh Arthritis Res Ther 2003, 5(Suppl 3):12 (12 September 2003)

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GRAIL: a gene related to anergy in lymphocytes

G Fathman, L Soares, N Anandasabapathy, C Seroogy Arthritis Res Ther 2003, 5(Suppl 3):13 (12 September 2003)

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Characterization of signaling complexes at the T-cell antigen receptor

L Samelson Arthritis Res Ther 2003, 5(Suppl 3):14 (12 September 2003)

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Toll-like receptor family: receptors essential for microbial recognition and immune responses

S Akira, M Yamamoto, K Takeda Arthritis Res Ther 2003, 5(Suppl 3):15 (12 September 2003)

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The actions of BAFF in B-lymphocyte maturation and its effects on the development of autoimmune disease

F Melchers Arthritis Res Ther 2003, 5(Suppl 3):16 (12 September 2003)

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Proteomic surveillance of autoimmunity in osteoarthritis

T Kato, Y Xiang, T Sekine, H Nakamura, S Imajoh-Ohmi, H Fukuda, K Nishioka Arthritis Res Ther 2003, 5(Suppl 3):17 (12 September 2003)

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Regulation of synovial cell function by adenovirus vector-mediated gene transduction

S Tanaka, H Seto, H Oda, K Nakamura Arthritis Res Ther 2003, 5(Suppl 3):18 (12 September 2003)

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Role of BH3-only protein Bim in autoimmune and degenerative diseases

P Bouillet, S Cory, J Adams, A Strasser Arthritis Res Ther 2003, 5(Suppl 3):19 (12 September 2003)

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Regulation of RANKL signaling in arthritic bone destruction

H Takayanagi Arthritis Res Ther 2003, 5(Suppl 3):20 (12 September 2003)

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Transcription mechanism of chondrogenesis

H Asahara Arthritis Res Ther 2003, 5(Suppl 3):21 (12 September 2003)

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Cellular therapies in musculoskeletal diseases: synovial-derived mesenchymal stem cells

F Luyten Arthritis Res Ther 2003, 5(Suppl 3):22 (12 September 2003)

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Role of bone morphogenetic protein signals during skeletal development

N Tsumaki, M Horiki, T Kimura, H Yoshikawa Arthritis Res Ther 2003, 5(Suppl 3):23 (12 September 2003)

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Implication of Synoviolin in pathogenesis of arthropathy

T Nakajima Arthritis Res Ther 2003, 5(Suppl 3):24 (12 September 2003)

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Cyclin kinase inhibitors and interferons in lupus

A Theofilopoulos Arthritis Res Ther 2003, 5(Suppl 3):25 (12 September 2003)

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Origins of systemic lupus erythematosus: genes, environment, and host immune response

JB Harley, JA Kelly, JA James Arthritis Res Ther 2003, 5(Suppl 3):26 (12 September 2003)

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Analysis of B-cell subpopulations in systemic lupus erythematosus

T Dorner, A Jacobi, M Odendahl, GR Burmester, A Radbruch, G Valet, PE Lipsky Arthritis Res Ther 2003, 5(Suppl 3):27 (12 September 2003)

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Antiphospholipid antibodies and thrombosis: pathogenesis of antiphospholipid syndrome

T Koike Arthritis Res Ther 2003, 5(Suppl 3):28 (12 September 2003)

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A Phase I trial of B-cell depletion with anti-CD20 monoclonal antibody (rituximab) in the treatment of systemic lupus erythematosus

R Eisenberg, D Albert, J Stansberry, D Tsai, S Kolasinski, S Khan Arthritis Res Ther 2003, 5(Suppl 3):29 (12 September 2003)

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Failure of receptor revision in the autoreactive B cells in patients with systemic lupus erythematosus

H Yoshikawa, H Nagafuchi, M Kurokawa, T Sakane, N Suzuki Arthritis Res Ther 2003, 5(Suppl 3):30 (12 September 2003)

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Chemokines in rheumatoid arthritis: novel, potential therapeutic targets of the CCR2 chemokine receptor signaling pathway

K Matsushima, Y Terashima, M Haino Arthritis Res Ther 2003, 5(Suppl 3):31 (12 September 2003)

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Effect of the combination of the proinflammatory cytokines IL-1, tumor necrosis factor-α and IL-17

P Miossec, C Granet, G Chevrel Arthritis Res Ther 2003, 5(Suppl 3):32 (12 September 2003)

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Human adipose tissue is an important novel source of IL-1Ra: a new connection between immuno-inflammatory diseases and lipid metabolism

J Dayer, C Meier Arthritis Res Ther 2003, 5(Suppl 3):33 (12 September 2003)

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IFN-β for the treatment of rheumatoid arthritis?

P Tak, J van Holten, K Reedquist, P Sattonet-Roche, T Smeets, M Vervoordeldonk, C Plater-Zyberk Arthritis Res Ther 2003, 5(Suppl 3):34 (12 September 2003)

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PPARγ ligands inhibit catabolic and inflammatory responses in articular joint cells

H Fahmi, J-P Pelletier, F Mineau, J Martel-Pelletier Arthritis Res Ther 2003, 5(Suppl 3):35 (12 September 2003)

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The role of mPGES-1 for prostaglandin E2 production in primary human synovial cells

L Crofford, M Qian, A Sampey, V Lath, S Guo, M Peters-Golden, M Goldring Arthritis Res Ther 2003, 5(Suppl 3):36 (12 September 2003)

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IL-21R mRNA is overexpressed in systemic sclerosis and contributes to the epidermal/dermal cross-talk

O Distler, J Distler, A Hirth, U Müller-Ladner, M Matucci-Cerinic, H Lorenz, S Gay Arthritis Res Ther 2003, 5(Suppl 3):37 (12 September 2003)

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Variability of pro-apoptotic properties of cyclooxygenase-2 inhibitors in rheumatoid synovial fibroblasts and cancer cell lines

S Kawai, N Kusunoki, R Yamazaki Arthritis Res Ther 2003, 5(Suppl 3):38 (12 September 2003)

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Complement, its role in innate immunity and autoimmunity

M Daha Arthritis Res Ther 2003, 5(Suppl 3):39 (12 September 2003)

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Activation of synovial fibroblasts via Toll-like receptor signaling

D Kyburz, M Pierer, J Rethage, R Seibl, RE Gay, DA Carson, S Gay Arthritis Res Ther 2003, 5(Suppl 3):40 (12 September 2003)

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TNF dependency of IL-17-induced joint pathology can be circumvented by Toll-like receptor-2 signaling

W Van den Berg, M Koenders, P van Lent, L Joosten, E Lubberts Arthritis Res Ther 2003, 5(Suppl 3):41 (12 September 2003)

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Candidate targets for antibody therapy of rheumatoid arthritis: CD64 and IL-15

J van de Winkel Arthritis Res Ther 2003, 5(Suppl 3):42 (12 September 2003)

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Mechanisms of resistance against Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts

T Pap, A Baier, I Meinecke, A Drynda, R Gay, W Neumann, S Gay Arthritis Res Ther 2003, 5(Suppl 3):43 (12 September 2003)

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Immunologic reactants in the pathogenesis of atherosclerosis in rheumatic diseases

B Cronstein, A Reiss Arthritis Res Ther 2003, 5(Suppl 3):44 (12 September 2003)

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Cell biology of synovial inflammation and secondary osteoporosis in rheumatoid arthritis

Y Tanaka, Y Okada, S Nakayamada, K Nakano, K Fujii, K Saito Arthritis Res Ther 2003, 5(Suppl 3):45 (12 September 2003)

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New strategies for the in vivo regulation of metalloprotease gene expression in osteoarthritis chondrocytes by inflammatory mediators

JP Pelletier, C Boileau, D Schrier, C Flory, J Brunet, F Mineau, G Tardif, M Boily, J Martel-Pelletier Arthritis Res Ther 2003, 5(Suppl 3):46 (12 September 2003)

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Regulation of collagenase-3 (MMP-13) gene and protein expression in human cartilage: when simple things get complicated

J Martel-Pelletier, G Tardif, JP Pelletier Arthritis Res Ther 2003, 5(Suppl 3):47 (12 September 2003)

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TIMP-3 inhibits aggrecan breakdown in pig articular cartilage stimulated with IL-1

H Nagase, C Gendron, M Kashiwagi Arthritis Res Ther 2003, 5(Suppl 3):48 (12 September 2003)

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Bone cell differentiation and the role of Fos/AP-1 proteins

E Wagner, R Eferl, A Hoebertz, L Kenner, K Matsuo Arthritis Res Ther 2003, 5(Suppl 3):49 (12 September 2003)

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Bone sparing effect of osteoprotegerin and anti-inflammatory cytokines in collagen-induced arthritis

M de Vernejoul, N Saidenberg, M Boissier, M Cohen-Solal Arthritis Res Ther 2003, 5(Suppl 3):50 (12 September 2003)

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The JAK/STAT pathway but not the Erk1/2 pathway mediates IL-6/sIL-6R downregulation of type II collagen, aggrecan core and link protein transcription in articular chondrocytes

P Bogdanowicz, F Legendre, J Dudhia, J-P Pujol Arthritis Res Ther 2003, 5(Suppl 3):51 (12 September 2003)

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Induction of heme oxygenase-1 inhibits IL-1b nitrite oxide production in articular chondrocytes

F Rannou Arthritis Res Ther 2003, 5(Suppl 3):52 (12 September 2003)

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Overexpression and induction of heat shock protein 70 protect chondrocytes from cell death in vitro and in vivo

L Grossin, C Cournil-Henrionnet, A Watrin-Pinzano, B Terlain, JY Jouzeau, P Netter, P Gillet Arthritis Res Ther 2003, 5(Suppl 3):53 (12 September 2003)

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Role of HC-gp39 in chondrogenesis: upregulation of SOX-9 expression by HC-gp39 in mouse chondrocytes

C Jacques, A Recklies, A Levy, A Labat, F Berenbaum Arthritis Res Ther 2003, 5(Suppl 3):54 (12 September 2003)

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Evidence that rosiglitazone acts as an antidegradative agent on cartilage cells in vitro

M Francois, L Tsagris, C Forest, P Richette, M Raymondjean, MT Corvol Arthritis Res Ther 2003, 5(Suppl 3):55 (12 September 2003)

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The effect of cyclooxygenase-2 selective inhibitors on the proliferation and apoptosis of human articular chondrocytes

YW Song, EB Lee, EM Park, JC Lee, YJ Lee Arthritis Res Ther 2003, 5(Suppl 3):56 (12 September 2003)

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The role of IL-4 in the control of mechanical stress-induced inflammatory mediators by rat chondrocytes

K Nishida, H Doi, A Shimizu, M Yorimitsu, M Takigawa, H Inoue Arthritis Res Ther 2003, 5(Suppl 3):57 (12 September 2003)

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TNF-alpha induced chondrocyte apoptosis in NF-κB suppression is augmented by inhibition of p38 mitogen-activated protein kinase or phosphatidylinositol 3-kinase

H Kim Arthritis Res Ther 2003, 5(Suppl 3):58 (12 September 2003)

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Cell biology and functional genomics of osteoarthritic chondrocytes

T Aigner, E Bartnik, R Zimmer Arthritis Res Ther 2003, 5(Suppl 3):59 (12 September 2003)

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CCAAT/enhancer-binding proteins mediate the repression of transcription of cartilage-derived retinoic acid-sensitive protein induced by IL-1β

K Okazaki, Y Iwamoto, L Sandell Arthritis Res Ther 2003, 5(Suppl 3):60 (12 September 2003)

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Tissue-engineered cartilage using thermoresponsive gelatin as an in situ forming and moldable scaffold with chondrocytes: in vitro and in vivo performances

S Ibusuki, T Matsuda, Y Iwamoto Arthritis Res Ther 2003, 5(Suppl 3):61 (12 September 2003)

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Cartilage-derived morphogenetic protein-1 and cartilage-derived morphogenetic protein-2 are present in ligament fibroblasts and lead to chondrogenic differentiation

K Bobacz, L Erlacher, J Smolen, W Graninger Arthritis Res Ther 2003, 5(Suppl 3):62 (12 September 2003)

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Altered phosphorylation of Syp may be responsible for abnormal insulin-like growth factor-1 signaling in human osteoarthritic osteoblasts

D Lajeunesse, F Massicotte, I Aubry, J Martel-Pelletier, J Pelletier Arthritis Res Ther 2003, 5(Suppl 3):63 (12 September 2003)

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15-deoxy-delta12,14-prostaglandin J2 induces apoptosis in human articular chondrocytes

K Masuko-Hongo, Z-Z Shang, T Kato, H Nakamura, K Nishioka Arthritis Res Ther 2003, 5(Suppl 3):64 (12 September 2003)

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Prostaglandin E2 is an enhancer for IL-1β-induced expression of membrane-associated prostaglandin E synthase in rheumatoid synovial fibroblasts

F Kojima, H Naraba, S Kawai Arthritis Res Ther 2003, 5(Suppl 3):65 (12 September 2003)

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IL-1 but not IL-18 induces osteoprotegerin and TRAIL in rheumatoid arthritis synovial fibroblasts

J Morel, R Audo, B Combe Arthritis Res Ther 2003, 5(Suppl 3):66 (12 September 2003)

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Negative regulation of the hypoxia-inducible transcription factors by IPAS defines a novel anti-angiogenesis therapeutic strategy

Y Makino, L Poellinger, H Nakamura, C Morimoto, H Tanaka Arthritis Res Ther 2003, 5(Suppl 3):67 (12 September 2003)

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Innate response cytokines in inflammatory synovitis: novel targets and strategies

I McInnes, BP Leung, JAG Gracie, D Xu, XQ Wei, J Brewer, FY Liew Arthritis Res Ther 2003, 5(Suppl 3):68 (12 September 2003)

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Role of lipoxins, antiflammins and serum amyloid A signaling via the common ALXR receptor in joint tissue inflammation

S Fiore, S Sodin-Semrl, G Antico, A Spagnolo, B Barbaro, J Varga, L Miele Arthritis Res Ther 2003, 5(Suppl 3):69 (12 September 2003)

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IL-6 as a therapeutic target in systemic-onset juvenile idiopathic arthritis

S Yokota, T Miyamae, T Imagawa, M Mori Arthritis Res Ther 2003, 5(Suppl 3):70 (12 September 2003)

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Synergistic interactions of proinflammatory cytokines with oncostatin M: implications for joint destruction

T Cawston, H Wang, C Richards, A Rowan Arthritis Res Ther 2003, 5(Suppl 3):71 (12 September 2003)

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Novel intracellular function of IL-1 receptor antagonist type 1 in endothelial cells

C Gabay, F Soussi, M Berti Arthritis Res Ther 2003, 5(Suppl 3):72 (12 September 2003)

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Unbalanced levels of bone resorption promoting factors in bone marrow from patients with rheumatoid arthritis in comparison to osteoarthritis

W Maslinski, J Jaworski, M Ziolkowska, J Kowalczewski, J Pazdur Arthritis Res Ther 2003, 5(Suppl 3):73 (12 September 2003)

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Molecular pain signalling in joints

H Sprott, H Shen, RE Gay, BA Michel, S Gay, A Aeschlimann Arthritis Res Ther 2003, 5(Suppl 3):74 (12 September 2003)

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Functional haplotypes in citrullinating enzyme peptidylarginine deiminase 4 are associated with rheumatoid arthritis

K Yamamoto, A Suzuki, X Chang, S Tokuhiro, T Sawada, Y Nakamura, R Yamada Arthritis Res Ther 2003, 5(Suppl 3):75 (12 September 2003)

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Analysis of IL-10 gene variants in rheumatoid arthritis

T Huizinga, J Schonkeren, F Kureeman, F van Gaalen, R Westendorp, FC Breedveld, R Toes Arthritis Res Ther 2003, 5(Suppl 3):76 (12 September 2003)

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OLF1/EBF-associated zinc finger protein gene: a novel lupus susceptibility locus on chromosome 16q identified in a Chinese cohort

N Shen, XB Fong, SL Chen, Y Wang, BH Hahn, BP Tsao Arthritis Res Ther 2003, 5(Suppl 3):77 (12 September 2003)

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Transcriptional co-activator CBP/p300 regulates chondrocyte-specific gene expression via association with Sox9

S Takahashi, M Tsuda, Y Takahashi, H Asahara Arthritis Res Ther 2003, 5(Suppl 3):78 (12 September 2003)

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Sox9 represses gene expression via histone deacetylase activity

M Tsuda, S Takahashi, N Taniguchi, T Furumatsu, H Asahara Arthritis Res Ther 2003, 5(Suppl 3):79 (12 September 2003)

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Novel function of GATA-3, revealed by conditional deficient mice

IC Ho, SY Pai, ML Truitt Arthritis Res Ther 2003, 5(Suppl 3):80 (12 September 2003)

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Novel tools for molecular analysis in synovium

U Mueller-Ladner, E Neumann, I Tarner, J Grifka, O Distler, A Wunder, S Gay Arthritis Res Ther 2003, 5(Suppl 3):81 (12 September 2003)

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Modulation of the gene expression pattern in peripheral blood mononuclear cells by biologicals in rheumatoid arthritis

J Kekow, D Koczan, S Drynda, A Drynda, H Thiesen Arthritis Res Ther 2003, 5(Suppl 3):82 (12 September 2003)

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The new application of chip technology to transcriptome and proteome analysis of rheumatoid disease

T Nakanishi, K Nishida, K Ohyama, M Takigawa, H Inoue Arthritis Res Ther 2003, 5(Suppl 3):83 (12 September 2003)

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Gene hunting in primary osteoarthritis

J Loughlin Arthritis Res Ther 2003, 5(Suppl 3):84 (12 September 2003)

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New approach to chemical biology for drug discovery: construction of new affinity beads and their application

H Handa Arthritis Res Ther 2003, 5(Suppl 3):85 (12 September 2003)

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Repertoire analysis of anergic B cells from patients with systemic lupus erythematosus

NS Longo, R Fischer, J Daruwalla, AC Grammer, PE Lipsky Arthritis Res Ther 2003, 5(Suppl 3):86 (12 September 2003)

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Transplant-tolerance induction by CTLA-4Ig in liver-transplanted rats: a lesson for the treatment of autoimmune diseases?

U Fischer, S Boas-Knoop, U Neumann Arthritis Res Ther 2003, 5(Suppl 3):87 (12 September 2003)

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The Th2 cytokines IL-4 and IL-10 are internal controllers of human Th1-biased immunity in vivo

A Skapenko, GU Niedobitek, JR Kalden, PE Lipsky, H Schulze-Koops Arthritis Res Ther 2003, 5(Suppl 3):88 (12 September 2003)

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Post-translational modification of type II collagen influences T-cell tolerance to self-type II collagen

H Yamada, R Holmdahl, T Shuto, Y Nakajima, J Shida, T Mawatari, Y Iwamoto Arthritis Res Ther 2003, 5(Suppl 3):89 (12 September 2003)

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Does sustained downregulation of the TCRzeta chain define the transition from antigen mode to inflammation mode in effector T lymphocytes?

A Cope, Z Zhang, J Clark, N Panesar, P Amjadi Arthritis Res Ther 2003, 5(Suppl 3):90 (12 September 2003)

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Role of β1 integrin and its signaling molecule, Cas-L, in pathophysiology and therapeutic interventigens of rheumatoid arthritis

C Morimoto Arthritis Res Ther 2003, 5(Suppl 3):91 (12 September 2003)

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Human cartilage glycoprotein-39 directed T-cell responses in health and arthritic diseases

R Toes, J Van Bilsen, L Lard, A Miltenburg, F Breedveld, T Huizinga, R De Vries Arthritis Res Ther 2003, 5(Suppl 3):92 (12 September 2003)

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IL-12 priming during initial antigen contact increases generation of effector and memory CD8 T cells by changing properties

J Chang, J-H Cho, S-Y Choi, S-J Ha, Y-C Sung Arthritis Res Ther 2003, 5(Suppl 3):93 (12 September 2003)

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Establishment of juvenile and tolerant immune systems in patients with autoimmune diseases treated with immunoablation and autologous stem cell therapy

A Radbruch, A Thiel, S Kimmig, T Alexander, E Gromnica-Ihle, F Hiepe, R Arnold Arthritis Res Ther 2003, 5(Suppl 3):94 (12 September 2003)

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The physiological immunosuppressive network and its putative role in the pathogenesis of autoimmunity: inhibition through signaling, cellular contact, anergy, apoptosis

H Lorenz, N Blank, M Kriegel, M Schiller, E Scherb, S Winkler, JR Kalden Arthritis Res Ther 2003, 5(Suppl 3):95 (12 September 2003)

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Circulating anergic B cells in the periphery of active systemic lupus erythematosus patients: functional and phenotypic characterization

A Grammer, R Fischer, R Slota, N Longo, H Sohn, C Yarboro, G Illei, S Pierce, P Lipsky Arthritis Res Ther 2003, 5(Suppl 3):96 (12 September 2003)

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Novel B-lymphocyte-deleting agents for the treatment of autoimmune diseases: induction of the mitochondrial pathway of apoptosis

G Silverman, CS Goodyear Arthritis Res Ther 2003, 5(Suppl 3):97 (12 September 2003)

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Impact of altered peptide derived from collagen II on T-cell activation and collagen-induced arthritis

Z Li, Q Zhou, Y Cheng, H Lu Arthritis Res Ther 2003, 5(Suppl 3):98 (12 September 2003)

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Multiplex autoantibody profiling using 'synovial proteome' microarrays identifies citrulline-modified peptides as major targets of the autoimmune response in rheumatoid arthritis

W Hueber, BJ Lee, M Genovese, W van Venrooij, L Steinman, PJ Utz, WH Robinson Arthritis Res Ther 2003, 5(Suppl 3):99 (12 September 2003)

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Antileukoproteinase: modulation of neutrophil function and therapeutic effects in anticollagen II antibody-induced arthritis

H Burkhardt, B Sehnert, A Cavcic, B Boehm, K Nandakumar, R Holmdahl Arthritis Res Ther 2003, 5(Suppl 3):100 (12 September 2003)

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Natural antibodies and antiphospholipid antibodies bind to injured tissues, activate complement and cause tissue damage

G Tsokos, S Fleming Arthritis Res Ther 2003, 5(Suppl 3):101 (12 September 2003)

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Search for the precursor of ectopic follicular dendritic cells

C de Groot, C de Groot, F Muller, J Haringman, P Tak Arthritis Res Ther 2003, 5(Suppl 3):102 (12 September 2003)

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Dendritic cells present a tissue-specific autoantigen under steady state and autoimmune conditions in the draining lymph node

C Scheinecker, R McHugh, E Shevach, R Germain Arthritis Res Ther 2003, 5(Suppl 3):103 (12 September 2003)

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Induction of type II collagen-reactive IL-10-producing CD11b+ dendritic cells in Payer's patch of orally tolerized animals

H Kim, M So-Youn, C Mi-La, L Jung-Eun, P Sung-Hwan, L Kang-Eun, P Kyung-Soo Arthritis Res Ther 2003, 5(Suppl 3):104 (12 September 2003)

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Immunosuppressive effect of mesenchymal stem cells in collagen-induced arthritis

C Jorgensen, F Djaoud, F Apparilly, J Sany, D Noel Arthritis Res Ther 2003, 5(Suppl 3):105 (12 September 2003)

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Immunosuppression and immunological tolerance induction: lessons from a transplant model

A Filatenkov, S Tullius, H Schmidt, A Selke, H Volk Arthritis Res Ther 2003, 5(Suppl 3):106 (12 September 2003)

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Antigen-specific suppression of inflammatory arthritis by dendritic cells

R Thomas, E Martin, B O'Sullivan Arthritis Res Ther 2003, 5(Suppl 3):107 (12 September 2003)

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Cell death and immune regulation: in vivo application of a novel agonistic monoclonal antibody for death receptor Fas

S Yonehara Arthritis Res Ther 2003, 5(Suppl 3):108 (12 September 2003)

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C5a controls the FcγR activation in inflammatory processes

R Schmidt Arthritis Res Ther 2003, 5(Suppl 3):109 (12 September 2003)

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Cas-L associates with human T-lymphotropic virus type I Tax and regulates its transactivation of NF-κB: possible role of Cas-L in pathophysiology of rheumatoid arthritis

S Iwata, A Souta-Kuribara, R Miyake-Nishijima, T Sasaki, H Kobayashi, H Tanaka, C Morimoto Arthritis Res Ther 2003, 5(Suppl 3):110 (12 September 2003)

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The impact of exogenous and endogenous nucleic acids on the development of joint inflammation

A Tarkowski, J Bjersing, M Bokarewa, LV Collins, GM Deng, S Hajizadeh, F Zare Arthritis Res Ther 2003, 5(Suppl 3):111 (12 September 2003)

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Serum activity of joint destruction proteinases in management of juvenile rheumatoid arthritis

E Yarygina, A Bogatyreva, S Zhanaeva, M Soboleva, T Korolenko Arthritis Res Ther 2003, 5(Suppl 3):112 (12 September 2003)

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Comparison of the nodule and synovial lesions of rheumatoid arthritis

J Highton, P Hessian Arthritis Res Ther 2003, 5(Suppl 3):113 (12 September 2003)

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Collagenous colitis and rheumatoid arthritis: is there a connection?

F Wollheim, A Domargård, J Bohr, C Tysk, T Skogh Arthritis Res Ther 2003, 5(Suppl 3):114 (12 September 2003)

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Evidence for functional variation of the death receptor 3 gene predisposing rheumatoid arthritis

S Shiozawa, K Komai, K Osaka, Y Miura, A Hashiramoto, K Shiozawa Arthritis Res Ther 2003, 5(Suppl 3):115 (12 September 2003)

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Lymphoid neogenesis in chronic inflammation

C Pitzalis, A Manzo, S Paoletti, F Barone, R Caporali, CM Montecucco, M Uguccioni Arthritis Res Ther 2003, 5(Suppl 3):116 (12 September 2003)

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T-cell regulation in the pathogenesis of autoimmune diseases

H Schulze-Koops, PE Lipsky, JR Kalden, A Skapenko Arthritis Res Ther 2003, 5(Suppl 3):117 (12 September 2003)

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Autoantibodies in very early rheumatoid arthritis: diagnostic tools or pathogenic players?

G Steiner, V Nell, G Eberl, S Hayer, K Machold, E Hoefler, J Smolen Arthritis Res Ther 2003, 5(Suppl 3):118 (12 September 2003)

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Expression of IgVH mRNAs in plasma cells derived from rheumatoid arthritis synovium detected by single-cell RT-PCR

J Vencovský, Z Cimburek, J Niederlová, O Horvath, O Kryštùfková, T Dörner, Š Rùzicková Arthritis Res Ther 2003, 5(Suppl 3):119 (12 September 2003)

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T cell contact-mediated induction of tumor necrosis factor alpha in peripheral blood monocytes is inhibited by autologous serum in rheumatoid arthritis

U Wagner, M Rossol, S Kaltenhäuser, S Hauschild, H Häntzschel Arthritis Res Ther 2003, 5(Suppl 3):120 (12 September 2003)

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The declining incidence of nonsteroidal anti-inflammatory drug gastropathy in rheumatoid arthritis patients: rates and reasons

J Fries, K Murtaugh, M Bennett, E Zatarain, B Lingala, B Bruce Arthritis Res Ther 2003, 5(Suppl 3):121 (12 September 2003)

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Significance of fatigue in patients with rheumatoid arthritis

G Singh, M Bennett, B Lingala, A Singh Arthritis Res Ther 2003, 5(Suppl 3):122 (12 September 2003)

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Skewed T-cell receptor BV14 and BV16 expression, and shared complementarity-determining region 3 sequence and common sequence motifs in synovial T cells of rheumatoid arthritis

W Sun, H Nie, N Li, Y Zang, D Zhang, G Feng, L Ni, R Xu, E Sercarz, JZ Zhang Arthritis Res Ther 2003, 5(Suppl 3):123 (12 September 2003)

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Changes in the synovial cell proteome induced by hypoxia

H El-Gabalawy, J Wilkins, K Dasuri, D Duggan Arthritis Res Ther 2003, 5(Suppl 3):124 (12 September 2003)

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CD44 regulates bone erosion and osteoclastogenesis in arthritis

G Schett, S Hayer, K Redlich, EF Wagner, G Kollias, G Steiner, JS Smolen Arthritis Res Ther 2003, 5(Suppl 3):125 (12 September 2003)

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Repair of local bone erosions by combined treatment with parathyroid hormone, osteoprotegerin and anti-tumor necrosis factor in tumor necrosis factor-transgenic mice

K Redlich, B Goertz, N Doerr, G Kollias, G Steiner, J Smolen, G Schett Arthritis Res Ther 2003, 5(Suppl 3):126 (12 September 2003)

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Essential role for migration inhibitory factor in IL-1 activation of mitogen-activated protein kinases

E Morand, D Lacey, Y Yang, M Leech, M Toh Arthritis Res Ther 2003, 5(Suppl 3):127 (12 September 2003)

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Regulatory T cells in experimental arthritis

R Bräuer, O Frey, PK Petrow, A Scheffold, A Radbruch Arthritis Res Ther 2003, 5(Suppl 3):128 (12 September 2003)

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Antirheumatic effects of humanized anti-Fas monoclonal antibody in human rheumatoid arthritis/SCID mouse chimera

H Matsuno, K Yudoh, K Nishioka Arthritis Res Ther 2003, 5(Suppl 3):129 (12 September 2003)

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TNF-alpha blockade by nonviral gene therapy in collagen-induced arthritis

MC Boissier, C Bloquel, P Bigey, V Deleuze, D Scherman, N Bessis Arthritis Res Ther 2003, 5(Suppl 3):130 (12 September 2003)

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Therapeutic inhibition of tumour necrosis factor alpha reduces oligoclonality in the selected T-cell receptor BV families in rheumatoid arthritis

M Pierer, U Wagner, S Kaltenhäuser, S Arnold, H Häntzschel Arthritis Res Ther 2003, 5(Suppl 3):131 (12 September 2003)

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Pathogenic roles of IL-6 and IL-6 blocking therapy on rheumatoid arthritis

K Yoshizaki, N Nishimoto, N Miyasaka, K Yamamoto, S Kawai, T Takeuchi, T Kishimoto Arthritis Res Ther 2003, 5(Suppl 3):132 (12 September 2003)

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Repeated B-cell depletion with rituximab in rheumatoid arthritis

J Edwards, M Leandro Arthritis Res Ther 2003, 5(Suppl 3):133 (12 September 2003)

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Gene transfer of p21Cip1 exerts multiple molecular effects in the treatment of arthritis

H Kohsaka, Y Nonomura, K Nagasaka, N Miyasaka Arthritis Res Ther 2003, 5(Suppl 3):134 (12 September 2003)

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The innate immune system as a therapeutic target in arthritis

M Corr, JY Choe, K Pekny Arthritis Res Ther 2003, 5(Suppl 3):135 (12 September 2003)

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Soluble 4A11 antigen: a novel mediator of leukocyte-endothelial adhesion and monocyte recruitment in rheumatoid arthritis

A Koch, K Zhu, M Amin, Y Zha, M Kim, C Park, H Ruth, H Castro-Rueda, C Haas Arthritis Res Ther 2003, 5(Suppl 3):136 (12 September 2003)

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Galectin-3 and galectin-3 binding protein in rheumatoid arthritis

S Ohshima, S Kuchen, C Seemayer, FT Liu, M Neidhart, RE Gay, S Gay Arthritis Res Ther 2003, 5(Suppl 3):137 (12 September 2003)

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Enumeration and phenotypic characterization of synovial fluid multipotential mesenchymal progenitor cells in inflammatory and degenerative arthritis

D McGonagle, E Jones, A English, P Emery Arthritis Res Ther 2003, 5(Suppl 3):138 (12 September 2003)

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IL-15 and its role in rheumatoid arthritis

M Kurowska-Stolarska, O Distler, W Rudnicka, J Distler, RE Gay, W Maslinski, S Gay Arthritis Res Ther 2003, 5(Suppl 3):139 (12 September 2003)

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Floating anchorage-independent fibroblast-like cells mediate cartilage destruction independently from the hyperplastic synovial tissue

M Neidhart, CA Seemayer, BA Michel, RE Gay, S Gay Arthritis Res Ther 2003, 5(Suppl 3):140 (12 September 2003)

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Pathogenetic roles of Synoviolin in synovial hyperplasia of rheumatoid arthritis

S Yamasaki, N Yagishita, T Amano, K Tsuchimochi, I Maruyama, K Nishioka, T Nakajima Arthritis Res Ther 2003, 5(Suppl 3):141 (12 September 2003)

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Transcriptional regulation of Synoviolin is important for the proliferation of rhumatoid synovial cells

K Tsuchimochi, S Yamasaki, N Yagishita, T Amano, S Komiya, I Maruyama, K Nishioka, T Nakajima Arthritis Res Ther 2003, 5(Suppl 3):142 (12 September 2003)

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The importance of Synoviolin in embryogenesis

N Yagishita, T Amano, S Yamasaki, T Tsuchimochi, K Nishioka, I Maruyama, A Fukamizu, T Nakajima Arthritis Res Ther 2003, 5(Suppl 3):143 (12 September 2003)

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Synoviolin as a novel pathogenic factor for arthropathy

T Amano, S Yamasaki, N Yagishita, K Tsuchimochi, A Fukamizu, I Maruyama, K Nishioka, T Nakajima Arthritis Res Ther 2003, 5(Suppl 3):144 (12 September 2003)

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Laminin, but not lipopolysaccharide, IL-1 or tumor necrosis factor alpha, induces IL-16 gene activity in synovial fibroblasts

W Aicher, D Alexander, T Pap, S Gay Arthritis Res Ther 2003, 5(Suppl 3):145 (12 September 2003)

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Triptolide, an active compound identified in a traditional Chinese herb, induces apoptosis of rheumatoid synovial fibroblasts

N Kusunoki, R Yamazaki, S Kawai Arthritis Res Ther 2003, 5(Suppl 3):146 (12 September 2003)

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The fibrinolytic pattern of rheumatoid synoviocytes is invasive like neoplastic cells

M Matucci-Cerinic, S Guiducci, A Del Rosso, M Cinelli, G Fibbi, M Del Rosso Arthritis Res Ther 2003, 5(Suppl 3):147 (12 September 2003)

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The synovial cadherin (cadherin-11) mediates tissue formation and promotes invasion of fibroblast-like synoviocytes

H Kiener, J Higgins, X Valencia, M Brenner Arthritis Res Ther 2003, 5(Suppl 3):148 (12 September 2003)

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Antiphospholipid antibodies harness innate effectors, neutrophils and an alternative pathway of complement, to induce fetal damage

J Salmon, G Girardi, J Berman, J Thurman, VM Holers Arthritis Res Ther 2003, 5(Suppl 3):149 (12 September 2003)

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The systemic lupus erythematosus VλJλ repertoire harbors characteristics of the natural antibody repertoire

J Lee, PE Lipsky Arthritis Res Ther 2003, 5(Suppl 3):150 (12 September 2003)

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Enhanced proliferative response of CD4+ T cells from patients with systemic lupus erythematosus by T-cell receptor stimulation

S Park, I Kang, H Kim, J Craft Arthritis Res Ther 2003, 5(Suppl 3):151 (12 September 2003)

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Evidence for an IFN-inducible gene, Ifi202, in the susceptibility to systemic lupus

S Rozzo, D Choubey, T Vyse, S Izui, J Allard, G Peltz, B Kotzin Arthritis Res Ther 2003, 5(Suppl 3):152 (12 September 2003)

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IgM and C1q function in the same pathway to promote the clearance of apoptotic cells in vivo

K Elkon, R Kowaleski, V Montenegro, SJ Kim Arthritis Res Ther 2003, 5(Suppl 3):153 (12 September 2003)

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New aspects of the etiopathogenesis of systemic lupus erythematosus

US Gaipl, TD Beyer, RE Voll, S Franz, JR Kalden, M Herrmann Arthritis Res Ther 2003, 5(Suppl 3):154 (12 September 2003)

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C-reactive protein is an important immunoregulatory molecule that decreases systemic inflammatory response and ameliorates autoimmune disease

T Du Clos Arthritis Res Ther 2003, 5(Suppl 3):155 (12 September 2003)

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Infliximab for severe ocular inflammation in patients with Behcet's disease

P Sfikakis, N Markomichelakis Arthritis Res Ther 2003, 5(Suppl 3):156 (12 September 2003)

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Identification of kinectin as a novel Behcet's disease-related autoantigen

Y Lu, P Ye, X Feng, S Chen, EM Tan, EKL Chan Arthritis Res Ther 2003, 5(Suppl 3):157 (12 September 2003)

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Expanded circulating transitional B cells in a patient with systemic lupus erythematosus

R Ettinger, GP Sims, E Tackey, C Yarboro, G Illei, PE Lipsky Arthritis Res Ther 2003, 5(Suppl 3):158 (12 September 2003)

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Immunological abnormality and regulation in patients with Sjögren's syndrome

T Sumida Arthritis Res Ther 2003, 5(Suppl 3):159 (12 September 2003)

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Humoral, hormonal and genetic determinants of cholinergic dysfunction in Sjögren's syndrome

M Rischmueller Arthritis Res Ther 2003, 5(Suppl 3):160 (12 September 2003)

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Apoptosis, loss of B-cell tolerance and lymphoid neogenesis in Sjögren's syndrome

R Jonsson Arthritis Res Ther 2003, 5(Suppl 3):161 (12 September 2003)

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Hepatocyte growth factor in osteoarthritis: when bone and cartilage decide to have a chat

P Reboul, M Guévremont, J Martel-Pelletier, F Massicotte, P Ranger, JP Pelletier, D Lajeunesse Arthritis Res Ther 2003, 5(Suppl 3):162 (12 September 2003)

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Potentiality of mesenchymal stem cells with ex vivo gene therapy for osteochondral defect in arthritis

H Inoue, N Abe, J Lieberman Arthritis Res Ther 2003, 5(Suppl 3):163 (12 September 2003)

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Oxidative stress induces chondrocyte telomere instability and chondrocyte dysfunctions in osteoarthritis

K Yudoh, N van Trieu, H Matsuno, K Nishioka Arthritis Res Ther 2003, 5(Suppl 3):164 (12 September 2003)

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Expression of focal adhesion kinase, Akt/PKB, Elk-1 and p90RSK in rheumatoid arthritis tissues but not at sites of cartilage invasion

CA Seemayer, S Kuchen, P Kuenzler, V Rihosková, J Schedel, M Neidhart, BA Michel, RE Gay, S Gay Arthritis Res Ther 2003, 5(Suppl 3):165 (12 September 2003)

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T cell–chondrocyte interaction in the pathogenesis of osteoarthritis

H Nakamura, T Kato, K Masuko-Hongo, M Tanaka, A Shibakawa, K Nishioka Arthritis Res Ther 2003, 5(Suppl 3):166 (12 September 2003)

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Pentosidine in serum and synovial fluid in patients with knee osteoarthritis and its potential role of prediction of osteoarthritis progression

K Pavelka, L Senolt, V Vilim, P Spacek, M Braun, S Forejtova Arthritis Res Ther 2003, 5(Suppl 3):167 (12 September 2003)

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Exercise: medicine for knee cartilage?

L Dahlberg, E Roos, J Svensson, P Leander, CJ Tiderius Arthritis Res Ther 2003, 5(Suppl 3):168 (12 September 2003)

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Structural and functional changes in the brains of fibromyalgia subjects evaluated with single photon emission computed spectrometry and magnetic resonance imaging

K Pile, L Barnden, S Behin-Ain, L Yelland, D Danda, R Casse, R Kwiatek Arthritis Res Ther 2003, 5(Suppl 3):169 (12 September 2003)

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Clinical feature of fibromyalgia syndrome in Japan and novel strategy in the treatment by bioproduct (Neurotropin)

H Nakamura, K Hoshi, T Kato, S Ozaki, M Nishioka, K Nishioka Arthritis Res Ther 2003, 5(Suppl 3):170 (12 September 2003)

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From clinical pharmacology to clinical rheumatology: bench to bedside

P Pispati Arthritis Res Ther 2003, 5(Suppl 3):171 (12 September 2003)

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Celecoxib: a selective cyclooxygenase-2 inhibitor

M Gandelman Arthritis Res Ther 2003, 5(Suppl 3):172 (12 September 2003)

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Bioethics and research: scientific autonomy versus social responsibility. Should we lead or be led?

A Rubinow Arthritis Res Ther 2003, 5(Suppl 3):173 (12 September 2003)

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