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	1. 10624 Accesses	Research article Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence Laurent G Ameye, Winnie SS Chee Arthritis Research & Therapy 2006, 8:R127 (19 July 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	2. 9307 Accesses	Review Degeneration of the intervertebral disc Jill PG Urban, Sally Roberts Arthritis Res Ther 2003, 5:120-130 (11 March 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment
	3. 8606 Accesses	Research article Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage Mathias Gebauer, Joachim Saas, Jochen Haag, Uwe Dietz, Masaharu Takigawa, Eckart Bartnik, Thomas Aigner Arthritis Res Ther 2005, 7:R274-R284 (11 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	4. 8501 Accesses	Research article A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin^®for treatment of osteoarthritis of the knee Krishanu Sengupta, Krishnaraju V Alluri, Andey Satish, Simanchala Mishra, Trimurtulu Golakoti, Kadainti VS Sarma, Dipak Dey, Siba P Raychaudhuri Arthritis Research & Therapy 2008, 10:R85 (30 July 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 \| Editor’s summary An enriched extract of the Indian frankincense herb, Boswellia serrata reduced pain and improved the physical function of osteoarthritis patients, in a double blind, randomized, placebo controlled trial.
	5. 7464 Accesses	Review Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases Sherine E Gabriel, Kaleb Michaud Arthritis Research & Therapy 2009, 11:229 (19 May 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	6. 7085 Accesses	Research article Gluten-free vegan diet induces decreased LDL and oxidized LDL levels and raised atheroprotective natural antibodies against phosphorylcholine in patients with rheumatoid arthritis: a randomized study Ann-Charlotte Elkan, Beatrice Sjöberg, Björn Kolsrud, Bo Ringertz, Ingiäld Hafström, Johan Frostegård Arthritis Research & Therapy 2008, 10:R34 (18 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A gluten-free vegan diet induces potentially atheroprotective and anti-inflammatory changes in rheumatoid arthritis patients, including reduced low density lipoprotein (LDL) and oxidated LDL levels and raised natural antibodies against phosphorylcholine.
	7. 6873 Accesses	Research article Vitamin D deficiency in undifferentiated connective tissue disease Eva Zold, Peter Szodoray, Janos Gaal, János Kappelmayer, Laszlo Csathy, Edit Gyimesi, Margit Zeher, Gyula Szegedi, Edit Bodolay Arthritis Research & Therapy 2008, 10:R123 (18 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 \| Editor’s summary A study of 161 patients with undifferentiated connective tissue disease suggests that vitamin D deficiency may be associated with the disease progressing into well-defined connective tissue diseases such as rheumatoid arthritis.
	8. 6783 Accesses	Research article A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis Rui Liu, Qian Wu, Dinglei Su, Nan Che, Haifeng Chen, Linyu Geng, Jinyun Chen, Wanjun Chen, Xia Li, Lingyun Sun Arthritis Research & Therapy 2012, 14:R255 (23 November 2012) Abstract \| Full text \| PDF \| PubMed
	9. 6591 Accesses	Review Mechanisms of B cell autoimmunity in SLE Thomas Dörner, Claudia Giesecke, Peter E Lipsky Arthritis Research & Therapy 2011, 13:243 (27 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	10. 6343 Accesses	Review Interstitial lung disease in connective tissue diseases: evolving concepts of pathogenesis and management Flavia V Castelino, John Varga Arthritis Research & Therapy 2010, 12:213 (23 August 2010) Abstract \| Full text \| PDF \| PubMed
	11. 6209 Accesses	Research article Osteoporosis in ankylosing spondylitis - prevalence, risk factors and methods of assessment Eva Klingberg, Mattias Lorentzon, Dan Mellström, Mats Geijer, Jan Göthlin, Elisabet Hilme, Martin Hedberg, Hans Carlsten, Helena Forsblad-d'Elia Arthritis Research & Therapy 2012, 14:R108 (8 May 2012) Abstract \| Full text \| PDF \| PubMed
	12. 6139 Accesses	Review Epidemiology and genetics of rheumatoid arthritis Alan J Silman, Jacqueline E Pearson Arthritis Res 2002, 4(Suppl 3):S265-S272 (9 May 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	13. 6097 Accesses	Review Interleukin-6 and chronic inflammation Cem Gabay Arthritis Research & Therapy 2006, 8(Suppl 2):S3 (28 July 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	14. 5723 Accesses	Research article The Revised Fibromyalgia Impact Questionnaire (FIQR): validation and psychometric properties Robert M Bennett, Ronald Friend, Kim D Jones, Rachel Ward, Bobby K Han, Rebecca L Ross Arthritis Research & Therapy 2009, 11:R120 (10 August 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	15. 5662 Accesses	Research article Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis Fiona E McCann, Andrew C Palfreeman, Melanie Andrews, Dany P Perocheau, Julia J Inglis, Peter Schafer, Marc Feldmann, Richard O Williams, Fionula M Brennan Arthritis Research & Therapy 2010, 12:R107 (2 June 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	16. 5620 Accesses	Research article TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro Jun Qin, Liang Shang, An-song Ping, Jing Li, Xiao-jun Li, Hong Yu, Jacques Magdalou, Liao-bin Chen, Hui Wang Arthritis Research & Therapy 2012, 14:R242 (7 November 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	17. 5520 Accesses	Review The inflammatory process of gout and its treatment Bruce N Cronstein, Robert Terkeltaub Arthritis Research & Therapy 2006, 8(Suppl 1):S3 (12 April 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	18. 5488 Accesses	Review Adult mesenchymal stem cells and cell-based tissue engineering Rocky S Tuan, Genevieve Boland, Richard Tuli Arthritis Res Ther 2003, 5:32-45 (11 December 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	19. 5459 Accesses	Research article Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation Benjamin Terrier, Nicolas Derian, Yoland Schoindre, Wahiba Chaara, Guillaume Geri, Noël Zahr, Kubéraka Mariampillai, Michelle Rosenzwajg, Wassila Carpentier, Lucile Musset, Jean-Charles Piette, Adrien Six, David Klatzmann, David Saadoun, Cacoub Patrice, Nathalie Costedoat-Chalumeau Arthritis Research & Therapy 2012, 14:R221 (17 October 2012) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology \| Editor’s summary Vitamin D supplementation in systemic lupus erythematosus (SLE) patients caused a reduction in B memory cells and effector T cells, and an increase in Tregs, suggesting vitamin D provides beneficial immunological effects for SLE.
	20. 5383 Accesses	Research article Clinical features of symptomatic patellofemoral joint osteoarthritis George Peat, Rachel C Duncan, Laurence RJ Wood, Elaine Thomas, Sara Muller Arthritis Research & Therapy 2012, 14:R63 (14 March 2012) Abstract \| Full text \| PDF \| PubMed
	21. 5323 Accesses	Review Platelet-rich plasma therapy - future or trend? Robinder S Dhillon, Edward M Schwarz, Michael D Maloney Arthritis Research & Therapy 2012, 14:219 (8 August 2012) Abstract \| Full text \| PDF \| PubMed
	22. 5318 Accesses	Review The genetics of lupus: a functional perspective Sandra G Guerra, Timothy J Vyse, Deborah S Cunninghame Graham Arthritis Research & Therapy 2012, 14:211 (29 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	23. 5306 Accesses	Review Cellular and molecular pathogenesis of systemic lupus erythematosus: lessons from animal models Simanta Pathak, Chandra Mohan Arthritis Research & Therapy 2011, 13:241 (30 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	24. 5246 Accesses	Research article Distinguishing fibromyalgia from rheumatoid arthritis and systemic lupus in clinical questionnaires: an analysis of the revised Fibromyalgia Impact Questionnaire (FIQR) and its variant, the Symptom Impact Questionnaire (SIQR), along with pain locations Ronald Friend, Robert M Bennett Arthritis Research & Therapy 2011, 13:R58 (8 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A combination of 2 questions from the symptom impact questionnaire plus pain in four locations identified the correct diagnosis in 97% of subjects with fibromyalgia, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
	25. 5059 Accesses	Review Complement and systemic lupus erythematosus Mark J Walport Arthritis Res 2002, 4(Suppl 3):S279-S293 (9 May 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	26. 4946 Accesses	Research article Effects of rehabilitative interventions on pain, function and physical impairments in people with hand osteoarthritis: a systematic review Liuzhen Ye, Leonid Kalichman, Alicia Spittle, Fiona Dobson, Kim Bennell Arthritis Research & Therapy 2011, 13:R28 (18 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Rehabilitative interventions such as exercise, splints, laser therapy and massage can improve pain, hand function, grip strength and range of motion in individuals with hand osteoarthritis.
	27. 4925 Accesses	Research article Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis Heidi Kokkonen, Mohammed Mullazehi, Ewa Berglin, Göran Hallmans, Göran Wadell, Johan Rönnelid, Solbritt Rantapää-Dahlqvist Arthritis Research & Therapy 2011, 13:R13 (3 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	28. 4866 Accesses	Research article TLR4-mediated IL-12 production enhances IFN-γ and IL-1β production, which inhibits TGF-β production and promotes antibody-induced joint inflammation Hye Kim, Doo Chung Arthritis Research & Therapy 2012, 14:R210 (4 October 2012) Abstract \| Full text \| PDF \| PubMed
	29. 4863 Accesses	Research article Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model Anika I Tsuchida, Michiel Beekhuizen, Marijn Rutgers, Gerjo JVM van Osch, Joris EJ Bekkers, Arjan GJ Bot, Bernd Geurts, Wouter JA Dhert, Daniel BF Saris, Laura B Creemers Arthritis Research & Therapy 2012, 14:R262 (3 December 2012) Abstract \| Full text \| PDF \| PubMed
	30. 4807 Accesses	Review Fish oil: what the prescriber needs to know Leslie G Cleland, Michael J James, Susanna M Proudman Arthritis Research & Therapy 2006, 8:202 (21 December 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	31. 4797 Accesses	Research article CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts Chun-Han Hou, Chih-Hsin Tang, Chin-Jung Hsu, Sheng-Mon Hou, Ju-Fang Liu Arthritis Research & Therapy 2013, 15:R19 (23 January 2013) Abstract \| Full text \| PDF \| PubMed
	32. 4778 Accesses	Review A concise history of gout and hyperuricemia and their treatment George Nuki, Peter A Simkin Arthritis Research & Therapy 2006, 8(Suppl 1):S1 (12 April 2006) Abstract \| Full text \| PDF \| PubMed
	33. 4755 Accesses	Review Pathogenesis of tendinopathies: inflammation or degeneration? Michele Abate, Karin Gravare Silbernagel, Carl Siljeholm, Angelo Di Iorio, Daniele De Amicis, Vincenzo Salini, Suzanne Werner, Roberto Paganelli Arthritis Research & Therapy 2009, 11:235 (30 June 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	34. 4679 Accesses	Review Recent advances in the diagnosis and treatment of hemophagocytic lymphohistiocytosis Sebastian FN Bode, Kai Lehmberg, Andrea Maul-Pavicic, Thomas Vraetz, Gritta Janka, Udo Stadt, Stephan Ehl Arthritis Research & Therapy 2012, 14:213 (8 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	35. 4564 Accesses	Research article Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis Yanying Liu, Rong Mu, Shiyao Wang, Li Long, Xia Liu, Ru Li, Jian Sun, Jianping Guo, Xiaoping Zhang, Jing Guo, Ping Yu, Chunlei Li, Xiangyuan Liu, Zhenyu Huang, Dapeng Wang, Hu Li, Zhifeng Gu, Bing Liu, Zhanguo Li Arthritis Research & Therapy 2010, 12:R210 (16 November 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	36. 4524 Accesses	Research article Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis Marina G Kazantseva, John Highton, Lisa K Stamp, Paul A Hessian Arthritis Research & Therapy 2012, 14:R208 (4 October 2012) Abstract \| Full text \| PDF \| PubMed
	37. 4440 Accesses	Research article The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial Michael A Becker, H Ralph Schumacher, Luis R Espinoza, Alvin F Wells, Patricia MacDonald, Eric Lloyd, Christopher Lademacher Arthritis Research & Therapy 2010, 12:R63 (6 April 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	38. 4438 Accesses	Review Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation Catherine M Kolf, Elizabeth Cho, Rocky S Tuan Arthritis Research & Therapy 2007, 9:204 (19 February 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	39. 4407 Accesses	Research article Enhanced interleukin-1β production of PBMCs from patients with gout after stimulation with Toll-like receptor-2 ligands and urate crystals Eleni E Mylona, Maria Mouktaroudi, Tania O Crisan, Stamatoula Makri, Aikaterini Pistiki, Marianna Georgitsi, Athina Savva, Mihai G Netea, Jos WM van der Meer, Evangelos J Giamarellos-Bourboulis, Leo AB Joosten Arthritis Research & Therapy 2012, 14:R158 (4 July 2012) Abstract \| Full text \| PDF \| PubMed
	40. 4431 Accesses	Research article Cigarette smoking and smoking cessation in relation to risk of rheumatoid arthritis in women Daniela Giuseppe, Nicola Orsini, Lars Alfredsson, Johan Askling, Alicja Wolk Arthritis Research & Therapy 2013, 15:R56 (22 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Smoking only a few cigarettes a day more than doubles the risk of developing rheumatoid arthritis and although this risk will lower with time after smoking cessation, it can remain elevated 15 years later.
	41. 4217 Accesses	Review Common variable immunodeficiency - an update Ulrich Salzer, Klaus Warnatz, Hans Peter Arthritis Research & Therapy 2012, 14:223 (24 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	42. 4202 Accesses	Research article Cardiovascular disease in patients with rheumatoid arthritis: results from the QUEST-RA study Antonio Naranjo, Tuulikki Sokka, Miguel A Descalzo, Jaime Calvo-Alén, Kim Hørslev-Petersen, Reijo K Luukkainen, Bernard Combe, Gerd R Burmester, Joe Devlin, Gianfranco Ferraccioli, Alessia Morelli, Monique Hoekstra, Maria Majdan, Stefan Sadkiewicz, Miguel Belmonte, Ann-Carin Holmqvist, Ernest Choy, Recep Tunc, Aleksander Dimic, Martin Bergman, Sergio Toloza, Theodore Pincus, the QUEST-RA Group Arthritis Research & Therapy 2008, 10:R30 (6 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Treating rheumatoid arthritis with disease-modifying anti-rheumatic drugs, such as methotrexate, reduces the risk of heart attacks and strokes, data from a study of 4,363 patients across 15 countries shows.
	43. 4200 Accesses	Research article A randomized controlled trial of qigong for fibromyalgia Mary Lynch, Jana Sawynok, Chok Hiew, Dana Marcon Arthritis Research & Therapy 2012, 14:R178 (3 August 2012) Abstract \| Full text \| PDF \| PubMed
	44. 4166 Accesses	Research article Sustained rheumatoid arthritis remission is uncommon in clinical practice Femke HM Prince, Vivian P Bykerk, Nancy A Shadick, Bing Lu, Jing Cui, Michelle Frits, Christine K Iannaccone, Michael E Weinblatt, Daniel H Solomon Arthritis Research & Therapy 2012, 14:R68 (19 March 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In clinical practice only a minority of patients with rheumatoid arthritis (RA) are in sustained remission, suggesting strict monitoring is required even once remission is reached.
	45. 4155 Accesses	Review Early diagnosis to enable early treatment of pre-osteoarthritis Constance R Chu, Ashley A Williams, Christian H Coyle, Megan E Bowers Arthritis Research & Therapy 2012, 14:212 (7 June 2012) Abstract \| Full text \| PDF \| PubMed
	46. 4132 Accesses	Review Osteoarthritis associated with estrogen deficiency Jorge A Roman-Blas, Santos Castañeda, Raquel Largo, Gabriel Herrero-Beaumont Arthritis Research & Therapy 2009, 11:241 (21 September 2009) Abstract \| Full text \| PDF \| PubMed
	47. 4052 Accesses	Research article Safety and clinical outcomes of rituximab therapy in patients with different autoimmune diseases: experience from a national registry (GRAID) Hans-Peter Tony, Gerd Burmester, Hendrik Schulze-Koops, Mathias Grunke, Joerg Henes, Ina Kötter, Judith Haas, Leonore Unger, Svjetlana Lovric, Marion Haubitz, Rebecca Fischer-Betz, Gamal Chehab, Andrea Rubbert-Roth, Christof Specker, Jutta Weinerth, Julia Holle, Ulf Müller-Ladner, Ramona König, Christoph Fiehn, Philip Burgwinkel, Klemens Budde, Helmut Sörensen, Michael Meurer, Martin Aringer, Bernd Kieseier, Cornelia Erfurt-Berge, Michael Sticherling, Roland Veelken, Ulf Ziemann, Frank Strutz et al. Arthritis Research & Therapy 2011, 13:R75 (13 May 2011) Abstract \| Full text \| PDF \| PubMed
	48. 4048 Accesses	Research article IL-32 and IL-17 interact and have the potential to aggravate osteoclastogenesis in rheumatoid arthritis Young-Mee Moon, Bo-Young Yoon, Yang-Mi Her, Hye-Joa Oh, Jae-Seon Lee, Kyoung-Woon Kim, Seon-Yeong Lee, Yun-Ju Woo, Kyung-Su Park, Sung-Hwan Park, Ho-Youn Kim, Mi-La Cho Arthritis Research & Therapy 2012, 14:R246 (13 November 2012) Abstract \| Full text \| PDF \| PubMed
	49. 3973 Accesses	Review The association between rheumatoid arthritis and periodontal disease Jacqueline Detert, Nicole Pischon, Gerd R Burmester, Frank Buttgereit Arthritis Research & Therapy 2010, 12:218 (22 October 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	50. 3958 Accesses	Research article Association between alcohol consumption and symptom severity and quality of life in patients with fibromyalgia Chul H Kim, Ann Vincent, Daniel J Clauw, Connie A Luedtke, Jeffrey M Thompson, Terry D Schneekloth, Terry H Oh Arthritis Research & Therapy 2013, 15:R42 (15 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Low to moderate alcohol consumption lessens symptom severity and betters quality of life for fibromyalgia patients when compared to no alcohol consumption.
	51. 3952 Accesses	Review Mucocutaneous candidiasis: the IL-17 pathway and implications for targeted immunotherapy Anna R Huppler, Shrinivas Bishu, Sarah L Gaffen Arthritis Research & Therapy 2012, 14:217 (23 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	52. 3894 Accesses	Research article MMP13 is a critical target gene during the progression of osteoarthritis Meina Wang, Erik R Sampson, Hongting Jin, Jia Li, Qiao H Ke, Hee-Jeong Im, Di Chen Arthritis Research & Therapy 2013, 15:R5 (8 January 2013) Abstract \| Full text \| PDF \| PubMed
	53. 3891 Accesses	Research article Minocycline and doxycycline therapy in community patients with rheumatoid arthritis: prescribing patterns, patient-level determinants of use, and patient-reported side effects Christopher J Smith, Harlan Sayles, Ted R Mikuls, Kaleb Michaud Arthritis Research & Therapy 2011, 13:R168 (18 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Although the drugs are generally well-tolerated, rheumatologists mostly prescribe minocycline or doxycycline in patients with long-standing rheumatoid arthritis (RA) where other treatments have failed, and not as a primary treatment option.
	54. 3881 Accesses	Review Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis? Yves Henrotin, Ali Mobasheri, Marc Marty Arthritis Research & Therapy 2012, 14:201 (30 January 2012) Abstract \| Full text \| PDF \| PubMed
	55. 3858 Accesses	Review Mechanisms of tissue injury in lupus nephritis Tamara K Nowling, Gary S Gilkeson Arthritis Research & Therapy 2011, 13:250 (21 December 2011) Abstract \| Full text \| PDF \| PubMed
	56. 3830 Accesses	Research article Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development James F Fries, Eswar Krishnan Arthritis Res Ther 2004, 6:R250-R255 (18 March 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The 'uncertainty principle' states that randomised controlled trials are only ethical if true uncertainty exists about which treatment is likely to be superior. Is this principle being violated in industry-sponsored trials?
	57. 3771 Accesses	Review Advances in rheumatology: new targeted therapeutics Paul P Tak, Joachim R Kalden Arthritis Research & Therapy 2011, 13(Suppl 1):S5 (25 May 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	58. 3759 Accesses	Review The clinical relevance of autoantibodies in scleroderma Khanh T Ho, John D Reveille Arthritis Res Ther 2003, 5:80-93 (12 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	59. 3740 Accesses	Review Infliximab: 12 years of experience Josef S Smolen, Paul Emery Arthritis Research & Therapy 2011, 13(Suppl 1):S2 (25 May 2011) Abstract \| Full text \| PDF \| PubMed
	60. 3739 Accesses	Research article Inflammation associated anemia and ferritin as disease markers in SLE Kamala Vanarsa, Yujin Ye, Jie Han, Chun Xie, Chandra Mohan, Tianfu Wu Arthritis Research & Therapy 2012, 14:R182 (7 August 2012) Abstract \| Full text \| PDF \| PubMed
	61. 3706 Accesses	Review Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action Larry W Moreland Arthritis Res Ther 2003, 5:54-67 (14 January 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	62. 3706 Accesses	Editorial Metabolic factors in osteoarthritis: obese people do not walk on their hands Erlangga Yusuf Arthritis Research & Therapy 2012, 14:123 (19 July 2012) Abstract \| Full text \| PDF \| PubMed
	63. 3684 Accesses	Review Gout. Novel therapies for treatment of gout and hyperuricemia Robert Terkeltaub Arthritis Research & Therapy 2009, 11:236 (23 July 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	64. 3671 Accesses	Research article Low-dose oral prednisone improves clinical and ultrasonographic remission rates in early rheumatoid arthritis: results of a 12-month open-label randomised study Carlomaurizio Montecucco, Monica Todoerti, Garifallia Sakellariou, Carlo Scirè, Roberto Caporali Arthritis Research & Therapy 2012, 14:R112 (14 May 2012) Abstract \| Full text \| PDF \| PubMed
	65. 3659 Accesses	Review Articular cartilage and changes in Arthritis: Cell biology of osteoarthritis Linda J Sandell, Thomas Aigner Arthritis Res 2001, 3:107-113 (22 January 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	66. 3631 Accesses	Research article Mechanisms of quadriceps muscle weakness in knee joint osteoarthritis: the effects of prolonged vibration on torque and muscle activation in osteoarthritic and healthy control subjects David A Rice, Peter J McNair, Gwyn N Lewis Arthritis Research & Therapy 2011, 13:R151 (20 September 2011) Abstract \| Full text \| PDF \| PubMed
	67. 3598 Accesses	Research article Rheumatic Diseases in China Qing Zeng, Ren Chen, John Darmawan, Zheng Xiao, Su Chen, Richard Wigley, Shun Le Chen, Nai Zhang Arthritis Research & Therapy 2008, 10:R17 (31 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A large population study found that the incidence of certain rheumatic diseases in China is becoming more like that of Western countries, but different joints are affected compared to Caucasian populations.
	68. 3583 Accesses	Research article A pilot study of IL-1 inhibition by anakinra in acute gout Alexander So, Thibaut De Smedt, Sylvie Revaz, Jürg Tschopp Arthritis Research & Therapy 2007, 9:R28 (12 March 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In a pilot study on 10 patients with gouty arthritis, IL-1 blockade with anakinra gave rapid relief of inflammatory symptoms where standard treatments had failed or were not tolerated.
	69. 3503 Accesses	Research article Autoantibody profiling to follow evolution of lupus syndromes Nancy J Olsen, Quan-Zhen Li, Jiexia Quan, Ling Wang, Azza Mutwally, David R Karp Arthritis Research & Therapy 2012, 14:R174 (27 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	70. 3503 Accesses	Review An update on the hyper-IgE syndromes Patrick FK Yong, Alexandra F Freeman, Karin R Engelhardt, Steven Holland, Jennifer M Puck, Bodo Grimbacher Arthritis Research & Therapy 2012, 14:228 (30 November 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	71. 3493 Accesses	Research article Efficacy of different types of aerobic exercise in fibromyalgia syndrome: a systematic review and meta-analysis of randomised controlled trials Winfried Häuser, Petra Klose, Jost Langhorst, Babak Moradi, Mario Steinbach, Marcus Schiltenwolf, Angela Busch Arthritis Research & Therapy 2010, 12:R79 (10 May 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	72. 3465 Accesses	Review Mesenchymal stem cells in arthritic diseases Faye H Chen, Rocky S Tuan Arthritis Research & Therapy 2008, 10:223 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	73. 3463 Accesses	Review What is MRI bone oedema in rheumatoid arthritis and why does it matter? Fiona M McQueen, Benedikt Ostendorf Arthritis Research & Therapy 2006, 8:222 (5 December 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	74. 3458 Accesses	Review Anti-inflammatory and immunosuppressive drugs and reproduction Monika Østensen, Munther Khamashta, Michael Lockshin, Ann Parke, Antonio Brucato, Howard Carp, Andrea Doria, Raj Rai, Pierluigi Meroni, Irene Cetin, Ronald Derksen, Ware Branch, Mario Motta, Caroline Gordon, Guillermo Ruiz-Irastorza, Arsenio Spinillo, Deborah Friedman, Rolando Cimaz, Andrew Czeizel, Jean Piette, Ricard Cervera, Roger A Levy, Maurizio Clementi, Sara De Carolis, Michelle Petri, Yehuda Shoenfeld, David Faden, Guido Valesini, Angela Tincani Arthritis Research & Therapy 2006, 8:209 (11 May 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	75. 3453 Accesses	Research article Nocturnal heart rate variability parameters as potential fibromyalgia biomarker: correlation with symptoms severity Claudia Lerma, Aline Martinez, Natllely Ruiz, Angelica Vargas, Oscar Infante, Manuel Martinez-Lavin Arthritis Research & Therapy 2011, 13:R185 (16 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Nocturnal heart rate variability parameters indicative of sympathetic predominance are significantly different in fibromyalgia patients compared to healthy individuals, and correlate with several symptoms including pain severity.
	76. 3444 Accesses	Review Epidemiology, risk factors, and lifestyle modifications for gout Kenneth G Saag, Hyon Choi Arthritis Research & Therapy 2006, 8(Suppl 1):S2 (12 April 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	77. 3407 Accesses	Commentary Promise and pitfalls of the Immunochip Adrian Cortes, Matthew A Brown Arthritis Research & Therapy 2011, 13:101 (1 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	78. 3399 Accesses	Research article Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen Julia J Inglis, Gabriel Criado, Mino Medghalchi, Melanie Andrews, Ann Sandison, Marc Feldmann, Richard O Williams Arthritis Research & Therapy 2007, 9:R113 (29 October 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary C57BL/6 mice may be useful for testing new therapeutics, particularly those directed against T cells, and investigating the action of current therapies in rheumatoid arthritis.
	79. 3398 Accesses	Research article Direct transplantation of mesenchymal stem cells into the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis Mitsuhiko Sato, Kenzo Uchida, Hideaki Nakajima, Tsuyoshi Miyazaki, Alexander Guerrero, Shuji Watanabe, Sally Roberts, Hisatoshi Baba Arthritis Research & Therapy 2012, 14:R31 (7 February 2012) Abstract \| Full text \| PDF \| PubMed \| F1000
	80. 3386 Accesses	Review New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options Martin K Lotz Arthritis Research & Therapy 2010, 12:211 (28 June 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	81. 3365 Accesses	Research article Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis Gurkirpal Singh, Olivia Wu, Peter Langhorne, Rajan Madhok Arthritis Research & Therapy 2006, 8:R153 (22 September 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary NSAIDs have been shown to be associated with an increased risk of acute myocardial infarctions, suggesting they should be used with caution in those with risk factors for cardiovascular disease.
	82. 3315 Accesses	Review Disturbances of apoptotic cell clearance in systemic lupus erythematosus Wen-Hai Shao, Philip L Cohen Arthritis Research & Therapy 2011, 13:202 (28 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	83. 3297 Accesses	Commentary Biosimilars: a regulatory perspective from America Jonathan Kay Arthritis Research & Therapy 2011, 13:112 (12 May 2011) Abstract \| Full text \| PDF \| PubMed
	84. 3281 Accesses	Research article Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance Ilias Stagakis, George Bertsias, Stylianos Karvounaris, Melina Kavousanaki, Dimitra Virla, Amalia Raptopoulou, Dimitrios Kardassis, Dimitrios T Boumpas, Prodromos I Sidiropoulos Arthritis Research & Therapy 2012, 14:R141 (12 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Twelve weeks of anti-tumor necrosis factor (TNF) therapy improved insulin sensitivity, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance.
	85. 3268 Accesses	Research article The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells Betty Y Chang, Min Huang, Michelle Francesco, Jun Chen, Jeremy Sokolove, Padmaja Magadala, William H Robinson, Joseph J Buggy Arthritis Research & Therapy 2011, 13:R115 (13 July 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	86. 3237 Accesses	Review Abnormalities of T cell signaling in systemic lupus erythematosus Vaishali R Moulton, George C Tsokos Arthritis Research & Therapy 2011, 13:207 (17 March 2011) Abstract \| Full text \| PDF \| PubMed
	87. 3229 Accesses	Research article Integrated safety in tocilizumab clinical trials Michael H Schiff, Joel M Kremer, Angelika Jahreis, Emma Vernon, John D Isaacs, Ronald F van Vollenhoven Arthritis Research & Therapy 2011, 13:R141 (1 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	88. 3219 Accesses	Research article Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture — primary culture cells markedly differ from fourth-passage cells Thomas Zimmermann, Elke Kunisch, Robert Pfeiffer, Astrid Hirth, Hans-Detlev Stahl, Ulrich Sack, Anke Laube, Eckehard Liesaus, Andreas Roth, Ernesta Palombo-Kinne, Frank Emmrich, Raimund W Kinne Arthritis Res 2001, 3:72-76 (21 November 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	89. 3187 Accesses	Research article Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models Jun Soo Bang, Da Hee Oh, Hyun Mi Choi, Bong-Jun Sur, Sung-Jig Lim, Jung Yeon Kim, Hyung-In Yang, Myung Chul Yoo, Dae-Hyun Hahm, Kyoung Soo Kim Arthritis Research & Therapy 2009, 11:R49 (30 March 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	90. 3186 Accesses	Research article Ultrasound of metacarpophalangeal joints is a sensitive and reliable endpoint for drug therapies in rheumatoid arthritis: results of a randomized, two-center placebo-controlled study Matthew W Seymour, Stephen Kelly, Chan R Beals, Marie-Pierre Malice, James A Bolognese, Bernard J Dardzinski, Amy S Cheng, Corinne E Cummings, Steven S Smugar, Catherine McClinton, Amy Fox, William M Dooley, Constantino Pitzalis, Peter C Taylor Arthritis Research & Therapy 2012, 14:R198 (12 September 2012) Abstract \| Full text \| PDF \| PubMed
	91. 3174 Accesses	Research article Properties and usefulness of aggregates of synovial mesenchymal stem cells as a source for cartilage regeneration Shiro Suzuki, Takeshi Muneta, Kunikazu Tsuji, Shizuko Ichinose, Hatsune Makino, Akihiro Umezawa, Ichiro Sekiya Arthritis Research & Therapy 2012, 14:R136 (7 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Aggregated mesenchymal stem cells are a useful source for cartilage regeneration, as they are easy to prepare, have high chondrogenic potential and attach efficiently.
	92. 3173 Accesses	Review Treatment targets in systemic lupus erythematosus: biology and clinical perspective Valentin Marian, Jennifer H Anolik Arthritis Research & Therapy 2012, 14(Suppl 4):S3 (30 November 2012) Abstract \| Full text \| PDF \| PubMed
	93. 3130 Accesses	Research article Can erosions on MRI of the sacroiliac joints be reliably detected in patients with ankylosing spondylitis? - A cross-sectional study Ulrich Weber, Susanne J Pedersen, Mikkel Østergaard, Kaspar Rufibach, Robert GW Lambert, Walter P Maksymowych Arthritis Research & Therapy 2012, 14:R124 (24 May 2012) Abstract \| Full text \| PDF \| PubMed
	94. 3102 Accesses	Research article Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes Feng-Cheng Liu, Li-Feng Hung, Wan-Lin Wu, Deh-Ming Chang, Chuan-Yueh Huang, Jenn-Haung Lai, Ling-Jun Ho Arthritis Research & Therapy 2010, 12:R167 (8 September 2010) Abstract \| Full text \| PDF \| PubMed
	95. 3096 Accesses	Research article Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies Chih Liu, Stephanie Tangsombatvisit, Jacob M Rosenberg, Gil Mandelbaum, Emily C Gillespie, Or P Gozani, Ash A Alizadeh, Paul J Utz Arthritis Research & Therapy 2012, 14:R25 (2 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	96. 3087 Accesses	Research article miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4 Jing Li, Jingang Huang, Liming Dai, Degang Yu, Qian Chen, Xiaoling Zhang, Kerong Dai Arthritis Research & Therapy 2012, 14:R75 (16 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The microRNA miR-146a may reduce cellular response to transforming growth factor-beta through targeted inhibition of Smad4 in cartilage, thus increasing vascular endothelial growth factor levels, and increasing chondrocyte apoptosis.
	97. 3055 Accesses	Primary research Monoarticular antigen-induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats Gisela von Banchet, Peter K Petrow, Rolf Bräuer, Hans-Georg Schaible Arthritis Res 2000, 2:424-427 (3 August 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	98. 3051 Accesses	Research article Vitamin D deficiency in rheumatoid arthritis: prevalence, determinants and associations with disease activity and disability Maurizio Rossini, Susanna Maddali Bongi, Giovanni La Montagna, Giovanni Minisola, Nazzarena Malavolta, Luigi Bernini, Enrico Cacace, Luigi Sinigaglia, Ombretta Di Munno, Silvano Adami Arthritis Research & Therapy 2010, 12:R216 (29 November 2010) Abstract \| Full text \| PDF \| PubMed \| F1000
	99. 2998 Accesses	Review Current treatment of hepatitis C-associated rheumatic diseases Clodoveo Ferri, Marco Sebastiani, Alessandro Antonelli, Michele Colaci, A Manfredi, Dilia Giuggioli Arthritis Research & Therapy 2012, 14:215 (25 June 2012) Abstract \| Full text \| PDF \| PubMed
	100. 2997 Accesses	Research article Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study Tuulikki Sokka, Sergio Toloza, Maurizio Cutolo, Hannu Kautiainen, Heidi Makinen, Feride Gogus, Vlado Skakic, Humeira Badsha, Tõnu Peets, Asta Baranauskaite, Pál Géher, Ilona Újfalussy, Fotini N Skopouli, Maria Mavrommati, Rieke Alten, Christof Pohl, Jean Sibilia, Andrea Stancati, Fausto Salaffi, Wojciech Romanowski, Danuta Zarowny-Wierzbinska, Dan Henrohn, Barry Bresnihan, Patricia Minnock, Lene Knudsen, Johannes WG Jacobs, Jaime Calvo-Alen, Juris Lazovskis, Geraldo Pinheiro, Dmitry Karateev, Daina Andersone, Sylejman Rexhepi, Yusuf Yazici, Theodore Pincus, the QUEST-RA Group et al. Arthritis Research & Therapy 2009, 11:R7 (14 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Rheumatoid arthritis was more severe in women in an analysis of more than 6,000 patients, although the effects of gender on standard disease activity measures may explain the difference.