Arthritis Research & Therapy | Volume 13 Issue 6

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	Volume 13 Issue 6
	Comment
	Editorial Multiplex, megaplex, index, and complex: the present and future of laboratory diagnostics in rheumatology Mark H Wener Arthritis Research & Therapy 2011, 13:134 (24 November 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Central pain contributions in osteoarthritis: next steps for improving recognition and treatment? Kelli Allen Arthritis Research & Therapy 2011, 13:133 (25 November 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Beyond cognitive-behavioral therapy for fibromyalgia: addressing stress by emotional exposure, processing, and resolution Mark A Lumley Arthritis Research & Therapy 2011, 13:136 (1 December 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial T cells as key players for bone destruction in gouty arthritis? Ulrike Harre, Anja Derer, Christine Schorn, Georg Schett, Martin Herrmann Arthritis Research & Therapy 2011, 13:135 (2 December 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial IL-21 and Sjögren's syndrome R Hal Scofield Arthritis Research & Therapy 2011, 13:137 (19 December 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial The 2011 ACR Meeting: what's new in the Windy City David S Pisetsky Arthritis Research & Therapy 2011, 13:138 (21 December 2011) Abstract \| Full text \| PDF \| PubMed
	Review
	Review Imaging in gout - What can we learn from MRI, CT, DECT and US? Fiona M McQueen, Anthony Doyle, Nicola Dalbeth Arthritis Research & Therapy 2011, 13:246 (4 November 2011) Abstract \| Full text \| PDF \| PubMed
	Review Why radiography should no longer be considered a surrogate outcome measure for longitudinal assessment of cartilage in knee osteoarthritis Ali Guermazi, Frank W Roemer, Deborah Burstein, Daichi Hayashi Arthritis Research & Therapy 2011, 13:247 (24 November 2011) Abstract \| Full text \| PDF \| PubMed
	Review Imaging modalities in hand osteoarthritis - status and perspectives of conventional radiography, magnetic resonance imaging, and ultrasonography Ida K Haugen, Pernille Bøyesen Arthritis Research & Therapy 2011, 13:248 (13 December 2011) Abstract \| Full text \| PDF \| PubMed
	Review Mechanisms of tissue injury in lupus nephritis Tamara K Nowling, Gary S Gilkeson Arthritis Research & Therapy 2011, 13:250 (21 December 2011) Abstract \| Full text \| PDF \| PubMed
	Review Type I interferon pathway in adult and juvenile dermatomyositis Emily C Baechler, Hatice Bilgic, Ann M Reed Arthritis Research & Therapy 2011, 13:249 (22 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research
	Research article Plasma proteomic profiles from disease-discordant monozygotic twins suggest that molecular pathways are shared in multiple systemic autoimmune diseases* Terrance P O'Hanlon, Zhuoyan Li, Lu Gan, Mark F Gourley, Lisa G Rider, Frederick W Miller Arthritis Research & Therapy 2011, 13:R181 (1 November 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Lymphotoxin-beta receptor blockade reduces CXCL13 in lacrimal glands and improves corneal integrity in the NOD model of Sjögren's syndrome Roy A Fava, Susan M Kennedy, Sheryl G Wood, Anne I Bolstad, Jadwiga Bienkowska, Adrian Papandile, John A Kelly, Clio P Mavragani, Margaret Gatumu, Kathrine Skarstein, Jeffrey L Browning Arthritis Research & Therapy 2011, 13:R182 (1 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Blockade of lymphotoxin-beta receptor pathways increased tear-fluid secretion and significantly improved ocular surface integrity score in a mouse model of Sjoegren's syndrome, suggesting this may have therapeutic potential.
	Research article Increased incidence of pregnancy complications in women who later develop scleroderma: a case control study Linda van Wyk, Jacolien van der Marel, Annemie JM Schuerwegh, Anne A Schouffoer, Alexandre E Voskuyl, Tom WJ Huizinga, Diana W Bianchi, Sicco A Scherjon Arthritis Research & Therapy 2011, 13:R183 (4 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Women who developed systemic sclerosis after pregnancy were more likely to have had a pregnancy history of hypertension or a fetus with intra-uterine growth restriction.
	Research article Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways Anna Koskinen, Sami Juslin, Riina Nieminen, Teemu Moilanen, Katriina Vuolteenaho, Eeva Moilanen Arthritis Research & Therapy 2011, 13:R184 (11 November 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Nocturnal heart rate variability parameters as potential fibromyalgia biomarker: correlation with symptoms severity Claudia Lerma, Aline Martinez, Natllely Ruiz, Angelica Vargas, Oscar Infante, Manuel Martinez-Lavin Arthritis Research & Therapy 2011, 13:R185 (16 November 2011) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Nocturnal heart rate variability parameters indicative of sympathetic predominance are significantly different in fibromyalgia patients compared to healthy individuals, and correlate with several symptoms including pain severity.
	Research article Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population Hua Zhong, Xiao-lan Li, Ming Li, Li-xia Hao, Rong-wei Chen, Kun Xiang, Xue-bin Qi, Runlin Z Ma, Bing Su Arthritis Research & Therapy 2011, 13:R186 (16 November 2011) Abstract \| Provisional PDF \| PubMed
	Research article Interleukin-1, tumor necrosis factor-alpha, and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration Katherine M Riera, Nicole E Rothfusz, Rebecca E Wilusz, JB Weinberg, Farshid Guilak, Amy L McNulty Arthritis Research & Therapy 2011, 13:R187 (16 November 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Ultrasound in the evaluation of enthesitis: status and perspectives Frédérique Gandjbakhch, Lene Terslev, Fredrick Joshua, Richard J Wakefield, Esperanza Naredo, Maria D'Agostino, OMERACT Ultrasound Task Force Arthritis Research & Therapy 2011, 13:R188 (17 November 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Primary care physicians' perspectives towards managing rheumatoid arthritis: room for improvement Katie L Garneau, Maura D Iversen, Hsun Tsao, Daniel H Solomon Arthritis Research & Therapy 2011, 13:R189 (18 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Rheumatoid arthritis patients in the US may not be receiving optimal care, as primary care physicians are uncomfortable prescribing disease-modifying anti-rheumatic drugs and report that their patients have difficulty accessing rheumatologists.
	Research article Cardiac autonomic impairment and chronotropic incompetence in fibromyalgia Roberta da Cunha Ribeiro, Hamilton Roschel, Guilherme Artioli, Thalita Dassouki, Luiz Perandini, Ana Calich, Ana de Sá Pinto, Fernanda Lima, Eloísa Bonfá, Bruno Gualano Arthritis Research & Therapy 2011, 13:R190 (18 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Fibromyalgia patients may suffer from chronotropic incompetence and delayed heart rate recovery, both of which are indicative of cardiac autonomic impairment and higher risk of cardiovascular events and mortality.
	Research article Detection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and pro-inflammatory role of citrullinated BiP in collagen-induced arthritis Hirofumi Shoda, Keishi Fujio, Mihoko Shibuya, Tomohisa Okamura, Shuji Sumitomo, Akiko Okamoto, Tetsuji Sawada, Kazuhiko Yamamoto Arthritis Research & Therapy 2011, 13:R191 (22 November 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats Guo-Xin Ni, Li-Qiong Zhan, Mei-Qin Gao, Lei Lei, Yue-Zhu Zhou, Yan-Xia Pan Arthritis Research & Therapy 2011, 13:R192 (24 November 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Follistatin-like protein 1: a serum biochemical marker reflecting the severity of joint damage in patients with osteoarthritis Yuji Wang, Dawei Li, Nanwei Xu, Weijian Tao, Ruixia Zhu, Rongbin Sun, Weiwei Fan, Ping Zhang, Tianhua Dong, Long Yu Arthritis Research & Therapy 2011, 13:R193 (25 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Serum levels of follistatin-like protein 1 (FSTL1) may reflect the severity of joint damage and have potential for monitoring disease course and treatment efficacy in osteoarthritis patients.
	Research article Proteomic analysis of saliva: a unique tool to distinguish primary Sjögren's syndrome from secondary Sjögren's syndrome and other sicca syndromes Chiara Baldini, Laura Giusti, Federica Ciregia, Ylenia Da Valle, Camillo Giacomelli, Elena Donadio, Francesca Sernissi, Laura Bazzichi, Gino Giannaccini, Stefano Bombardieri, Antonio Lucacchini Arthritis Research & Therapy 2011, 13:R194 (25 November 2011) Abstract \| Full text \| PDF \| PubMed
	Research article The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA Parawee Suwannalai, Annemiek Willemze, Linda van Toorn, Gerrie Stoeken-Rijsbergen, Nivine Levarht, Jan Drijfhout, Tom W J Huizinga, Rene E M Toes, Leendert A Trouw Arthritis Research & Therapy 2011, 13:R195 (30 November 2011) Abstract \| Full text \| PDF \| PubMed
	Research article NLRP3 E311K mutation in a large family with Muckle-Wells syndrome - description of a heterogeneous phenotype and response to treatment Jasmin B Kuemmerle-Deschner, Peter Lohse, Ina Koetter, Guenther E Dannecker, Fabian Reess, Katharina Ummenhofer, Silvia Koch, Nikolay Tzaribachev, Anja Bialkowski, Susanne M Benseler Arthritis Research & Therapy 2011, 13:R196 (6 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article A_2Aand A₃adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release Katia Varani, Melissa Padovan, Fabrizio Vincenzi, Martina Targa, Francesco Trotta, Marcello Govoni, Pier Borea Arthritis Research & Therapy 2011, 13:R197 (6 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury Robert A Mooney, Erik R Sampson, Jaclyn Lerea, Randy N Rosier, Michael J Zuscik Arthritis Research & Therapy 2011, 13:R198 (7 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Identification of urinary metabolites that distinguish membranous lupus nephritis from proliferative lupus nephritis and focal segmental glomerulosclerosis Lindsey E Romick-Rosendale, Hermine I Brunner, Michael R Bennett, Rina Mina, Shannen Nelson, Michelle Petri, Adnan Kiani, Prasad Devarajan, Michael A Kennedy Arthritis Research & Therapy 2011, 13:R199 (7 December 2011) Abstract \| Provisional PDF \| PubMed
	Research article Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis Zhongying Zhang, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Takashi Yurube, Minoru Doita, Masahiro Kurosaka, Kotaro Nishida Arthritis Research & Therapy 2011, 13:R200 (8 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration Nan Hu, Johanna Westra, Abraham Rutgers, Berber Doornbos-Van der Meer, Minke G Huitema, Coen A Stegeman, Wayel H Abdulahad, Simon C Satchell, Peter W Mathieson, Peter Heeringa, Cees G M Kallenberg Arthritis Research & Therapy 2011, 13:R201 (8 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Sustained remission of symptoms and improved health-related quality of life in patients with cryopyrin-associated periodic syndrome treated with canakinumab: results of a double-blind placebo-controlled randomized withdrawal study Isabelle Koné-Paut, Helen J Lachmann, Jasmin B Kuemmerle-Deschner, Eric Hachulla, Kieron S Leslie, Richard Mouy, Alberto Ferreira, Karine Lheritier, Neha Patel, Ralph Preiss, Philip N Hawkins, on behalf of the Canakinumab in CAPS Study Group Arthritis Research & Therapy 2011, 13:R202 (9 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis Rhian S Thomas, Alan R Clarke, Victor C Duance, Emma J Blain Arthritis Research & Therapy 2011, 13:R203 (9 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Abatacept with methotrexate versus other biologic agents in treatment of patients with active rheumatoid arthritis despite methotrexate: a network meta-analysis Patricia Guyot, Peter Taylor, Robin Christensen, Louisa Pericleous, Coralie Poncet, Maximilian Lebmeier, Pieter Drost, Gert Bergman Arthritis Research & Therapy 2011, 13:R204 (12 December 2011) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Abatacept in combination with methotrexate (MTX) is superior to placebo and comparable to other biologic agents in the treatment of patients with rheumatoid arthritis who have inadequate response to MTX alone.
	Research article Advanced glycation endproducts are increased in rheumatoid arthritis patients with controlled disease Lodewijk de Groot, Helmy Hinkema, Johanna Westra, Andries J Smit, Cees GM Kallenberg, Marc Bijl, Marcel D Posthumus Arthritis Research & Therapy 2011, 13:R205 (14 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus Andreas Jönsen, Sara C Nilsson, Emma Ahlqvist, Elisabet Svenungsson, Iva Gunnarsson, Karin G Eriksson, Anders Bengtsson, Agneta Zickert, Maija-Leena Eloranta, Lennart Truedsson, Lars Rönnblom, Gunnel Nordmark, Gunnar Sturfelt, Anna M Blom Arthritis Research & Therapy 2011, 13:R206 (15 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Regenerative potential of human muscle stem cells in chronic inflammation Bouke J Duijnisveld, Anne Bigot, Karel GM Beenakker, Débora M Portilho, Vered Raz, Huub JL van der Heide, Cornelis PJ Visser, Soraya Chaouch, Kamel Mamchaoui, Rudi GJ Westendorp, Vincent Mouly, Gillian S Butler-Browne, Rob GHH Nelissen, Andrea B Maier Arthritis Research & Therapy 2011, 13:R207 (15 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects Paul Eggleton, Edwin Bremer, Joanna M Tarr, Marco de Bruyn, Wijnand Helfrich, Alexandra Kendall, Richard C Haigh, Nick J Viner, Paul G Winyard Arthritis Research & Therapy 2011, 13:R208 (15 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Decreased influenza-specific B cell responses in rheumatoid arthritis patients treated with anti-tumor necrosis factor James J Kobie, Bo Zheng, Peter Bryk, Michael Barnes, Christopher T Ritchlin, Darren A Tabechian, Allen P Anandarajah, R Looney, Ralf G Thiele, Jennifer H Anolik, Andreea Coca, Chungwen Wei, Alexander F Rosenberg, Changyong Feng, John J Treanor, F Eun-Hyung Lee, Ignacio Sanz Arthritis Research & Therapy 2011, 13:R209 (16 December 2011) Abstract \| Provisional PDF \| PubMed
	Research article Application of in vivo micro-computed tomography in the temporal characterisation of subchondral bone architecture in a rat model of low-dose monosodium iodoacetate-induced osteoarthritis Geetha Mohan, Egon Perilli, Julia S Kuliwaba, Julia M Humphries, Ian H Parkinson, Nicola L Fazzalari Arthritis Research & Therapy 2011, 13:R210 (21 December 2011) Abstract \| Provisional PDF \| PubMed
	Research article Prevalence, correlates and clinical usefulness of antibodies to RNA polymerase III in systemic sclerosis: a cross-sectional analysis of data from an Australian cohort Mandana Nikpour, Pravin Hissaria, Jillian Byron, Joanne Sahhar, Maree Micallef, William Paspaliaris, Janet Roddy, Peter Nash, Alan Sturgess, Susanna Proudman, Wendy Stevens Arthritis Research & Therapy 2011, 13:R211 (22 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article IL-10 signaling in CD4+ T Cells is critical for the pathogenesis of collagen-induced arthritis Jian Tao, Masahito Kamanaka, Jianlei Hao, Zhifang Hao, Xi Jiang, Joe E Craft, Richard A Flavell, Zhenzhou Wu, Zhangyong Hong, Liqing Zhao, Zhinan Yin Arthritis Research & Therapy 2011, 13:R212 (22 December 2011) Abstract \| Provisional PDF \| PubMed
	Research article Correlation of antinuclear antibody and anti-double-stranded DNA antibody with clinical response to infliximab in patients with rheumatoid arthritis: a retrospective clinical study Naoichiro Yukawa, Takao Fujii, Seiko Kondo-Ishikawa, Hajime Yoshifuji, Daisuke Kawabata, Takaki Nojima, Koichiro Ohmura, Takashi Usui, Tsuneyo Mimori Arthritis Research & Therapy 2011, 13:R213 (22 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The antinuclear antibodies (ANA) titer before starting treatment may predict clinical response to infliximab, while increased ANA titers or development of anti-ds-DNA antibodies after infliximab treatment may be useful markers of no response.
	Research article Epidemiologic study of clinically amyopathic dermatomyositis and anti-melanoma differentiation-associated gene 5 antibodies in central Japan Yoshinao Muro, Kazumitsu Sugiura, Kei Hoshino, Masashi Akiyama, Koji Tamakoshi Arthritis Research & Therapy 2011, 13:R214 (22 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration W Erwin, Diana Islam, Robert D Inman, Michael G Fehlings, Florence WL Tsui Arthritis Research & Therapy 2011, 13:R215 (29 December 2011) Abstract \| Full text \| PDF \| PubMed

	Volume 13 Issue 6
	Comment
	Editorial Multiplex, megaplex, index, and complex: the present and future of laboratory diagnostics in rheumatology Mark H Wener Arthritis Research & Therapy 2011, 13:134 (24 November 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Central pain contributions in osteoarthritis: next steps for improving recognition and treatment? Kelli Allen Arthritis Research & Therapy 2011, 13:133 (25 November 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Beyond cognitive-behavioral therapy for fibromyalgia: addressing stress by emotional exposure, processing, and resolution Mark A Lumley Arthritis Research & Therapy 2011, 13:136 (1 December 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial T cells as key players for bone destruction in gouty arthritis? Ulrike Harre, Anja Derer, Christine Schorn, Georg Schett, Martin Herrmann Arthritis Research & Therapy 2011, 13:135 (2 December 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial IL-21 and Sjögren's syndrome R Hal Scofield Arthritis Research & Therapy 2011, 13:137 (19 December 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial The 2011 ACR Meeting: what's new in the Windy City David S Pisetsky Arthritis Research & Therapy 2011, 13:138 (21 December 2011) Abstract \| Full text \| PDF \| PubMed
	Review
	Review Imaging in gout - What can we learn from MRI, CT, DECT and US? Fiona M McQueen, Anthony Doyle, Nicola Dalbeth Arthritis Research & Therapy 2011, 13:246 (4 November 2011) Abstract \| Full text \| PDF \| PubMed
	Review Why radiography should no longer be considered a surrogate outcome measure for longitudinal assessment of cartilage in knee osteoarthritis Ali Guermazi, Frank W Roemer, Deborah Burstein, Daichi Hayashi Arthritis Research & Therapy 2011, 13:247 (24 November 2011) Abstract \| Full text \| PDF \| PubMed
	Review Imaging modalities in hand osteoarthritis - status and perspectives of conventional radiography, magnetic resonance imaging, and ultrasonography Ida K Haugen, Pernille Bøyesen Arthritis Research & Therapy 2011, 13:248 (13 December 2011) Abstract \| Full text \| PDF \| PubMed
	Review Mechanisms of tissue injury in lupus nephritis Tamara K Nowling, Gary S Gilkeson Arthritis Research & Therapy 2011, 13:250 (21 December 2011) Abstract \| Full text \| PDF \| PubMed
	Review Type I interferon pathway in adult and juvenile dermatomyositis Emily C Baechler, Hatice Bilgic, Ann M Reed Arthritis Research & Therapy 2011, 13:249 (22 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research
	Research article Plasma proteomic profiles from disease-discordant monozygotic twins suggest that molecular pathways are shared in multiple systemic autoimmune diseases* Terrance P O'Hanlon, Zhuoyan Li, Lu Gan, Mark F Gourley, Lisa G Rider, Frederick W Miller Arthritis Research & Therapy 2011, 13:R181 (1 November 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Lymphotoxin-beta receptor blockade reduces CXCL13 in lacrimal glands and improves corneal integrity in the NOD model of Sjögren's syndrome Roy A Fava, Susan M Kennedy, Sheryl G Wood, Anne I Bolstad, Jadwiga Bienkowska, Adrian Papandile, John A Kelly, Clio P Mavragani, Margaret Gatumu, Kathrine Skarstein, Jeffrey L Browning Arthritis Research & Therapy 2011, 13:R182 (1 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Blockade of lymphotoxin-beta receptor pathways increased tear-fluid secretion and significantly improved ocular surface integrity score in a mouse model of Sjoegren's syndrome, suggesting this may have therapeutic potential.
	Research article Increased incidence of pregnancy complications in women who later develop scleroderma: a case control study Linda van Wyk, Jacolien van der Marel, Annemie JM Schuerwegh, Anne A Schouffoer, Alexandre E Voskuyl, Tom WJ Huizinga, Diana W Bianchi, Sicco A Scherjon Arthritis Research & Therapy 2011, 13:R183 (4 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Women who developed systemic sclerosis after pregnancy were more likely to have had a pregnancy history of hypertension or a fetus with intra-uterine growth restriction.
	Research article Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways Anna Koskinen, Sami Juslin, Riina Nieminen, Teemu Moilanen, Katriina Vuolteenaho, Eeva Moilanen Arthritis Research & Therapy 2011, 13:R184 (11 November 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Nocturnal heart rate variability parameters as potential fibromyalgia biomarker: correlation with symptoms severity Claudia Lerma, Aline Martinez, Natllely Ruiz, Angelica Vargas, Oscar Infante, Manuel Martinez-Lavin Arthritis Research & Therapy 2011, 13:R185 (16 November 2011) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Nocturnal heart rate variability parameters indicative of sympathetic predominance are significantly different in fibromyalgia patients compared to healthy individuals, and correlate with several symptoms including pain severity.
	Research article Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population Hua Zhong, Xiao-lan Li, Ming Li, Li-xia Hao, Rong-wei Chen, Kun Xiang, Xue-bin Qi, Runlin Z Ma, Bing Su Arthritis Research & Therapy 2011, 13:R186 (16 November 2011) Abstract \| Provisional PDF \| PubMed
	Research article Interleukin-1, tumor necrosis factor-alpha, and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration Katherine M Riera, Nicole E Rothfusz, Rebecca E Wilusz, JB Weinberg, Farshid Guilak, Amy L McNulty Arthritis Research & Therapy 2011, 13:R187 (16 November 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Ultrasound in the evaluation of enthesitis: status and perspectives Frédérique Gandjbakhch, Lene Terslev, Fredrick Joshua, Richard J Wakefield, Esperanza Naredo, Maria D'Agostino, OMERACT Ultrasound Task Force Arthritis Research & Therapy 2011, 13:R188 (17 November 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Primary care physicians' perspectives towards managing rheumatoid arthritis: room for improvement Katie L Garneau, Maura D Iversen, Hsun Tsao, Daniel H Solomon Arthritis Research & Therapy 2011, 13:R189 (18 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Rheumatoid arthritis patients in the US may not be receiving optimal care, as primary care physicians are uncomfortable prescribing disease-modifying anti-rheumatic drugs and report that their patients have difficulty accessing rheumatologists.
	Research article Cardiac autonomic impairment and chronotropic incompetence in fibromyalgia Roberta da Cunha Ribeiro, Hamilton Roschel, Guilherme Artioli, Thalita Dassouki, Luiz Perandini, Ana Calich, Ana de Sá Pinto, Fernanda Lima, Eloísa Bonfá, Bruno Gualano Arthritis Research & Therapy 2011, 13:R190 (18 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Fibromyalgia patients may suffer from chronotropic incompetence and delayed heart rate recovery, both of which are indicative of cardiac autonomic impairment and higher risk of cardiovascular events and mortality.
	Research article Detection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and pro-inflammatory role of citrullinated BiP in collagen-induced arthritis Hirofumi Shoda, Keishi Fujio, Mihoko Shibuya, Tomohisa Okamura, Shuji Sumitomo, Akiko Okamoto, Tetsuji Sawada, Kazuhiko Yamamoto Arthritis Research & Therapy 2011, 13:R191 (22 November 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats Guo-Xin Ni, Li-Qiong Zhan, Mei-Qin Gao, Lei Lei, Yue-Zhu Zhou, Yan-Xia Pan Arthritis Research & Therapy 2011, 13:R192 (24 November 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Follistatin-like protein 1: a serum biochemical marker reflecting the severity of joint damage in patients with osteoarthritis Yuji Wang, Dawei Li, Nanwei Xu, Weijian Tao, Ruixia Zhu, Rongbin Sun, Weiwei Fan, Ping Zhang, Tianhua Dong, Long Yu Arthritis Research & Therapy 2011, 13:R193 (25 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Serum levels of follistatin-like protein 1 (FSTL1) may reflect the severity of joint damage and have potential for monitoring disease course and treatment efficacy in osteoarthritis patients.
	Research article Proteomic analysis of saliva: a unique tool to distinguish primary Sjögren's syndrome from secondary Sjögren's syndrome and other sicca syndromes Chiara Baldini, Laura Giusti, Federica Ciregia, Ylenia Da Valle, Camillo Giacomelli, Elena Donadio, Francesca Sernissi, Laura Bazzichi, Gino Giannaccini, Stefano Bombardieri, Antonio Lucacchini Arthritis Research & Therapy 2011, 13:R194 (25 November 2011) Abstract \| Full text \| PDF \| PubMed
	Research article The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA Parawee Suwannalai, Annemiek Willemze, Linda van Toorn, Gerrie Stoeken-Rijsbergen, Nivine Levarht, Jan Drijfhout, Tom W J Huizinga, Rene E M Toes, Leendert A Trouw Arthritis Research & Therapy 2011, 13:R195 (30 November 2011) Abstract \| Full text \| PDF \| PubMed
	Research article NLRP3 E311K mutation in a large family with Muckle-Wells syndrome - description of a heterogeneous phenotype and response to treatment Jasmin B Kuemmerle-Deschner, Peter Lohse, Ina Koetter, Guenther E Dannecker, Fabian Reess, Katharina Ummenhofer, Silvia Koch, Nikolay Tzaribachev, Anja Bialkowski, Susanne M Benseler Arthritis Research & Therapy 2011, 13:R196 (6 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article A_2Aand A₃adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release Katia Varani, Melissa Padovan, Fabrizio Vincenzi, Martina Targa, Francesco Trotta, Marcello Govoni, Pier Borea Arthritis Research & Therapy 2011, 13:R197 (6 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury Robert A Mooney, Erik R Sampson, Jaclyn Lerea, Randy N Rosier, Michael J Zuscik Arthritis Research & Therapy 2011, 13:R198 (7 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Identification of urinary metabolites that distinguish membranous lupus nephritis from proliferative lupus nephritis and focal segmental glomerulosclerosis Lindsey E Romick-Rosendale, Hermine I Brunner, Michael R Bennett, Rina Mina, Shannen Nelson, Michelle Petri, Adnan Kiani, Prasad Devarajan, Michael A Kennedy Arthritis Research & Therapy 2011, 13:R199 (7 December 2011) Abstract \| Provisional PDF \| PubMed
	Research article Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis Zhongying Zhang, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Takashi Yurube, Minoru Doita, Masahiro Kurosaka, Kotaro Nishida Arthritis Research & Therapy 2011, 13:R200 (8 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration Nan Hu, Johanna Westra, Abraham Rutgers, Berber Doornbos-Van der Meer, Minke G Huitema, Coen A Stegeman, Wayel H Abdulahad, Simon C Satchell, Peter W Mathieson, Peter Heeringa, Cees G M Kallenberg Arthritis Research & Therapy 2011, 13:R201 (8 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Sustained remission of symptoms and improved health-related quality of life in patients with cryopyrin-associated periodic syndrome treated with canakinumab: results of a double-blind placebo-controlled randomized withdrawal study Isabelle Koné-Paut, Helen J Lachmann, Jasmin B Kuemmerle-Deschner, Eric Hachulla, Kieron S Leslie, Richard Mouy, Alberto Ferreira, Karine Lheritier, Neha Patel, Ralph Preiss, Philip N Hawkins, on behalf of the Canakinumab in CAPS Study Group Arthritis Research & Therapy 2011, 13:R202 (9 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis Rhian S Thomas, Alan R Clarke, Victor C Duance, Emma J Blain Arthritis Research & Therapy 2011, 13:R203 (9 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Abatacept with methotrexate versus other biologic agents in treatment of patients with active rheumatoid arthritis despite methotrexate: a network meta-analysis Patricia Guyot, Peter Taylor, Robin Christensen, Louisa Pericleous, Coralie Poncet, Maximilian Lebmeier, Pieter Drost, Gert Bergman Arthritis Research & Therapy 2011, 13:R204 (12 December 2011) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Abatacept in combination with methotrexate (MTX) is superior to placebo and comparable to other biologic agents in the treatment of patients with rheumatoid arthritis who have inadequate response to MTX alone.
	Research article Advanced glycation endproducts are increased in rheumatoid arthritis patients with controlled disease Lodewijk de Groot, Helmy Hinkema, Johanna Westra, Andries J Smit, Cees GM Kallenberg, Marc Bijl, Marcel D Posthumus Arthritis Research & Therapy 2011, 13:R205 (14 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus Andreas Jönsen, Sara C Nilsson, Emma Ahlqvist, Elisabet Svenungsson, Iva Gunnarsson, Karin G Eriksson, Anders Bengtsson, Agneta Zickert, Maija-Leena Eloranta, Lennart Truedsson, Lars Rönnblom, Gunnel Nordmark, Gunnar Sturfelt, Anna M Blom Arthritis Research & Therapy 2011, 13:R206 (15 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Regenerative potential of human muscle stem cells in chronic inflammation Bouke J Duijnisveld, Anne Bigot, Karel GM Beenakker, Débora M Portilho, Vered Raz, Huub JL van der Heide, Cornelis PJ Visser, Soraya Chaouch, Kamel Mamchaoui, Rudi GJ Westendorp, Vincent Mouly, Gillian S Butler-Browne, Rob GHH Nelissen, Andrea B Maier Arthritis Research & Therapy 2011, 13:R207 (15 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects Paul Eggleton, Edwin Bremer, Joanna M Tarr, Marco de Bruyn, Wijnand Helfrich, Alexandra Kendall, Richard C Haigh, Nick J Viner, Paul G Winyard Arthritis Research & Therapy 2011, 13:R208 (15 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Decreased influenza-specific B cell responses in rheumatoid arthritis patients treated with anti-tumor necrosis factor James J Kobie, Bo Zheng, Peter Bryk, Michael Barnes, Christopher T Ritchlin, Darren A Tabechian, Allen P Anandarajah, R Looney, Ralf G Thiele, Jennifer H Anolik, Andreea Coca, Chungwen Wei, Alexander F Rosenberg, Changyong Feng, John J Treanor, F Eun-Hyung Lee, Ignacio Sanz Arthritis Research & Therapy 2011, 13:R209 (16 December 2011) Abstract \| Provisional PDF \| PubMed
	Research article Application of in vivo micro-computed tomography in the temporal characterisation of subchondral bone architecture in a rat model of low-dose monosodium iodoacetate-induced osteoarthritis Geetha Mohan, Egon Perilli, Julia S Kuliwaba, Julia M Humphries, Ian H Parkinson, Nicola L Fazzalari Arthritis Research & Therapy 2011, 13:R210 (21 December 2011) Abstract \| Provisional PDF \| PubMed
	Research article Prevalence, correlates and clinical usefulness of antibodies to RNA polymerase III in systemic sclerosis: a cross-sectional analysis of data from an Australian cohort Mandana Nikpour, Pravin Hissaria, Jillian Byron, Joanne Sahhar, Maree Micallef, William Paspaliaris, Janet Roddy, Peter Nash, Alan Sturgess, Susanna Proudman, Wendy Stevens Arthritis Research & Therapy 2011, 13:R211 (22 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article IL-10 signaling in CD4+ T Cells is critical for the pathogenesis of collagen-induced arthritis Jian Tao, Masahito Kamanaka, Jianlei Hao, Zhifang Hao, Xi Jiang, Joe E Craft, Richard A Flavell, Zhenzhou Wu, Zhangyong Hong, Liqing Zhao, Zhinan Yin Arthritis Research & Therapy 2011, 13:R212 (22 December 2011) Abstract \| Provisional PDF \| PubMed
	Research article Correlation of antinuclear antibody and anti-double-stranded DNA antibody with clinical response to infliximab in patients with rheumatoid arthritis: a retrospective clinical study Naoichiro Yukawa, Takao Fujii, Seiko Kondo-Ishikawa, Hajime Yoshifuji, Daisuke Kawabata, Takaki Nojima, Koichiro Ohmura, Takashi Usui, Tsuneyo Mimori Arthritis Research & Therapy 2011, 13:R213 (22 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The antinuclear antibodies (ANA) titer before starting treatment may predict clinical response to infliximab, while increased ANA titers or development of anti-ds-DNA antibodies after infliximab treatment may be useful markers of no response.
	Research article Epidemiologic study of clinically amyopathic dermatomyositis and anti-melanoma differentiation-associated gene 5 antibodies in central Japan Yoshinao Muro, Kazumitsu Sugiura, Kei Hoshino, Masashi Akiyama, Koji Tamakoshi Arthritis Research & Therapy 2011, 13:R214 (22 December 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration W Erwin, Diana Islam, Robert D Inman, Michael G Fehlings, Florence WL Tsui Arthritis Research & Therapy 2011, 13:R215 (29 December 2011) Abstract \| Full text \| PDF \| PubMed

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