Related Articles for PubMed (Select 18513402)

Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity.

Karsdal MA, Madsen SH, Christiansen C, Henriksen K, Fosang AJ, Sondergaard BC.

Arthritis Res Ther. 2008;10(3):R63. Epub 2008 May 30.

PMID: 18513402 [PubMed - in process]

Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation.

Karsdal MA, Sumer EU, Wulf H, Madsen SH, Christiansen C, Fosang AJ, Sondergaard BC.

Arthritis Rheum. 2007 May;56(5):1549-58.

PMID: 17469134 [PubMed - indexed for MEDLINE]

Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.

Little CB, Flannery CR, Hughes CE, Mort JS, Roughley PJ, Dent C, Caterson B.

Biochem J. 1999 Nov 15;344 Pt 1:61-8.

PMID: 10548534 [PubMed - indexed for MEDLINE]

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Anabolic and catabolic function of chondrocyte ex vivo is reflected by the metabolic processing of type II collagen.

Olsen AK, Sondergaard BC, Byrjalsen I, Tanko LB, Christiansen C, Müller A, Hein GE, Karsdal MA, Qvist P.

Osteoarthritis Cartilage. 2007 Mar;15(3):335-42. Epub 2006 Oct 11.

PMID: 17045814 [PubMed - indexed for MEDLINE]

Detection of aggrecanase- and MMP-generated catabolic neoepitopes in the rat iodoacetate model of cartilage degeneration.

Janusz MJ, Little CB, King LE, Hookfin EB, Brown KK, Heitmeyer SA, Caterson B, Poole AR, Taiwo YO.

Osteoarthritis Cartilage. 2004 Sep;12(9):720-8.

PMID: 15325638 [PubMed - indexed for MEDLINE]

Relative contribution of matrix metalloprotease and cysteine protease activities to cytokine-stimulated articular cartilage degradation.

Sondergaard BC, Henriksen K, Wulf H, Oestergaard S, Schurigt U, Bräuer R, Danielsen I, Christiansen C, Qvist P, Karsdal MA.

Osteoarthritis Cartilage. 2006 Aug;14(8):738-48. Epub 2006 Mar 23.

PMID: 16563811 [PubMed - indexed for MEDLINE]

The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases.

Stanton H, Ung L, Fosang AJ.

Biochem J. 2002 May 15;364(Pt 1):181-90.

PMID: 11988091 [PubMed - indexed for MEDLINE]

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Calcitonin directly attenuates collagen type II degradation by inhibition of matrix metalloproteinase expression and activity in articular chondrocytes.

Sondergaard BC, Wulf H, Henriksen K, Schaller S, Oestergaard S, Qvist P, Tankó LB, Bagger YZ, Christiansen C, Karsdal MA.

Osteoarthritis Cartilage. 2006 Aug;14(8):759-68. Epub 2006 Mar 20.

PMID: 16549372 [PubMed - indexed for MEDLINE]

Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.

Lark MW, Bayne EK, Flanagan J, Harper CF, Hoerrner LA, Hutchinson NI, Singer II, Donatelli SA, Weidner JR, Williams HR, Mumford RA, Lohmander LS.

J Clin Invest. 1997 Jul 1;100(1):93-106.

PMID: 9202061 [PubMed - indexed for MEDLINE]

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Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage.

Yasuda T, Tchetina E, Ohsawa K, Roughley PJ, Wu W, Mousa A, Ionescu M, Pidoux I, Poole AR.

Matrix Biol. 2006 Sep;25(7):419-29. Epub 2006 Jun 30.

PMID: 16919430 [PubMed - indexed for MEDLINE]

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Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans: relationship to mediators of systemic and local inflammation.

Fraser A, Fearon U, Billinghurst RC, Ionescu M, Reece R, Barwick T, Emery P, Poole AR, Veale DJ.

Arthritis Rheum. 2003 Nov;48(11):3085-95.

PMID: 14613270 [PubMed - indexed for MEDLINE]

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Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage.

Little CB, Hughes CE, Curtis CL, Jones SA, Caterson B, Flannery CR.

Arthritis Rheum. 2002 Jan;46(1):124-9.

PMID: 11817583 [PubMed - indexed for MEDLINE]

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Mechanisms involved in cartilage proteoglycan catabolism.

Caterson B, Flannery CR, Hughes CE, Little CB.

Matrix Biol. 2000 Aug;19(4):333-44. Review.

PMID: 10963994 [PubMed - indexed for MEDLINE]

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Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase.

Billinghurst RC, Wu W, Ionescu M, Reiner A, Dahlberg L, Chen J, van Wart H, Poole AR.

Arthritis Rheum. 2000 Mar;43(3):664-72.

PMID: 10728761 [PubMed - indexed for MEDLINE]

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Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase.

Arner EC, Hughes CE, Decicco CP, Caterson B, Tortorella MD.

Osteoarthritis Cartilage. 1998 May;6(3):214-28.

PMID: 9682788 [PubMed - indexed for MEDLINE]

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Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis.

van Meurs JB, van Lent PL, Holthuysen AE, Singer II, Bayne EK, van den Berg WB.

Arthritis Rheum. 1999 Jun;42(6):1128-39.

PMID: 10366105 [PubMed - indexed for MEDLINE]

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The effect of electrical fields on gene and protein expression in human osteoarthritic cartilage explants.

Brighton CT, Wang W, Clark CC.

J Bone Joint Surg Am. 2008 Apr;90(4):833-48.

PMID: 18381322 [PubMed - indexed for MEDLINE]

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Effects of transforming growth factor-beta on aggrecanase production and proteoglycan degradation by human chondrocytes in vitro.

Moulharat N, Lesur C, Thomas M, Rolland-Valognes G, Pastoureau P, Anract P, De Ceuninck F, Sabatini M.

Osteoarthritis Cartilage. 2004 Apr;12(4):296-305.

PMID: 15023381 [PubMed - indexed for MEDLINE]

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Thyroid hormone enhances aggrecanase-2/ADAM-TS5 expression and proteoglycan degradation in growth plate cartilage.

Makihira S, Yan W, Murakami H, Furukawa M, Kawai T, Nikawa H, Yoshida E, Hamada T, Okada Y, Kato Y.

Endocrinology. 2003 Jun;144(6):2480-8.

PMID: 12746310 [PubMed - indexed for MEDLINE]

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Degradation of type II collagen, but not proteoglycan, correlates with matrix metalloproteinase activity in cartilage explant cultures.

Kozaci LD, Buttle DJ, Hollander AP.

Arthritis Rheum. 1997 Jan;40(1):164-74.

PMID: 9008612 [PubMed - indexed for MEDLINE]

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