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1:

Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets.

van der Helm-van Mil AH, Huizinga TW.

Arthritis Res Ther. 2008;10(2):205. Epub 2008 Mar 31. Review.

PMID: 18394179 [PubMed - indexed for MEDLINE]

2:

Immunity to citrullinated proteins in rheumatoid arthritis.

Klareskog L, Rönnelid J, Lundberg K, Padyukov L, Alfredsson L.

Annu Rev Immunol. 2008;26:651-75. Review.

PMID: 18173373 [PubMed - indexed for MEDLINE]

3:

Heterogeneity of rheumatoid arthritis: from phenotypes to genotypes.

Weyand CM, Klimiuk PA, Goronzy JJ.

Springer Semin Immunopathol. 1998;20(1-2):5-22.

PMID: 9836366 [PubMed - indexed for MEDLINE]

4:

A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in rheumatoid arthritis.

Gourraud PA, Dieudé P, Boyer JF, Nogueira L, Cambon-Thomsen A, Mazières B, Cornélis F, Serre G, Cantagrel A, Constantin A.

Arthritis Res Ther. 2007;9(2):R27.

PMID: 17328818 [PubMed - indexed for MEDLINE]

5:

Fine specificity of the anti-citrullinated protein antibody response is influenced by the shared epitope alleles.

Verpoort KN, Cheung K, Ioan-Facsinay A, van der Helm-van Mil AH, de Vries-Bouwstra JK, Allaart CF, Drijfhout JW, de Vries RR, Breedveld FC, Huizinga TW, Pruijn GJ, Toes RE.

Arthritis Rheum. 2007 Dec;56(12):3949-52.

PMID: 18050209 [PubMed - indexed for MEDLINE]

6:

Risk of progression from undifferentiated arthritis to rheumatoid arthritis: the effect of the PTPN22 1858T-allele in anti-citrullinated peptide antibody positive patients.

Feitsma AL, Toes RE, Begovich AB, Chokkalingam AP, de Vries RR, Huizinga TW, van der Helm-van Mil AH.

Rheumatology (Oxford). 2007 Jul;46(7):1092-5. Epub 2007 Mar 6.

PMID: 17341507 [PubMed - indexed for MEDLINE]

7:

Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis.

van der Helm-van Mil AH, Verpoort KN, Breedveld FC, Toes RE, Huizinga TW.

Arthritis Res Ther. 2005;7(5):R949-58. Epub 2005 Jun 14.

PMID: 16207336 [PubMed - indexed for MEDLINE]

8:

HLA-DMA*0103 and HLA-DMB*0104 alleles as novel prognostic factors in rheumatoid arthritis.

Morel J, Roch-Bras F, Molinari N, Sany J, Eliaou JF, Combe B.

Ann Rheum Dis. 2004 Dec;63(12):1581-6.

PMID: 15547082 [PubMed - indexed for MEDLINE]

9:

Redefining the HLA and RA association: to be or not to be anti-CCP positive.

de Vries RR, Huizinga TW, Toes RE.

J Autoimmun. 2005;25 Suppl:21-5. Epub 2005 Oct 27. Review.

PMID: 16257178 [PubMed - indexed for MEDLINE]

10:

HLA-DRB1 genotype influences risk for and severity of rheumatoid arthritis.

Meyer JM, Evans TI, Small RE, Redford TW, Han J, Singh R, Moxley G.

J Rheumatol. 1999 May;26(5):1024-34.

PMID: 10332964 [PubMed - indexed for MEDLINE]

11:

A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination.

Klareskog L, Stolt P, Lundberg K, Källberg H, Bengtsson C, Grunewald J, Rönnelid J, Harris HE, Ulfgren AK, Rantapää-Dahlqvist S, Eklund A, Padyukov L, Alfredsson L.

Arthritis Rheum. 2006 Jan;54(1):38-46.

PMID: 16385494 [PubMed - indexed for MEDLINE]

12:

Protection against severe disease is conferred by DERAA-bearing HLA-DRB1 alleles among HLA-DQ3 and HLA-DQ5 positive rheumatoid arthritis patients.

Seidl C, Körbitzer J, Badenhoop K, Seifried E, Hoelzer D, Zanelli E, Kaltwasser JP.

Hum Immunol. 2001 May;62(5):523-9.

PMID: 11334677 [PubMed - indexed for MEDLINE]

13:

Expression of QK/QR/RRRAA or DERAA motifs at the third hypervariable region of HLA-DRB1 and disease severity in rheumatoid arthritis.

Khani-Hanjani A, Lacaille D, Horne C, Chalmers A, Hoar DI, Balshaw R, Keown PA.

J Rheumatol. 2002 Jul;29(7):1358-65.

PMID: 12136889 [PubMed - indexed for MEDLINE]

14:

Influence of human leukocyte antigen-DRB1 on the susceptibility and severity of rheumatoid arthritis.

Gonzalez-Gay MA, Garcia-Porrua C, Hajeer AH.

Semin Arthritis Rheum. 2002 Jun;31(6):355-60. Review.

PMID: 12077707 [PubMed - indexed for MEDLINE]

15:

The HLA-DRB1 shared epitope is associated with susceptibility to rheumatoid arthritis in African Americans through European genetic admixture.

Hughes LB, Morrison D, Kelley JM, Padilla MA, Vaughan LK, Westfall AO, Dwivedi H, Mikuls TR, Holers VM, Parrish LA, Alarcón GS, Conn DL, Jonas BL, Callahan LF, Smith EA, Gilkeson GS, Howard G, Moreland LW, Patterson N, Reich D, Bridges SL Jr.

Arthritis Rheum. 2008 Feb;58(2):349-58.

PMID: 18240241 [PubMed - indexed for MEDLINE]

16:

Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis.

Kallberg H, Padyukov L, Plenge RM, Ronnelid J, Gregersen PK, van der Helm-van Mil AH, Toes RE, Huizinga TW, Klareskog L, Alfredsson L; Epidemiological Investigation of Rheumatoid Arthritis study group.

Am J Hum Genet. 2007 May;80(5):867-75. Epub 2007 Apr 2.

PMID: 17436241 [PubMed - indexed for MEDLINE]

17:

Differential responsiveness to immunoablative therapy in refractory rheumatoid arthritis is associated with level and avidity of anti-cyclic citrullinated protein autoantibodies: a case study.

Teng YK, Verburg RJ, Verpoort KN, Diepenhorst GM, Bajema IM, van Tol MJ, Jol-van der Zijde EC, Toes RE, Huizinga TW, van Laar JM.

Arthritis Res Ther. 2007;9(5):R106.

PMID: 17927821 [PubMed - indexed for MEDLINE]

18:

A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for rheumatoid arthritis structural severity.

Gourraud PA, Boyer JF, Barnetche T, Abbal M, Cambon-Thomsen A, Cantagrel A, Constantin A.

Arthritis Rheum. 2006 Feb;54(2):593-9.

PMID: 16447236 [PubMed - indexed for MEDLINE]

19:

Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies.

Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ.

J Clin Invest. 1998 Jan 1;101(1):273-81.

PMID: 9421490 [PubMed - indexed for MEDLINE]

20:

HLA and RA revisited: citrullinated food for the SE hypothesis, the DR6 effect, and NIMA.

de Vries RR, Huizinga TW, Toes RE.

Hum Immunol. 2006 Jun;67(6):454-9. Epub 2006 Apr 3. Review.

PMID: 16728269 [PubMed - indexed for MEDLINE]

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