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	1. 4504 Accesses	Research article Cigarette smoking and smoking cessation in relation to risk of rheumatoid arthritis in women Daniela Giuseppe, Nicola Orsini, Lars Alfredsson, Johan Askling, Alicja Wolk Arthritis Research & Therapy 2013, 15:R56 (22 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Smoking only a few cigarettes a day more than doubles the risk of developing rheumatoid arthritis and although this risk will lower with time after smoking cessation, it can remain elevated 15 years later.
	2. 2137 Accesses	Research article Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis Gurkirpal Singh, Olivia Wu, Peter Langhorne, Rajan Madhok Arthritis Research & Therapy 2006, 8:R153 (22 September 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary NSAIDs have been shown to be associated with an increased risk of acute myocardial infarctions, suggesting they should be used with caution in those with risk factors for cardiovascular disease.
	3. 1604 Accesses	Research article Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage Mathias Gebauer, Joachim Saas, Jochen Haag, Uwe Dietz, Masaharu Takigawa, Eckart Bartnik, Thomas Aigner Arthritis Res Ther 2005, 7:R274-R284 (11 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	4. 1586 Accesses	Research article Open label study of escalating doses of oral treprostinil diethanolamine in patients with systemic sclerosis and digital ischemia: pharmacokinetics and correlation with digital perfusion Ami A Shah, Elena Schiopu, Laura K Hummers, Michael Wade, Kristine Phillips, Cynthia Anderson, Robert Wise, Francesco Boin, James R Seibold, Fredrick Wigley, Kristan D Rollins Arthritis Research & Therapy 2013, 15:R54 (18 April 2013) Abstract \| Provisional PDF \| PubMed
	5. 1298 Accesses	Review Mechanisms of B cell autoimmunity in SLE Thomas Dörner, Claudia Giesecke, Peter E Lipsky Arthritis Research & Therapy 2011, 13:243 (27 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	6. 1260 Accesses	Editorial Mesenchymal stem cell therapy in osteoarthritis: advanced tissue repair or intervention with smouldering synovial activation? Peter LEM van Lent, Wim B van den Berg Arthritis Research & Therapy 2013, 15:112 (20 March 2013) Abstract \| Full text \| PDF \| PubMed
	7. 1021 Accesses	Research article Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence Laurent G Ameye, Winnie SS Chee Arthritis Research & Therapy 2006, 8:R127 (19 July 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	8. 1022 Accesses	Editorial A complicated liaison: IL-33 and IL-33R in arthritis pathogenesis Thomas Kamradt, Sebastian Drube Arthritis Research & Therapy 2013, 15:115 (2 May 2013) Abstract \| Full text \| PDF \| PubMed
	9. 954 Accesses	Review The inflammatory process of gout and its treatment Bruce N Cronstein, Robert Terkeltaub Arthritis Research & Therapy 2006, 8(Suppl 1):S3 (12 April 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	10. 889 Accesses	Review IL-10-producing regulatory B cells (B10 cells) in autoimmune disease Ioannis Kalampokis, Ayumi Yoshizaki, Thomas F Tedder Arthritis Research & Therapy 2013, 15(Suppl 1):S1 (11 February 2013) Abstract \| Full text \| PDF \| PubMed
	11. 877 Accesses	Review Early diagnosis to enable early treatment of pre-osteoarthritis Constance R Chu, Ashley A Williams, Christian H Coyle, Megan E Bowers Arthritis Research & Therapy 2012, 14:212 (7 June 2012) Abstract \| Full text \| PDF \| PubMed
	12. 835 Accesses	Research article Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis Jérôme Avouac, Maeva Vallucci, Vanessa Smith, Patricia Senet, Barbara Ruiz, Alberto Sulli, Carmen Pizzorni, Camille Frances, Gilles Chiocchia, Maurizio Cutolo, Yannick Allanore Arthritis Research & Therapy 2013, 15:R55 (19 April 2013) Abstract \| Provisional PDF \| PubMed
	13. 825 Accesses	Research article A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin^®for treatment of osteoarthritis of the knee Krishanu Sengupta, Krishnaraju V Alluri, Andey Satish, Simanchala Mishra, Trimurtulu Golakoti, Kadainti VS Sarma, Dipak Dey, Siba P Raychaudhuri Arthritis Research & Therapy 2008, 10:R85 (30 July 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 \| Editor’s summary An enriched extract of the Indian frankincense herb, Boswellia serrata reduced pain and improved the physical function of osteoarthritis patients, in a double blind, randomized, placebo controlled trial.
	14. 826 Accesses	Research article Adenosine A2A receptors promote collagen production by a Fli1- and CTGF-mediated mechanism Edwin SL Chan, Hailing Liu, Patricia Fernandez, Alex Luna, Miguel Perez-Aso, Andreea M Bujor, Maria Trojanowska, Bruce N Cronstein Arthritis Research & Therapy 2013, 15:R58 (11 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Adenosine promotion of dermal fibrosis in conditions such as scleroderma is mediated by the transcription factor Fli1 and growth factor CTFG, highlighting potential targets for future anti-fibrotic therapies.
	15. 793 Accesses	Research article MMP-2 mediates local degradation and remodeling of collagen by annulus fibrosus cells of the intervertebral disc Anshu Rastogi, Hyunchul Kim, Julianne D Twomey, Adam H Hsieh Arthritis Research & Therapy 2013, 15:R57 (27 April 2013) Abstract \| Provisional PDF \| PubMed
	16. 758 Accesses	Review Platelet-rich plasma therapy - future or trend? Robinder S Dhillon, Edward M Schwarz, Michael D Maloney Arthritis Research & Therapy 2012, 14:219 (8 August 2012) Abstract \| Full text \| PDF \| PubMed
	17. 731 Accesses	Research article Osteoporosis in ankylosing spondylitis - prevalence, risk factors and methods of assessment Eva Klingberg, Mattias Lorentzon, Dan Mellström, Mats Geijer, Jan Göthlin, Elisabet Hilme, Martin Hedberg, Hans Carlsten, Helena Forsblad-d'Elia Arthritis Research & Therapy 2012, 14:R108 (8 May 2012) Abstract \| Full text \| PDF \| PubMed
	18. 684 Accesses	Research article Anti-inflammatory properties of a dual PPARgamma/alpha agonist muraglitazar in in vitro and in vivo models Erja-Leena Paukkeri, Tiina Leppanen, Mira Lindholm, Mun Fei Yam, Mohd. Zaini Asmawi, Anne Kolmonen, Paula H Aulaskari, Eeva Moilanen Arthritis Research & Therapy 2013, 15:R51 (17 April 2013) Abstract \| Provisional PDF \| PubMed
	19. 678 Accesses	Research article The Revised Fibromyalgia Impact Questionnaire (FIQR): validation and psychometric properties Robert M Bennett, Ronald Friend, Kim D Jones, Rachel Ward, Bobby K Han, Rebecca L Ross Arthritis Research & Therapy 2009, 11:R120 (10 August 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	20. 673 Accesses	Research article Association between alcohol consumption and symptom severity and quality of life in patients with fibromyalgia Chul H Kim, Ann Vincent, Daniel J Clauw, Connie A Luedtke, Jeffrey M Thompson, Terry D Schneekloth, Terry H Oh Arthritis Research & Therapy 2013, 15:R42 (15 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Low to moderate alcohol consumption lessens symptom severity and betters quality of life for fibromyalgia patients when compared to no alcohol consumption.
	21. 673 Accesses	Review Degeneration of the intervertebral disc Jill PG Urban, Sally Roberts Arthritis Res Ther 2003, 5:120-130 (11 March 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment
	22. 663 Accesses	Review Complement and systemic lupus erythematosus Mark J Walport Arthritis Res 2002, 4(Suppl 3):S279-S293 (9 May 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	23. 639 Accesses	Research article Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGFbeta1) gene in knee and hip osteoarthritis Stella G Muthuri, Sally Doherty, Weiya Zhang, Rose A Maciewicz, Kenneth Muir, Michael Doherty Arthritis Research & Therapy 2013, 15:R52 (18 April 2013) Abstract \| Provisional PDF \| PubMed
	24. 636 Accesses	Research article A pilot study of IL-1 inhibition by anakinra in acute gout Alexander So, Thibaut De Smedt, Sylvie Revaz, Jürg Tschopp Arthritis Research & Therapy 2007, 9:R28 (12 March 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In a pilot study on 10 patients with gouty arthritis, IL-1 blockade with anakinra gave rapid relief of inflammatory symptoms where standard treatments had failed or were not tolerated.
	25. 622 Accesses	Review Common variable immunodeficiency - an update Ulrich Salzer, Klaus Warnatz, Hans Peter Arthritis Research & Therapy 2012, 14:223 (24 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	26. 610 Accesses	Review Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases Sherine E Gabriel, Kaleb Michaud Arthritis Research & Therapy 2009, 11:229 (19 May 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	27. 605 Accesses	Editorial Kidney disease in lupus is not always 'lupus nephritis' Hans-Joachim Anders, Jan J Weening Arthritis Research & Therapy 2013, 15:108 (1 March 2013) Abstract \| Full text \| PDF \| PubMed
	28. 603 Accesses	Commentary What can rheumatologists learn from translational cancer therapy? Jonathan P Sherlock, Andrew D Filer, John D Isaacs, Christopher D Buckley Arthritis Research & Therapy 2013, 15:114 (1 May 2013) Abstract \| Full text \| PDF \| PubMed
	29. 601 Accesses	Review Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action Larry W Moreland Arthritis Res Ther 2003, 5:54-67 (14 January 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	30. 599 Accesses	Review Epidemiology and genetics of rheumatoid arthritis Alan J Silman, Jacqueline E Pearson Arthritis Res 2002, 4(Suppl 3):S265-S272 (9 May 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	31. 590 Accesses	Review microRNA-mediated regulation of innate immune response in rheumatic diseases Xiaobing Luo, Koustubh Ranade, Ronel Talker, Bahija Jallal, Nan Shen, Yihong Yao Arthritis Research & Therapy 2013, 15:210 (9 April 2013) Abstract \| Full text \| PDF \| PubMed
	32. 581 Accesses	Research article Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay Michael Mahler, Cristina Gascon, Sima Patel, Angela Ceribelli, Marvin J Fritzler, Andreas Swart, Edward KL Chan, Minoru Satoh Arthritis Research & Therapy 2013, 15:R50 (12 April 2013) Abstract \| Full text \| PDF \| PubMed
	33. 577 Accesses	Research article RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis Maria J Martínez-Calatrava, Ivan Prieto-Potín, Jorge A Roman-Blas, Lidia Tardio, Raquel Largo, Gabriel Herrero-Beaumont Arthritis Research & Therapy 2012, 14:R149 (18 June 2012) Abstract \| Full text \| PDF \| PubMed
	34. 576 Accesses	Review Interleukin-6 and chronic inflammation Cem Gabay Arthritis Research & Therapy 2006, 8(Suppl 2):S3 (28 July 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	35. 572 Accesses	Research article Shear stress modulates macrophage-induced urokinase plasminogen activator expression in human chondrocytes Chih-Chang Yeh, Shun-Fu Chang, Ting-Ying Huang, Hsin-I Chang, Hsing-Chun Kuo, Yi-Chien Wu, Ching-Hsiang Hsieh, Chung-Sheng Shi, Cheng-Nan Chen Arthritis Research & Therapy 2013, 15:R53 (18 April 2013) Abstract \| Provisional PDF \| PubMed
	36. 569 Accesses	Primary research Monoarticular antigen-induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats Gisela von Banchet, Peter K Petrow, Rolf Bräuer, Hans-Georg Schaible Arthritis Res 2000, 2:424-427 (3 August 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	37. 553 Accesses	Editorial Cardiovascular risk management in rheumatoid arthritis: are we still waiting for the first step? Mike JL Peters, Michael T Nurmohamed Arthritis Research & Therapy 2013, 15:111 (19 March 2013) Abstract \| Full text \| PDF \| PubMed
	38. 552 Accesses	Review Interstitial lung disease in connective tissue diseases: evolving concepts of pathogenesis and management Flavia V Castelino, John Varga Arthritis Research & Therapy 2010, 12:213 (23 August 2010) Abstract \| Full text \| PDF \| PubMed
	39. 539 Accesses	Review Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases? Udo Oppermann Arthritis Research & Therapy 2013, 15:209 (3 April 2013) Abstract \| Full text \| PDF \| PubMed
	40. 530 Accesses	Review B-cell targeted therapeutics in clinical development Stephan Blüml, Kathleen McKeever, Rachel Ettinger, Josef Smolen, Ronald Herbst Arthritis Research & Therapy 2013, 15(Suppl 1):S4 (4 April 2013) Abstract \| Full text \| PDF \| PubMed
	41. 524 Accesses	Review Recent advances in the diagnosis and treatment of hemophagocytic lymphohistiocytosis Sebastian FN Bode, Kai Lehmberg, Andrea Maul-Pavicic, Thomas Vraetz, Gritta Janka, Udo Stadt, Stephan Ehl Arthritis Research & Therapy 2012, 14:213 (8 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	42. 522 Accesses	Research article Effects of rehabilitative interventions on pain, function and physical impairments in people with hand osteoarthritis: a systematic review Liuzhen Ye, Leonid Kalichman, Alicia Spittle, Fiona Dobson, Kim Bennell Arthritis Research & Therapy 2011, 13:R28 (18 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Rehabilitative interventions such as exercise, splints, laser therapy and massage can improve pain, hand function, grip strength and range of motion in individuals with hand osteoarthritis.
	43. 498 Accesses	Review Osteoarthritis associated with estrogen deficiency Jorge A Roman-Blas, Santos Castañeda, Raquel Largo, Gabriel Herrero-Beaumont Arthritis Research & Therapy 2009, 11:241 (21 September 2009) Abstract \| Full text \| PDF \| PubMed
	44. 496 Accesses	Correction Correction: TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β- induced rat osteoarthritis chondrocytes in vitro Jun Qin, Liang Shang, An-song Ping, Jing Li, Xiao-jun Li, Hong Yu, Jacques Magdalou, Liao-bin Chen, Hui Wang Arthritis Research & Therapy 2013, 15:407 (10 May 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	45. 495 Accesses	Research article Efficacy of different types of aerobic exercise in fibromyalgia syndrome: a systematic review and meta-analysis of randomised controlled trials Winfried Häuser, Petra Klose, Jost Langhorst, Babak Moradi, Mario Steinbach, Marcus Schiltenwolf, Angela Busch Arthritis Research & Therapy 2010, 12:R79 (10 May 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	46. 495 Accesses	Research article Possible rheumatoid arthritis subtypes in terms of rheumatoid factor, depression, diagnostic delay and emotional expression: an exploratory case-control study Taavi Tillmann, Rajeev Krishnadas, Jonathan Cavanagh, KV Petrides Arthritis Research & Therapy 2013, 15:R45 (21 March 2013) Abstract \| Full text \| PDF \| PubMed
	47. 495 Accesses	Review Adult and juvenile dermatomyositis: are the distinct clinical features explained by our current understanding of serological subgroups and pathogenic mechanisms? Sarah L Tansley, Neil J McHugh, Lucy R Wedderburn Arthritis Research & Therapy 2013, 15:211 (8 April 2013) Abstract \| Full text \| PDF \| PubMed
	48. 483 Accesses	Research article Vitamin D deficiency in undifferentiated connective tissue disease Eva Zold, Peter Szodoray, Janos Gaal, János Kappelmayer, Laszlo Csathy, Edit Gyimesi, Margit Zeher, Gyula Szegedi, Edit Bodolay Arthritis Research & Therapy 2008, 10:R123 (18 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 \| Editor’s summary A study of 161 patients with undifferentiated connective tissue disease suggests that vitamin D deficiency may be associated with the disease progressing into well-defined connective tissue diseases such as rheumatoid arthritis.
	49. 467 Accesses	Review Cellular and molecular pathogenesis of systemic lupus erythematosus: lessons from animal models Simanta Pathak, Chandra Mohan Arthritis Research & Therapy 2011, 13:241 (30 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	50. 461 Accesses	Review An update on the hyper-IgE syndromes Patrick FK Yong, Alexandra F Freeman, Karin R Engelhardt, Steven Holland, Jennifer M Puck, Bodo Grimbacher Arthritis Research & Therapy 2012, 14:228 (30 November 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central