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26.

687
Accesses

Research article   Open Access

RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis

Maria J Martínez-Calatrava, Ivan Prieto-Potín, Jorge A Roman-Blas, Lidia Tardio, Raquel Largo, Gabriel Herrero-Beaumont Arthritis Research & Therapy 2012, 14:R149 (18 June 2012)

Abstract | Full text | PDF | PubMed

27.

649
Accesses

Review   Free Highly Accessed

Common variable immunodeficiency - an update

Ulrich Salzer, Klaus Warnatz, Hans Peter Arthritis Research & Therapy 2012, 14:223 (24 September 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

28.

642
Accesses

Research article   Open Access Highly Accessed

Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay

Michael Mahler, Cristina Gascon, Sima Patel, Angela Ceribelli, Marvin J Fritzler, Andreas Swart, Edward KL Chan, Minoru Satoh Arthritis Research & Therapy 2013, 15:R50 (12 April 2013)

Abstract | Full text | PDF | PubMed

29.

617
Accesses

Review   Free Highly Accessed

Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases

Sherine E Gabriel, Kaleb Michaud Arthritis Research & Therapy 2009, 11:229 (19 May 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

30.

617
Accesses

Editorial   Free Highly Accessed

Kidney disease in lupus is not always 'lupus nephritis'

Hans-Joachim Anders, Jan J Weening Arthritis Research & Therapy 2013, 15:108 (1 March 2013)

Abstract | Full text | PDF | PubMed

31.

615
Accesses

Review   Subscription Highly Accessed

microRNA-mediated regulation of innate immune response in rheumatic diseases

Xiaobing Luo, Koustubh Ranade, Ronel Talker, Bahija Jallal, Nan Shen, Yihong Yao Arthritis Research & Therapy 2013, 15:210 (9 April 2013)

Abstract | Full text | PDF | PubMed

32.

596
Accesses

Review   Free

Epidemiology and genetics of rheumatoid arthritis

Alan J Silman, Jacqueline E Pearson Arthritis Res 2002, 4(Suppl 3):S265-S272 (9 May 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

33.

588
Accesses

Review   Free Highly Accessed

Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action

Larry W Moreland Arthritis Res Ther 2003, 5:54-67 (14 January 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

34.

577
Accesses

Commentary   Subscription

What can rheumatologists learn from translational cancer therapy?

Jonathan P Sherlock, Andrew D Filer, John D Isaacs, Christopher D Buckley Arthritis Research & Therapy 2013, 15:114 (1 May 2013)

Abstract | Full text | PDF | PubMed

35.

575
Accesses

Review   Free Highly Accessed

Recent advances in the diagnosis and treatment of hemophagocytic lymphohistiocytosis

Sebastian FN Bode, Kai Lehmberg, Andrea Maul-Pavicic, Thomas Vraetz, Gritta Janka, Udo Stadt, Stephan Ehl Arthritis Research & Therapy 2012, 14:213 (8 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

36.

572
Accesses

Review   Subscription

Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases?

Udo Oppermann Arthritis Research & Therapy 2013, 15:209 (3 April 2013)

Abstract | Full text | PDF | PubMed

37.

569
Accesses

Review   Free Highly Accessed

Interstitial lung disease in connective tissue diseases: evolving concepts of pathogenesis and management

Flavia V Castelino, John Varga Arthritis Research & Therapy 2010, 12:213 (23 August 2010)

Abstract | Full text | PDF | PubMed

38.

563
Accesses

Primary research   Open Access

Monoarticular antigen-induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats

Gisela von Banchet, Peter K Petrow, Rolf Bräuer, Hans-Georg Schaible Arthritis Res 2000, 2:424-427 (3 August 2000)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

39.

554
Accesses

Review   Free Highly Accessed

Interleukin-6 and chronic inflammation

Cem Gabay Arthritis Research & Therapy 2006, 8(Suppl 2):S3 (28 July 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

40.

554
Accesses

Editorial   Free Highly Accessed

Cardiovascular risk management in rheumatoid arthritis: are we still waiting for the first step?

Mike JL Peters, Michael T Nurmohamed Arthritis Research & Therapy 2013, 15:111 (19 March 2013)

Abstract | Full text | PDF | PubMed

41.

545
Accesses

Review   Free

B-cell targeted therapeutics in clinical development

Stephan Blüml, Kathleen McKeever, Rachel Ettinger, Josef Smolen, Ronald Herbst Arthritis Research & Therapy 2013, 15(Suppl 1):S4 (4 April 2013)

Abstract | Full text | PDF | PubMed

42.

523
Accesses

Review   Subscription Highly Accessed

Adult and juvenile dermatomyositis: are the distinct clinical features explained by our current understanding of serological subgroups and pathogenic mechanisms?

Sarah L Tansley, Neil J McHugh, Lucy R Wedderburn Arthritis Research & Therapy 2013, 15:211 (8 April 2013)

Abstract | Full text | PDF | PubMed

43.

520
Accesses

Research article   Open Access Highly Accessed

Vitamin D deficiency in undifferentiated connective tissue disease

Eva Zold, Peter Szodoray, Janos Gaal, János Kappelmayer, Laszlo Csathy, Edit Gyimesi, Margit Zeher, Gyula Szegedi, Edit Bodolay Arthritis Research & Therapy 2008, 10:R123 (18 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 |  Editor’s summary

A study of 161 patients with undifferentiated connective tissue disease suggests that vitamin D deficiency may be associated with the disease progressing into well-defined connective tissue diseases such as rheumatoid arthritis.

44.

518
Accesses

Research article   Open Access Highly Accessed

Effects of rehabilitative interventions on pain, function and physical impairments in people with hand osteoarthritis: a systematic review

Liuzhen Ye, Leonid Kalichman, Alicia Spittle, Fiona Dobson, Kim Bennell Arthritis Research & Therapy 2011, 13:R28 (18 February 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Rehabilitative interventions such as exercise, splints, laser therapy and massage can improve pain, hand function, grip strength and range of motion in individuals with hand osteoarthritis.

45.

511
Accesses

Research article   Open Access Highly Accessed

Efficacy of different types of aerobic exercise in fibromyalgia syndrome: a systematic review and meta-analysis of randomised controlled trials

Winfried Häuser, Petra Klose, Jost Langhorst, Babak Moradi, Mario Steinbach, Marcus Schiltenwolf, Angela Busch Arthritis Research & Therapy 2010, 12:R79 (10 May 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

46.

511
Accesses

Review   Free Highly Accessed

Osteoarthritis associated with estrogen deficiency

Jorge A Roman-Blas, Santos Castañeda, Raquel Largo, Gabriel Herrero-Beaumont Arthritis Research & Therapy 2009, 11:241 (21 September 2009)

Abstract | Full text | PDF | PubMed

47.

494
Accesses

Research article   Open Access Highly Accessed

Possible rheumatoid arthritis subtypes in terms of rheumatoid factor, depression, diagnostic delay and emotional expression: an exploratory case-control study

Taavi Tillmann, Rajeev Krishnadas, Jonathan Cavanagh, KV Petrides Arthritis Research & Therapy 2013, 15:R45 (21 March 2013)

Abstract | Full text | PDF | PubMed

48.

491
Accesses

Research article   Open Access Highly Accessed

The granulocyte colony stimulating factor pathway regulates autoantibody production in a murine induced model of systemic lupus erythematosus

Margareta Lantow, Ramya Sivakumar, Leilani Zeumer, Clive Wasserfall, Ying-Yi Zheng, Mark A Atkinson, Laurence Morel Arthritis Research & Therapy 2013, 15:R49 (8 April 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

B6.Sle2c2 mice are resistant to lupus due to a mutation in the granulocyte colony stimulating factor pathway, suggesting autoantibody production is inhibited by reduced neutrophil activation.

49.

488
Accesses

Review   Subscription Highly Accessed

An update on the hyper-IgE syndromes

Patrick FK Yong, Alexandra F Freeman, Karin R Engelhardt, Steven Holland, Jennifer M Puck, Bodo Grimbacher Arthritis Research & Therapy 2012, 14:228 (30 November 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

50.

486
Accesses

Review   Free Highly Accessed

Cellular and molecular pathogenesis of systemic lupus erythematosus: lessons from animal models

Simanta Pathak, Chandra Mohan Arthritis Research & Therapy 2011, 13:241 (30 September 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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