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Inhibition of established collagen-induced arthritis with a tumour necrosis factor-alpha inhibitor expressed from a self-contained doxycycline regulated plasmid.

Gould DJ, Bright C, Chernajovsky Y.

Arthritis Res Ther. 2004;6(2):R103-13. Epub 2003 Dec 22.

PMID: 15059273 [PubMed - indexed for MEDLINE]

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Gene therapy with an improved doxycycline-regulated plasmid encoding a tumour necrosis factor-alpha inhibitor in experimental arthritis.

Gould D, Yousaf N, Fatah R, Subang MC, Chernajovsky Y.

Arthritis Res Ther. 2007;9(1):R7.

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Gene therapy of collagen-induced arthritis by electrotransfer of human tumor necrosis factor-alpha soluble receptor I variants.

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Electro-gene therapy of collagen-induced arthritis by using an expression plasmid for the soluble p75 tumor necrosis factor receptor-Fc fusion protein.

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TNF receptor gene therapy results in suppression of IgG2a anticollagen antibody in collagen induced arthritis.

Mukherjee P, Wu B, Mayton L, Kim SH, Robbins PD, Wooley PH.

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Inflammation-inducible anti-TNF gene expression mediated by intra-articular injection of serotype 5 adeno-associated virus reduces arthritis.

Khoury M, Adriaansen J, Vervoordeldonk MJ, Gould D, Chernajovsky Y, Bigey P, Bloquel C, Scherman D, Tak PP, Jorgensen C, Apparailly F.

J Gene Med. 2007 Jul;9(7):596-604.

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Suppression of collagen-induced arthritis through adenovirus-mediated transfer of a modified tumor necrosis factor alpha receptor gene.

Le CH, Nicolson AG, Morales A, Sewell KL.

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Tumour necrosis factor receptor gene therapy affects cellular immune responses in collagen induced arthritis in mice.

Mukherjee P, Yang SY, Wu B, Song Z, Myers LK, Robbins PD, Wooley PH.

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Amelioration of collagen-induced arthritis and suppression of interferon-gamma, interleukin-12, and tumor necrosis factor alpha production by interferon-beta gene therapy.

Triantaphyllopoulos KA, Williams RO, Tailor H, Chernajovsky Y.

Arthritis Rheum. 1999 Jan;42(1):90-9.

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Prevention of collagen-induced arthritis by gene delivery of soluble p75 tumour necrosis factor receptor.

Mageed RA, Adams G, Woodrow D, Podhajcer OL, Chernajovsky Y.

Gene Ther. 1998 Dec;5(12):1584-92.

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Paradoxical effects of tissue inhibitor of metalloproteinases 1 gene transfer in collagen-induced arthritis.

Apparailly F, Noël D, Millet V, Baker AH, Lisignoli G, Jacquet C, Kaiser MJ, Sany J, Jorgensen C.

Arthritis Rheum. 2001 Jun;44(6):1444-54.

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Viral IL-10 and soluble TNF receptor act synergistically to inhibit collagen-induced arthritis following adenovirus-mediated gene transfer.

Kim KN, Watanabe S, Ma Y, Thornton S, Giannini EH, Hirsch R.

J Immunol. 2000 Feb 1;164(3):1576-81.

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Immune modulation of collagen-induced arthritis by intranasal cytokine gene delivery: a model for the therapy of rheumatoid arthritis.

Woods AM, Thompson SJ, Wooley PH, Panayi G, Klavinskis LS.

Arthritis Rheum. 2005 Dec;52(12):3761-71.

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Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritis.

Schiffelers RM, Xu J, Storm G, Woodle MC, Scaria PV.

Arthritis Rheum. 2005 Apr;52(4):1314-8.

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Plasmid encoding interleukin-4 in the amelioration of murine collagen-induced arthritis.

Kageyama Y, Koide Y, Uchijima M, Nagata T, Yoshida A, Taiki A, Miura T, Nagafusa T, Nagano A.

Arthritis Rheum. 2004 Mar;50(3):968-75.

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Intra-articular electrotransfer of plasmid encoding soluble TNF receptor variants in normal and arthritic mice.

Bloquel C, Denys A, Boissier MC, Apparailly F, Bigey P, Scherman D, Bessis N.

J Gene Med. 2007 Nov;9(11):986-93.

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A comparative study on intra-articular versus systemic gene electrotransfer in experimental arthritis.

Khoury M, Bigey P, Louis-Plence P, Noel D, Rhinn H, Scherman D, Jorgensen C, Apparailly F.

J Gene Med. 2006 Aug;8(8):1027-36.

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Protection against collagen-induced arthritis by intramuscular gene therapy with an expression plasmid for the interleukin-1 receptor antagonist.

Kim JM, Jeong JG, Ho SH, Hahn W, Park EJ, Kim S, Yu SS, Lee YW, Kim S.

Gene Ther. 2003 Sep;10(18):1543-50.

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Paradoxical effects of adenovirus-mediated blockade of TNF activity in murine collagen-induced arthritis.

Quattrocchi E, Walmsley M, Browne K, Williams RO, Marinova-Mutafchieva L, Buurman W, Butler DM, Feldmann M.

J Immunol. 1999 Jul 15;163(2):1000-9.

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A novel doxycycline inducible autoregulatory plasmid which displays "on"/"off" regulation suited to gene therapy applications.

Gould DJ, Berenstein M, Dreja H, Ledda F, Podhajcer OL, Chernajovsky Y.

Gene Ther. 2000 Dec;7(24):2061-70.

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