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1.

97171
Accesses

Research article   Open Access Highly Accessed

Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage

Mathias Gebauer, Joachim Saas, Jochen Haag, Uwe Dietz, Masaharu Takigawa, Eckart Bartnik, Thomas Aigner Arthritis Res Ther 2005, 7:R274-R284 (11 January 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

2.

46866
Accesses

Research article   Open Access Highly Accessed

Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence

Laurent G Ameye, Winnie SS Chee Arthritis Research & Therapy 2006, 8:R127 (19 July 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

3.

38268
Accesses

Review   Free Highly Accessed

Degeneration of the intervertebral disc

Jill PG Urban, Sally Roberts Arthritis Res Ther 2003, 5:120-130 (11 March 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

4.

36380
Accesses

Review   Free Highly Accessed

Adult mesenchymal stem cells and cell-based tissue engineering

Rocky S Tuan, Genevieve Boland, Richard Tuli Arthritis Res Ther 2003, 5:32-45 (11 December 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

5.

36283
Accesses

Research article   Open Access Highly Accessed

A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee

Krishanu Sengupta, Krishnaraju V Alluri, Andey Satish, Simanchala Mishra, Trimurtulu Golakoti, Kadainti VS Sarma, Dipak Dey, Siba P Raychaudhuri Arthritis Research & Therapy 2008, 10:R85 (30 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 |  Editor’s summary

An enriched extract of the Indian frankincense herb, Boswellia serrata reduced pain and improved the physical function of osteoarthritis patients, in a double blind, randomized, placebo controlled trial.

6.

33723
Accesses

Research article   Open Access Highly Accessed

Gluten-free vegan diet induces decreased LDL and oxidized LDL levels and raised atheroprotective natural antibodies against phosphorylcholine in patients with rheumatoid arthritis: a randomized study

Ann-Charlotte Elkan, Beatrice Sjöberg, Björn Kolsrud, Bo Ringertz, Ingiäld Hafström, Johan Frostegård Arthritis Research & Therapy 2008, 10:R34 (18 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A gluten-free vegan diet induces potentially atheroprotective and anti-inflammatory changes in rheumatoid arthritis patients, including reduced low density lipoprotein (LDL) and oxidated LDL levels and raised natural antibodies against phosphorylcholine.

7.

32103
Accesses

Review   Free Highly Accessed

Epidemiology, risk factors, and lifestyle modifications for gout

Kenneth G Saag, Hyon Choi Arthritis Research & Therapy 2006, 8(Suppl 1):S2 (12 April 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

8.

31937
Accesses

Review   Free

Epidemiology and genetics of rheumatoid arthritis

Alan J Silman, Jacqueline E Pearson Arthritis Res 2002, 4(Suppl 3):S265-S272 (9 May 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

9.

29076
Accesses

Primary research   Open Access

Monoarticular antigen-induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats

Gisela von Banchet, Peter K Petrow, Rolf Bräuer, Hans-Georg Schaible Arthritis Res 2000, 2:424-427 (3 August 2000)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

10.

28791
Accesses

Review   Free Highly Accessed

Fish oil: what the prescriber needs to know

Leslie G Cleland, Michael J James, Susanna M Proudman Arthritis Research & Therapy 2006, 8:202 (21 December 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

11.

25523
Accesses

Research article   Open Access Highly Accessed

Vitamin D deficiency in undifferentiated connective tissue disease

Eva Zold, Peter Szodoray, Janos Gaal, János Kappelmayer, Laszlo Csathy, Edit Gyimesi, Margit Zeher, Gyula Szegedi, Edit Bodolay Arthritis Research & Therapy 2008, 10:R123 (18 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 |  Editor’s summary

A study of 161 patients with undifferentiated connective tissue disease suggests that vitamin D deficiency may be associated with the disease progressing into well-defined connective tissue diseases such as rheumatoid arthritis.

12.

25288
Accesses

Review   Free Highly Accessed

Anti-inflammatory and immunosuppressive drugs and reproduction

Monika Østensen, Munther Khamashta, Michael Lockshin, Ann Parke, Antonio Brucato, Howard Carp, Andrea Doria, Raj Rai, Pierluigi Meroni, Irene Cetin, Ronald Derksen, Ware Branch, Mario Motta, Caroline Gordon, Guillermo Ruiz-Irastorza, Arsenio Spinillo, Deborah Friedman, Rolando Cimaz, Andrew Czeizel, Jean Piette, Ricard Cervera, Roger A Levy, Maurizio Clementi, Sara De Carolis, Michelle Petri, Yehuda Shoenfeld, David Faden, Guido Valesini, Angela Tincani Arthritis Research & Therapy 2006, 8:209 (11 May 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

13.

24748
Accesses

Review   Free Highly Accessed

Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation

Catherine M Kolf, Elizabeth Cho, Rocky S Tuan Arthritis Research & Therapy 2007, 9:204 (19 February 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

14.

24745
Accesses

Review   Free Highly Accessed

Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases

Sherine E Gabriel, Kaleb Michaud Arthritis Research & Therapy 2009, 11:229 (19 May 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

15.

24524
Accesses

Research article   Open Access Highly Accessed

Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin

Karim Raza, Francesco Falciani, S John Curnow, Emma J Ross, Chi-Yeung Lee, Arne N Akbar, Janet M Lord, Caroline Gordon, Christopher D Buckley, Mike Salmon Arthritis Research & Therapy 2005, 7:R784-R795 (7 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Patients with early arthritis who subsequently develop rheumatoid arthritis (RA) have a distinct but transient synovial fluid cytokine profile. This not only gives clues about the pathology of RA, but also has potential for use as a diagnostic tool.

16.

24045
Accesses

Research article   Open Access Highly Accessed

Aerobic exercise and its impact on musculoskeletal pain in older adults: a 14 year prospective, longitudinal study

Bonnie Bruce, James F Fries, Deborah P Lubeck Arthritis Research & Therapy 2005, 7:R1263-R1270 (19 September 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Pain increases with age, however people who regularly carry out brisk aerobic exercise such as running, experience 25% less musculoskeletal pain in old age than those who exercise infrequently.

17.

23463
Accesses

Review   Free Highly Accessed

Interleukin-6 and chronic inflammation

Cem Gabay Arthritis Research & Therapy 2006, 8(Suppl 2):S3 (28 July 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

18.

23103
Accesses

Review   Free Highly Accessed

Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action

Larry W Moreland Arthritis Res Ther 2003, 5:54-67 (14 January 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

19.

22691
Accesses

Review   Free Highly Accessed

The inflammatory process of gout and its treatment

Bruce N Cronstein, Robert Terkeltaub Arthritis Research & Therapy 2006, 8(Suppl 1):S3 (12 April 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

20.

22559
Accesses

Review   Free Highly Accessed

Articular cartilage and changes in Arthritis: Cell biology of osteoarthritis

Linda J Sandell, Thomas Aigner Arthritis Res 2001, 3:107-113 (22 January 2001)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

21.

21897
Accesses

Review   Free Highly Accessed

The molecular mechanism of osteoclastogenesis in rheumatoid arthritis

Nobuyuki Udagawa, Shigeru Kotake, Naoyuki Kamatani, Naoyuki Takahashi, Tatsuo Suda Arthritis Res 2002, 4:281-289 (12 April 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

22.

21103
Accesses

Review   Free Highly Accessed

Mesenchymal stem cells in arthritic diseases

Faye H Chen, Rocky S Tuan Arthritis Research & Therapy 2008, 10:223 (10 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

23.

20872
Accesses

Review   Free Highly Accessed

A concise history of gout and hyperuricemia and their treatment

George Nuki, Peter A Simkin Arthritis Research & Therapy 2006, 8(Suppl 1):S1 (12 April 2006)

Abstract | Full text | PDF | PubMed

24.

20795
Accesses

Research article   Open Access Highly Accessed

Cardiovascular disease in patients with rheumatoid arthritis: results from the QUEST-RA study

Antonio Naranjo, Tuulikki Sokka, Miguel A Descalzo, Jaime Calvo-Alén, Kim Hørslev-Petersen, Reijo K Luukkainen, Bernard Combe, Gerd R Burmester, Joe Devlin, Gianfranco Ferraccioli, Alessia Morelli, Monique Hoekstra, Maria Majdan, Stefan Sadkiewicz, Miguel Belmonte, Ann-Carin Holmqvist, Ernest Choy, Recep Tunc, Aleksander Dimic, Martin Bergman, Sergio Toloza, Theodore Pincus, the QUEST-RA Group Arthritis Research & Therapy 2008, 10:R30 (6 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Treating rheumatoid arthritis with disease-modifying anti-rheumatic drugs, such as methotrexate, reduces the risk of heart attacks and strokes, data from a study of 4,363 patients across 15 countries shows.

25.

20280
Accesses

Supplement   Free

How does infliximab work in rheumatoid arthritis?

Ravinder N Maini, Marc Feldmann Arthritis Res 2002, 4(Suppl 2):S22-S28 (27 March 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

26.

19925
Accesses

Review   Free

Complement and systemic lupus erythematosus

Mark J Walport Arthritis Res 2002, 4(Suppl 3):S279-S293 (9 May 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

27.

19444
Accesses

Research article   Open Access

Mesenchymal precursor cells in the blood of normal individuals

Nathan J Zvaifler, Lilla Marinova-Mutafchieva, Gill Adams, Christopher J Edwards, Jill Moss, Jan A Burger, Ravinder N Maini Arthritis Res 2000, 2:477-488 (31 August 2000)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

28.

19170
Accesses

Review   Free Highly Accessed

What is MRI bone oedema in rheumatoid arthritis and why does it matter?

Fiona M McQueen, Benedikt Ostendorf Arthritis Research & Therapy 2006, 8:222 (5 December 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

29.

19017
Accesses

Research article   Open Access Highly Accessed

Dermatological conditions during TNF-α-blocking therapy in patients with rheumatoid arthritis: a prospective study

Marcel Flendrie, Wynand HPM Vissers, Marjonne CW Creemers, Elke MGJ de Jong, Peter CM van de Kerkhof, Piet LCM van Riel Arthritis Research & Therapy 2005, 7:R666-R676 (4 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

TNF-α blocking therapies have shown considerable success in moderating disease activity in rheumatic diseases, however a recent study has shown that in 25% of patients, their prescription results in dermatological conditions, including eczema and skin infections.

30.

18431
Accesses

Research article   Open Access Highly Accessed

Autologous chondrocyte implantation for cartilage repair: monitoring its success by magnetic resonance imaging and histology

Sally Roberts, Iain W McCall, Alan J Darby, Janis Menage, Helena Evans, Paul E Harrison, James B Richardson Arthritis Res Ther 2003, 5:R60-R73 (13 November 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

31.

18409
Accesses

Research article   Open Access Highly Accessed

Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin

Erik R Vossenaar, Normand Després, Elvy Lapointe, Annemarie van der Heijden, Maximillian Lora, Tatsuo Senshu, Walther J van Venrooij, Henri A Ménard Arthritis Res Ther 2004, 6:R142-R150 (5 February 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

32.

18335
Accesses

Review   Free Highly Accessed

Molecular action of methotrexate in inflammatory diseases

Edwin SL Chan, Bruce N Cronstein Arthritis Res 2002, 4:266-273 (19 March 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

33.

18258
Accesses

Review   Free

HLA-B27: natural function and pathogenic role in spondyloarthritis

Andrew McMichael, Paul Bowness Arthritis Res 2002, 4(Suppl 3):S153-S158 (9 May 2002)

Abstract | Full text | PDF | PubMed

34.

18051
Accesses

Review   Free Highly Accessed

Arthritis and pain. Future targets to control osteoarthritis pain

Andy Dray, Simon J Read Arthritis Research & Therapy 2007, 9:212 (30 May 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

35.

17697
Accesses

Review   Free Highly Accessed

Articular cartilage and changes in Arthritis: Collagen of articular cartilage

David Eyre Arthritis Res 2002, 4:30-35 (5 October 2001)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

36.

17576
Accesses

Research article   Open Access Highly Accessed

Association between occupational exposure to mineral oil and rheumatoid arthritis: results from the Swedish EIRA case–control study

Berit Sverdrup, Henrik Källberg, Camilla Bengtsson, Ingvar Lundberg, Leonid Padyukov, Lars Alfredsson, Lars Klareskog, the Epidemiological Investigation of Rheumatoid Arthritis study group Arthritis Research & Therapy 2005, 7:R1296-R1303 (23 September 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A population based case-controlled study has found that occupational exposure to mineral oils, in particular hydraulic or motor oil, increases the risk of developing rheumatoid arthritis by 30%.

37.

17552
Accesses

Review   Free Highly Accessed

Arthritis and pain. Current approaches in the treatment of arthritic pain

Bruce L Kidd, Richard M Langford, Theresa Wodehouse Arthritis Research & Therapy 2007, 9:214 (11 June 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

38.

17448
Accesses

Review   Free

Tissue engineering: chondrocytes and cartilage

Tim Hardingham, Simon Tew, Alan Murdoch Arthritis Res 2002, 4(Suppl 3):S63-S68 (9 May 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

39.

17428
Accesses

Review   Free Highly Accessed

Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors

Matthew P Vincenti, Constance E Brinckerhoff Arthritis Res 2002, 4:157-164 (23 November 2001)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

40.

17343
Accesses

Review   Free

The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma

Rick Brouwer, Ger JM Pruijn, Walther J van Venrooij Arthritis Res 2001, 3:102-106 (20 December 2000)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

41.

17058
Accesses

Meeting abstract   Free

Abatacept (CTLA4Ig) treatment increases the remission rate in rheumatoid arthritis patients refractory to methotrexate treatment

R Westhovens, P van Riel, J Sibilia, G Vratsanos, I Nuamah, JC Becker Arthritis Res Ther 2004, 6(Suppl 1):86 (24 February 2004)

Full text | PDF

42.

17008
Accesses

Review   Free Highly Accessed

Human Th17 cells

Sergio Romagnani Arthritis Research & Therapy 2008, 10:206 (18 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

43.

16724
Accesses

Research article   Open Access Highly Accessed

What do we know about communicating risk? A brief review and suggestion for contextualising serious, but rare, risk, and the example of cox-2 selective and non-selective NSAIDs

R Andrew Moore, Sheena Derry, Henry J McQuay, John Paling Arthritis Research & Therapy 2008, 10:R20 (7 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

44.

16687
Accesses

Research article   Open Access Highly Accessed

Methotrexate in rheumatoid arthritis is frequently effective, even if re-employed after a previous failure

Theresa Kapral, Tanja Stamm, Klaus P Machold, Karin Montag, Josef S Smolen, Daniel Aletaha Arthritis Research & Therapy 2006, 8:R46 (24 February 2006)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Administering a second course of methotrexate to rheumatoid arthritis sufferers proved beneficial in nearly half of the patients studied, for whom a previous treatment with the drug was ineffective.

45.

16586
Accesses

Research article   Open Access Highly Accessed

Relationship between radiographic grading of osteoarthritis and the biochemical markers for arthritis in knee osteoarthritis

Masaaki Takahashi, Kenichi Naito, Masashi Abe, Tomokazu Sawada, Akira Nagano Arthritis Res Ther 2004, 6:R208-R212 (12 March 2004)

Abstract | Full text | PDF | PubMed

46.

16258
Accesses

Research article   Open Access Highly Accessed

Cardiovascular risk in rheumatoid arthritis versus osteoarthritis: acute phase response related decreased insulin sensitivity and high-density lipoprotein cholesterol as well as clustering of metabolic syndrome features in rheumatoid arthritis

Patrick H Dessein, Anne E Stanwix, Barry I Joffe Arthritis Res 2002, 4:R5 (19 June 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

47.

16226
Accesses

Review   Free Highly Accessed

Biology and therapy of fibromyalgia. New therapies in fibromyalgia

Lesley M Arnold Arthritis Research & Therapy 2006, 8:212 (1 June 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

48.

16135
Accesses

Review   Free Highly Accessed

Therapy of ankylosing spondylitis and other spondyloarthritides: established medical treatment, anti-TNF-α therapy and other novel approaches

Juergen Braun, Joachim Sieper Arthritis Res 2002, 4:307-321 (6 August 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

49.

16044
Accesses

Review   Free

The vasculature and its role in the damaged and healing tendon

Steven A Fenwick, Brian L Hazleman, Graham P Riley Arthritis Res 2002, 4:252-260 (13 February 2002)

Abstract | Full text | PDF | PubMed

50.

15943
Accesses

Research article   Open Access Highly Accessed

Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus

Michelle Jackson, Yasmeen Ahmad, Ian N Bruce, Beatrice Coupes, Paul EC Brenchley Arthritis Research & Therapy 2006, 8:R81 (28 April 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Low efficiency of activation of transforming growth factor beta-1 is associated with increased risk of cardiovascular disease and may modulate development of atherosclerosis in patients with lupus.

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