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1:

Methotrexate in rheumatoid arthritis is frequently effective, even if re-employed after a previous failure.

Kapral T, Stamm T, Machold KP, Montag K, Smolen JS, Aletaha D.

Arthritis Res Ther. 2006;8(2):R46. Epub 2006 Feb 24.

PMID: 16507172 [PubMed - indexed for MEDLINE]

2:

The rheumatoid arthritis patient in the clinic: comparing more than 1,300 consecutive DMARD courses.

Aletaha D, Smolen JS.

Rheumatology (Oxford). 2002 Dec;41(12):1367-74.

PMID: 12468815 [PubMed - indexed for MEDLINE]

3:

Step-up combination versus switching of non-biological disease-modifying antirheumatic drugs in rheumatoid arthritis: results from a retrospective observational study.

Schoels M, Kapral T, Stamm T, Smolen JS, Aletaha D.

Ann Rheum Dis. 2007 Aug;66(8):1059-65. Epub 2007 Feb 16.

PMID: 17307765 [PubMed - indexed for MEDLINE]

4:

Risk factors associated with the cumulative survival of low-dose methotrexate in 273 Japanese patients with rheumatoid arthritis.

Ideguchi H, Ohno S, Ishigatsubo Y.

J Clin Rheumatol. 2007 Apr;13(2):73-8.

PMID: 17414533 [PubMed - indexed for MEDLINE]

5:

A systematic review of the effectiveness of adalimumab, etanercept and infliximab for the treatment of rheumatoid arthritis in adults and an economic evaluation of their cost-effectiveness.

Chen YF, Jobanputra P, Barton P, Jowett S, Bryan S, Clark W, Fry-Smith A, Burls A.

Health Technol Assess. 2006 Nov;10(42):iii-iv, xi-xiii, 1-229. Review.

PMID: 17049139 [PubMed - indexed for MEDLINE]

7:

Disappointing longterm results with disease modifying antirheumatic drugs. A practice based study.

Galindo-Rodriguez G, Aviña-Zubieta JA, Russell AS, Suarez-Almazor ME.

J Rheumatol. 1999 Nov;26(11):2337-43.

PMID: 10555887 [PubMed - indexed for MEDLINE]

8:

Toward a definition and method of assessment of treatment failure and treatment effectiveness: the case of leflunomide versus methotrexate.

Wolfe F, Michaud K, Stephenson B, Doyle J.

J Rheumatol. 2003 Aug;30(8):1725-32.

PMID: 12913927 [PubMed - indexed for MEDLINE]

9:

Longterm methotrexate use in rheumatoid arthritis: 12 year followup of 460 patients treated in community practice.

Wluka A, Buchbinder R, Mylvaganam A, Hall S, Harkness A, Lewis D, Littlejohn GO, Miller MH, Ryan PF.

J Rheumatol. 2000 Aug;27(8):1864-71.

PMID: 10955325 [PubMed - indexed for MEDLINE]

11:

Survival and effectiveness of leflunomide compared with methotrexate and sulfasalazine in rheumatoid arthritis: a matched observational study.

Aletaha D, Stamm T, Kapral T, Eberl G, Grisar J, Machold KP, Smolen JS.

Ann Rheum Dis. 2003 Oct;62(10):944-51.

PMID: 12972472 [PubMed - indexed for MEDLINE]

12:

Patient, disease, and therapy-related factors that influence discontinuation of disease-modifying antirheumatic drugs: a population-based incidence cohort of patients with rheumatoid arthritis.

Maradit-Kremers H, Nicola PJ, Crowson CS, O'Fallon WM, Gabriel SE.

J Rheumatol. 2006 Feb;33(2):248-55. Epub 2005 Dec 15.

PMID: 16358365 [PubMed - indexed for MEDLINE]

13:

Methotrexate, hydroxychloroquine, and intramuscular gold in rheumatoid arthritis: relative area under the curve effectiveness and sequence effects.

Hurst S, Kallan MJ, Wolfe FJ, Fries JF, Albert DA.

J Rheumatol. 2002 Aug;29(8):1639-45.

PMID: 12180722 [PubMed - indexed for MEDLINE]

14:

Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients with rheumatoid arthritis with a suboptimal response to sulfasalazine: results from the double-blind placebo-controlled MASCOT study.

Capell HA, Madhok R, Porter DR, Munro RA, McInnes IB, Hunter JA, Steven M, Zoma A, Morrison E, Sambrook M, Wui Poon F, Hampson R, McDonald F, Tierney A, Henderson N, Ford I.

Ann Rheum Dis. 2007 Feb;66(2):235-41. Epub 2006 Aug 22.

PMID: 16926184 [PubMed - indexed for MEDLINE]

15:

Outcomes after switching from one anti-tumor necrosis factor alpha agent to a second anti-tumor necrosis factor alpha agent in patients with rheumatoid arthritis: results from a large UK national cohort study.

Hyrich KL, Lunt M, Watson KD, Symmons DP, Silman AJ; British Society for Rheumatology Biologics Register.

Arthritis Rheum. 2007 Jan;56(1):13-20.

PMID: 17195186 [PubMed - indexed for MEDLINE]

16:

Anti-tumor necrosis factor alpha therapy and the risk of serious bacterial infections in elderly patients with rheumatoid arthritis.

Schneeweiss S, Setoguchi S, Weinblatt ME, Katz JN, Avorn J, Sax PE, Levin R, Solomon DH.

Arthritis Rheum. 2007 Jun;56(6):1754-64.

PMID: 17530704 [PubMed - indexed for MEDLINE]

17:

The ability of disease modifying antirheumatic drugs to induce and maintain improvement in patients with rheumatoid arthritis. epidemiology of DMARDs treatment in Japan.

Nagashima M, Shu G, Yamamoto K, Yamahatsu S, Yoshino S.

Clin Exp Rheumatol. 2005 Jan-Feb;23(1):27-35.

PMID: 15789884 [PubMed - indexed for MEDLINE]

18:

Factors influencing length of time taking methotrexate in rheumatoid arthritis.

Ortendahl M, Schettler JD, Fries JF.

J Rheumatol. 2000 May;27(5):1139-47.

PMID: 10813279 [PubMed - indexed for MEDLINE]

19:

Preliminary evaluation in rheumatoid arthritis activity in patients treated with TNF-alpha blocker plus methotrexate versus methotrexate or leflunomide alone.

Wisłowska M, Jakubicz D.

Rheumatol Int. 2007 May;27(7):641-7. Epub 2007 Jan 18.

PMID: 17235556 [PubMed - indexed for MEDLINE]

20:

Treatment of early seropositive rheumatoid arthritis: doxycycline plus methotrexate versus methotrexate alone.

O'Dell JR, Elliott JR, Mallek JA, Mikuls TR, Weaver CA, Glickstein S, Blakely KM, Hausch R, Leff RD.

Arthritis Rheum. 2006 Feb;54(2):621-7.

PMID: 16447240 [PubMed - indexed for MEDLINE]

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