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1.

2457
Accesses

Research article   Open Access Highly Accessed

Cigarette smoking and smoking cessation in relation to risk of rheumatoid arthritis in women

Daniela Di Giuseppe, Nicola Orsini, Lars Alfredsson, Johan Askling, Alicja Wolk Arthritis Research & Therapy 2013, 15:R56 (22 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Smoking only a few cigarettes a day more than doubles the risk of developing rheumatoid arthritis and although this risk will lower with time after smoking cessation, it can remain elevated 15 years later.

2.

1577
Accesses

Research article   Open Access Highly Accessed

Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage

Mathias Gebauer, Joachim Saas, Jochen Haag, Uwe Dietz, Masaharu Takigawa, Eckart Bartnik, Thomas Aigner Arthritis Res Ther 2005, 7:R274-R284 (11 January 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

3.

1421
Accesses

Research article   Open Access Highly Accessed

Open label study of escalating doses of oral treprostinil diethanolamine in patients with systemic sclerosis and digital ischemia: pharmacokinetics and correlation with digital perfusion

Ami A Shah, Elena Schiopu, Laura K Hummers, Michael Wade, Kristine Phillips, Cynthia Anderson, Robert Wise, Francesco Boin, James R Seibold, Fredrick Wigley, Kristan D Rollins Arthritis Research & Therapy 2013, 15:R54 (18 April 2013)

Abstract | Provisional PDF | PubMed

4.

1257
Accesses

Editorial   Free Highly Accessed

Mesenchymal stem cell therapy in osteoarthritis: advanced tissue repair or intervention with smouldering synovial activation?

Peter LEM van Lent, Wim B van den Berg Arthritis Research & Therapy 2013, 15:112 (20 March 2013)

Abstract | Full text | PDF | PubMed

5.

1175
Accesses

Review   Free Highly Accessed

Mechanisms of B cell autoimmunity in SLE

Thomas Dörner, Claudia Giesecke, Peter E Lipsky Arthritis Research & Therapy 2011, 13:243 (27 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

6.

1108
Accesses

Editorial   Free

A complicated liaison: IL-33 and IL-33R in arthritis pathogenesis

Thomas Kamradt, Sebastian Drube Arthritis Research & Therapy 2013, 15:115 (2 May 2013)

Abstract | Full text | PDF | PubMed

7.

1049
Accesses

Research article   Open Access Highly Accessed

Adenosine A2A receptors promote collagen production by a Fli1- and CTGF-mediated mechanism

Edwin SL Chan, Hailing Liu, Patricia Fernandez, Alex Luna, Miguel Perez-Aso, Andreea M Bujor, Maria Trojanowska, Bruce N Cronstein Arthritis Research & Therapy 2013, 15:R58 (11 May 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Adenosine promotion of dermal fibrosis in conditions such as scleroderma is mediated by the transcription factor Fli1 and growth factor CTFG, highlighting potential targets for future anti-fibrotic therapies.

8.

1013
Accesses

Research article   Open Access Highly Accessed

Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence

Laurent G Ameye, Winnie SS Chee Arthritis Research & Therapy 2006, 8:R127 (19 July 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

9.

915
Accesses

Research article   Open Access

MMP-2 mediates local degradation and remodeling of collagen by annulus fibrosus cells of the intervertebral disc

Anshu Rastogi, Hyunchul Kim, Julianne D Twomey, Adam H Hsieh Arthritis Research & Therapy 2013, 15:R57 (27 April 2013)

Abstract | Provisional PDF | PubMed

10.

900
Accesses

Review   Free Highly Accessed

The inflammatory process of gout and its treatment

Bruce N Cronstein, Robert Terkeltaub Arthritis Research & Therapy 2006, 8(Suppl 1):S3 (12 April 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

11.

878
Accesses

Review   Free

IL-10-producing regulatory B cells (B10 cells) in autoimmune disease

Ioannis Kalampokis, Ayumi Yoshizaki, Thomas F Tedder Arthritis Research & Therapy 2013, 15(Suppl 1):S1 (11 February 2013)

Abstract | Full text | PDF | PubMed

12.

867
Accesses

Research article   Open Access Highly Accessed

Osteoporosis in ankylosing spondylitis - prevalence, risk factors and methods of assessment

Eva Klingberg, Mattias Lorentzon, Dan Mellström, Mats Geijer, Jan Göthlin, Elisabet Hilme, Martin Hedberg, Hans Carlsten, Helena Forsblad-d'Elia Arthritis Research & Therapy 2012, 14:R108 (8 May 2012)

Abstract | Full text | PDF | PubMed

13.

810
Accesses

Research article   Open Access Highly Accessed

A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee

Krishanu Sengupta, Krishnaraju V Alluri, Andey Satish, Simanchala Mishra, Trimurtulu Golakoti, Kadainti VS Sarma, Dipak Dey, Siba P Raychaudhuri Arthritis Research & Therapy 2008, 10:R85 (30 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 |  Editor’s summary

An enriched extract of the Indian frankincense herb, Boswellia serrata reduced pain and improved the physical function of osteoarthritis patients, in a double blind, randomized, placebo controlled trial.

14.

697
Accesses

Commentary   Subscription

What can rheumatologists learn from translational cancer therapy?

Jonathan P Sherlock, Andrew D Filer, John D Isaacs, Christopher D Buckley Arthritis Research & Therapy 2013, 15:114 (1 May 2013)

Abstract | Full text | PDF | PubMed

15.

693
Accesses

Research article   Open Access Highly Accessed

Association between alcohol consumption and symptom severity and quality of life in patients with fibromyalgia

Chul H Kim, Ann Vincent, Daniel J Clauw, Connie A Luedtke, Jeffrey M Thompson, Terry D Schneekloth, Terry H Oh Arthritis Research & Therapy 2013, 15:R42 (15 March 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Low to moderate alcohol consumption lessens symptom severity and betters quality of life for fibromyalgia patients when compared to no alcohol consumption.

16.

692
Accesses

Review   Free Highly Accessed

Degeneration of the intervertebral disc

Jill PG Urban, Sally Roberts Arthritis Res Ther 2003, 5:120-130 (11 March 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

17.

678
Accesses

Review   Free

Complement and systemic lupus erythematosus

Mark J Walport Arthritis Res 2002, 4(Suppl 3):S279-S293 (9 May 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

18.

642
Accesses

Research article   Open Access Highly Accessed

A pilot study of IL-1 inhibition by anakinra in acute gout

Alexander So, Thibaut De Smedt, Sylvie Revaz, Jürg Tschopp Arthritis Research & Therapy 2007, 9:R28 (12 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In a pilot study on 10 patients with gouty arthritis, IL-1 blockade with anakinra gave rapid relief of inflammatory symptoms where standard treatments had failed or were not tolerated.

19.

635
Accesses

Research article   Open Access Highly Accessed

The Revised Fibromyalgia Impact Questionnaire (FIQR): validation and psychometric properties

Robert M Bennett, Ronald Friend, Kim D Jones, Rachel Ward, Bobby K Han, Rebecca L Ross Arthritis Research & Therapy 2009, 11:R120 (10 August 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

20.

633
Accesses

Review   Free Highly Accessed

Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases

Sherine E Gabriel, Kaleb Michaud Arthritis Research & Therapy 2009, 11:229 (19 May 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

21.

635
Accesses

Research article   Open Access

A novel in vitro bovine cartilage punch model for assessing the regeneration of focal cartilage defects with biocompatible bacterial nanocellulose

David Pretzel, Stefanie Linss, Hannes Ahrem, Michaela Endres, Christian Kaps, Dieter Klemm, Raimund W. Kinne Arthritis Research & Therapy 2013, 15:R59 (14 May 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

In vitro bovine cartilage punch model is a novel tool developed to evaluate potential bio-materials for use in cartilage regeneration and repair.

22.

608
Accesses

Review   Free Highly Accessed

Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action

Larry W Moreland Arthritis Res Ther 2003, 5:54-67 (14 January 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

23.

592
Accesses

Research article   Open Access

Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis

Jérôme Avouac, Maeva Vallucci, Vanessa Smith, Patricia Senet, Barbara Ruiz, Alberto Sulli, Carmen Pizzorni, Camille Frances, Gilles Chiocchia, Maurizio Cutolo, Yannick Allanore Arthritis Research & Therapy 2013, 15:R55 (19 April 2013)

Abstract | Provisional PDF | PubMed

24.

594
Accesses

Editorial   Free Highly Accessed

Kidney disease in lupus is not always 'lupus nephritis'

Hans-Joachim Anders, Jan J Weening Arthritis Research & Therapy 2013, 15:108 (1 March 2013)

Abstract | Full text | PDF | PubMed

25.

594
Accesses

Review   Free

Epidemiology and genetics of rheumatoid arthritis

Alan J Silman, Jacqueline E Pearson Arthritis Res 2002, 4(Suppl 3):S265-S272 (9 May 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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