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Arthritis Research & Therapy publishes selected collections of research articles, conference proceedings, reviews and reports as supplements, which are free to access online. All articles published in supplements are subject to peer review; meeting abstracts undergo review and selection by the conference. Find out more about publishing a supplement with BioMed Central.

Volume 14 Supplement 3

Lupus 2012: New targets, new approaches

Meeting abstracts

Lupus 2012: New targets, new approaches

Whistler, Canada

27-30 September 2012

Edited by Peter E Lipsky, John M Esdaile, Matthew H Liang and Paul R Fortin

Meeting abstract   Free

Epigenetics and lupus

B Richardson Arthritis Research & Therapy 2012, 14(Suppl 3):A1 (27 September 2012)

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Meeting abstract   Free

Follicular helper T Cells and the B cells they help

A Poholek, J-Y Choi, S Hernandez, J Weinstein, S Kim, V Bunin, J Odegard, L DiPlacido, J Craft Arthritis Research & Therapy 2012, 14(Suppl 3):A2 (27 September 2012)

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Meeting abstract   Free

Longitudinal analysis of mRNA transcripts and plasma proteins to define a biomarker associated with lupus disease activity

M Olferiev, W-T Huang, KA Kirou, E Gkrouzman, D Lundsgaard, KS Frederiksen, J Fleckner, MK Crow Arthritis Research & Therapy 2012, 14(Suppl 3):A3 (27 September 2012)

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Meeting abstract   Free

New therapies

David Wofsy Arthritis Research & Therapy 2012, 14(Suppl 3):A4 (27 September 2012)

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Meeting abstract   Free

MicroRNA-3148 modulates differential gene expression of the SLE-associated TLR7 variant

Y Deng, J Zhao, D Sakurai, KM Kaufman, JC Edberg, RP Kimberly, DL Kamen, GS Gilkeson, CO Jacob, RH Scofield, CD Langefeld, JA Kelly, ME Alarcón-Riquelme, BIOLUPUS and GENLES Networks, JB Harley, TJ Vyse, BI Freedman, PM Gaffney, KM Sivils, JA James, TB Niewold, RM Cantor, W Chen, BH Hahn, EE Brown, PROFILE, BP Tsao Arthritis Research & Therapy 2012, 14(Suppl 3):A5 (27 September 2012)

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Meeting abstract   Free

Differential DNA methylation associated with anti-dsDNA autoantibody production in systemic lupus erythematosus

SA Chung, J French, KE Taylor, E Elboudwarej, HL Quach, LF Barcellos, LA Criswell Arthritis Research & Therapy 2012, 14(Suppl 3):A6 (27 September 2012)

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Meeting abstract   Free

Area-level socioeconomic status and variation in medication use among Medicaid enrollees with incident systemic lupus erythematosus, 2000 to 2004

CH Feldman, LT Hiraki, J Lui, GS Alarcón, MA Fischer, J Yazdany, KH Costenbader Arthritis Research & Therapy 2012, 14(Suppl 3):A7 (27 September 2012)

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Meeting abstract   Free

SLE risk alleles and cell development and activation

SJ Kim, N Manjarrez Orduno, PK Gregersen, B Diamond Arthritis Research & Therapy 2012, 14(Suppl 3):A8 (27 September 2012)

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Meeting abstract   Free

Genetic-epigenetic interaction in lupus

AH Sawalha Arthritis Research & Therapy 2012, 14(Suppl 3):A9 (27 September 2012)

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Meeting abstract   Free

Serum chemokine levels predict flares of disease activity in two independent systemic lupus erythematosus cohorts

H Bilgic, T Koeuth, J Wilson, M Petri, E Baechler Gillespie Arthritis Research & Therapy 2012, 14(Suppl 3):A10 (27 September 2012)

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Meeting abstract   Free

Major congenital anomalies in children born to women with systemic lupus erythematosus

E Vinet, CA Pineau, AE Clarke, M Kaouache, C Gordon, R Platt, S Bernatsky Arthritis Research & Therapy 2012, 14(Suppl 3):A11 (27 September 2012)

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Meeting abstract   Free

Contemporary estimates of the risk of end-stage renal disease in the first decade of proliferative lupus nephritis

MM Ward, M Tektonidou Arthritis Research & Therapy 2012, 14(Suppl 3):A12 (27 September 2012)

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Meeting abstract   Free

Impact of systemic lupus erythematosus organ damage on unemployment or disability from a population-based cohort

SS Lim, M Agan, CM Drenkard Arthritis Research & Therapy 2012, 14(Suppl 3):A13 (27 September 2012)

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Meeting abstract   Free

Population-based study of preventable infections in hospitalized patients with systemic lupus erythematosus

CE Barber, C Barnabe, D Marshall, J Esdaile Arthritis Research & Therapy 2012, 14(Suppl 3):A14 (27 September 2012)

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Meeting abstract   Free

Lung cancer in systemic lupus erythematosus

M Kale, R Ramsey-Goldman, S Bernatsky, MB Urowitz, D Gladman, PR Fortin, M Petri, E Yelin, S Manzi, S Edworthy, O Nived, S-C Bae, D Isenberg, A Rahman, JG Hanly, C Gordon, S Jacobsen, E Ginzler, DJ Wallace, GS Alarcón, MA Dooley, L Gottesman, K Steinsson, A Zoma, J-L Senécal, S Barr, G Sturfelt, L Dreyer, L Criswell, J Sibley, JL Lee, AE Clarke et al. Arthritis Research & Therapy 2012, 14(Suppl 3):A15 (27 September 2012)

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Meeting abstract   Free

Lymphoma risk in systemic lupus: effects of treatment versus disease activity

AE Clarke, S Bernatsky, KH Costenbader, MB Urowitz, DD Gladman, PR Fortin, M Petri, S Manzi, DA Isenberg, A Rahman, D Wallace, C Gordon, C Peschken, MA Dooley, EM Ginzler, C Aranow, SM Edworthy, O Nived, S Jacobsen, G Ruiz-Irastorza, E Yelin, SG Barr, L Criswell, G Sturfelt, L Dreyer, I Blanco, L Gottesman, CH Feldman, R Ramsey-Goldman Arthritis Research & Therapy 2012, 14(Suppl 3):A16 (27 September 2012)

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Meeting abstract   Free

Usual source of care and geographic region are largest predictors of healthcare quality for incident lupus nephritis in US Medicaid recipients

J Yazdany, C Feldman, J Liu, MM Ward, MA Fischer, KH Costenbader Arthritis Research & Therapy 2012, 14(Suppl 3):A17 (27 September 2012)

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Meeting abstract   Free

Neuropsychiatric events in SLE: determination of attribution and assessment of outcome

JG Hanly, Systemic Lupus International Collaborating Clinics Arthritis Research & Therapy 2012, 14(Suppl 3):A18 (27 September 2012)

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Meeting abstract   Free

Seafood consumption and persistent organic pollutants as triggers of autoimmunity among Gullah African Americans

DL Kamen, MM Peden-Adams, JE Vena, GS Gilkeson, TC Hulsey, L Moultrie, BE Stevens Arthritis Research & Therapy 2012, 14(Suppl 3):A19 (27 September 2012)

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Meeting abstract   Free

Rising prevalence of systemic autoimmune rheumatic disease: increased awareness, increased disease or increased survival?

CA Peschken, CA Hitchon Arthritis Research & Therapy 2012, 14(Suppl 3):A20 (27 September 2012)

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Meeting abstract   Free

Soluble E-selectin may predict progression of subclinical atherosclerosis, as measured by coronary artery calcium score and aorta calcium score, in women with systemic lupus erythematosus

A Lertratanakul, P Wu, A Dyer, W Pearce, G Kondos, D Edmundowicz, J Carr, R Ramsey-Goldman Arthritis Research & Therapy 2012, 14(Suppl 3):A21 (27 September 2012)

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Meeting abstract   Free

Serum α-chlorofatty acid as a biomarker for baseline subclinical cardiovascular disease in systemic lupus erythematosus

MA Mahieu, C Guild, CJ Albert, G Kondos, J Carr, D Edmundowicz, DA Ford, R Ramsey-Goldman Arthritis Research & Therapy 2012, 14(Suppl 3):A22 (27 September 2012)

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Meeting abstract   Free

Differing environmental risk factors for membranous versus proliferative lupus nephritis

MA Dooley, CG Parks, GS Cooper Arthritis Research & Therapy 2012, 14(Suppl 3):A23 (27 September 2012)

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B cells at the adaptive-innate immune system interface in SLE

JH Anolik, A Palanichamy, J Bauer, J Barnard, J Biear, R Dedrick, I Sanz, J Liesveld, E Baechler Arthritis Research & Therapy 2012, 14(Suppl 3):A24 (27 September 2012)

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Meeting abstract   Free

In situ cognate interactions between T-follicular helper cells and B cells characterize severe tubulointerstitial inflammation in human lupus nephritis

MR Clark, M Giger, Y Jiang, V Liarski Arthritis Research & Therapy 2012, 14(Suppl 3):A25 (27 September 2012)

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SLE patients and autoantibody-positive healthy individuals display unique cytokine profiles: shared features of inflammation as well as select features of immunosuppression in autoantibody-positive healthy individuals

LL Ritterhouse, HT Maecker, CG Fathman, JT Merrill, JM Guthridge, JA James Arthritis Research & Therapy 2012, 14(Suppl 3):A26 (27 September 2012)

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Meeting abstract   Free

Regulatory natural autoantibodies suppress inflammation and SLE disease activity

GJ Silverman, J Vas, C Grönwall Arthritis Research & Therapy 2012, 14(Suppl 3):A27 (27 September 2012)

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Genetic polymorphisms leading to altered T-cell and dendritic cell function cooperate to produce expansion of proinflammatory T-cell subsets in NZB c1 congenic mice

N Talaei, C Landolt-Marticorena, B Noamani, E Pau, N-H Chang, JE Wither Arthritis Research & Therapy 2012, 14(Suppl 3):A28 (27 September 2012)

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Meeting abstract   Free

Abstract withdrawn

Arthritis Research & Therapy 2012, 14(Suppl 3):A29 (27 September 2012)

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Meeting abstract   Free

Dysregulation of the serine/threonine phosphatase PP2A contributes to autoimmunity

JC Crispín Arthritis Research & Therapy 2012, 14(Suppl 3):A30 (27 September 2012)

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Spontaneous aggregation of the anti-viral MAVS protein in systemic lupus erythematosus: a possible cause of excessive type I interferon production

PL Cohen, B Hilliard, W-H Shao Arthritis Research & Therapy 2012, 14(Suppl 3):A31 (27 September 2012)

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Meeting abstract   Free

IRF5 expression profiling in SLE patients: new leads to a pathogenic signature?

BJ Barnes, RC Stone, P Du, D Feng Arthritis Research & Therapy 2012, 14(Suppl 3):A32 (27 September 2012)

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Meeting abstract   Free

Role of MIF gene polymorphisms in systemic lupus erythematosus and prospects for therapeutic intervention

R Bucala Arthritis Research & Therapy 2012, 14(Suppl 3):A33 (27 September 2012)

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Interplay of neutrophils and type I interferons in the development of end-organ damage in SLE

MJ Kaplan Arthritis Research & Therapy 2012, 14(Suppl 3):A34 (27 September 2012)

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Metabolic control of systemic lupus erythematosus: convergence of genetic and environmental factors on mitochondrial dysfunction and mTOR reveal treatment targets in lupus

A Perl Arthritis Research & Therapy 2012, 14(Suppl 3):A35 (27 September 2012)

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Meeting abstract   Free

Microparticles as autoantigens in human and murine lupus

A Ullal, DS Pisetsky Arthritis Research & Therapy 2012, 14(Suppl 3):A36 (27 September 2012)

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Innate sensors for nucleic acids and lupus pathogenesis

AN Theofilopoulos, R Gonzalez-Quintial, Y-T Koh, R Baccala, DH Kono Arthritis Research & Therapy 2012, 14(Suppl 3):A37 (27 September 2012)

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Meeting abstract   Free

Evaluating the B-cell C3d:CR2 innate-adaptive immune interaction as a therapeutic target in lupus

VM Holers, JM Thurman, JP Hannan, L Kulik Arthritis Research & Therapy 2012, 14(Suppl 3):A38 (27 September 2012)

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Meeting abstract   Free

PROMISSE: progress in understanding pregnancy complications in patients with SLE

JE Salmon Arthritis Research & Therapy 2012, 14(Suppl 3):A39 (27 September 2012)

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Complement deficiencies and susceptibility to systemic lupus erythematosus revisited

KB Elkon, DM Santer, A Wiedeman Arthritis Research & Therapy 2012, 14(Suppl 3):A40 (27 September 2012)

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Connecting the molecular dots from inaccessible antigen to organ injury in the pathogenesis of cardiac manifestations of neonatal lupus

JP Buyon Arthritis Research & Therapy 2012, 14(Suppl 3):A41 (27 September 2012)

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Meeting abstract   Free

MicroRNAs in innate immune responses and autoimmune diseases

EKL Chan Arthritis Research & Therapy 2012, 14(Suppl 3):A42 (27 September 2012)

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Meeting abstract   Free

Skin-antigen specific antibodies are detected in UV irradiation and TLR7 agonist induced lupus-like disease in autoimmune prone NOD mice and in pediatric SLE

M Ghoreishi, L Tucker, JP Dutz Arthritis Research & Therapy 2012, 14(Suppl 3):A43 (27 September 2012)

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Meeting abstract   Free

SLE: insights from array-based proteomics

T Wu, Y Du, L Davis, C Mohan Arthritis Research & Therapy 2012, 14(Suppl 3):A44 (27 September 2012)

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Meeting abstract   Free

Renal flare as a biomarker of incident and progressive chronic kidney disease in patients with lupus nephritis

S Parikh, A McKinley, BH Rovin Arthritis Research & Therapy 2012, 14(Suppl 3):A45 (27 September 2012)

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Meeting abstract   Free

Cytokine profiles of lupus patients with or without nephritis

BH Rovin, H Song, CL Hines, X Zhang Arthritis Research & Therapy 2012, 14(Suppl 3):A46 (27 September 2012)

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Meeting abstract   Free

Which lupus trial endpoints best reflect clinical judgment or biomarker improvement?

A Thanou, M Munroe, S Kamp, F Carthen, JA James, JT Merrill Arthritis Research & Therapy 2012, 14(Suppl 3):A47 (27 September 2012)

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Meeting abstract   Free

'MiLES' population-based survey of the incidence and prevalence of systemic lupus erythematosus in Southeastern Michigan

EC Somers, W Marder, P Cagnoli, EE Lewis, P DeGuire, C Gordon, CG Helmick, L Wang, JJ Wing, JP Dhar, J Liesen, WJ McCune, MiLES Group Arthritis Research & Therapy 2012, 14(Suppl 3):A48 (27 September 2012)

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Meeting abstract   Free

Sociodemographic characteristics of SLE patients in a large metropolitan area with a high Afro-Caribbean population

J Cabas-Vargas, NM Patel, J Cohen, EM Ginzler Arthritis Research & Therapy 2012, 14(Suppl 3):A49 (27 September 2012)

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Meeting abstract   Free

High score on PREDICTS is associated with 10-fold increased odds for the progression of subclinical atherosclerosis in SLE

M McMahon, Lori Sahakian, J Grossman, B Skaggs, J Fitzgerald, C Charles-Schoeman, N Ragavendra, A Gorn, G Karpouzas, M Weisman, D Wallace, B Hahn Arthritis Research & Therapy 2012, 14(Suppl 3):A50 (27 September 2012)

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Meeting abstract   Free

Thinking toward improved treatments of systemic lupus erythematosus

BH Hahn, J Grossman, B Skaggs, E Lourenco, M Wong Arthritis Research & Therapy 2012, 14(Suppl 3):A51 (27 September 2012)

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Meeting abstract   Free

Hopkins Lupus Cohort: assessment of treatment effects

M Petri Arthritis Research & Therapy 2012, 14(Suppl 3):A52 (27 September 2012)

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Meeting abstract   Free

Risk of pulmonary embolism and deep vein thrombosis in systemic lupus erythematosus: a population-based cohort study

JA Aviña-Zubieta, D Lacaille, EC Sayre, J Kopec, HK Choi, JM Esdaile Arthritis Research & Therapy 2012, 14(Suppl 3):A53 (27 September 2012)

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Meeting abstract   Free

Poor methodological reporting in lupus clinical trials found in Cochrane reviews

CH Goldsmith Arthritis Research & Therapy 2012, 14(Suppl 3):A54 (27 September 2012)

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Meeting abstract   Free

Development validation and reliability of the Systemic Lupus Erythematosus Disease Activity Index 2000 Responder Index-50

Z Touma, DD Gladman, MB Urowitz Arthritis Research & Therapy 2012, 14(Suppl 3):A55 (27 September 2012)

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Meeting abstract   Free

Clinical and immunological response to pneumococcal vaccination in pediatric systemic lupus erythematosus

D Rigdon, AC Gotte, MG Punaro, TB Wright Arthritis Research & Therapy 2012, 14(Suppl 3):A56 (27 September 2012)

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Meeting abstract   Free

Role of anti-Ro autoantibodies in systemic lupus erythematosus patients with recurrent myositis

S Umer, S Hayat, G Caldito, SM Berney Arthritis Research & Therapy 2012, 14(Suppl 3):A57 (27 September 2012)

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Meeting abstract   Free

Variation in renal biopsy and medication prescribing practices among pediatric Medicaid patients with lupus nephritis prior to end-stage renal disease in the US, 2000 to 2004

LT Hiraki, CH Feldman, J Liu, GS Alarcón, MA Fischer, WC Winkelmayer, KH Costenbader Arthritis Research & Therapy 2012, 14(Suppl 3):A58 (27 September 2012)

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Meeting abstract   Free

Hospitalizations in patients with systemic lupus erythematosus: updated analyses from 2006 to 2011

K Chan, A Dekis, AE Clarke, CA Pineau, E Vinet, E Nashi, S Bernatsky Arthritis Research & Therapy 2012, 14(Suppl 3):A59 (27 September 2012)

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Meeting abstract   Free

B-cell receptor signaling studies in patients with lupus: preliminary results

M Faludi, A Mao, E Vinet, A Clarke, C Pineau, S Bernatsky, E Nashi Arthritis Research & Therapy 2012, 14(Suppl 3):A60 (27 September 2012)

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Meeting abstract   Free

Lupus cardiomyopathy: a reversible form of left ventricular dysfunction

ML Ishimori, M Agarwal, RK Ng, LD Nugent, DJ Wallace, RJ Siegel, MH Weisman Arthritis Research & Therapy 2012, 14(Suppl 3):A61 (27 September 2012)

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Meeting abstract   Free

Prevalence of angina in patients with systemic lupus erythematosus

ML Ishimori, NJ Gal, A Rogatko, DS Berman, A Wilson, DJ Wallace, NB Merz, MH Weisman Arthritis Research & Therapy 2012, 14(Suppl 3):A62 (27 September 2012)

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Meeting abstract   Free

Functional genetic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients

MA Jensen, KC Patterson, AA Kumar, M Kumabe, BS Franek, TB Niewold Arthritis Research & Therapy 2012, 14(Suppl 3):A63 (27 September 2012)

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Meeting abstract   Free

Nonlymphoma hematological malignancies in systemic lupus erythematosus

M Lu, R Ramsey-Goldman, S Bernatsky, M Petri, S Manzi, MB Urowitz, D Gladman, PR Fortin, E Ginzler, E Yelin, S-C Bae, DJ Wallace, S Jacobsen, MA Dooley, CA Peschken, GS Alarcón, O Nived, L Gottesman, L Criswell, G Sturfelt, L Dreyer, JL Lee, AE Clarke Arthritis Research & Therapy 2012, 14(Suppl 3):A64 (27 September 2012)

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