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The Scientific Basis of Rheumatology: A Decade of Progress

Collection published: 10 October 2008

Last updated: 14 October 2009

This special collection of reviews - published to mark Arthritis Research & Therapy's 10th anniversary - provides an in depth overview of the current status of basic and clinical research in rheumatology, and focuses particularly on developments in the past decade, during which there has been an explosion of new information in the field.

Corporate sponsorship from Schering-Plough and Wyeth has enabled BioMed Central to make these reviews free to access online. No sponsor has had input into the content of the publication or the articles themselves. All published articles have been independently prepared by the authors, and have been subject to the journal's standard peer review process.

		Review Progress in osteoporosis and fracture prevention: focus on postmenopausal women Kenneth G Saag, Piet Geusens Arthritis Research & Therapy 2009, 11:251 (14 October 2009) Abstract \| Full text \| PDF \| PubMed
		Review Lessons from animal models of arthritis over the past decade Wim Berg Arthritis Research & Therapy 2009, 11:250 (14 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Developments in the scientific understanding of rheumatoid arthritis Jörg J Goronzy, Cornelia M Weyand Arthritis Research & Therapy 2009, 11:249 (14 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Genetics of rheumatic disease Alex Clarke, Timothy J Vyse Arthritis Research & Therapy 2009, 11:248 (14 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review B cells in autoimmunity Thomas Dörner, Annett M Jacobi, Peter E Lipsky Arthritis Research & Therapy 2009, 11:247 (14 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Cytokines in chronic rheumatic diseases: is everything lack of homeostatic balance? Carlo Chizzolini, Jean-Michel Dayer, Pierre Miossec Arthritis Research & Therapy 2009, 11:246 (14 October 2009) Abstract \| Full text \| PDF \| PubMed
		Review Developments in the clinical understanding of lupus Mary K Crow Arthritis Research & Therapy 2009, 11:245 (14 October 2009) Abstract \| Full text \| PDF \| PubMed
		Review Outcome measures in inflammatory rheumatic diseases Jaap Fransen, Piet LCM van Riel Arthritis Research & Therapy 2009, 11:244 (14 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Toll-like receptors and NOD-like receptors in rheumatic diseases William J McCormack, Andrew E Parker, Luke A O'Neill Arthritis Research & Therapy 2009, 11:243 (14 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Developments in the scientific and clinical understanding of fibromyalgia Dan Buskila Arthritis Research & Therapy 2009, 11:242 (14 October 2009) Abstract \| Full text \| PDF \| PubMed
		Review The biological and clinical importance of the 'new generation' cytokines in rheumatic diseases Cem Gabay, Iain B McInnes Arthritis Research & Therapy 2009, 11:230 (19 May 2009) Abstract \| Full text \| PDF \| PubMed
		Review Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases Sherine E Gabriel, Kaleb Michaud Arthritis Research & Therapy 2009, 11:229 (19 May 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Developments in the scientific understanding of osteoporosis Nancy E Lane, Wei Yao Arthritis Research & Therapy 2009, 11:228 (19 May 2009) Abstract \| Full text \| PDF \| PubMed
		Review Developments in the scientific understanding of osteoarthritis Steven B Abramson, Mukundan Attur Arthritis Research & Therapy 2009, 11:227 (19 May 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis Emma Ahlqvist, Malin Hultqvist, Rikard Holmdahl Arthritis Research & Therapy 2009, 11:226 (19 May 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Antibody engineering to develop new antirheumatic therapies John D Isaacs Arthritis Research & Therapy 2009, 11:225 (19 May 2009) Abstract \| Full text \| PDF \| PubMed
		Review Cartilage homeostasis in health and rheumatic diseases Mary B Goldring, Kenneth B Marcu Arthritis Research & Therapy 2009, 11:224 (19 May 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review What epidemiology has told us about risk factors and aetiopathogenesis in rheumatic diseases Jacqueline E Oliver, Alan J Silman Arthritis Research & Therapy 2009, 11:223 (19 May 2009) Abstract \| Full text \| PDF \| PubMed
		Review Developments in the scientific and clinical understanding of autoinflammatory disorders Helen J Lachmann, Philip N Hawkins Arthritis Research & Therapy 2009, 11:212 (30 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Tissue engineering in the rheumatic diseases Jochen Ringe, Michael Sittinger Arthritis Research & Therapy 2009, 11:211 (30 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Osteoimmunology in rheumatic diseases Georg Schett Arthritis Research & Therapy 2009, 11:210 (30 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Gene therapy of the rheumatic diseases: 1998 to 2008 Christopher H Evans, Steven C Ghivizzani, Paul D Robbins Arthritis Research & Therapy 2009, 11:209 (30 January 2009) Abstract \| Full text \| PDF \| PubMed
		Review Developments in the scientific and clinical understanding of the spondyloarthritides Joachim Sieper Arthritis Research & Therapy 2009, 11:208 (30 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Transcription profiling of rheumatic diseases Lisa GM van Baarsen, Carina L Bos, Tineke Pouw Kraan, Cornelis L Verweij Arthritis Research & Therapy 2009, 11:207 (30 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Garden of therapeutic delights: new targets in rheumatic diseases Jean M Waldburger, Gary S Firestein Arthritis Research & Therapy 2009, 11:206 (30 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Randomized controlled trial design in rheumatoid arthritis: the past decade Vibeke Strand, Jeremy Sokolove Arthritis Research & Therapy 2009, 11:205 (30 January 2009) Abstract \| Full text \| PDF \| PubMed
		Review Developments in the clinical understanding of rheumatoid arthritis Josef S Smolen, Daniel Aletaha Arthritis Research & Therapy 2009, 11:204 (30 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Developments in the clinical understanding of osteoarthritis David T Felson Arthritis Research & Therapy 2009, 11:203 (30 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Antigen receptor signaling in the rheumatic diseases Julie Zikherman, Arthur Weiss Arthritis Research & Therapy 2009, 11:202 (30 January 2009) Abstract \| Full text \| PDF \| PubMed
		Review Vascular involvement in rheumatic diseases: 'vascular rheumatology' Zoltán Szekanecz, Alisa E Koch Arthritis Research & Therapy 2008, 10:224 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Mesenchymal stem cells in arthritic diseases Faye H Chen, Rocky S Tuan Arthritis Research & Therapy 2008, 10:223 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review What magnetic resonance imaging has told us about the pathogenesis of rheumatoid arthritis – the first 50 years Dennis McGonagle, Ai Tan Arthritis Research & Therapy 2008, 10:222 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Developments in the scientific and clinical understanding of gout Alexander So Arthritis Research & Therapy 2008, 10:221 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Developments in the scientific and clinical understanding of inflammatory myopathies Ingrid E Lundberg, Cecilia Grundtman Arthritis Research & Therapy 2008, 10:220 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Epigenetic modifications in rheumatoid arthritis Simon Strietholt, Britta Maurer, Marvin A Peters, Thomas Pap, Steffen Gay Arthritis Research & Therapy 2008, 10:219 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Developments in the scientific understanding of lupus Stacy P Ardoin, David S Pisetsky Arthritis Research & Therapy 2008, 10:218 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Stem cell transplantation for rheumatic autoimmune diseases Thomas Hügle, Jacob M van Laar Arthritis Research & Therapy 2008, 10:217 (10 October 2008) Abstract \| Full text \| PDF \| PubMed
		Review Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis Stefan K Drexler, Philip L Kong, Jeremy Wales, Brian M Foxwell Arthritis Research & Therapy 2008, 10:216 (10 October 2008) Abstract \| Full text \| PDF \| PubMed
		Editorial Introducing Arthritis Research & Therapy's 10th anniversary issue, 'The Scientific Basis of Rheumatology: A Decade of Progress' Iain Hrynaszkiewicz, Peter E Lipsky, Ravinder N Maini Arthritis Research & Therapy 2008, 10:119 (10 October 2008) Full text \| PDF \| PubMed \| Cited on BioMed Central

		Review Progress in osteoporosis and fracture prevention: focus on postmenopausal women Kenneth G Saag, Piet Geusens Arthritis Research & Therapy 2009, 11:251 (14 October 2009) Abstract \| Full text \| PDF \| PubMed
		Review Lessons from animal models of arthritis over the past decade Wim Berg Arthritis Research & Therapy 2009, 11:250 (14 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Developments in the scientific understanding of rheumatoid arthritis Jörg J Goronzy, Cornelia M Weyand Arthritis Research & Therapy 2009, 11:249 (14 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Genetics of rheumatic disease Alex Clarke, Timothy J Vyse Arthritis Research & Therapy 2009, 11:248 (14 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review B cells in autoimmunity Thomas Dörner, Annett M Jacobi, Peter E Lipsky Arthritis Research & Therapy 2009, 11:247 (14 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Cytokines in chronic rheumatic diseases: is everything lack of homeostatic balance? Carlo Chizzolini, Jean-Michel Dayer, Pierre Miossec Arthritis Research & Therapy 2009, 11:246 (14 October 2009) Abstract \| Full text \| PDF \| PubMed
		Review Developments in the clinical understanding of lupus Mary K Crow Arthritis Research & Therapy 2009, 11:245 (14 October 2009) Abstract \| Full text \| PDF \| PubMed
		Review Outcome measures in inflammatory rheumatic diseases Jaap Fransen, Piet LCM van Riel Arthritis Research & Therapy 2009, 11:244 (14 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Toll-like receptors and NOD-like receptors in rheumatic diseases William J McCormack, Andrew E Parker, Luke A O'Neill Arthritis Research & Therapy 2009, 11:243 (14 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Developments in the scientific and clinical understanding of fibromyalgia Dan Buskila Arthritis Research & Therapy 2009, 11:242 (14 October 2009) Abstract \| Full text \| PDF \| PubMed
		Review The biological and clinical importance of the 'new generation' cytokines in rheumatic diseases Cem Gabay, Iain B McInnes Arthritis Research & Therapy 2009, 11:230 (19 May 2009) Abstract \| Full text \| PDF \| PubMed
		Review Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases Sherine E Gabriel, Kaleb Michaud Arthritis Research & Therapy 2009, 11:229 (19 May 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Developments in the scientific understanding of osteoporosis Nancy E Lane, Wei Yao Arthritis Research & Therapy 2009, 11:228 (19 May 2009) Abstract \| Full text \| PDF \| PubMed
		Review Developments in the scientific understanding of osteoarthritis Steven B Abramson, Mukundan Attur Arthritis Research & Therapy 2009, 11:227 (19 May 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis Emma Ahlqvist, Malin Hultqvist, Rikard Holmdahl Arthritis Research & Therapy 2009, 11:226 (19 May 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Antibody engineering to develop new antirheumatic therapies John D Isaacs Arthritis Research & Therapy 2009, 11:225 (19 May 2009) Abstract \| Full text \| PDF \| PubMed
		Review Cartilage homeostasis in health and rheumatic diseases Mary B Goldring, Kenneth B Marcu Arthritis Research & Therapy 2009, 11:224 (19 May 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review What epidemiology has told us about risk factors and aetiopathogenesis in rheumatic diseases Jacqueline E Oliver, Alan J Silman Arthritis Research & Therapy 2009, 11:223 (19 May 2009) Abstract \| Full text \| PDF \| PubMed
		Review Developments in the scientific and clinical understanding of autoinflammatory disorders Helen J Lachmann, Philip N Hawkins Arthritis Research & Therapy 2009, 11:212 (30 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Tissue engineering in the rheumatic diseases Jochen Ringe, Michael Sittinger Arthritis Research & Therapy 2009, 11:211 (30 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Osteoimmunology in rheumatic diseases Georg Schett Arthritis Research & Therapy 2009, 11:210 (30 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Gene therapy of the rheumatic diseases: 1998 to 2008 Christopher H Evans, Steven C Ghivizzani, Paul D Robbins Arthritis Research & Therapy 2009, 11:209 (30 January 2009) Abstract \| Full text \| PDF \| PubMed
		Review Developments in the scientific and clinical understanding of the spondyloarthritides Joachim Sieper Arthritis Research & Therapy 2009, 11:208 (30 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Transcription profiling of rheumatic diseases Lisa GM van Baarsen, Carina L Bos, Tineke Pouw Kraan, Cornelis L Verweij Arthritis Research & Therapy 2009, 11:207 (30 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Garden of therapeutic delights: new targets in rheumatic diseases Jean M Waldburger, Gary S Firestein Arthritis Research & Therapy 2009, 11:206 (30 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Randomized controlled trial design in rheumatoid arthritis: the past decade Vibeke Strand, Jeremy Sokolove Arthritis Research & Therapy 2009, 11:205 (30 January 2009) Abstract \| Full text \| PDF \| PubMed
		Review Developments in the clinical understanding of rheumatoid arthritis Josef S Smolen, Daniel Aletaha Arthritis Research & Therapy 2009, 11:204 (30 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Developments in the clinical understanding of osteoarthritis David T Felson Arthritis Research & Therapy 2009, 11:203 (30 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Antigen receptor signaling in the rheumatic diseases Julie Zikherman, Arthur Weiss Arthritis Research & Therapy 2009, 11:202 (30 January 2009) Abstract \| Full text \| PDF \| PubMed
		Review Vascular involvement in rheumatic diseases: 'vascular rheumatology' Zoltán Szekanecz, Alisa E Koch Arthritis Research & Therapy 2008, 10:224 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Mesenchymal stem cells in arthritic diseases Faye H Chen, Rocky S Tuan Arthritis Research & Therapy 2008, 10:223 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review What magnetic resonance imaging has told us about the pathogenesis of rheumatoid arthritis – the first 50 years Dennis McGonagle, Ai Tan Arthritis Research & Therapy 2008, 10:222 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Developments in the scientific and clinical understanding of gout Alexander So Arthritis Research & Therapy 2008, 10:221 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Developments in the scientific and clinical understanding of inflammatory myopathies Ingrid E Lundberg, Cecilia Grundtman Arthritis Research & Therapy 2008, 10:220 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Epigenetic modifications in rheumatoid arthritis Simon Strietholt, Britta Maurer, Marvin A Peters, Thomas Pap, Steffen Gay Arthritis Research & Therapy 2008, 10:219 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Developments in the scientific understanding of lupus Stacy P Ardoin, David S Pisetsky Arthritis Research & Therapy 2008, 10:218 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Stem cell transplantation for rheumatic autoimmune diseases Thomas Hügle, Jacob M van Laar Arthritis Research & Therapy 2008, 10:217 (10 October 2008) Abstract \| Full text \| PDF \| PubMed
		Review Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis Stefan K Drexler, Philip L Kong, Jeremy Wales, Brian M Foxwell Arthritis Research & Therapy 2008, 10:216 (10 October 2008) Abstract \| Full text \| PDF \| PubMed
		Editorial Introducing Arthritis Research & Therapy's 10th anniversary issue, 'The Scientific Basis of Rheumatology: A Decade of Progress' Iain Hrynaszkiewicz, Peter E Lipsky, Ravinder N Maini Arthritis Research & Therapy 2008, 10:119 (10 October 2008) Full text \| PDF \| PubMed \| Cited on BioMed Central