Arthritis Research & Therapy

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		Research article A novel in vitro bovine cartilage punch model for assessing the regeneration of focal cartilage defects with biocompatible bacterial nanocellulose David Pretzel, Stefanie Linss, Hannes Ahrem, Michaela Endres, Christian Kaps, Dieter Klemm, Raimund W. Kinne Arthritis Research & Therapy 2013, 15:R59 (14 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary In vitro bovine cartilage punch model is a novel tool developed to evaluate potential bio-materials for use in cartilage regeneration and repair.
		Research article Adenosine A2A receptors promote collagen production by a Fli1- and CTGF-mediated mechanism Edwin SL Chan, Hailing Liu, Patricia Fernandez, Alex Luna, Miguel Perez-Aso, Andreea M Bujor, Maria Trojanowska, Bruce N Cronstein Arthritis Research & Therapy 2013, 15:R58 (11 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Adenosine promotion of dermal fibrosis in conditions such as scleroderma is mediated by the transcription factor Fli1 and growth factor CTFG, highlighting potential targets for future anti-fibrotic therapies.
		Correction Correction: TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β- induced rat osteoarthritis chondrocytes in vitro Jun Qin, Liang Shang, An-song Ping, Jing Li, Xiao-jun Li, Hong Yu, Jacques Magdalou, Liao-bin Chen, Hui Wang Arthritis Research & Therapy 2013, 15:407 (10 May 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Editorial A complicated liaison: IL-33 and IL-33R in arthritis pathogenesis Thomas Kamradt, Sebastian Drube Arthritis Research & Therapy 2013, 15:115 (2 May 2013) Abstract \| Full text \| PDF \| PubMed
		Commentary What can rheumatologists learn from translational cancer therapy? Jonathan P Sherlock, Andrew D Filer, John D Isaacs, Christopher D Buckley Arthritis Research & Therapy 2013, 15:114 (1 May 2013) Abstract \| Full text \| PDF \| PubMed
		Research article MMP-2 mediates local degradation and remodeling of collagen by annulus fibrosus cells of the intervertebral disc Anshu Rastogi, Hyunchul Kim, Julianne D Twomey, Adam H Hsieh Arthritis Research & Therapy 2013, 15:R57 (27 April 2013) Abstract \| Provisional PDF \| PubMed
		Research article Cigarette smoking and smoking cessation in relation to risk of rheumatoid arthritis in women Daniela Di Giuseppe, Nicola Orsini, Lars Alfredsson, Johan Askling, Alicja Wolk Arthritis Research & Therapy 2013, 15:R56 (22 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Smoking only a few cigarettes a day more than doubles the risk of developing rheumatoid arthritis and although this risk will lower with time after smoking cessation, it can remain elevated 15 years later.
		Research article Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis Jérôme Avouac, Maeva Vallucci, Vanessa Smith, Patricia Senet, Barbara Ruiz, Alberto Sulli, Carmen Pizzorni, Camille Frances, Gilles Chiocchia, Maurizio Cutolo, Yannick Allanore Arthritis Research & Therapy 2013, 15:R55 (19 April 2013) Abstract \| Provisional PDF \| PubMed
		Research article Open label study of escalating doses of oral treprostinil diethanolamine in patients with systemic sclerosis and digital ischemia: pharmacokinetics and correlation with digital perfusion Ami A Shah, Elena Schiopu, Laura K Hummers, Michael Wade, Kristine Phillips, Cynthia Anderson, Robert Wise, Francesco Boin, James R Seibold, Fredrick Wigley, Kristan D Rollins Arthritis Research & Therapy 2013, 15:R54 (18 April 2013) Abstract \| Provisional PDF \| PubMed
		Research article Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGFbeta1) gene in knee and hip osteoarthritis Stella G Muthuri, Sally Doherty, Weiya Zhang, Rose A Maciewicz, Kenneth Muir, Michael Doherty Arthritis Research & Therapy 2013, 15:R52 (18 April 2013) Abstract \| Provisional PDF \| PubMed
		Research article Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay Michael Mahler, Cristina Gascon, Sima Patel, Angela Ceribelli, Marvin J Fritzler, Andreas Swart, Edward KL Chan, Minoru Satoh Arthritis Research & Therapy 2013, 15:R50 (12 April 2013) Abstract \| Full text \| PDF \| PubMed
		Review microRNA-mediated regulation of innate immune response in rheumatic diseases Xiaobing Luo, Koustubh Ranade, Ronel Talker, Bahija Jallal, Nan Shen, Yihong Yao Arthritis Research & Therapy 2013, 15:210 (9 April 2013) Abstract \| Full text \| PDF \| PubMed
		Review Adult and juvenile dermatomyositis: are the distinct clinical features explained by our current understanding of serological subgroups and pathogenic mechanisms? Sarah L Tansley, Neil J McHugh, Lucy R Wedderburn Arthritis Research & Therapy 2013, 15:211 (8 April 2013) Abstract \| Full text \| PDF \| PubMed
		Letter Response to 'Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis' - authors' reply Qin Shi, Jamilah Abusarah, Ghayath Baroudi, Julio C Fernandes, Hassan Fahmi, Mohamed Benderdour Arthritis Research & Therapy 2013, 15:406 (3 April 2013) Abstract \| Full text \| PDF \| PubMed
		Letter Response to 'Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis' Di Wang, Shanshan Hu, Wei Wei Arthritis Research & Therapy 2013, 15:405 (3 April 2013) Abstract \| Full text \| PDF \| PubMed
		Review Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases? Udo Oppermann Arthritis Research & Therapy 2013, 15:209 (3 April 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Germline deletion of β2 microglobulin or CD1d reduces anti-phospholipid antibody, but increases autoantibodies against non-phospholipid antigens in the NZB/W F1 model of lupus Ram Singh, Jun-Qi Yang, Peter J Kim, Ramesh C Halder Arthritis Research & Therapy 2013, 15:R47 (27 March 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Exercise training in childhood-onset systemic lupus erythematosus: a controlled randomized trial Danilo ML Prado, Fabiana B Benatti, Ana L de Sá-Pinto, Ana P Hayashi, Bruno Gualano, Rosa MR Pereira, Adriana ME Sallum, Eloisa Bonfá, Clovis A Silva, Hamilton Roschel Arthritis Research & Therapy 2013, 15:R46 (26 March 2013) Abstract \| Provisional PDF \| PubMed
		Editorial Canonical Wnt signaling and caveolae play a role in intervertebral disc degeneration; the continuing saga of the mysterious notochordal cell Mark Erwin Arthritis Research & Therapy 2013, 15:113 (22 March 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Possible rheumatoid arthritis subtypes in terms of rheumatoid factor, depression, diagnostic delay and emotional expression: an exploratory case-control study Taavi Tillmann, Rajeev Krishnadas, Jonathan Cavanagh, KV Petrides Arthritis Research & Therapy 2013, 15:R45 (21 March 2013) Abstract \| Full text \| PDF \| PubMed
		Review Cortical remodeling during menopause, rheumatoid arthritis, glucocorticoid and bisphosphonate therapy Daniel Aeberli, Georg Schett Arthritis Research & Therapy 2013, 15:208 (21 March 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Monitoring cartilage loss in the hands and wrists in rheumatoid arthritis with magnetic resonance imaging in a multi-center clinical trial: IMPRESS (NCT00425932) Charles G Peterfy, Ewa Olech, Julie C DiCarlo, Joan T Merrill, Peter J Countryman, Norman B Gaylis Arthritis Research & Therapy 2013, 15:R44 (20 March 2013) Abstract \| Provisional PDF \| PubMed
		Editorial Mesenchymal stem cell therapy in osteoarthritis: advanced tissue repair or intervention with smouldering synovial activation? Peter LEM van Lent, Wim B van den Berg Arthritis Research & Therapy 2013, 15:112 (20 March 2013) Abstract \| Full text \| PDF \| PubMed
		Editorial Cardiovascular risk management in rheumatoid arthritis: are we still waiting for the first step? Mike JL Peters, Michael T Nurmohamed Arthritis Research & Therapy 2013, 15:111 (19 March 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Treatment of rheumatoid arthritis in the Medicare Current Beneficiary Survey Daniel H Solomon, Edward Yelin, Jeffrey N Katz, Bing Lu, Tamara Shaykevich, John Z Ayanian Arthritis Research & Therapy 2013, 15:R43 (18 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Medicare patients with rheumatoid arthritis are less likely to receive disease-modifying anti-rheumatic drug (DMARD) treatment if they are not seeing a rheumatologist, have a lower income, or are older.

	All
		Research article A novel in vitro bovine cartilage punch model for assessing the regeneration of focal cartilage defects with biocompatible bacterial nanocellulose David Pretzel, Stefanie Linss, Hannes Ahrem, Michaela Endres, Christian Kaps, Dieter Klemm, Raimund W. Kinne Arthritis Research & Therapy 2013, 15:R59 (14 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary In vitro bovine cartilage punch model is a novel tool developed to evaluate potential bio-materials for use in cartilage regeneration and repair.
		Research article Adenosine A2A receptors promote collagen production by a Fli1- and CTGF-mediated mechanism Edwin SL Chan, Hailing Liu, Patricia Fernandez, Alex Luna, Miguel Perez-Aso, Andreea M Bujor, Maria Trojanowska, Bruce N Cronstein Arthritis Research & Therapy 2013, 15:R58 (11 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Adenosine promotion of dermal fibrosis in conditions such as scleroderma is mediated by the transcription factor Fli1 and growth factor CTFG, highlighting potential targets for future anti-fibrotic therapies.
		Correction Correction: TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β- induced rat osteoarthritis chondrocytes in vitro Jun Qin, Liang Shang, An-song Ping, Jing Li, Xiao-jun Li, Hong Yu, Jacques Magdalou, Liao-bin Chen, Hui Wang Arthritis Research & Therapy 2013, 15:407 (10 May 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Editorial A complicated liaison: IL-33 and IL-33R in arthritis pathogenesis Thomas Kamradt, Sebastian Drube Arthritis Research & Therapy 2013, 15:115 (2 May 2013) Abstract \| Full text \| PDF \| PubMed
		Commentary What can rheumatologists learn from translational cancer therapy? Jonathan P Sherlock, Andrew D Filer, John D Isaacs, Christopher D Buckley Arthritis Research & Therapy 2013, 15:114 (1 May 2013) Abstract \| Full text \| PDF \| PubMed
		Research article MMP-2 mediates local degradation and remodeling of collagen by annulus fibrosus cells of the intervertebral disc Anshu Rastogi, Hyunchul Kim, Julianne D Twomey, Adam H Hsieh Arthritis Research & Therapy 2013, 15:R57 (27 April 2013) Abstract \| Provisional PDF \| PubMed
		Research article Cigarette smoking and smoking cessation in relation to risk of rheumatoid arthritis in women Daniela Di Giuseppe, Nicola Orsini, Lars Alfredsson, Johan Askling, Alicja Wolk Arthritis Research & Therapy 2013, 15:R56 (22 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Smoking only a few cigarettes a day more than doubles the risk of developing rheumatoid arthritis and although this risk will lower with time after smoking cessation, it can remain elevated 15 years later.
		Research article Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis Jérôme Avouac, Maeva Vallucci, Vanessa Smith, Patricia Senet, Barbara Ruiz, Alberto Sulli, Carmen Pizzorni, Camille Frances, Gilles Chiocchia, Maurizio Cutolo, Yannick Allanore Arthritis Research & Therapy 2013, 15:R55 (19 April 2013) Abstract \| Provisional PDF \| PubMed
		Research article Open label study of escalating doses of oral treprostinil diethanolamine in patients with systemic sclerosis and digital ischemia: pharmacokinetics and correlation with digital perfusion Ami A Shah, Elena Schiopu, Laura K Hummers, Michael Wade, Kristine Phillips, Cynthia Anderson, Robert Wise, Francesco Boin, James R Seibold, Fredrick Wigley, Kristan D Rollins Arthritis Research & Therapy 2013, 15:R54 (18 April 2013) Abstract \| Provisional PDF \| PubMed
		Research article Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGFbeta1) gene in knee and hip osteoarthritis Stella G Muthuri, Sally Doherty, Weiya Zhang, Rose A Maciewicz, Kenneth Muir, Michael Doherty Arthritis Research & Therapy 2013, 15:R52 (18 April 2013) Abstract \| Provisional PDF \| PubMed
		Research article Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay Michael Mahler, Cristina Gascon, Sima Patel, Angela Ceribelli, Marvin J Fritzler, Andreas Swart, Edward KL Chan, Minoru Satoh Arthritis Research & Therapy 2013, 15:R50 (12 April 2013) Abstract \| Full text \| PDF \| PubMed
		Review microRNA-mediated regulation of innate immune response in rheumatic diseases Xiaobing Luo, Koustubh Ranade, Ronel Talker, Bahija Jallal, Nan Shen, Yihong Yao Arthritis Research & Therapy 2013, 15:210 (9 April 2013) Abstract \| Full text \| PDF \| PubMed
		Review Adult and juvenile dermatomyositis: are the distinct clinical features explained by our current understanding of serological subgroups and pathogenic mechanisms? Sarah L Tansley, Neil J McHugh, Lucy R Wedderburn Arthritis Research & Therapy 2013, 15:211 (8 April 2013) Abstract \| Full text \| PDF \| PubMed
		Letter Response to 'Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis' - authors' reply Qin Shi, Jamilah Abusarah, Ghayath Baroudi, Julio C Fernandes, Hassan Fahmi, Mohamed Benderdour Arthritis Research & Therapy 2013, 15:406 (3 April 2013) Abstract \| Full text \| PDF \| PubMed
		Letter Response to 'Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis' Di Wang, Shanshan Hu, Wei Wei Arthritis Research & Therapy 2013, 15:405 (3 April 2013) Abstract \| Full text \| PDF \| PubMed
		Review Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases? Udo Oppermann Arthritis Research & Therapy 2013, 15:209 (3 April 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Germline deletion of β2 microglobulin or CD1d reduces anti-phospholipid antibody, but increases autoantibodies against non-phospholipid antigens in the NZB/W F1 model of lupus Ram Singh, Jun-Qi Yang, Peter J Kim, Ramesh C Halder Arthritis Research & Therapy 2013, 15:R47 (27 March 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Exercise training in childhood-onset systemic lupus erythematosus: a controlled randomized trial Danilo ML Prado, Fabiana B Benatti, Ana L de Sá-Pinto, Ana P Hayashi, Bruno Gualano, Rosa MR Pereira, Adriana ME Sallum, Eloisa Bonfá, Clovis A Silva, Hamilton Roschel Arthritis Research & Therapy 2013, 15:R46 (26 March 2013) Abstract \| Provisional PDF \| PubMed
		Editorial Canonical Wnt signaling and caveolae play a role in intervertebral disc degeneration; the continuing saga of the mysterious notochordal cell Mark Erwin Arthritis Research & Therapy 2013, 15:113 (22 March 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Possible rheumatoid arthritis subtypes in terms of rheumatoid factor, depression, diagnostic delay and emotional expression: an exploratory case-control study Taavi Tillmann, Rajeev Krishnadas, Jonathan Cavanagh, KV Petrides Arthritis Research & Therapy 2013, 15:R45 (21 March 2013) Abstract \| Full text \| PDF \| PubMed
		Review Cortical remodeling during menopause, rheumatoid arthritis, glucocorticoid and bisphosphonate therapy Daniel Aeberli, Georg Schett Arthritis Research & Therapy 2013, 15:208 (21 March 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Monitoring cartilage loss in the hands and wrists in rheumatoid arthritis with magnetic resonance imaging in a multi-center clinical trial: IMPRESS (NCT00425932) Charles G Peterfy, Ewa Olech, Julie C DiCarlo, Joan T Merrill, Peter J Countryman, Norman B Gaylis Arthritis Research & Therapy 2013, 15:R44 (20 March 2013) Abstract \| Provisional PDF \| PubMed
		Editorial Mesenchymal stem cell therapy in osteoarthritis: advanced tissue repair or intervention with smouldering synovial activation? Peter LEM van Lent, Wim B van den Berg Arthritis Research & Therapy 2013, 15:112 (20 March 2013) Abstract \| Full text \| PDF \| PubMed
		Editorial Cardiovascular risk management in rheumatoid arthritis: are we still waiting for the first step? Mike JL Peters, Michael T Nurmohamed Arthritis Research & Therapy 2013, 15:111 (19 March 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Treatment of rheumatoid arthritis in the Medicare Current Beneficiary Survey Daniel H Solomon, Edward Yelin, Jeffrey N Katz, Bing Lu, Tamara Shaykevich, John Z Ayanian Arthritis Research & Therapy 2013, 15:R43 (18 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Medicare patients with rheumatoid arthritis are less likely to receive disease-modifying anti-rheumatic drug (DMARD) treatment if they are not seeing a rheumatologist, have a lower income, or are older.