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1.

98217
Accesses

Research article   Open Access Highly Accessed

Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage

Mathias Gebauer, Joachim Saas, Jochen Haag, Uwe Dietz, Masaharu Takigawa, Eckart Bartnik, Thomas Aigner Arthritis Res Ther 2005, 7:R274-R284 (11 January 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

2.

47916
Accesses

Research article   Open Access Highly Accessed

Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence

Laurent G Ameye, Winnie SS Chee Arthritis Research & Therapy 2006, 8:R127 (19 July 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

3.

38943
Accesses

Review   Free Highly Accessed

Degeneration of the intervertebral disc

Jill PG Urban, Sally Roberts Arthritis Res Ther 2003, 5:120-130 (11 March 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

4.

36878
Accesses

Research article   Open Access Highly Accessed

A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee

Krishanu Sengupta, Krishnaraju V Alluri, Andey Satish, Simanchala Mishra, Trimurtulu Golakoti, Kadainti VS Sarma, Dipak Dey, Siba P Raychaudhuri Arthritis Research & Therapy 2008, 10:R85 (30 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 |  Editor’s summary

An enriched extract of the Indian frankincense herb, Boswellia serrata reduced pain and improved the physical function of osteoarthritis patients, in a double blind, randomized, placebo controlled trial.

5.

36681
Accesses

Review   Free Highly Accessed

Adult mesenchymal stem cells and cell-based tissue engineering

Rocky S Tuan, Genevieve Boland, Richard Tuli Arthritis Res Ther 2003, 5:32-45 (11 December 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

6.

34039
Accesses

Research article   Open Access Highly Accessed

Gluten-free vegan diet induces decreased LDL and oxidized LDL levels and raised atheroprotective natural antibodies against phosphorylcholine in patients with rheumatoid arthritis: a randomized study

Ann-Charlotte Elkan, Beatrice Sjöberg, Björn Kolsrud, Bo Ringertz, Ingiäld Hafström, Johan Frostegård Arthritis Research & Therapy 2008, 10:R34 (18 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A gluten-free vegan diet induces potentially atheroprotective and anti-inflammatory changes in rheumatoid arthritis patients, including reduced low density lipoprotein (LDL) and oxidated LDL levels and raised natural antibodies against phosphorylcholine.

7.

32301
Accesses

Review   Free Highly Accessed

Epidemiology, risk factors, and lifestyle modifications for gout

Kenneth G Saag, Hyon Choi Arthritis Research & Therapy 2006, 8(Suppl 1):S2 (12 April 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

8.

32296
Accesses

Review   Free

Epidemiology and genetics of rheumatoid arthritis

Alan J Silman, Jacqueline E Pearson Arthritis Res 2002, 4(Suppl 3):S265-S272 (9 May 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

9.

29489
Accesses

Primary research   Open Access

Monoarticular antigen-induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats

Gisela von Banchet, Peter K Petrow, Rolf Bräuer, Hans-Georg Schaible Arthritis Res 2000, 2:424-427 (3 August 2000)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

10.

29032
Accesses

Review   Free Highly Accessed

Fish oil: what the prescriber needs to know

Leslie G Cleland, Michael J James, Susanna M Proudman Arthritis Research & Therapy 2006, 8:202 (21 December 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

11.

25766
Accesses

Research article   Open Access Highly Accessed

Vitamin D deficiency in undifferentiated connective tissue disease

Eva Zold, Peter Szodoray, Janos Gaal, János Kappelmayer, Laszlo Csathy, Edit Gyimesi, Margit Zeher, Gyula Szegedi, Edit Bodolay Arthritis Research & Therapy 2008, 10:R123 (18 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 |  Editor’s summary

A study of 161 patients with undifferentiated connective tissue disease suggests that vitamin D deficiency may be associated with the disease progressing into well-defined connective tissue diseases such as rheumatoid arthritis.

12.

25532
Accesses

Review   Free Highly Accessed

Anti-inflammatory and immunosuppressive drugs and reproduction

Monika Østensen, Munther Khamashta, Michael Lockshin, Ann Parke, Antonio Brucato, Howard Carp, Andrea Doria, Raj Rai, Pierluigi Meroni, Irene Cetin, Ronald Derksen, Ware Branch, Mario Motta, Caroline Gordon, Guillermo Ruiz-Irastorza, Arsenio Spinillo, Deborah Friedman, Rolando Cimaz, Andrew Czeizel, Jean Piette, Ricard Cervera, Roger A Levy, Maurizio Clementi, Sara De Carolis, Michelle Petri, Yehuda Shoenfeld, David Faden, Guido Valesini, Angela Tincani Arthritis Research & Therapy 2006, 8:209 (11 May 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

13.

25268
Accesses

Review   Free Highly Accessed

Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases

Sherine E Gabriel, Kaleb Michaud Arthritis Research & Therapy 2009, 11:229 (19 May 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

14.

24975
Accesses

Review   Free Highly Accessed

Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation

Catherine M Kolf, Elizabeth Cho, Rocky S Tuan Arthritis Research & Therapy 2007, 9:204 (19 February 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

15.

24752
Accesses

Research article   Open Access Highly Accessed

Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin

Karim Raza, Francesco Falciani, S John Curnow, Emma J Ross, Chi-Yeung Lee, Arne N Akbar, Janet M Lord, Caroline Gordon, Christopher D Buckley, Mike Salmon Arthritis Research & Therapy 2005, 7:R784-R795 (7 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Patients with early arthritis who subsequently develop rheumatoid arthritis (RA) have a distinct but transient synovial fluid cytokine profile. This not only gives clues about the pathology of RA, but also has potential for use as a diagnostic tool.

16.

24154
Accesses

Research article   Open Access Highly Accessed

Aerobic exercise and its impact on musculoskeletal pain in older adults: a 14 year prospective, longitudinal study

Bonnie Bruce, James F Fries, Deborah P Lubeck Arthritis Research & Therapy 2005, 7:R1263-R1270 (19 September 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Pain increases with age, however people who regularly carry out brisk aerobic exercise such as running, experience 25% less musculoskeletal pain in old age than those who exercise infrequently.

17.

23810
Accesses

Review   Free Highly Accessed

Interleukin-6 and chronic inflammation

Cem Gabay Arthritis Research & Therapy 2006, 8(Suppl 2):S3 (28 July 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

18.

23442
Accesses

Review   Free Highly Accessed

Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action

Larry W Moreland Arthritis Res Ther 2003, 5:54-67 (14 January 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

19.

23180
Accesses

Review   Free Highly Accessed

The inflammatory process of gout and its treatment

Bruce N Cronstein, Robert Terkeltaub Arthritis Research & Therapy 2006, 8(Suppl 1):S3 (12 April 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

20.

22808
Accesses

Review   Free Highly Accessed

Articular cartilage and changes in Arthritis: Cell biology of osteoarthritis

Linda J Sandell, Thomas Aigner Arthritis Res 2001, 3:107-113 (22 January 2001)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

21.

22026
Accesses

Review   Free Highly Accessed

The molecular mechanism of osteoclastogenesis in rheumatoid arthritis

Nobuyuki Udagawa, Shigeru Kotake, Naoyuki Kamatani, Naoyuki Takahashi, Tatsuo Suda Arthritis Res 2002, 4:281-289 (12 April 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

22.

21250
Accesses

Review   Free Highly Accessed

Mesenchymal stem cells in arthritic diseases

Faye H Chen, Rocky S Tuan Arthritis Research & Therapy 2008, 10:223 (10 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

23.

21161
Accesses

Review   Free Highly Accessed

A concise history of gout and hyperuricemia and their treatment

George Nuki, Peter A Simkin Arthritis Research & Therapy 2006, 8(Suppl 1):S1 (12 April 2006)

Abstract | Full text | PDF | PubMed

24.

21026
Accesses

Research article   Open Access Highly Accessed

Cardiovascular disease in patients with rheumatoid arthritis: results from the QUEST-RA study

Antonio Naranjo, Tuulikki Sokka, Miguel A Descalzo, Jaime Calvo-Alén, Kim Hørslev-Petersen, Reijo K Luukkainen, Bernard Combe, Gerd R Burmester, Joe Devlin, Gianfranco Ferraccioli, Alessia Morelli, Monique Hoekstra, Maria Majdan, Stefan Sadkiewicz, Miguel Belmonte, Ann-Carin Holmqvist, Ernest Choy, Recep Tunc, Aleksander Dimic, Martin Bergman, Sergio Toloza, Theodore Pincus, the QUEST-RA Group Arthritis Research & Therapy 2008, 10:R30 (6 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Treating rheumatoid arthritis with disease-modifying anti-rheumatic drugs, such as methotrexate, reduces the risk of heart attacks and strokes, data from a study of 4,363 patients across 15 countries shows.

25.

20421
Accesses

Supplement   Free

How does infliximab work in rheumatoid arthritis?

Ravinder N Maini, Marc Feldmann Arthritis Res 2002, 4(Suppl 2):S22-S28 (27 March 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

26.

20400
Accesses

Review   Free

Complement and systemic lupus erythematosus

Mark J Walport Arthritis Res 2002, 4(Suppl 3):S279-S293 (9 May 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

27.

19515
Accesses

Research article   Open Access

Mesenchymal precursor cells in the blood of normal individuals

Nathan J Zvaifler, Lilla Marinova-Mutafchieva, Gill Adams, Christopher J Edwards, Jill Moss, Jan A Burger, Ravinder N Maini Arthritis Res 2000, 2:477-488 (31 August 2000)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

28.

19343
Accesses

Review   Free Highly Accessed

What is MRI bone oedema in rheumatoid arthritis and why does it matter?

Fiona M McQueen, Benedikt Ostendorf Arthritis Research & Therapy 2006, 8:222 (5 December 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

29.

19103
Accesses

Research article   Open Access Highly Accessed

Dermatological conditions during TNF-α-blocking therapy in patients with rheumatoid arthritis: a prospective study

Marcel Flendrie, Wynand HPM Vissers, Marjonne CW Creemers, Elke MGJ de Jong, Peter CM van de Kerkhof, Piet LCM van Riel Arthritis Research & Therapy 2005, 7:R666-R676 (4 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

TNF-α blocking therapies have shown considerable success in moderating disease activity in rheumatic diseases, however a recent study has shown that in 25% of patients, their prescription results in dermatological conditions, including eczema and skin infections.

30.

18592
Accesses

Research article   Open Access Highly Accessed

Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin

Erik R Vossenaar, Normand Després, Elvy Lapointe, Annemarie van der Heijden, Maximillian Lora, Tatsuo Senshu, Walther J van Venrooij, Henri A Ménard Arthritis Res Ther 2004, 6:R142-R150 (5 February 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

31.

18523
Accesses

Research article   Open Access Highly Accessed

Autologous chondrocyte implantation for cartilage repair: monitoring its success by magnetic resonance imaging and histology

Sally Roberts, Iain W McCall, Alan J Darby, Janis Menage, Helena Evans, Paul E Harrison, James B Richardson Arthritis Res Ther 2003, 5:R60-R73 (13 November 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

32.

18491
Accesses

Review   Free Highly Accessed

Molecular action of methotrexate in inflammatory diseases

Edwin SL Chan, Bruce N Cronstein Arthritis Res 2002, 4:266-273 (19 March 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

33.

18464
Accesses

Review   Free

HLA-B27: natural function and pathogenic role in spondyloarthritis

Andrew McMichael, Paul Bowness Arthritis Res 2002, 4(Suppl 3):S153-S158 (9 May 2002)

Abstract | Full text | PDF | PubMed

34.

18229
Accesses

Review   Free Highly Accessed

Arthritis and pain. Future targets to control osteoarthritis pain

Andy Dray, Simon J Read Arthritis Research & Therapy 2007, 9:212 (30 May 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

35.

17893
Accesses

Review   Free Highly Accessed

Articular cartilage and changes in Arthritis: Collagen of articular cartilage

David Eyre Arthritis Res 2002, 4:30-35 (5 October 2001)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

36.

17698
Accesses

Review   Free Highly Accessed

Arthritis and pain. Current approaches in the treatment of arthritic pain

Bruce L Kidd, Richard M Langford, Theresa Wodehouse Arthritis Research & Therapy 2007, 9:214 (11 June 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

37.

17645
Accesses

Review   Free Highly Accessed

Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors

Matthew P Vincenti, Constance E Brinckerhoff Arthritis Res 2002, 4:157-164 (23 November 2001)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

38.

17639
Accesses

Research article   Open Access Highly Accessed

Association between occupational exposure to mineral oil and rheumatoid arthritis: results from the Swedish EIRA case–control study

Berit Sverdrup, Henrik Källberg, Camilla Bengtsson, Ingvar Lundberg, Leonid Padyukov, Lars Alfredsson, Lars Klareskog, the Epidemiological Investigation of Rheumatoid Arthritis study group Arthritis Research & Therapy 2005, 7:R1296-R1303 (23 September 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A population based case-controlled study has found that occupational exposure to mineral oils, in particular hydraulic or motor oil, increases the risk of developing rheumatoid arthritis by 30%.

39.

17493
Accesses

Review   Free

Tissue engineering: chondrocytes and cartilage

Tim Hardingham, Simon Tew, Alan Murdoch Arthritis Res 2002, 4(Suppl 3):S63-S68 (9 May 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

40.

17381
Accesses

Review   Free

The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma

Rick Brouwer, Ger JM Pruijn, Walther J van Venrooij Arthritis Res 2001, 3:102-106 (20 December 2000)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

41.

17086
Accesses

Meeting abstract   Free

Abatacept (CTLA4Ig) treatment increases the remission rate in rheumatoid arthritis patients refractory to methotrexate treatment

R Westhovens, P van Riel, J Sibilia, G Vratsanos, I Nuamah, JC Becker Arthritis Res Ther 2004, 6(Suppl 1):86 (24 February 2004)

Full text | PDF

42.

17064
Accesses

Review   Free Highly Accessed

Human Th17 cells

Sergio Romagnani Arthritis Research & Therapy 2008, 10:206 (18 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

43.

16944
Accesses

Research article   Open Access Highly Accessed

What do we know about communicating risk? A brief review and suggestion for contextualising serious, but rare, risk, and the example of cox-2 selective and non-selective NSAIDs

R Andrew Moore, Sheena Derry, Henry J McQuay, John Paling Arthritis Research & Therapy 2008, 10:R20 (7 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

44.

16806
Accesses

Research article   Open Access Highly Accessed

Methotrexate in rheumatoid arthritis is frequently effective, even if re-employed after a previous failure

Theresa Kapral, Tanja Stamm, Klaus P Machold, Karin Montag, Josef S Smolen, Daniel Aletaha Arthritis Research & Therapy 2006, 8:R46 (24 February 2006)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Administering a second course of methotrexate to rheumatoid arthritis sufferers proved beneficial in nearly half of the patients studied, for whom a previous treatment with the drug was ineffective.

45.

16699
Accesses

Research article   Open Access Highly Accessed

Relationship between radiographic grading of osteoarthritis and the biochemical markers for arthritis in knee osteoarthritis

Masaaki Takahashi, Kenichi Naito, Masashi Abe, Tomokazu Sawada, Akira Nagano Arthritis Res Ther 2004, 6:R208-R212 (12 March 2004)

Abstract | Full text | PDF | PubMed

46.

16339
Accesses

Research article   Open Access Highly Accessed

Cardiovascular risk in rheumatoid arthritis versus osteoarthritis: acute phase response related decreased insulin sensitivity and high-density lipoprotein cholesterol as well as clustering of metabolic syndrome features in rheumatoid arthritis

Patrick H Dessein, Anne E Stanwix, Barry I Joffe Arthritis Res 2002, 4:R5 (19 June 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

47.

16339
Accesses

Review   Free Highly Accessed

Biology and therapy of fibromyalgia. New therapies in fibromyalgia

Lesley M Arnold Arthritis Research & Therapy 2006, 8:212 (1 June 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

48.

16307
Accesses

Review   Free Highly Accessed

Therapy of ankylosing spondylitis and other spondyloarthritides: established medical treatment, anti-TNF-α therapy and other novel approaches

Juergen Braun, Joachim Sieper Arthritis Res 2002, 4:307-321 (6 August 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

49.

16239
Accesses

Review   Free

The vasculature and its role in the damaged and healing tendon

Steven A Fenwick, Brian L Hazleman, Graham P Riley Arthritis Res 2002, 4:252-260 (13 February 2002)

Abstract | Full text | PDF | PubMed

50.

16007
Accesses

Research article   Open Access Highly Accessed

Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus

Michelle Jackson, Yasmeen Ahmad, Ian N Bruce, Beatrice Coupes, Paul EC Brenchley Arthritis Research & Therapy 2006, 8:R81 (28 April 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Low efficiency of activation of transforming growth factor beta-1 is associated with increased risk of cardiovascular disease and may modulate development of atherosclerosis in patients with lupus.

51.

15908
Accesses

Review   Free Highly Accessed

Interleukin-6: discovery of a pleiotropic cytokine

Tadamitsu Kishimoto Arthritis Research & Therapy 2006, 8(Suppl 2):S2 (28 July 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

52.

15855
Accesses

Research article   Open Access Highly Accessed

Relationship between physical activity and stiff or painful joints in mid-aged women and older women: a 3-year prospective study

Kristiann C Heesch, Yvette D Miller, Wendy J Brown Arthritis Research & Therapy 2007, 9:R34 (29 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

53.

15618
Accesses

Review   Free Highly Accessed

Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics

Robert Terkeltaub, David A Bushinsky, Michael A Becker Arthritis Research & Therapy 2006, 8(Suppl 1):S4 (12 April 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

54.

15551
Accesses

Research article   Open Access Highly Accessed

Anti-TNF-α antibody allows healing of joint damage in polyarthritic transgenic mice

David J Shealy, Paul H Wooley, Eva Emmell, Amy Volk, Amy Rosenberg, George Treacy, Carrie L Wagner, Lois Mayton, Don E Griswold, Xiao-yu R Song Arthritis Res 2002, 4:R7 (28 June 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

55.

15507
Accesses

Research article   Open Access Highly Accessed

Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study

Steeve Tat, Jean-Pierre Pelletier, Josep Vergés, Daniel Lajeunesse, Eulàlia Montell, Hassan Fahmi, Martin Lavigne, Johanne Martel-Pelletier Arthritis Research & Therapy 2007, 9:R117 (9 November 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A combination of glucosamine sulphate and chondroitin sulphate markedly reduces the resorptive activity of subchondral bone osteoblasts, suggesting a positive effect on early bone structural changes in osteoarthritis.

56.

15476
Accesses

Research article   Open Access Highly Accessed

A critical appraisal of guidelines for the management of knee osteoarthritis using Appraisal of Guidelines Research and Evaluation criteria

Stéphane Poitras, Jérôme Avouac, Michel Rossignol, Bernard Avouac, Christine Cedraschi, Margareta Nordin, Chantal Rousseaux, Sylvie Rozenberg, Bernard Savarieau, Philippe Thoumie, Jean-Pierre Valat, Éric Vignon, Pascal Hilliquin Arthritis Research & Therapy 2007, 9:R126 (6 December 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Guidelines for treating knee osteoarthritis were found to lack educational information and differ in treatments addressed when they were reviewed using the Appraisal of Guidelines Research and Evaluation (AGREE) criteria.

57.

15429
Accesses

Review   Free Highly Accessed

Arthritis and Pain. Neurogenic origin of joint pain

Jason J McDougall Arthritis Research & Therapy 2006, 8:220 (10 November 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

58.

15283
Accesses

Review   Free

Macrophages in rheumatoid arthritis

Raimund W Kinne, Rolf Bräuer, Bruno Stuhlmüller, Ernesta Palombo-Kinne, Gerd-R Burmester Arthritis Res 2000, 2:189-202 (12 April 2000)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

59.

15281
Accesses

Review   Free Highly Accessed

Negative regulation of cytokine signaling and immune responses by SOCS proteins

Akihiko Yoshimura, Hitomi Nishinakamura, Yumiko Matsumura, Toshikatsu Hanada Arthritis Research & Therapy 2005, 7:100-110 (30 March 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

60.

15234
Accesses

Research article   Open Access Highly Accessed

Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis

Fiona E McCann, Andrew C Palfreeman, Melanie Andrews, Dany P Perocheau, Julia J Inglis, Peter Schafer, Marc Feldmann, Richard O Williams, Fionula M Brennan Arthritis Research & Therapy 2010, 12:R107 (2 June 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

61.

15226
Accesses

Review   Free Highly Accessed

Arthritis and pain. Psychosocial aspects in the management of arthritis pain

Catherine L Backman Arthritis Research & Therapy 2006, 8:221 (5 December 2006)

Abstract | Full text | PDF | PubMed | 1 comment

62.

15153
Accesses

Research article   Open Access Highly Accessed

Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial reports

R Andrew Moore, Sheena Derry, Geoffrey T Makinson, Henry J McQuay Arthritis Research & Therapy 2005, 7:R644-R665 (24 March 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

63.

15130
Accesses

Research article   Open Access Highly Accessed

The Revised Fibromyalgia Impact Questionnaire (FIQR): validation and psychometric properties

Robert M Bennett, Ronald Friend, Kim D Jones, Rachel Ward, Bobby K Han, Rebecca L Ross Arthritis Research & Therapy 2009, 11:R120 (10 August 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

64.

15118
Accesses

Review   Free Highly Accessed

Magnetic resonance imaging in psoriatic arthritis: a review of the literature

Fiona McQueen, Marissa Lassere, Mikkel Østergaard Arthritis Research & Therapy 2006, 8:207 (23 March 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

65.

15109
Accesses

Review   Free

Is juvenile rheumatoid arthritis/juvenile idiopathic arthritis different from rheumatoid arthritis?

Sampath Prahalad, David N Glass Arthritis Res 2002, 4(Suppl 3):303-310 (24 July 2002)

Abstract | Full text | PDF

66.

15060
Accesses

Review   Free

Signaling for survival and apoptosis in the immune system

Tak W Mak, Wen-Chen Yeh Arthritis Res 2002, 4(Suppl 3):S243-S252 (9 May 2002)

Abstract | Full text | PDF | PubMed

67.

15026
Accesses

Review   Free

The clinical relevance of autoantibodies in scleroderma

Khanh T Ho, John D Reveille Arthritis Res Ther 2003, 5:80-93 (12 February 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

68.

14873
Accesses

Research article   Open Access Highly Accessed

Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study

Tuulikki Sokka, Sergio Toloza, Maurizio Cutolo, Hannu Kautiainen, Heidi Makinen, Feride Gogus, Vlado Skakic, Humeira Badsha, Tõnu Peets, Asta Baranauskaite, Pál Géher, Ilona Újfalussy, Fotini N Skopouli, Maria Mavrommati, Rieke Alten, Christof Pohl, Jean Sibilia, Andrea Stancati, Fausto Salaffi, Wojciech Romanowski, Danuta Zarowny-Wierzbinska, Dan Henrohn, Barry Bresnihan, Patricia Minnock, Lene Knudsen, Johannes WG Jacobs, Jaime Calvo-Alen, Juris Lazovskis, Geraldo Pinheiro, Dmitry Karateev, Daina Andersone, Sylejman Rexhepi, Yusuf Yazici, Theodore Pincus, the QUEST-RA Group et al. Arthritis Research & Therapy 2009, 11:R7 (14 January 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Rheumatoid arthritis was more severe in women in an analysis of more than 6,000 patients, although the effects of gender on standard disease activity measures may explain the difference.

69.

14707
Accesses

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Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti-TNF protocols

Eleni Douni, Petros P Sfikakis, Sylva Haralambous, Peter Fernandes, George Kollias Arthritis Res Ther 2004, 6:R65-R72 (7 November 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

70.

14690
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Review   Free

Matrix metalloproteinases in arthritic disease

Gillian Murphy, Vera Knäuper, Susan Atkinson, George Butler, William English, Mike Hutton, Jan Stracke, Ian Clark Arthritis Res 2002, 4(Suppl 3):S39-S49 (9 May 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

71.

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Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture — primary culture cells markedly differ from fourth-passage cells

Thomas Zimmermann, Elke Kunisch, Robert Pfeiffer, Astrid Hirth, Hans-Detlev Stahl, Ulrich Sack, Anke Laube, Eckehard Liesaus, Andreas Roth, Ernesta Palombo-Kinne, Frank Emmrich, Raimund W Kinne Arthritis Res 2001, 3:72-76 (21 November 2000)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

72.

14651
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A critical appraisal of clinical practice guidelines for the treatment of lower-limb osteoarthritis

James N Pencharz, Elizabeth Grigoriadis, Gwenderlyn F Jansz, Claire Bombardier Arthritis Res 2002, 4:36-44 (16 October 2001)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

73.

14631
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Gout. Novel therapies for treatment of gout and hyperuricemia

Robert Terkeltaub Arthritis Research & Therapy 2009, 11:236 (23 July 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

74.

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DAS28 best reflects the physician's clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment

Bert Vander Cruyssen, Stijn Van Looy, Bart Wyns, Rene Westhovens, Patrick Durez, Filip Van den Bosch, Eric M Veys, Herman Mielants, Luc De Clerck, Anne Peretz, Michel Malaise, Leon Verbruggen, Nathan Vastesaeger, Anja Geldhof, Luc Boullart, Filip De Keyser Arthritis Research & Therapy 2005, 7:R1063-R1071 (8 July 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

75.

14458
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Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value

Martinus AM van Boekel, Erik R Vossenaar, Frank HJ van den Hoogen, Walther J van Venrooij Arthritis Res 2002, 4:87-93 (6 November 2001)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

76.

14402
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The paradigm of IL-6: from basic science to medicine

Tetsuji Naka, Norihiro Nishimoto, Tadamitsu Kishimoto Arthritis Res 2002, 4(Suppl 3):S233-S242 (9 May 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

77.

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Relevance of the stroma and epithelial-mesenchymal transition (EMT) for the rheumatic diseases

Nathan J Zvaifler Arthritis Research & Therapy 2006, 8:210 (9 May 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

78.

14373
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Interstitial lung disease in connective tissue diseases: evolving concepts of pathogenesis and management

Flavia V Castelino, John Varga Arthritis Research & Therapy 2010, 12:213 (23 August 2010)

Abstract | Full text | PDF | PubMed

79.

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Research article   Open Access

Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1

Helena d'Elia, Lars-Åke Mattsson, Claes Ohlsson, Elisabeth Nordborg, Hans Carlsten Arthritis Res Ther 2003, 5:R202-R209 (1 May 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

80.

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A pilot study of IL-1 inhibition by anakinra in acute gout

Alexander So, Thibaut De Smedt, Sylvie Revaz, Jürg Tschopp Arthritis Research & Therapy 2007, 9:R28 (12 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In a pilot study on 10 patients with gouty arthritis, IL-1 blockade with anakinra gave rapid relief of inflammatory symptoms where standard treatments had failed or were not tolerated.

81.

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Biology of RANK, RANKL, and osteoprotegerin

Brendan F Boyce, Lianping Xing Arthritis Research & Therapy 2007, 9(Suppl 1):S1 (29 June 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

82.

14193
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Biology and therapy of fibromyalgia. Stress, the stress response system, and fibromyalgia

Manuel Martinez-Lavin Arthritis Research & Therapy 2007, 9:216 (6 July 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

83.

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Oxidation in rheumatoid arthritis

Carol A Hitchon, Hani S El-Gabalawy Arthritis Res Ther 2004, 6:265-278 (13 October 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

84.

14099
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The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial

Michael A Becker, H Ralph Schumacher, Luis R Espinoza, Alvin F Wells, Patricia MacDonald, Eric Lloyd, Christopher Lademacher Arthritis Research & Therapy 2010, 12:R63 (6 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

85.

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Research article   Open Access

Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset

Raphaela Goldbach-Mansky, Jennifer Lee, Angela McCoy, Joseph Hoxworth, Cheryl Yarboro, Josef S Smolen, Günter Steiner, Antony Rosen, Cindy Zhang, Henri A Ménard, Zhi Jie Zhou, Timo Palosuo, Walther J Van Venrooij, Ronald L Wilder, John H Klippel, H Ralph Schumacher, Hani S El-Gabalawy Arthritis Res 2000, 2:236-243 (31 March 2000)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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Does a positive anti-CCP test identify a distinct arthritis entity?

Thomas Skogh Arthritis Research & Therapy 2005, 7:230-232 (16 September 2005)

Abstract | Full text | PDF | PubMed

87.

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Identification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen-induced arthritis model

Jianyong Shou, Christopher M Bull, Li Li, Hui-Rong Qian, Tao Wei, Shuang Luo, Douglas Perkins, Patricia J Solenberg, Seng-Lai Tan, Xin-Yi Chen, Neal W Roehm, Jeffrey A Wolos, Jude E Onyia Arthritis Research & Therapy 2006, 8:R28 (10 January 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

88.

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Switching TNF antagonists in patients with chronic arthritis: an observational study of 488 patients over a four-year period

Juan J Gomez-Reino, Loreto Carmona, the BIOBADASER Group Arthritis Research & Therapy 2006, 8:R29 (6 January 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

89.

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Perspectives for TNF-α-targeting therapies

Hanns-Martin Lorenz, Joachim R Kalden Arthritis Res 2002, 4(Suppl 3):S17-S24 (9 May 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

90.

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Angiogenesis in rheumatoid arthritis

Ewa M Paleolog Arthritis Res 2002, 4(Suppl 3):S81-S90 (9 May 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

91.

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The life cycle of chondrocytes in the developing skeleton

Lillian Shum, Glen Nuckolls Arthritis Res 2002, 4:94-106 (8 November 2001)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

92.

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Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen

Julia J Inglis, Gabriel Criado, Mino Medghalchi, Melanie Andrews, Ann Sandison, Marc Feldmann, Richard O Williams Arthritis Research & Therapy 2007, 9:R113 (29 October 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

C57BL/6 mice may be useful for testing new therapeutics, particularly those directed against T cells, and investigating the action of current therapies in rheumatoid arthritis.

93.

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Rheumatic Diseases in China

Qing Zeng, Ren Chen, John Darmawan, Zheng Xiao, Su Chen, Richard Wigley, Shun Le Chen, Nai Zhang Arthritis Research & Therapy 2008, 10:R17 (31 January 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A large population study found that the incidence of certain rheumatic diseases in China is becoming more like that of Western countries, but different joints are affected compared to Caucasian populations.

94.

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The evolving clinical profile of abatacept (CTLA4–Ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis

Eric M Ruderman, Richard M Pope Arthritis Research & Therapy 2005, 7(Suppl 2):S21-S25 (16 March 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

95.

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Environmental risk factors differ between rheumatoid arthritis with and without auto-antibodies against cyclic citrullinated peptides

Merete Pedersen, Søren Jacobsen, Mette Klarlund, Bo V Pedersen, Allan Wiik, Jan Wohlfahrt, Morten Frisch Arthritis Research & Therapy 2006, 8:R133 (27 July 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

96.

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Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells

Kutty Nandakumar, Johan Bäcklund, Mikael Vestberg, Rikard Holmdahl Arthritis Res Ther 2004, 6:R544-R550 (23 September 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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Epstein–Barr virus and rheumatoid arthritis: is there a link?

Karen H Costenbader, Elizabeth W Karlson Arthritis Research & Therapy 2006, 8:204 (16 January 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

98.

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Supplement   Free

Autoantibodies in rheumatoid arthritis and their clinical significance

Günter Steiner, Josef Smolen Arthritis Res 2002, 4(Suppl 2):S1-S5 (26 April 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

99.

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Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis

C Thomas G Appleton, David D McErlain, Vasek Pitelka, Neil Schwartz, Suzanne M Bernier, James L Henry, David W Holdsworth, Frank Beier Arthritis Research & Therapy 2007, 9:R13 (6 February 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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Masitinib in the treatment of active rheumatoid arthritis: results of a multicentre, open-label, dose-ranging, phase 2a study

Jacques Tebib, Xavier Mariette, Pierre Bourgeois, René-Marc Flipo, Philippe Gaudin, Xavier Le Loët, Paul Gineste, Laurent Guy, Colin D Mansfield, Alain Moussy, Patrice Dubreuil, Olivier Hermine, Jean Sibilia Arthritis Research & Therapy 2009, 11:R95 (23 June 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A small clinical trial has shown masitinib to be generally well tolerated and effective in the treatment of rheumatoid arthritis, indicating the need for further placebo-controlled studies.

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