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1:

Genetic factors in systemic sclerosis.

Mayes MD, Trojanowska M.

Arthritis Res Ther. 2007;9 Suppl 2:S5. Review.

PMID: 17767743 [PubMed - indexed for MEDLINE]

2:

Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts.

Wang Y, Fan PS, Kahaleh B.

Arthritis Rheum. 2006 Jul;54(7):2271-9.

PMID: 16802366 [PubMed - indexed for MEDLINE]

3:

Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin.

Kubo M, Czuwara-Ladykowska J, Moussa O, Markiewicz M, Smith E, Silver RM, Jablonska S, Blaszczyk M, Watson DK, Trojanowska M.

Am J Pathol. 2003 Aug;163(2):571-81.

PMID: 12875977 [PubMed - indexed for MEDLINE]

4:

Systemic sclerosis (scleroderma): specific autoantigen genes are selectively overexpressed in scleroderma fibroblasts.

Zhou X, Tan FK, Xiong M, Milewicz DM, Feghali CA, Fritzler MJ, Reveille JD, Arnett FC.

J Immunol. 2001 Dec 15;167(12):7126-33.

PMID: 11739535 [PubMed - indexed for MEDLINE]

5:

Chemokine receptor CCR2 expression by systemic sclerosis fibroblasts: evidence for autocrine regulation of myofibroblast differentiation.

Carulli MT, Ong VH, Ponticos M, Shiwen X, Abraham DJ, Black CM, Denton CP.

Arthritis Rheum. 2005 Dec;52(12):3772-82.

PMID: 16320328 [PubMed - indexed for MEDLINE]

6:

Genetic factors in scleroderma.

Briggs D, Black C, Welsh K.

Rheum Dis Clin North Am. 1990 Feb;16(1):31-51. Review.

PMID: 2406810 [PubMed - indexed for MEDLINE]

7:

A model of anti-angiogenesis: differential transcriptosome profiling of microvascular endothelial cells from diffuse systemic sclerosis patients.

Giusti B, Fibbi G, Margheri F, Serratì S, Rossi L, Poggi F, Lapini I, Magi A, Del Rosso A, Cinelli M, Guiducci S, Kahaleh B, Bazzichi L, Bombardieri S, Matucci-Cerinic M, Gensini GF, Del Rosso M, Abbate R.

Arthritis Res Ther. 2006;8(4):R115. Epub 2006 Jul 19.

PMID: 16859528 [PubMed - indexed for MEDLINE]

8:

Increased levels of transforming growth factor beta receptor type I and up-regulation of matrix gene program: A model of scleroderma.

Pannu J, Gardner H, Shearstone JR, Smith E, Trojanowska M.

Arthritis Rheum. 2006 Sep;54(9):3011-21.

PMID: 16947635 [PubMed - indexed for MEDLINE]

9:

Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts.

Gardner H, Shearstone JR, Bandaru R, Crowell T, Lynes M, Trojanowska M, Pannu J, Smith E, Jablonska S, Blaszczyk M, Tan FK, Mayes MD.

Arthritis Rheum. 2006 Jun;54(6):1961-73.

PMID: 16736506 [PubMed - indexed for MEDLINE]

10:

Systemic sclerosis: the susceptible host (genetics and environment).

Tan FK.

Rheum Dis Clin North Am. 2003 May;29(2):211-37. Review.

PMID: 12841292 [PubMed - indexed for MEDLINE]

11:

Systemic sclerosis fibroblasts inhibit in vitro angiogenesis by MMP-12-dependent cleavage of the endothelial cell urokinase receptor.

Serratì S, Cinelli M, Margheri F, Guiducci S, Del Rosso A, Pucci M, Fibbi G, Bazzichi L, Bombardieri S, Matucci-Cerinic M, Del Rosso M.

J Pathol. 2006 Oct;210(2):240-8.

PMID: 16917801 [PubMed - indexed for MEDLINE]

12:

Angiotensin-converting enzyme in systemic sclerosis: from endothelial injury to a genetic polymorphism.

Guiducci S, Fatini C, Rogai V, Cinelli M, Sticchi E, Abbate R, Cerinic MM.

Ann N Y Acad Sci. 2006 Jun;1069:10-9.

PMID: 16855131 [PubMed - indexed for MEDLINE]

13:

Alterations in the regulation of expression of the alpha 1(I) collagen gene (COL1A1) in systemic sclerosis (scleroderma).

Jimenez SA, Saitta B.

Springer Semin Immunopathol. 1999;21(4):397-414. Review.

PMID: 10945033 [PubMed - indexed for MEDLINE]

14:

Pathogenesis of systemic sclerosis: altered B cell function is the key linking systemic autoimmunity and tissue fibrosis.

Hasegawa M, Fujimoto M, Takehara K, Sato S.

J Dermatol Sci. 2005 Jul;39(1):1-7. Review.

PMID: 15885984 [PubMed - indexed for MEDLINE]

15:

The -2518 promotor polymorphism in the MCP-1 gene is associated with systemic sclerosis.

Karrer S, Bosserhoff AK, Weiderer P, Distler O, Landthaler M, Szeimies RM, Müller-Ladner U, Schölmerich J, Hellerbrand C.

J Invest Dermatol. 2005 Jan;124(1):92-8.

PMID: 15654958 [PubMed - indexed for MEDLINE]

16:

Polymorphisms in COL15 gene are not associated with systemic sclerosis.

Pushpakom SP, Herrick AL, Kumar S, Worthington J.

J Rheumatol. 2008 Feb;35(2):251-3. Epub 2008 Jan 15.

PMID: 18203317 [PubMed - indexed for MEDLINE]

17:

Monozygotic twins clinically discordant for scleroderma show concordance for fibroblast gene expression profiles.

Zhou X, Tan FK, Xiong M, Arnett FC, Feghali-Bostwick CA.

Arthritis Rheum. 2005 Oct;52(10):3305-14.

PMID: 16200604 [PubMed - indexed for MEDLINE]

18:

Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: important pathogenetic steps in early and late stage of systemic scleroderma?

Brinckmann J, Kim S, Wu J, Reinhardt DP, Batmunkh C, Metzen E, Notbohm H, Bank RA, Krieg T, Hunzelmann N.

Matrix Biol. 2005 Oct;24(7):459-68. Epub 2005 Sep 1.

PMID: 16139999 [PubMed - indexed for MEDLINE]

19:

Vascular damage and lack of angiogenesis in systemic sclerosis skin.

Konttinen YT, Mackiewicz Z, Ruuttila P, Ceponis A, Sukura A, Povilenaite D, Hukkanen M, Virtanen I.

Clin Rheumatol. 2003 Sep;22(3):196-202.

PMID: 14505210 [PubMed - indexed for MEDLINE]

20:

A novel protein highly expressed in testis is overexpressed in systemic sclerosis fibroblasts and targeted by autoantibodies.

Yasuoka H, Ihn H, Medsger TA Jr, Hirakata M, Kawakami Y, Ikeda Y, Kuwana M.

J Immunol. 2003 Dec 15;171(12):6883-90.

PMID: 14662895 [PubMed - indexed for MEDLINE]

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