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	51. 3972 Accesses	Review Mucocutaneous candidiasis: the IL-17 pathway and implications for targeted immunotherapy Anna R Huppler, Shrinivas Bishu, Sarah L Gaffen Arthritis Research & Therapy 2012, 14:217 (23 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	52. 3925 Accesses	Research article Minocycline and doxycycline therapy in community patients with rheumatoid arthritis: prescribing patterns, patient-level determinants of use, and patient-reported side effects Christopher J Smith, Harlan Sayles, Ted R Mikuls, Kaleb Michaud Arthritis Research & Therapy 2011, 13:R168 (18 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Although the drugs are generally well-tolerated, rheumatologists mostly prescribe minocycline or doxycycline in patients with long-standing rheumatoid arthritis (RA) where other treatments have failed, and not as a primary treatment option.
	53. 3919 Accesses	Research article MMP13 is a critical target gene during the progression of osteoarthritis Meina Wang, Erik R Sampson, Hongting Jin, Jia Li, Qiao H Ke, Hee-Jeong Im, Di Chen Arthritis Research & Therapy 2013, 15:R5 (8 January 2013) Abstract \| Full text \| PDF \| PubMed
	54. 3898 Accesses	Review Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis? Yves Henrotin, Ali Mobasheri, Marc Marty Arthritis Research & Therapy 2012, 14:201 (30 January 2012) Abstract \| Full text \| PDF \| PubMed
	55. 3886 Accesses	Review Mechanisms of tissue injury in lupus nephritis Tamara K Nowling, Gary S Gilkeson Arthritis Research & Therapy 2011, 13:250 (21 December 2011) Abstract \| Full text \| PDF \| PubMed
	56. 3856 Accesses	Research article Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development James F Fries, Eswar Krishnan Arthritis Res Ther 2004, 6:R250-R255 (18 March 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The 'uncertainty principle' states that randomised controlled trials are only ethical if true uncertainty exists about which treatment is likely to be superior. Is this principle being violated in industry-sponsored trials?
	57. 3803 Accesses	Review Advances in rheumatology: new targeted therapeutics Paul P Tak, Joachim R Kalden Arthritis Research & Therapy 2011, 13(Suppl 1):S5 (25 May 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	58. 3783 Accesses	Review The clinical relevance of autoantibodies in scleroderma Khanh T Ho, John D Reveille Arthritis Res Ther 2003, 5:80-93 (12 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	59. 3767 Accesses	Review Gout. Novel therapies for treatment of gout and hyperuricemia Robert Terkeltaub Arthritis Research & Therapy 2009, 11:236 (23 July 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	60. 3762 Accesses	Review Infliximab: 12 years of experience Josef S Smolen, Paul Emery Arthritis Research & Therapy 2011, 13(Suppl 1):S2 (25 May 2011) Abstract \| Full text \| PDF \| PubMed
	61. 3761 Accesses	Research article Inflammation associated anemia and ferritin as disease markers in SLE Kamala Vanarsa, Yujin Ye, Jie Han, Chun Xie, Chandra Mohan, Tianfu Wu Arthritis Research & Therapy 2012, 14:R182 (7 August 2012) Abstract \| Full text \| PDF \| PubMed
	62. 3749 Accesses	Review Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action Larry W Moreland Arthritis Res Ther 2003, 5:54-67 (14 January 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	63. 3730 Accesses	Review Articular cartilage and changes in Arthritis: Cell biology of osteoarthritis Linda J Sandell, Thomas Aigner Arthritis Res 2001, 3:107-113 (22 January 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	64. 3712 Accesses	Editorial Metabolic factors in osteoarthritis: obese people do not walk on their hands Erlangga Yusuf Arthritis Research & Therapy 2012, 14:123 (19 July 2012) Abstract \| Full text \| PDF \| PubMed
	65. 3689 Accesses	Research article Low-dose oral prednisone improves clinical and ultrasonographic remission rates in early rheumatoid arthritis: results of a 12-month open-label randomised study Carlomaurizio Montecucco, Monica Todoerti, Garifallia Sakellariou, Carlo Scirè, Roberto Caporali Arthritis Research & Therapy 2012, 14:R112 (14 May 2012) Abstract \| Full text \| PDF \| PubMed
	66. 3665 Accesses	Research article Mechanisms of quadriceps muscle weakness in knee joint osteoarthritis: the effects of prolonged vibration on torque and muscle activation in osteoarthritic and healthy control subjects David A Rice, Peter J McNair, Gwyn N Lewis Arthritis Research & Therapy 2011, 13:R151 (20 September 2011) Abstract \| Full text \| PDF \| PubMed
	67. 3627 Accesses	Research article Rheumatic Diseases in China Qing Zeng, Ren Chen, John Darmawan, Zheng Xiao, Su Chen, Richard Wigley, Shun Le Chen, Nai Zhang Arthritis Research & Therapy 2008, 10:R17 (31 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A large population study found that the incidence of certain rheumatic diseases in China is becoming more like that of Western countries, but different joints are affected compared to Caucasian populations.
	68. 3608 Accesses	Research article A pilot study of IL-1 inhibition by anakinra in acute gout Alexander So, Thibaut De Smedt, Sylvie Revaz, Jürg Tschopp Arthritis Research & Therapy 2007, 9:R28 (12 March 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In a pilot study on 10 patients with gouty arthritis, IL-1 blockade with anakinra gave rapid relief of inflammatory symptoms where standard treatments had failed or were not tolerated.
	69. 3537 Accesses	Review An update on the hyper-IgE syndromes Patrick FK Yong, Alexandra F Freeman, Karin R Engelhardt, Steven Holland, Jennifer M Puck, Bodo Grimbacher Arthritis Research & Therapy 2012, 14:228 (30 November 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	70. 3518 Accesses	Research article Autoantibody profiling to follow evolution of lupus syndromes Nancy J Olsen, Quan-Zhen Li, Jiexia Quan, Ling Wang, Azza Mutwally, David R Karp Arthritis Research & Therapy 2012, 14:R174 (27 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	71. 3513 Accesses	Research article Efficacy of different types of aerobic exercise in fibromyalgia syndrome: a systematic review and meta-analysis of randomised controlled trials Winfried Häuser, Petra Klose, Jost Langhorst, Babak Moradi, Mario Steinbach, Marcus Schiltenwolf, Angela Busch Arthritis Research & Therapy 2010, 12:R79 (10 May 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	72. 3490 Accesses	Review What is MRI bone oedema in rheumatoid arthritis and why does it matter? Fiona M McQueen, Benedikt Ostendorf Arthritis Research & Therapy 2006, 8:222 (5 December 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	73. 3488 Accesses	Review Mesenchymal stem cells in arthritic diseases Faye H Chen, Rocky S Tuan Arthritis Research & Therapy 2008, 10:223 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	74. 3487 Accesses	Review Anti-inflammatory and immunosuppressive drugs and reproduction Monika Østensen, Munther Khamashta, Michael Lockshin, Ann Parke, Antonio Brucato, Howard Carp, Andrea Doria, Raj Rai, Pierluigi Meroni, Irene Cetin, Ronald Derksen, Ware Branch, Mario Motta, Caroline Gordon, Guillermo Ruiz-Irastorza, Arsenio Spinillo, Deborah Friedman, Rolando Cimaz, Andrew Czeizel, Jean Piette, Ricard Cervera, Roger A Levy, Maurizio Clementi, Sara De Carolis, Michelle Petri, Yehuda Shoenfeld, David Faden, Guido Valesini, Angela Tincani Arthritis Research & Therapy 2006, 8:209 (11 May 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	75. 3466 Accesses	Review Epidemiology, risk factors, and lifestyle modifications for gout Kenneth G Saag, Hyon Choi Arthritis Research & Therapy 2006, 8(Suppl 1):S2 (12 April 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	76. 3464 Accesses	Research article Nocturnal heart rate variability parameters as potential fibromyalgia biomarker: correlation with symptoms severity Claudia Lerma, Aline Martinez, Natllely Ruiz, Angelica Vargas, Oscar Infante, Manuel Martinez-Lavin Arthritis Research & Therapy 2011, 13:R185 (16 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Nocturnal heart rate variability parameters indicative of sympathetic predominance are significantly different in fibromyalgia patients compared to healthy individuals, and correlate with several symptoms including pain severity.
	77. 3420 Accesses	Commentary Promise and pitfalls of the Immunochip Adrian Cortes, Matthew A Brown Arthritis Research & Therapy 2011, 13:101 (1 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	78. 3420 Accesses	Review New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options Martin K Lotz Arthritis Research & Therapy 2010, 12:211 (28 June 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	79. 3418 Accesses	Research article Direct transplantation of mesenchymal stem cells into the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis Mitsuhiko Sato, Kenzo Uchida, Hideaki Nakajima, Tsuyoshi Miyazaki, Alexander Guerrero, Shuji Watanabe, Sally Roberts, Hisatoshi Baba Arthritis Research & Therapy 2012, 14:R31 (7 February 2012) Abstract \| Full text \| PDF \| PubMed \| F1000
	80. 3415 Accesses	Research article Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen Julia J Inglis, Gabriel Criado, Mino Medghalchi, Melanie Andrews, Ann Sandison, Marc Feldmann, Richard O Williams Arthritis Research & Therapy 2007, 9:R113 (29 October 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary C57BL/6 mice may be useful for testing new therapeutics, particularly those directed against T cells, and investigating the action of current therapies in rheumatoid arthritis.
	81. 3375 Accesses	Research article Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis Gurkirpal Singh, Olivia Wu, Peter Langhorne, Rajan Madhok Arthritis Research & Therapy 2006, 8:R153 (22 September 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary NSAIDs have been shown to be associated with an increased risk of acute myocardial infarctions, suggesting they should be used with caution in those with risk factors for cardiovascular disease.
	82. 3337 Accesses	Review Disturbances of apoptotic cell clearance in systemic lupus erythematosus Wen-Hai Shao, Philip L Cohen Arthritis Research & Therapy 2011, 13:202 (28 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	83. 3325 Accesses	Commentary Biosimilars: a regulatory perspective from America Jonathan Kay Arthritis Research & Therapy 2011, 13:112 (12 May 2011) Abstract \| Full text \| PDF \| PubMed
	84. 3290 Accesses	Research article Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance Ilias Stagakis, George Bertsias, Stylianos Karvounaris, Melina Kavousanaki, Dimitra Virla, Amalia Raptopoulou, Dimitrios Kardassis, Dimitrios T Boumpas, Prodromos I Sidiropoulos Arthritis Research & Therapy 2012, 14:R141 (12 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Twelve weeks of anti-tumor necrosis factor (TNF) therapy improved insulin sensitivity, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance.
	85. 3290 Accesses	Research article The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells Betty Y Chang, Min Huang, Michelle Francesco, Jun Chen, Jeremy Sokolove, Padmaja Magadala, William H Robinson, Joseph J Buggy Arthritis Research & Therapy 2011, 13:R115 (13 July 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	86. 3260 Accesses	Review Abnormalities of T cell signaling in systemic lupus erythematosus Vaishali R Moulton, George C Tsokos Arthritis Research & Therapy 2011, 13:207 (17 March 2011) Abstract \| Full text \| PDF \| PubMed
	87. 3254 Accesses	Research article Integrated safety in tocilizumab clinical trials Michael H Schiff, Joel M Kremer, Angelika Jahreis, Emma Vernon, John D Isaacs, Ronald F van Vollenhoven Arthritis Research & Therapy 2011, 13:R141 (1 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	88. 3230 Accesses	Research article Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture — primary culture cells markedly differ from fourth-passage cells Thomas Zimmermann, Elke Kunisch, Robert Pfeiffer, Astrid Hirth, Hans-Detlev Stahl, Ulrich Sack, Anke Laube, Eckehard Liesaus, Andreas Roth, Ernesta Palombo-Kinne, Frank Emmrich, Raimund W Kinne Arthritis Res 2001, 3:72-76 (21 November 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	89. 3221 Accesses	Review Treatment targets in systemic lupus erythematosus: biology and clinical perspective Valentin Marian, Jennifer H Anolik Arthritis Research & Therapy 2012, 14(Suppl 4):S3 (30 November 2012) Abstract \| Full text \| PDF \| PubMed
	90. 3212 Accesses	Research article Ultrasound of metacarpophalangeal joints is a sensitive and reliable endpoint for drug therapies in rheumatoid arthritis: results of a randomized, two-center placebo-controlled study Matthew W Seymour, Stephen Kelly, Chan R Beals, Marie-Pierre Malice, James A Bolognese, Bernard J Dardzinski, Amy S Cheng, Corinne E Cummings, Steven S Smugar, Catherine McClinton, Amy Fox, William M Dooley, Constantino Pitzalis, Peter C Taylor Arthritis Research & Therapy 2012, 14:R198 (12 September 2012) Abstract \| Full text \| PDF \| PubMed
	91. 3210 Accesses	Research article Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models Jun Soo Bang, Da Hee Oh, Hyun Mi Choi, Bong-Jun Sur, Sung-Jig Lim, Jung Yeon Kim, Hyung-In Yang, Myung Chul Yoo, Dae-Hyun Hahm, Kyoung Soo Kim Arthritis Research & Therapy 2009, 11:R49 (30 March 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	92. 3189 Accesses	Research article Properties and usefulness of aggregates of synovial mesenchymal stem cells as a source for cartilage regeneration Shiro Suzuki, Takeshi Muneta, Kunikazu Tsuji, Shizuko Ichinose, Hatsune Makino, Akihiro Umezawa, Ichiro Sekiya Arthritis Research & Therapy 2012, 14:R136 (7 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Aggregated mesenchymal stem cells are a useful source for cartilage regeneration, as they are easy to prepare, have high chondrogenic potential and attach efficiently.
	93. 3151 Accesses	Research article Can erosions on MRI of the sacroiliac joints be reliably detected in patients with ankylosing spondylitis? - A cross-sectional study Ulrich Weber, Susanne J Pedersen, Mikkel Østergaard, Kaspar Rufibach, Robert GW Lambert, Walter P Maksymowych Arthritis Research & Therapy 2012, 14:R124 (24 May 2012) Abstract \| Full text \| PDF \| PubMed
	94. 3114 Accesses	Primary research Monoarticular antigen-induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats Gisela von Banchet, Peter K Petrow, Rolf Bräuer, Hans-Georg Schaible Arthritis Res 2000, 2:424-427 (3 August 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	95. 3112 Accesses	Research article Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes Feng-Cheng Liu, Li-Feng Hung, Wan-Lin Wu, Deh-Ming Chang, Chuan-Yueh Huang, Jenn-Haung Lai, Ling-Jun Ho Arthritis Research & Therapy 2010, 12:R167 (8 September 2010) Abstract \| Full text \| PDF \| PubMed
	96. 3111 Accesses	Research article Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies Chih Liu, Stephanie Tangsombatvisit, Jacob M Rosenberg, Gil Mandelbaum, Emily C Gillespie, Or P Gozani, Ash A Alizadeh, Paul J Utz Arthritis Research & Therapy 2012, 14:R25 (2 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	97. 3096 Accesses	Research article miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4 Jing Li, Jingang Huang, Liming Dai, Degang Yu, Qian Chen, Xiaoling Zhang, Kerong Dai Arthritis Research & Therapy 2012, 14:R75 (16 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The microRNA miR-146a may reduce cellular response to transforming growth factor-beta through targeted inhibition of Smad4 in cartilage, thus increasing vascular endothelial growth factor levels, and increasing chondrocyte apoptosis.
	98. 3083 Accesses	Research article Vitamin D deficiency in rheumatoid arthritis: prevalence, determinants and associations with disease activity and disability Maurizio Rossini, Susanna Maddali Bongi, Giovanni La Montagna, Giovanni Minisola, Nazzarena Malavolta, Luigi Bernini, Enrico Cacace, Luigi Sinigaglia, Ombretta Di Munno, Silvano Adami Arthritis Research & Therapy 2010, 12:R216 (29 November 2010) Abstract \| Full text \| PDF \| PubMed \| F1000
	99. 3013 Accesses	Research article Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study Tuulikki Sokka, Sergio Toloza, Maurizio Cutolo, Hannu Kautiainen, Heidi Makinen, Feride Gogus, Vlado Skakic, Humeira Badsha, Tõnu Peets, Asta Baranauskaite, Pál Géher, Ilona Újfalussy, Fotini N Skopouli, Maria Mavrommati, Rieke Alten, Christof Pohl, Jean Sibilia, Andrea Stancati, Fausto Salaffi, Wojciech Romanowski, Danuta Zarowny-Wierzbinska, Dan Henrohn, Barry Bresnihan, Patricia Minnock, Lene Knudsen, Johannes WG Jacobs, Jaime Calvo-Alen, Juris Lazovskis, Geraldo Pinheiro, Dmitry Karateev, Daina Andersone, Sylejman Rexhepi, Yusuf Yazici, Theodore Pincus, the QUEST-RA Group et al. Arthritis Research & Therapy 2009, 11:R7 (14 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Rheumatoid arthritis was more severe in women in an analysis of more than 6,000 patients, although the effects of gender on standard disease activity measures may explain the difference.
	100. 3012 Accesses	Review Current treatment of hepatitis C-associated rheumatic diseases Clodoveo Ferri, Marco Sebastiani, Alessandro Antonelli, Michele Colaci, A Manfredi, Dilia Giuggioli Arthritis Research & Therapy 2012, 14:215 (25 June 2012) Abstract \| Full text \| PDF \| PubMed