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51.

383
Accesses

Review   Free

B-cell targeted therapeutics in clinical development

Stephan Blüml, Kathleen McKeever, Rachel Ettinger, Josef Smolen, Ronald Herbst Arthritis Research & Therapy 2013, 15(Suppl 1):S4 (4 April 2013)

Abstract | Full text | PDF | PubMed

52.

378
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Review   Free Highly Accessed

Adult mesenchymal stem cells and cell-based tissue engineering

Rocky S Tuan, Genevieve Boland, Richard Tuli Arthritis Res Ther 2003, 5:32-45 (11 December 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

53.

373
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Review   Free Highly Accessed

A concise history of gout and hyperuricemia and their treatment

George Nuki, Peter A Simkin Arthritis Research & Therapy 2006, 8(Suppl 1):S1 (12 April 2006)

Abstract | Full text | PDF | PubMed

54.

372
Accesses

Research article   Open Access

Anti-cyclic citrullinated peptide antibody titer predicts time to rheumatoid arthritis onset in patients with undifferentiated arthritis: results from a 2-year prospective study

Nicola Bizzaro, Elena Bartoloni, Gabriella Morozzi, Stefania Manganelli, Valeria Riccieri, Paola Sabatini, Matteo Filippini, Marilina Tampoia, Antonella Afeltra, Giandomenico Sebastiani, Claudia Alpini, Vittorio Bini, Onelia Bistoni, Alessia Alunno, Roberto Gerli, the Forum Interdisciplinare per la Ricerca nelle Malattie Autoimmuni (FIRMA Group) Arthritis Research & Therapy 2013, 15:R16 (22 January 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

55.

365
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Editorial   Free Highly Accessed

A complicated liaison: IL-33 and IL-33R in arthritis pathogenesis

Thomas Kamradt, Sebastian Drube Arthritis Research & Therapy 2013, 15:115 (2 May 2013)

Abstract | Full text | PDF | PubMed

56.

354
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Research article   Open Access Highly Accessed

Rheumatic Diseases in China

Qing Zeng, Ren Chen, John Darmawan, Zheng Xiao, Su Chen, Richard Wigley, Shun Le Chen, Nai Zhang Arthritis Research & Therapy 2008, 10:R17 (31 January 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A large population study found that the incidence of certain rheumatic diseases in China is becoming more like that of Western countries, but different joints are affected compared to Caucasian populations.

57.

354
Accesses

Research article   Open Access

Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis

Jérôme Avouac, Maeva Vallucci, Vanessa Smith, Patricia Senet, Barbara Ruiz, Alberto Sulli, Carmen Pizzorni, Camille Frances, Gilles Chiocchia, Maurizio Cutolo, Yannick Allanore Arthritis Research & Therapy 2013, 15:R55 (19 April 2013)

Abstract | Full text | PDF | PubMed

58.

353
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Research article   Open Access Highly Accessed

Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis

Heidi Kokkonen, Mohammed Mullazehi, Ewa Berglin, Göran Hallmans, Göran Wadell, Johan Rönnelid, Solbritt Rantapää-Dahlqvist Arthritis Research & Therapy 2011, 13:R13 (3 February 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

59.

351
Accesses

Research article   Open Access

MMP-2 mediates local degradation and remodeling of collagen by annulus fibrosus cells of the intervertebral disc

Anshu Rastogi, Hyunchul Kim, Julianne D Twomey, Adam H Hsieh Arthritis Research & Therapy 2013, 15:R57 (27 April 2013)

Abstract | Full text | PDF | PubMed

60.

350
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Articular cartilage and changes in Arthritis: Cell biology of osteoarthritis

Linda J Sandell, Thomas Aigner Arthritis Res 2001, 3:107-113 (22 January 2001)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

61.

347
Accesses

Research article   Open Access Highly Accessed

Anti-inflammatory properties of a dual PPARgamma/alpha agonist muraglitazar in in vitro and in vivo models

Erja-Leena Paukkeri, Tiina Leppänen, Mira Lindholm, Mun Fei Yam, Mohd Asmawi, Anne Kolmonen, Paula H Aulaskari, Eeva Moilanen Arthritis Research & Therapy 2013, 15:R51 (17 April 2013)

Abstract | Full text | PDF | PubMed

62.

345
Accesses

Research article   Open Access Highly Accessed

Distinguishing fibromyalgia from rheumatoid arthritis and systemic lupus in clinical questionnaires: an analysis of the revised Fibromyalgia Impact Questionnaire (FIQR) and its variant, the Symptom Impact Questionnaire (SIQR), along with pain locations

Ronald Friend, Robert M Bennett Arthritis Research & Therapy 2011, 13:R58 (8 April 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A combination of 2 questions from the symptom impact questionnaire plus pain in four locations identified the correct diagnosis in 97% of subjects with fibromyalgia, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).

63.

344
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Review   Free Highly Accessed

Common variable immunodeficiency - an update

Ulrich Salzer, Klaus Warnatz, Hans Peter Arthritis Research & Therapy 2012, 14:223 (24 September 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

64.

336
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Research article   Open Access Highly Accessed

Mechanisms of quadriceps muscle weakness in knee joint osteoarthritis: the effects of prolonged vibration on torque and muscle activation in osteoarthritic and healthy control subjects

David A Rice, Peter J McNair, Gwyn N Lewis Arthritis Research & Therapy 2011, 13:R151 (20 September 2011)

Abstract | Full text | PDF | PubMed

65.

335
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Research article   Open Access Highly Accessed

Phytalgic®, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial

Alain Jacquet, Pierre-Olivier Girodet, Antoine Pariente, Karelle Forest, Laurent Mallet, Nicholas Moore Arthritis Research & Therapy 2009, 11:R192 (16 December 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 |  Editor’s summary

A food supplement containing fish oils, Urtica dioica (the common nettle), zinc and vitamin E decreases the need for painkillers and reduces symptoms of osteoarthritis, a randomised trial has found.

66.

330
Accesses

Review   Free Highly Accessed

Cellular and molecular pathogenesis of systemic lupus erythematosus: lessons from animal models

Simanta Pathak, Chandra Mohan Arthritis Research & Therapy 2011, 13:241 (30 September 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

67.

327
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Research article   Open Access Highly Accessed

Vitamin D deficiency in undifferentiated connective tissue disease

Eva Zold, Peter Szodoray, Janos Gaal, János Kappelmayer, Laszlo Csathy, Edit Gyimesi, Margit Zeher, Gyula Szegedi, Edit Bodolay Arthritis Research & Therapy 2008, 10:R123 (18 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 |  Editor’s summary

A study of 161 patients with undifferentiated connective tissue disease suggests that vitamin D deficiency may be associated with the disease progressing into well-defined connective tissue diseases such as rheumatoid arthritis.

68.

328
Accesses

Research article   Open Access Highly Accessed

Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis

Natalie A Carter, Elizabeth C Rosser, Claudia Mauri Arthritis Research & Therapy 2012, 14:R32 (8 February 2012)

Abstract | Full text | PDF | PubMed

69.

324
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Research article   Open Access Highly Accessed

Inflammation associated anemia and ferritin as disease markers in SLE

Kamala Vanarsa, Yujin Ye, Jie Han, Chun Xie, Chandra Mohan, Tianfu Wu Arthritis Research & Therapy 2012, 14:R182 (7 August 2012)

Abstract | Full text | PDF | PubMed

70.

320
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Research article   Open Access Highly Accessed

A pilot study of IL-1 inhibition by anakinra in acute gout

Alexander So, Thibaut De Smedt, Sylvie Revaz, Jürg Tschopp Arthritis Research & Therapy 2007, 9:R28 (12 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In a pilot study on 10 patients with gouty arthritis, IL-1 blockade with anakinra gave rapid relief of inflammatory symptoms where standard treatments had failed or were not tolerated.

71.

322
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Review   Free Highly Accessed

Anti-inflammatory and immunosuppressive drugs and reproduction

Monika Østensen, Munther Khamashta, Michael Lockshin, Ann Parke, Antonio Brucato, Howard Carp, Andrea Doria, Raj Rai, Pierluigi Meroni, Irene Cetin, Ronald Derksen, Ware Branch, Mario Motta, Caroline Gordon, Guillermo Ruiz-Irastorza, Arsenio Spinillo, Deborah Friedman, Rolando Cimaz, Andrew Czeizel, Jean Piette, Ricard Cervera, Roger A Levy, Maurizio Clementi, Sara De Carolis, Michelle Petri, Yehuda Shoenfeld, David Faden, Guido Valesini, Angela Tincani Arthritis Research & Therapy 2006, 8:209 (11 May 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

72.

322
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Review   Free Highly Accessed

Platelet-rich plasma therapy - future or trend?

Robinder S Dhillon, Edward M Schwarz, Michael D Maloney Arthritis Research & Therapy 2012, 14:219 (8 August 2012)

Abstract | Full text | PDF | PubMed

73.

318
Accesses

Research article   Open Access Highly Accessed

The spectrum of renal thrombotic microangiopathy in lupus nephritis

Di Song, Li-hua Wu, Feng-mei Wang, Xiao-wei Yang, Di Zhu, Min Chen, Feng Yu, Gang Liu, Ming-hui Zhao Arthritis Research & Therapy 2013, 15:R12 (15 January 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

74.

316
Accesses

Research article   Open Access Highly Accessed

Integrated safety in tocilizumab clinical trials

Michael H Schiff, Joel M Kremer, Angelika Jahreis, Emma Vernon, John D Isaacs, Ronald F van Vollenhoven Arthritis Research & Therapy 2011, 13:R141 (1 September 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

75.

318
Accesses

Research article   Open Access Highly Accessed

Vitamin K-dependent proteins GAS6 and Protein S and TAM receptors in patients of systemic lupus erythematosus: correlation with common genetic variants and disease activity

Pedro Recarte-Pelz, Dolors Tàssies, Gerard Espinosa, Begoña Hurtado, Núria Sala, Ricard Cervera, Joan Reverter, Pablo de Frutos Arthritis Research & Therapy 2013, 15:R41 (12 March 2013)

Abstract | Full text | PDF | PubMed

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