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Arthritis Research & Therapy publishes selected collections of research articles, conference proceedings, reviews and reports as supplements, which are free to access online. All articles published in supplements are subject to peer review; meeting abstracts undergo review and selection by the conference. Find out more about publishing a supplement with BioMed Central.

Volume 14 Supplement 1

Proceedings of the 8th Global Arthritis Research Network (GARN) Meeting and 1st Bio-Rheumatology International Congress (BRIC)

Meeting abstracts

8th Global Arthritis Research Network (GARN) Meeting and 1st Bio-Rheumatology International Congress (BRIC)

Tokyo, Japan

14-16 November 2011

Additional Information

Oral presentation   Free

Future direction of pathogenesis and treatment for rheumatic disorders

Steffen Gay Arthritis Research & Therapy 2012, 14(Suppl 1):O1 (9 February 2012)

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From rheumatic diseases to cancer - role of autoantibodies as diagnostic biomarkers

Eng M Tan Arthritis Research & Therapy 2012, 14(Suppl 1):O2 (9 February 2012)

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Etiology and molecular pathogenesis of RA; how can we best use European initiatives to advance our knowledge?

Lars Klareskog Arthritis Research & Therapy 2012, 14(Suppl 1):O3 (9 February 2012)

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Clinically isolated syndrome in collagen diseases; approaches and treatments

Kazumasa Yokoyama, Nobutaka Hattori Arthritis Research & Therapy 2012, 14(Suppl 1):O4 (9 February 2012)

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Research platform for fibromyalgia in Japan

Kusuki Nishioka Arthritis Research & Therapy 2012, 14(Suppl 1):O5 (9 February 2012)

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Recent advances in understanding of various chronic pain mechanisms through lysophosphatidic acid (LPA) receptor signaling

Hiroshi Ueda Arthritis Research & Therapy 2012, 14(Suppl 1):O6 (9 February 2012)

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The role of mRNA degradation in immunity and inflammation

Shizuo Akira Arthritis Research & Therapy 2012, 14(Suppl 1):O7 (9 February 2012)

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Death receptor-induced apoptosis signalling - essential guardian against autoimmune disease

Andreas Strasser, Lorraine A O'Reilly, Philipp Jost, Thomas Kaufmann, Stephanie Grabow, Elizabeth Kruse, Lin Tai, Mark Smyth, Philippe Bouillet Arthritis Research & Therapy 2012, 14(Suppl 1):O8 (9 February 2012)

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Cancer immunotherapy; integration of T cell biology with nanogel- and vector-technology in translational research

Hiroshi Shiku Arthritis Research & Therapy 2012, 14(Suppl 1):O9 (9 February 2012)

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Autoimmune arthritis caused by altered thymic T-cell selection due to a mutation of the ZAP-70 gene

Yoshinaga Ito, Shimon Sakaguchi Arthritis Research & Therapy 2012, 14(Suppl 1):O10 (9 February 2012)

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Anti-Fas IgM monoclonal antibody (anti-Fas mAb) effect on haemophilic arthropathy (HA) synoviocytes

Serena Guiducci, Eloisa Romano, Claudia Ceccarelli, Daniela Melchiorre, Mirko Manetti, Anna F Milia, Lidia Manneshi, Kusuki Nishioka, Marco Cerinic Arthritis Research & Therapy 2012, 14(Suppl 1):O11 (9 February 2012)

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Overview of osteoimmunology: What's happened? And what's going on?

Hiroshi Takayanagi Arthritis Research & Therapy 2012, 14(Suppl 1):O12 (9 February 2012)

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Regulation of bone mass at unloaded condition by osteocyte network

Toshihisa Komori Arthritis Research & Therapy 2012, 14(Suppl 1):O13 (9 February 2012)

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Assessment of histological alterations in cartilage and extracellular matrix driven by collagen-induced arthritis in Macaca fascicularis

Norio Amizuka, Hiromi Hongo, Muneteru Sasaki, Tomoka Hasegawa, Paulo de Freitas, Hiroshi Mori, Minqi Li Arthritis Research & Therapy 2012, 14(Suppl 1):O14 (9 February 2012)

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Evidence for synovial fibroblasts spreading rheumatoid arthritis

Ulf Müller-Ladner, Stefanie Lefèvre, Birgit Zimmermann, Ingo H Tarner, Robert Dinser, Thomas Pap, Steffen Gay, Elena Neumann Arthritis Research & Therapy 2012, 14(Suppl 1):O15 (9 February 2012)

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Skeletal involvement in the pathogenesis and outcomes of rheumatoid arthritis and osteoarthritis

Jean-Pierre Pelletier Arthritis Research & Therapy 2012, 14(Suppl 1):O16 (9 February 2012)

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Fcγ receptor targeting in RA

Toshiyuki Takai, Akira Nakamura, Akiko Tobinai, Shota Endo, Masanori Inui Arthritis Research & Therapy 2012, 14(Suppl 1):O17 (9 February 2012)

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Therapeutic targets for rheumatoid arthritis: lessons from animal models

Yoichiro Iwakura, Shinobu Saijo, Susumu Nakae, Noriyuki Fujikado, Harumichi Ishigame, Masanori Murayama Arthritis Research & Therapy 2012, 14(Suppl 1):O18 (9 February 2012)

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Abnormal osteogenesis in osteoarthritis: gone with the Wnt?

Daniel Lajeunesse, Thomas F Chan, Aline Delalandre, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Élie Abed Arthritis Research & Therapy 2012, 14(Suppl 1):O19 (9 February 2012)

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Understanding the role of Fas-Fas ligand system in bone

Ana Marusic, Natasa Kovacic, Ivan Lukic, Vedran Katavic, Danka Grcevic Arthritis Research & Therapy 2012, 14(Suppl 1):O20 (9 February 2012)

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Regulation of inflammatory immune responses leading to the development of bone destructive autoimmune disease rheumatoid arthritis by IL-27

Takayuki Yoshimoto, Mingli Xu, Izuru Mizuguchi, Yukino Chiba, Sadahiro Kamiya, Masanori Matsui, Shiva Shahrara, Junichiro Mizuguchi Arthritis Research & Therapy 2012, 14(Suppl 1):O21 (9 February 2012)

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Postnatal Syk deletion in mice clarifies the function of Syk in an anti-collagen antibody-induced arthritis model

Naoko Ozaki, Shinobu Suzuki, Hiromitsu Hara, Hiroki Yoshida Arthritis Research & Therapy 2012, 14(Suppl 1):O22 (9 February 2012)

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Synoviolin meets metabolic disorders

Naoko Yagishita, Satoko Aratani, Daisuke Hasegawa, Yoshihisa Yamano, Kusuki Nishioka, Toshihiro Nakajima Arthritis Research & Therapy 2012, 14(Suppl 1):O23 (9 February 2012)

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IL-17, synoviolin and rheumatoid arthritis chronicity

Pierre Miossec Arthritis Research & Therapy 2012, 14(Suppl 1):O24 (9 February 2012)

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Implication of microRNA-140 in osteoarthritis

Johanne Martel-Pelletier Arthritis Research & Therapy 2012, 14(Suppl 1):O25 (9 February 2012)

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Osteoclastic bone resorption directly activates osteoblast function

Nobuyuki Udagawa Arthritis Research & Therapy 2012, 14(Suppl 1):O26 (9 February 2012)

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Directed induction of chondrogenic cells from mouse dermal fibroblast culture

Noriyuki Tsumaki Arthritis Research & Therapy 2012, 14(Suppl 1):O27 (9 February 2012)

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A systems approach reveals that the musculoskeletal tissues development and homeostasis network

Hiroshi Asahara Arthritis Research & Therapy 2012, 14(Suppl 1):O28 (9 February 2012)

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Angiogenesis in rheumatoid arthritis: the role of fut 1

Alisa Koch Arthritis Research & Therapy 2012, 14(Suppl 1):O29 (9 February 2012)

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Citrullination of fibrinogen: generation of neoepitopes and enhancement of immunostimulatory properties

William H Robinson, Jeremy Sokolove Arthritis Research & Therapy 2012, 14(Suppl 1):O30 (9 February 2012)

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Novel regulatory T cells controlling antibody production and systemic autoimmunity

Kazuhiko Yamamoto, Tomohisa Okamura, Keishi Fujio Arthritis Research & Therapy 2012, 14(Suppl 1):O31 (9 February 2012)

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Innate and adaptive immune responses to dead and dying cells

Keith B Elkon, Yueng Peng Arthritis Research & Therapy 2012, 14(Suppl 1):O32 (9 February 2012)

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From discovery of RANKL to clinical application of anti-human RANKL antibody

Hisataka Yasuda, Yuriko Furuya, Kohji Uchida Arthritis Research & Therapy 2012, 14(Suppl 1):O33 (9 February 2012)

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Microparticles as antigenic targets in human and murine SLE

Anirudh Ullal, David S Pisetsky Arthritis Research & Therapy 2012, 14(Suppl 1):O34 (9 February 2012)

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New mechanisms of action and signaling by TNF-α

Lionel B Ivashkiv Arthritis Research & Therapy 2012, 14(Suppl 1):O35 (9 February 2012)

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Synovial fibroblasts display an uncontrolled inflammatory and tissue destructive response to TNF-α

George D Kalliolias, Janice Chen, Galina Grigoriev, Lionel B Ivashkiv Arthritis Research & Therapy 2012, 14(Suppl 1):O36 (9 February 2012)

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Interleukin-6 as a therapeutic target in locomotor disorders

Norihiro Nishimoto, Miho Murakami, Takaji Matsutani, Jun Hashimoto, Nobuhiro Takagi Arthritis Research & Therapy 2012, 14(Suppl 1):O37 (9 February 2012)

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Signal transduction inhibitors for the treatment of rheumatoid arthritis

Yoshiya Tanaka, Kunihiro Yamaoka Arthritis Research & Therapy 2012, 14(Suppl 1):O38 (9 February 2012)

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Adult stem cell-based therapy for degenerative joint diseases

Peter G Alexander, Rocky S Tuan Arthritis Research & Therapy 2012, 14(Suppl 1):O39 (9 February 2012)

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Peptide therapy in sepsis and inflammation: a novel strategy to suppress inflammation

Hidechika Okada, Alan Okada Arthritis Research & Therapy 2012, 14(Suppl 1):O40 (9 February 2012)

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Overview of biotherapy in rheumatoid arthritis (RA)

Tsutomu Takeuchi, Hideto Kameda Arthritis Research & Therapy 2012, 14(Suppl 1):O41 (9 February 2012)

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Anti-TNF antibody therapy induces IL-17 suppressing regulatory T cells in patients with rheumatoid arthritis

Jenny McGovern, Clare A Notley, Dao Nguyen, Claudia Mauri, David A Isenberg, Michael R Ehrenstein Arthritis Research & Therapy 2012, 14(Suppl 1):O42 (9 February 2012)

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Combined effects of the hedgehog pathway inhibitor LDE225 and nilotinib in a random mutagenesis screen

Tetsuzo Tauchi Arthritis Research & Therapy 2012, 14(Suppl 1):O43 (9 February 2012)

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Molecular mechanism of unloading-mediated muscle atrophy and development of its countermeasures

Takeshi Nikawa Arthritis Research & Therapy 2012, 14(Suppl 1):O44 (9 February 2012)

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Regulation of immune cell responses by semaphorins and their receptors

Atsushi Kumanogoh, Hyota Takamatsu Arthritis Research & Therapy 2012, 14(Suppl 1):O45 (9 February 2012)

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A novel NEDD8-binding protein modulates NF-κB signaling pathway

Osamu Takashima, Fuminori Tsuruta, Manato Ebina, Yu Kigoshi, Shingo Nakamura, Tomoki Chiba Arthritis Research & Therapy 2012, 14(Suppl 1):O46 (9 February 2012)

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Reconstruction of injured spinal cord by epigenetic regulation of transplanted neural stem cells

Masahiko Abematsu, Keita Tsujimura, Mariko Yamano, Michiko Saito, Kenji Kohno, Takao Setoguchi, Kazunori Yone, Kinichi Nakashima, Setsuro Komiya Arthritis Research & Therapy 2012, 14(Suppl 1):P1 (9 February 2012)

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Fukushimura Brain Bank (FBB) -Based in a private geriatric hospital-

Hiroyasu Akatsu, Akira Hori, Hidechika Okada, Yoshio Hashizume, Takayuki Yamamoto Arthritis Research & Therapy 2012, 14(Suppl 1):P2 (9 February 2012)

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IL-17-producing ©™T cells are important for the development of arthritis in a rheumatoid arthritis model

Aoi Akitsu, Harumichi Ishigame, Shigeru Kakuta, Shinobu Saijo, Yoichiro Iwakura Arthritis Research & Therapy 2012, 14(Suppl 1):P3 (9 February 2012)

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Osteoporosis in Iraqi patients with thalassemia

Salim M AL Jadir, Mohamed Z Jalal, Median F AL Ghreer, Mozahem S AL Hamdani, Wamid R AL Omaree Arthritis Research & Therapy 2012, 14(Suppl 1):P4 (9 February 2012)

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A novel role for monosodium urate monohydrate crystals and gouty synovial fluids in monocyte migration in gout

M Asif Amin, Qiang Shu, Jonathon W Vargo, Jeffrey H Ruth, Takeo Isozaki, Solhee Lee, Alisa E Koch Arthritis Research & Therapy 2012, 14(Suppl 1):P5 (9 February 2012)

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Intermittent cold stress-induced experimental fibromyalgia model in mice - pharmacology and neurobiology

Kohei Araki, Michiko Nishiyori, Hiroshi Ueda Arthritis Research & Therapy 2012, 14(Suppl 1):P6 (9 February 2012)

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Frequency of appearance of anemias at rheumatoid arthritis - a disease of autoimmune genesis (on the data of retrospective study)

Abdumalik N Aripov, Marif SH Karimov, Aida A Eshmurzaeva Arthritis Research & Therapy 2012, 14(Suppl 1):P7 (9 February 2012)

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The bacterial effector protein YopM reduces rheumatoid arthritis (RA) outcome by inhibiting inflammation and bone destruction

J Bertrand, C Rueter, C Cromme, J Scharnert, A Schmidt, T Pap Arthritis Research & Therapy 2012, 14(Suppl 1):P8 (9 February 2012)

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PTEN in antigen presenting cells is a master regulator for Th17-mediated autoimmune pathology

Stephan Blüml, Gernot Schabbauer, Eva Hainzl, Birgit Niederreiter, Anastasia Hladik, Tobias Lohmeyer, Michael Bonelli, Elisabeth Zinser, Marije Koenders, Wim van den Berg, Giulio Superti-Furga, Josef S Smolen, Kurt Redlich Arthritis Research & Therapy 2012, 14(Suppl 1):P9 (9 February 2012)

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Acute Serum Amyloid A induces cell migration cytoskeletal rearrangement and Notch signalling in rheumatoid arthritis

Mary Connolly, Peadar Rooney, Wei Gao, Douglas Veale, Ursula Fearon Arthritis Research & Therapy 2012, 14(Suppl 1):P10 (9 February 2012)

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Cigarette smoke downregulates HDAC2 in rheumatoid arthritis synovial fibroblasts

Anna Engler, Astrid Jüngel, Christoph Kolling, Beat A Michel, Renate Gay, Steffen Gay, Caroline Ospelt Arthritis Research & Therapy 2012, 14(Suppl 1):P11 (9 February 2012)

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Egr-1 mediates the suppressive effect of IL-1 on PPARg expression in human OA chondrocytes

Sarah S Nebbaki, Fatima El Mansouri, Mohamed Benderdour, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Hassan Fahmi Arthritis Research & Therapy 2012, 14(Suppl 1):P12 (9 February 2012)

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Prevalence of interstitial lung disease among patients with systemic sclerosis in Iraqi Kurdistan

Taha Qaradakhy, Kosar Ali, Omer Karim Arthritis Research & Therapy 2012, 14(Suppl 1):P13 (9 February 2012)

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MiRs in RA: possible biomarkers and therapeutic targets

Maria Filkova, Caroline Ospelt, Joanna Stanczyk, Serena Vettori, Ladislav Senolt, Mojca Frank, Christoph Kolling, Beat A Michel, Renate E Gay, Steffen Gay, Astrid Jüngel Arthritis Research & Therapy 2012, 14(Suppl 1):P14 (9 February 2012)

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Immune cell - derived microparticles contribute to the resistance of rheumatoid arthritis synovial fibroblasts to death receptor-mediated apoptosis

Mojca Frank, Meike Dahlhaus, Maria Filkova, Christoph Kolling, Beat A Michel, Diego Kyburz, Blaž Rozman, Renate E Gay, David Pisetsky, Steffen Gay, Astrid Jüngel Arthritis Research & Therapy 2012, 14(Suppl 1):P15 (9 February 2012)

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Increased concentration of serum soluble LAG3 in systemic lupus erythematosus

Seri Yu, Keishi Fujio, Kazuyoshi Ishigaki, Hirofumi Shoda, Tomohisa Okamura, Tanita Noor, Shuji Sumitomo, Kazuhiko Yamamoto Arthritis Research & Therapy 2012, 14(Suppl 1):P16 (9 February 2012)

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GCIP, Id like HLH protein, negatively regulates cell proliferation of rheumatoid synovial cells via interaction with CBP

Hidetoshi Fujita, Minako Nakazawa, Satoko Aratani, Kusuki Nishioka, Akiyoshi Fukamizu, Toshihiro Nakajima Arthritis Research & Therapy 2012, 14(Suppl 1):P17 (9 February 2012)

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Unc93 homolog B1 restricts systemic lethal inflammation by orchestrating TLR7 and TLR9 response

Ryutaro Fukui, Shin-Ichiroh Saitoh, Atsuo Kanno, Masahiro Onji, Takuma Shibata, Akihiko Ito, Morikazu Onji, Mitsuru Matsumoto, Shizuo Akira, Nobuaki Yoshida, Kensuke Miyake Arthritis Research & Therapy 2012, 14(Suppl 1):P18 (9 February 2012)

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Balb/c FasKO mice develop allergic blepharitis associated with hyper-production of IgE

Ayumi Fukuoka, Shizue Yumikura-Futatsugi, Suzuka Takahashi, Hirotaka Kazama, Kenji Nakanishi, Shin Yonehara Arthritis Research & Therapy 2012, 14(Suppl 1):P19 (9 February 2012)

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Stimulation of bone formation in cortical bone of the mice treated with a novel bone anabolic peptide with osteoclastogenesis inhibitory activity

Yuriko Furuya, Kohji Uchida, Hisataka Yasuda Arthritis Research & Therapy 2012, 14(Suppl 1):P20 (9 February 2012)

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T-regs/Th17 function defect in systemic autoimmunity as a result of "recent thymic emigrants" maturation defect

Mark Goloviznin, Natalia Lakhonina, Alexander Yarilin, Yulia Buldakova, Vitaly Timofeev, Tatiana Kremenchugskaya, Marina Struchkova Arthritis Research & Therapy 2012, 14(Suppl 1):P21 (9 February 2012)

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Dendritic cell immunoreceptor (DCIR) is associated with anti-cyclic citrullinated peptides (anti-CCP) antibody - negative rheumatoid arthritis in Chinese Han population

Jianping Guo, Xinyu Wu, Xiaolan Lu, Yin Su, Ru Li, Jing He, Xu Liu, Zhanguo Li Arthritis Research & Therapy 2012, 14(Suppl 1):P22 (9 February 2012)

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Association between serum level of Vitamin D with autoantibodies expression, disease activity (SLEDAI) and bone mineral density (BMD) in patients with Systemic Lupus Erythematosus (SLE)

Handono Kalim, Singgih Wahono, Putra BP, Lenny Puspitasari, Fajar Wijayanto, Kusworini Handono Arthritis Research & Therapy 2012, 14(Suppl 1):P23 (9 February 2012)

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Uncoupling protein 3 attenuates generation of reactive oxygen species by interacting with thioredoxin 2 in the mitochondrial intermembrane space

Katsuya Hirasaka, Edward M Mills, Shohei Kohno, Tomoki Abe, Chika Ikeda, Tasuku Maeda, Shigetada Kondo, Ayako Maita, Yuushi Okumura, Takeshi Nikawa Arthritis Research & Therapy 2012, 14(Suppl 1):P24 (9 February 2012)

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Conditional inactivation of the ectodomain shedding of pro-TNFα in monocytes prevents lethality from LPS-induced septic shock

Keisuke Horiuchi, Tokuhiro Kimura, Yasunori Okada, Kazuhiro Chiba, Carl P Blobel, Yoshiaki Toyama Arthritis Research & Therapy 2012, 14(Suppl 1):P25 (9 February 2012)

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Community-based epidemiological study on hyperuricemia and gout over 5 years in Huang-pu district, Shanghai

Hui Du, Shun-Le Chen, Chun-De Bao, Xiao-Dong Wang, Yuan Wang, Yue-Ying Gu, Kusuki Nishioka Arthritis Research & Therapy 2012, 14(Suppl 1):P26 (9 February 2012)

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Adrenal function in rheumatoid arthritis: a correlation with disease activity

Richard Imrich, Miroslav Vlcek, Jana Kerlik, Michael Vogeser, Fabian Kirchhoff, Adela Penesova, Zofia Radikova, Jozef Lukac, Jozef Rovensky Arthritis Research & Therapy 2012, 14(Suppl 1):P27 (9 February 2012)

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Rheumatoid arthritis fibroblast-like synoviocytes show the upregulation of myeloid cell specific transcription factor PU.1 and B cell specific transcriptional co-activator OBF-1, and express functional BCMA

Kenji Itoh, Katsuya Nagatani Arthritis Research & Therapy 2012, 14(Suppl 1):P28 (9 February 2012)

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Methyl glyoxal increase apoptosis (CASPASE-3 expression) in pre-osteoblast MC3T3E1 cell line via SOD activity

Izaak Akbar, Handono Kalim, Djoko Soeatmadji, Mohammad Hidayat Arthritis Research & Therapy 2012, 14(Suppl 1):P29 (9 February 2012)

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Discrepancy between patient and physician in assessment of global severity in early rheumatoid arthritis

Yuko Kaneko, Masataka Kuwana, Tsutomu Takeuchi Arthritis Research & Therapy 2012, 14(Suppl 1):P30 (9 February 2012)

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Cartilage-specific deletion of prar-gamma in mice results in early endochondral ossification defects and accelerated aging-dependent development of osteoarthritis

Roxana Monemdjou, Faezeh Vasheghani, Hassan Fahmi, Gemma Perez, Meryem Blati, Noboru Taniguchi, Martin Lotz, René St-Arnaud, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Frank Beier, Mohit Kapoor Arthritis Research & Therapy 2012, 14(Suppl 1):P31 (9 February 2012)

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Average findings of uric acid in blood in patients with gout with different categories of hyperglycemia

Ulugbek K Kayumov, Marif Karimov, Nargiza A Abdukhakimova Arthritis Research & Therapy 2012, 14(Suppl 1):P32 (9 February 2012)

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Effect of B cell depletion using peptide tetramers in collagen-induced arthritis

Kazuya Michishita, Kimito Kawahata, Takeyuki Kanzaki, Lisa Akahira, Toshiki Eri, Kazuhiko Yamamoto Arthritis Research & Therapy 2012, 14(Suppl 1):P33 (9 February 2012)

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Peripheral tolerance induced by apoptotic cells and PD-1+ CD8 T cells

Hirotaka Kazama, Tomonori Iyoda, Satoko Yokoyama, Kayo Inaba, Thomas A Ferguson, Shin Yonehara Arthritis Research & Therapy 2012, 14(Suppl 1):P34 (9 February 2012)

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Decreased plating efficiency, proliferation and osteogenic differentiation of synovial fluid mesenchymal progenitors as a marker of severity of juvenile idiopathic arthritis

Elvira Mosler, Marija Jelusic-Drazic, Danka Grcevic, Ana Marusic, Natasa Kovacic Arthritis Research & Therapy 2012, 14(Suppl 1):P35 (9 February 2012)

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LC-MS/MS-based shotgun proteomics identified the targets of arthritis-related microRNA

Riho Kurata, Tomo Yonezawa, Hideki Nakajima, Shyuji Takada, Hiroshi Asahara Arthritis Research & Therapy 2012, 14(Suppl 1):P36 (9 February 2012)

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T cell receptor rearrangement excision circles (TREC) study as an approach to "in vivo" thymus gland function investigation

Natalia Lakhonina, Mark Goloviznin, Almira Donetskova, Margarita Nikonova, Alexander Yarilin, Yulia Buldakova, Anna Tektova Arthritis Research & Therapy 2012, 14(Suppl 1):P37 (9 February 2012)

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Fas deficiency attenuates bone loss during antigen induced arthritis in mice

Elvira Mosler, Sania Kuzmac, Sanja Ivcevic, Danka Grcevic, Ana Marusic, Natasa Kovacic Arthritis Research & Therapy 2012, 14(Suppl 1):P38 (9 February 2012)

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Abnormal expressions of immune response-related genes in RA bone marrow cells

Hooi-Ming Lee, Chieko Aoki, Yasunori Shimaoka, Kensuke Ochi, Takahiro Ochi, Norihiro Nishimoto Arthritis Research & Therapy 2012, 14(Suppl 1):P39 (9 February 2012)

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Risk factors for latent tuberculosis infection in RA patients treated with anti-tumor necrosis factor

Shiang-Fen Huang, Wei-Juin Su, Sheng-Yuan Ruan, Chong-Jen Yu, Song-Chou Hsieh, Yu-Chih Liu, Yeong-Jian Wu, Hsiao-Yi Lin Arthritis Research & Therapy 2012, 14(Suppl 1):P40 (9 February 2012)

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TGF-β signaling induces SnoN to suppress BMP-induced hypertrophic maturation of chondrocytes

Shingo Maeda, Ichiro Kawamura, Yasuhiro Ishidou, Katsuyuki Imamura, Masahiro Yokouchi, Setsuro Komiya Arthritis Research & Therapy 2012, 14(Suppl 1):P41 (9 February 2012)

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Activation of TRPV4 promotes osteoclasts differentiation

Ritsuko Masuyama Arthritis Research & Therapy 2012, 14(Suppl 1):P42 (9 February 2012)

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STAT3 is critical to promote inflammatory cytokines and RANKL expression in inflammatory arthritis

Takeshi Miyamoto, Tomoaki Mori, Akihiko Yoshimura, Toshiaki Toyama Arthritis Research & Therapy 2012, 14(Suppl 1):P43 (9 February 2012)

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Combined depletion of interleukin-1 and interleukin-6 does not exceed single depletion of interleukin -1 in TNF-mediated arthritis

Silvia Hayer, B Niederreiter, J Smolen, K Redlich Arthritis Research & Therapy 2012, 14(Suppl 1):P44 (9 February 2012)

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The functions of the post-translational modifications in rheumatoid arthritis

Satoko Aratani, Naoko Yagishita, Teruhisa Kanazawa, Fukami Nakajima, Yoshihisa Yamano, Kusuki Nishioka, Toshihiro Nakajima Arthritis Research & Therapy 2012, 14(Suppl 1):P45 (9 February 2012)

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Neutrophils are the source of IL-17 and RANKL in zymosan induced arthritis

Viktoriya I Milanova, Nina D Ivanovska, Petya A Dimitrova Arthritis Research & Therapy 2012, 14(Suppl 1):P46 (9 February 2012)

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Role of HLA-antigens class 1 in the development of rheumatoid arthritis in Uzbek women

Nazima N Mirakhmedova, Mavlyuda I Mirzakhanova Arthritis Research & Therapy 2012, 14(Suppl 1):P47 (9 February 2012)

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SNP algorithms for prediction of efficacy and adverse events of abatacept (ABT)

James E Middleton, Tsukasa Matsubara, Keiko Funahashi, Satoru Koyano, Takafumi Hagiwara, Takako Miura, Kosuke Okuda, Takeshi Nakamura, Mitsuyoshi Iwahashi, Tomomi Tsuru, Shoichi Uchimura, Shigeru Honjo Arthritis Research & Therapy 2012, 14(Suppl 1):P48 (9 February 2012)

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Maintenance of mitochondrial DNA copy number is essential for osteoclast survival

Tsuyoshi Miyazaki, Shuuichi Mori, Kazuhiro Shigemoto, Nils-Goran Larsson, Takeshi Nakamura, Shigekaki Kato, Tomoki Nakashima, Hiroshi Takayanagi, Sakae Tanaka Arthritis Research & Therapy 2012, 14(Suppl 1):P49 (9 February 2012)

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Over expression of toll-like receptors in peripheral blood and synovial fluid monocytes of enthesitis related arthritis category of juvenile idiopathic arthritis (JIA-ERA) patients contributes to secretion of inflammatory mediators

Arpita Myles, Amita Aggarwal Arthritis Research & Therapy 2012, 14(Suppl 1):P50 (9 February 2012)

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Pilocarpine suppresses hyperalgesia induced by intermittent cold stress (ICS) as an experimental fibromyalgia model in mice

Jun Nagai, Michiko Nishiyori, Hiroshi Ueda Arthritis Research & Therapy 2012, 14(Suppl 1):P51 (9 February 2012)

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Application of tetraspanin CD81 RNAi for diagnosis and therapy of rheumatoid arthritis (RA)

Tohru Nakanishi, Yuji Arai, Hiroki Mori, Toshihiro Nakajima, Toshikazu Kubo Arthritis Research & Therapy 2012, 14(Suppl 1):P52 (9 February 2012)

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The crucial role of osteocyte-derived RANKL in bone homeostasis

Tomoki Nakashima, Mikihito Hayashi, Hiroshi Takayanagi Arthritis Research & Therapy 2012, 14(Suppl 1):P53 (9 February 2012)

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Active repression by Blimp1 play an important role in osteoclast differentiation

Keizo Nishikawa, Tomoki Nakashima, Mikihito Hayashi, Takanobu Fukunaga, Shigeaki Kato, Tatsuhiko Kodama, Satoru Takahashi, Kathryn Calame, Hiroshi Takayanagi Arthritis Research & Therapy 2012, 14(Suppl 1):P54 (9 February 2012)

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Smoking induces expression of ligands of the immune receptor NKG2D

Caroline Ospelt, Giovanni G Camici, Fabia Brentano, Peter Künzler, Christoph Kolling, Renate E Gay, Beat A Michel, Steffen Gay Arthritis Research & Therapy 2012, 14(Suppl 1):P58 (9 February 2012)

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Association of microRNA-221/222 and -323-3p with rheumatoid arthritis via predictions using the human TNF transgenic mouse model

Ioannis Pandis, Caroline Ospelt, Niki Karagianni, Maria Denis, Martin Reczko, Carme Camps, Artemis Hatzigeorgiou, Jiannis Ragoussis, Steffen Gay, George Kollias Arthritis Research & Therapy 2012, 14(Suppl 1):P59 (9 February 2012)

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Methotrexate alone and methotrexate combined with etanercept in treatment of rheumatoid arthritis

Sylejman Rexhepi, Mjellma Rexhepi, Blerta Rexhepi, Vjollca Sahatçiu-Meka, Vigan Mahmutaj Arthritis Research & Therapy 2012, 14(Suppl 1):P60 (9 February 2012)

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SPACIA1/SAAL1: a newly identified gene associated with aberrant proliferation of synovial fibroblasts

Tomoo Sato, Ryoji Fujii, Koji Konomi, Naoko Yagishita, Satoko Aratani, Natsumi Araya, Hiroyuki Aono, Kazuo Yudoh, Noboru Suzuki, Moroe Beppu, Yoshihisa Yamano, Kusuki Nishioka, Toshihiro Nakajima Arthritis Research & Therapy 2012, 14(Suppl 1):P61 (9 February 2012)

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Two cases of multiple-drug-resistant adult-onset Still's disease treated successfully with tocilizumab - the relationship between interleukin 6 and 18

Kojiro Sato, Akinori Yamamoto, Yoshihiro Yoshida, Toshihide Mimura Arthritis Research & Therapy 2012, 14(Suppl 1):P62 (9 February 2012)

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GI-REASONS: a novel 6-month, prospective, randomized, open-label, blinded end point (PROBE) trial

Byron Cryer, Chunming Li, Lee S Simon, Gurkirpal Singh, Martin J Stillman, Manuela Berger Arthritis Research & Therapy 2012, 14(Suppl 1):P63 (9 February 2012)

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Inhibition of Syndecan-4 by therapeutic antibodies reduces TNFα dependent joint destruction in mice

Athanasios Stratis, Katja Neugebauer, Mareike Frohling, Peter Paruzel, Berno Dankbar, Corinna Wemeyer, Christoph Cromme, Lars Godmann, Jessica Bertrand, Adelheide Korb, Frank Echtermeyer, George Kollias, Thomas Pap Arthritis Research & Therapy 2012, 14(Suppl 1):P64 (9 February 2012)

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Clinical-experimental assessment of simvastatin efficiency in the treatment of rheumatoid arthritis

Rikhikhon N Tadjikhodjaeva, Nargiza G Khabibullaeva Arthritis Research & Therapy 2012, 14(Suppl 1):P65 (9 February 2012)

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Metabolic syndrome in Indian patients with rheumatoid arthritis and its correlation with disease activity

Aman Sharma, Nilesh Bhilave, Kusum Sharma, Indu Varma Arthritis Research & Therapy 2012, 14(Suppl 1):P66 (9 February 2012)

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Osteoprotegerin induction in response to microbial infection

Yasunari Takada, Koichi Matsuo Arthritis Research & Therapy 2012, 14(Suppl 1):P67 (9 February 2012)

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Expression patterns and function of chromatin protein HMGB2 during mesenchymal stem cell differentiation

Noboru Taniguchi, Beatriz Caramés, Yasuhiko Kawakami, Martin Lotz Arthritis Research & Therapy 2012, 14(Suppl 1):P68 (9 February 2012)

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Age features of metabolic syndrome and cardiovascular disorders in gout

Surayo Shukurova, Khisrav Toirov, Nabijon Hamidov, Dilfuza Jonnazarova Arthritis Research & Therapy 2012, 14(Suppl 1):P69 (9 February 2012)

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Unfolded protein response mediator, the IRE1α-XBP1 pathway is involved in osteoblast differentiation

Takahide Tohmonda, Kazuhiro Chiba, Yoshiaki Toyama, Keisuke Horiuchi Arthritis Research & Therapy 2012, 14(Suppl 1):P70 (9 February 2012)

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Resistance to morphine analgesia and its underlying mechanisms in an experimental mouse model of fibromyalgia

Hitoshi Uchida, Michiko Nishiyori, Hiroshi Ueda Arthritis Research & Therapy 2012, 14(Suppl 1):P71 (9 February 2012)

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Brain perfusion in fibromyalgia patients and its differences between responders and poor responders to gabapentin

Chie Usui, Kotaro Hatta, Nagafumi Doi, Atsushi Nakanishi, Hiroyuki Nakamura, Kusuki Nishioka Arthritis Research & Therapy 2012, 14(Suppl 1):P72 (9 February 2012)

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Pathogenic protease expression in murine OA is critically dependent upon mechanical joint loading

Annika Burleigh, Anastasios Chanalaris, Jeremy Saklatvala, Tonia Vincent Arthritis Research & Therapy 2012, 14(Suppl 1):P73 (9 February 2012)

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Helicobacter pylori infection in rheumatic diseases

Hongyan Wen, Jing Luo, Junxia Li, Xiaofeng Li Arthritis Research & Therapy 2012, 14(Suppl 1):P74 (9 February 2012)

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Importance of E3 ubiquitin ligase Synoviolin in fibrogenesis

Naoko Yagishita, Daisuke Hasegawa, Satoko Aratani, Yoshihisa Yamano, Toshihiro Nakajima Arthritis Research & Therapy 2012, 14(Suppl 1):P75 (9 February 2012)

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Human retrovirus promotes the plasticity of regulatory T cells into T helper type 1-like cells through the T-bet transcriptional activation in neuroinflammatory disease

Yoshihisa Yamano Arthritis Research & Therapy 2012, 14(Suppl 1):P76 (9 February 2012)

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AJAK inhibitor, tofacitinibreduces IL-6 and matrix metalloproteinase-3 productionin rheumatoid arthritis with suppressed cartilage destruction

Kunihiro Yamaoka, Satoshi Kubo, Koshiro Sonomoto, Keisuke Maeshima, Yoshiya Tanaka Arthritis Research & Therapy 2012, 14(Suppl 1):P77 (9 February 2012)

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Regulation of macrophage-mediated chronic inflammation by JAK inhibitors

Anna Yarilina, Kai Xu, Chunhin Chan, Lionel B Ivashkiv Arthritis Research & Therapy 2012, 14(Suppl 1):P78 (9 February 2012)

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Th17 is involved in the pathogenesis of Bechet's disease via CCL20-CCR6 axis

Hidekata Yasuoka, Zhu Chen, Tsutomu Takeuchi, Masataka Kuwana Arthritis Research & Therapy 2012, 14(Suppl 1):P79 (9 February 2012)

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The association of autoantibodies expression, Th1/Th2 cytokines balance and IFNG polymorphism with histological phenotype of lupusnephritis

Kusworini Handono, Atma Gunawan, Singgih Wahono, Rulli Rosandi, Wivina, Natalina Mallo, Handono Kalim Arthritis Research & Therapy 2012, 14(Suppl 1):P80 (9 February 2012)

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Tks5-dependent formation of circumferential podosomes mediates cell-cell fusion

Tsukasa Oikawa, Masaaki Oyama, Hiroko Kozuka-Hata, Shunsuke Uehara, Nobuyuki Udagawa, Hideyuki Saya, Koichi Matsuo Arthritis Research & Therapy 2012, 14(Suppl 1):P55 (9 February 2012)

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An essential role of IκBζ in the transcriptional program in Th17 development

Kazuo Okamoto, Masatsugu Oh-hora, Hiroshi Takayanagi Arthritis Research & Therapy 2012, 14(Suppl 1):P56 (9 February 2012)

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Features of rheumatic fever in adult patients in modern Kyrgyzstan

Nazgul A Omurzakova, Aynagul S Djumagulova, Raisa I Rudenko, Kusuki Nishioka, Toshihiro Nakajima Arthritis Research & Therapy 2012, 14(Suppl 1):P57 (9 February 2012)

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