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Bone and cartilage in osteoarthritis: is what's best for one good or bad for the other?
Steven R Goldring, Mary B Goldring Arthritis Research & Therapy 2010, 12:143 (19 October 2010)
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Pomegranate extract inhibits the interleukin-1β-induced activation of MKK-3, p38α-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes
Zafar Rasheed, Nahid Akhtar, Tariq M Haqqi Arthritis Research & Therapy 2010, 12:R195 (18 October 2010)
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Editor’s summary
Pomegranate extract inhibits activation of MKK3, a mediator of cartilage catabolism in osteoarthritis (OA), in a cellular model, suggesting that it could be developed into a treatment for OA and other degenerative diseases.
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Autoantibodies to BRAF, a new family of autoantibodies associated with rheumatoid arthritis
Caroline Charpin, Marielle Martin, Nathalie Balandraud, Jean Roudier, Isabelle Auger Arthritis Research & Therapy 2010, 12:R194 (18 October 2010)
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Lifestyle factors and lumbar disc disease: results of a German multi-center case-control study (EPILIFT)
Barbara Schumann, Ulrich Bolm-Audorff, Annekatrin Bergmann, Rolf Ellegast, Gine Elsner, Joachim Grifka, Johannes Haerting, Matthias Jäger, Martina Michaelis, Andreas Seidler Arthritis Research & Therapy 2010, 12:R193 (18 October 2010)
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A phase 2 randomized, double-blind study of AMG 108, a fully human monoclonal antibody to IL-1R, in patients with rheumatoid arthritis
Mario H Cardiel, Paul P Tak, William Bensen, Francis X Burch, Sarka Forejtova, Janusz E Badurski, Tarundeep Kakkar, Terry Bevirt, Liyun Ni, Ellen McCroskery, Angelika Jahreis, Debra J Zack Arthritis Research & Therapy 2010, 12:R192 (15 October 2010)
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Disease-specific definitions of vitamin D deficiency need to be established in autoimmune and non-autoimmune chronic diseases: a retrospective comparison of three chronic diseases
Anna R Broder, Jonathan N Tobin, Chaim Putterman Arthritis Research & Therapy 2010, 12:R191 (14 October 2010)
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Adrenomedullin increases fibroblast-like synoviocyte adhesion to extracellular matrix proteins by upregulating integrin activation
Marie-Dominique Ah Kioon, Carine Asensio, Hang-Korng Ea, Benjamin Uzan, Martine Cohen-Solal, Frédéric Lioté Arthritis Research & Therapy 2010, 12:R190 (14 October 2010)
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Does moderate-to-high intensity Nordic walking improve functional capacity and pain in fibromyalgia? A prospective randomized controlled trial
Kaisa Mannerkorpi, Lena Nordeman, Åsa Cider, Gunilla Jonsson Arthritis Research & Therapy 2010, 12:R189 (13 October 2010)
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Editor’s summary
Nordic Walking is a feasible mode of exercise for women with fibromyalgia that can improve functional capacity and reduce the level of activity limitations without risking a pain flare.
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CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis
Soo-Hyun Chung, Keisuke Seki, Byung-Il Choi, Keiko B Kimura, Akihiko Ito, Noriyuki Fujikado, Shinobu Saijo, Yoichiro Iwakura Arthritis Research & Therapy 2010, 12:R188 (12 October 2010)
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CXC chemokine 4 (CXCR4) expression contributes to the development of murine collagen-induced arthritis by recruiting activated T cells into inflammatory sites, highlighting CXCR4 as a potential therapeutic target for rheumatoid arthritis.
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Prediction model for knee osteoarthritis based on genetic and clinical information
Hiroshi Takahashi, Masahiro Nakajima, Kouichi Ozaki, Toshihiro Tanaka, Naoyuki Kamatani, Shiro Ikegawa Arthritis Research & Therapy 2010, 12:R187 (12 October 2010)
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Influence of depression symptoms on serum tumor necrosis factor-α of patients with chronic low back pain
Haili Wang, Carsten Ahrens, Winfried Rief, Simone Gantz, Marcus Schiltenwolf, Wiltrud Richter Arthritis Research & Therapy 2010, 12:R186 (11 October 2010)
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Influence of comorbidity with depression on interdisciplinary therapy: outcomes in patients with chronic low back pain
Haili Wang, Carsten Ahrens, Winfried Rief, Marcus Schiltenwolf Arthritis Research & Therapy 2010, 12:R185 (11 October 2010)
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Histone deacetylases in RA: epigenetics and epiphenomena
Aleksander M Grabiec, Kris A Reedquist Arthritis Research & Therapy 2010, 12:142 (11 October 2010)
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Rheumatoid synovial fluid interleukin-17-producing CD4 T cells have abundant tumor necrosis factor-alpha co-expression, but little interleukin-22 and interleukin-23R expression
Leigh D Church, Andrew D Filer, Esther Hidalgo, Katherine A Howlett, Andrew MC Thomas, Stephen Rapecki, Dagmar Scheel-Toellner, Christopher D Buckley, Karim Raza Arthritis Research & Therapy 2010, 12:R184 (7 October 2010)
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Rheumatoid arthritis patients receive less frequent acute reperfusion and secondary prevention therapy after myocardial infarction compared with the general population
Sharon Van Doornum, Caroline Brand, Vijaya Sundararajan, Andrew E Ajani, Ian P Wicks Arthritis Research & Therapy 2010, 12:R183 (7 October 2010)
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Rheumatoid arthritis patients are less likely to receive acute reperfusion and secondary prevention therapy after myocardial infarction compared to the general population.
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Oestrogen is important for maintenance of cartilage and subchondral bone in a murine model of knee osteoarthritis
Yvonne H Sniekers, Harrie Weinans, Gerjo JVM van Osch, Johannes PTM van Leeuwen Arthritis Research & Therapy 2010, 12:R182 (5 October 2010)
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Combination of ovariectomy with a mild osteoarthritis trigger significantly decreases subchondral cortical thickness in a mouse model, demonstrating the significance of estrogen for articular cartilage and maintenance of healthy joints.
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Elevated excitatory neurotransmitter levels in the fibromyalgia brain
Richard E Harris Arthritis Research & Therapy 2010, 12:141 (1 October 2010)
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The increased cardiovascular risk in rheumatoid arthritis: when does it start?
Michael T Nurmohamed Arthritis Research & Therapy 2010, 12:140 (29 September 2010)
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Small artery elasticity is decreased in patients with systemic lupus erythematosus without increased intima media thickness
Hans LA Nienhuis, Karina de Leeuw, Johan Bijzet, Jasper J van Doormaal, Arie M van Roon, Andries J Smit, Reindert Graaff, Cees GM Kallenberg, Marc Bijl Arthritis Research & Therapy 2010, 12:R181 (28 September 2010)
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Heritability patterns in hand osteoarthritis: the role of osteophytes
Mariko L Ishimori, Roy D Altman, Myles J Cohen, Jinrui Cui, Xiuqing Guo, Jerome I Rotter, Michael H Weisman Arthritis Research & Therapy 2010, 12:R180 (28 September 2010)
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Validity of clinical associations of biomarkers in translational research studies: the case of systemic autoimmune diseases
Maria G Tektonidou, Michael M Ward Arthritis Research & Therapy 2010, 12:R179 (27 September 2010)
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Intravenous administration of anti-vascular endothelial growth factor humanized monoclonal antibody bevacizumab improves articular cartilage repair
Toshihiro Nagai, Masato Sato, Toshiharu Kutsuna, Mami Kokubo, Goro Ebihara, Naoshi Ohta, Joji Mochida Arthritis Research & Therapy 2010, 12:R178 (24 September 2010)
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Anti-VEGF humanized monoclonal antibody bevacizumab improves articular cartilage repair in an osteochondral defect rabbit model, presenting a possible alternative to using cultured cells or artificial scaffolds.
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Advances in gout: some answers, more questions
Jasvinder A Singh Arthritis Research & Therapy 2010, 12:136 (24 September 2010)
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Validity of the work productivity and activity impairment questionnaire - general health version in patients with rheumatoid arthritis
Wei Zhang, Nick Bansback, Annelies Boonen, Adam Young, Amitabh Singh, Aslam H Anis Arthritis Research & Therapy 2010, 12:R177 (22 September 2010)
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Effect of etanercept in polymyalgia rheumatica: a randomized controlled trial
Frederik Kreiner, Henrik Galbo Arthritis Research & Therapy 2010, 12:R176 (20 September 2010)
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Editor’s summary
Etanercept monotherapy decreases disease activity by 24% in patients with polymyalgia rheumatica (PMR), indicating that tumour necrosis factor-alpha plays only a minor role in the pathophysiology of PMR.
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Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease
Stephen Eyre, Anne Hinks, John Bowes, Edward Flynn, Paul Martin, Anthony G Wilson, Ann W Morgan, Paul Emery, Sophia Steer, Lynne J Hocking, David M Reid, Pille Harrison, Paul Wordsworth, Yorkshire Early Arthritis (YEAR) Consortium, Biologics in RA Control (BIRAC) Consortium, Wendy Thomson, Jane Worthington, Anne Barton Arthritis Research & Therapy 2010, 12:R175 (20 September 2010)
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Editor’s summary
The TAGAP (T-cell activation RhoGTPase activating protein) gene, previously associated with both type 1 diabetes and coeliac disease, is also associated with rheumatoid arthritis susceptibility.
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Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study
Aya Kawasaki, Satoshi Ito, Hiroshi Furukawa, Taichi Hayashi, Daisuke Goto, Isao Matsumoto, Makio Kusaoi, Jun Ohashi, Robert R Graham, Kunio Matsuta, Timothy W Behrens, Shigeto Tohma, Yoshinari Takasaki, Hiroshi Hashimoto, Takayuki Sumida, Naoyuki Tsuchiya Arthritis Research & Therapy 2010, 12:R174 (17 September 2010)
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Editor’s summary
TNIP1 is associated with increased risk of systemic lupus erythematosus (SLE) in both Asian and Caucasian populations, with a greater genetic contribution found in Japanese and Chinese populations.
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Fully automated system for the quantification of human osteoarthritic knee joint effusion volume using magnetic resonance imaging
Wei Li, François Abram, Jean-Pierre Pelletier, Jean-Pierre Raynauld, Marc Dorais, Marc-André d'Anjou, Johanne Martel-Pelletier Arthritis Research & Therapy 2010, 12:R173 (16 September 2010)
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Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders
Rita Dreier Arthritis Research & Therapy 2010, 12:216 (16 September 2010)
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Longitudinal assessment of cyst-like lesions of the knee and their relation to radiographic osteoarthritis and MRI-detected effusion and synovitis in patients with knee pain
Daichi Hayashi, Frank W Roemer, Zineb Dhina, C Kent Kwoh, Michael J Hannon, Carolyn Moore, Ali Guermazi Arthritis Research & Therapy 2010, 12:R172 (15 September 2010)
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Sizing up stability: combination therapy with Apo-AI peptide mimetics and statins in systemic lupus erythematosus-mediated atherosclerosis
Yanice Mendez-Fernandez, Amy Major Arthritis Research & Therapy 2010, 12:139 (15 September 2010)
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Assessment of myocardial abnormalities in rheumatoid arthritis using a comprehensive cardiac magnetic resonance approach: a pilot study
Yasuyuki Kobayashi, Jon T Giles, Masaharu Hirano, Isamu Yokoe, Yasuo Nakajima, Joan M Bathon, Joao AC Lima, Hitomi Kobayashi Arthritis Research & Therapy 2010, 12:R171 (13 September 2010)
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Editor’s summary
MRI-detected myocardial abnormalities were associated with higher rheumatoid arthritis (RA) disease activity in patients without known cardiac disease, suggesting a role for inflammation in the pathogenesis of myocardial involvement in RA.
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Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy
Ling-dong Quan, P Edward Purdue, Xin-ming Liu, Michael D Boska, Subodh M Lele, Geoffrey M Thiele, Ted R Mikuls, Huanyu Dou, Steven R Goldring, Dong Wang Arthritis Research & Therapy 2010, 12:R170 (13 September 2010)
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The Belgian MIRA (MabThera In Rheumatoid Arthritis) registry: clues for the optimization of rituximab treatment strategies
Bert Vander Cruyssen, Patrick Durez, Rene Westhovens, Marie-Joelle Kaiser, Ilse Hoffman, Filip De Keyser, The MIRA Study Group Arthritis Research & Therapy 2010, 12:R169 (10 September 2010)
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Borrelia burgdorferi stimulation of chemokine secretion by cells of monocyte lineage in patients with Lyme arthritis
Junghee J Shin, Klemen Strle, Lisa J Glickstein, Andrew D Luster, Allen C Steere Arthritis Research & Therapy 2010, 12:R168 (9 September 2010)
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Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes
Feng-Cheng Liu, Li-Feng Hung, Wan-Lin Wu, Deh-Ming Chang, Chuan-Yueh Huang, Jenn-Haung Lai, Ling-Jun Ho Arthritis Research & Therapy 2010, 12:R167 (8 September 2010)
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Predictors of interstitial lung disease in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort
Shervin Assassi, Roozbeh Sharif, Robert E Lasky, Terry A McNearney, Rosa M Estrada-Y-Martin, Hilda Draeger, Deepthi K Nair, Marvin J Fritzler, John D Reveille, Frank C Arnett, Maureen D Mayes, the GENISOS Study Group Arthritis Research & Therapy 2010, 12:R166 (2 September 2010)
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New developments in osteoarthritis. Prevention of injury-related knee osteoarthritis: opportunities for the primary and secondary prevention of knee osteoarthritis
Charles R Ratzlaff, Matthew H Liang Arthritis Research & Therapy 2010, 12:215 (31 August 2010)
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High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes
Isabel García-Arnandis, Maria Isabel Guillén, Francisco Gomar, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Maria José Alcaraz Arthritis Research & Therapy 2010, 12:R165 (27 August 2010)
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Circulating mediators of bone remodeling in psoriatic arthritis: implications for disordered osteoclastogenesis and bone erosion
Nicola Dalbeth, Bregina Pool, Timothy Smith, Karen E Callon, Maria Lobo, William J Taylor, Peter B Jones, Jillian Cornish, Fiona M McQueen Arthritis Research & Therapy 2010, 12:R164 (26 August 2010)
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A new tool for detection of type I interferon activation in systemic lupus erythematosus
Kyriakos A Kirou, George D Kalliolias Arthritis Research & Therapy 2010, 12:138 (26 August 2010)
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The effect of risedronate on osteogenic lineage is mediated by cyclooxygenase-2 gene upregulation
Maria Teresa Valenti, Sandro Giannini, Luca Donatelli, Mirko Zanatta, Francesco Bertoldo, Stefania Sella, Maria Teresa Vilei, Elena Ossi, Giuseppe Realdi, Vincenzo Lo Cascio, Luca Dalle Carbonare Arthritis Research & Therapy 2010, 12:R163 (25 August 2010)
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Relationship between patient-reported disease severity in osteoarthritis and self-reported pain, function and work productivity
Alesia B Sadosky, Andrew G Bushmakin, Joseph C Cappelleri, David R Lionberger Arthritis Research & Therapy 2010, 12:R162 (25 August 2010)
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Monocytes/macrophages express chemokine receptor CCR9 in rheumatoid arthritis and CCL25 stimulates their differentiation
Caroline Schmutz, Alison Cartwright, Helen Williams, Oliver Haworth, John HH Williams, Andrew Filer, Mike Salmon, Christopher D Buckley, Jim Middleton Arthritis Research & Therapy 2010, 12:R161 (25 August 2010)
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Arthritis Research & Therapy evolves: online only from 2011
Iain Hrynaszkiewicz, Peter E Lipsky, Ravinder N Maini Arthritis Research & Therapy 2010, 12:137 (25 August 2010)
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Rationale of using different biological therapies in rheumatoid arthritis
Matthias Geyer, Ulf Müller-Ladner Arthritis Research & Therapy 2010, 12:214 (24 August 2010)
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A multiparameter approach to monitor disease activity in collagen-induced arthritis
Sylvie Seeuws, Peggy Jacques, Jens Van Praet, Michael Drennan, Julie Coudenys, Tine Decruy, Ellen Deschepper, Lien Lepescheux, Philippe Pujuguet, Line Oste, Nick Vandeghinste, Reginald Brys, Gust Verbruggen, Dirk Elewaut Arthritis Research & Therapy 2010, 12:R160 (23 August 2010)
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Interstitial lung disease in connective tissue diseases: evolving concepts of pathogenesis and management
Flavia V Castelino, John Varga Arthritis Research & Therapy 2010, 12:213 (23 August 2010)
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Mesenchymal stem cells in arthritis: role of bone marrow microenvironment
Christian Jorgensen Arthritis Research & Therapy 2010, 12:135 (23 August 2010)
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Polymorphisms in the glucocorticoid receptor gene that modulate glucocorticoid sensitivity are associated with rheumatoid arthritis
Manon JM van Oosten, Radboud JEM Dolhain, Jan W Koper, Elisabeth FC van Rossum, Marieke Emonts, Khik H Han, Jacques MGW Wouters, Johanne MW Hazes, Steven WJ Lamberts, Richard A Feelders Arthritis Research & Therapy 2010, 12:R159 (21 August 2010)
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Editor’s summary
Glucocorticoid receptor gene polymorphisms ER22/23EK and 9beta are associated with an enhanced predisposition to develop rheumatoid arthritis and suggest a role for constitutionally determined glucocorticoid sensitivity in auto-immunity development.
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Atherosclerosis in early rheumatoid arthritis: very early endothelial activation and rapid progression of intima media thickness
Anna Södergren, Kjell Karp, Kurt Boman, Catharina Eriksson, Elisabet Lundström, Torgny Smedby, Lisbet Söderlund, Solbritt Rantapää-Dahlqvist, Solveig Wållberg-Jonsson Arthritis Research & Therapy 2010, 12:R158 (16 August 2010)
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A personal journey from the joint to the heart
Bruce N Cronstein Arthritis Research & Therapy 2010, 12:134 (13 August 2010)
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Could the expression of CD86 and FcγRIIB on B cells be functionally related and involved in driving rheumatoid arthritis?
Claudia Mauri, Elizabeth C Jury Arthritis Research & Therapy 2010, 12:133 (13 August 2010)
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Comparison of laser Doppler imaging, fingertip lacticemy test, and nailfold capillaroscopy for assessment of digital microcirculation in systemic sclerosis
Marcelo JU Correa, Luis EC Andrade, Cristiane Kayser Arthritis Research & Therapy 2010, 12:R157 (10 August 2010)
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Bone events and evolution of biologic markers in Gaucher disease before and during treatment
Jérôme Stirnemann, Nadia Belmatoug, Corine Vincent, Olivier Fain, Bruno Fantin, France Mentré Arthritis Research & Therapy 2010, 12:R156 (9 August 2010)
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Visualization and phenotyping of proinflammatory antigen-specific T cells during collagen-induced arthritis in a mouse with a fixed collagen type II-specific transgenic T-cell receptor β-chain
Patrick Merky, Tsvetelina Batsalova, Robert Bockermann, Balik Dzhambazov, Bettina Sehnert, Harald Burkhardt, Johan Bäcklund Arthritis Research & Therapy 2010, 12:R155 (3 August 2010)
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Risk of osteoporotic fracture in a large population-based cohort of patients with rheumatoid arthritis
Seo Young Kim, Sebastian Schneeweiss, Jun Liu, Gregory W Daniel, Chun-Lan Chang, Katie Garneau, Daniel H Solomon Arthritis Research & Therapy 2010, 12:R154 (3 August 2010)
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Prevalence and risk factors of vertebral compression fractures in female SLE patients
Katarina Almehed, Szabolcs Hetényi, Claes Ohlsson, Hans Carlsten, Helena Forsblad-d'Elia Arthritis Research & Therapy 2010, 12:R153 (2 August 2010)
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Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis
Miriam Bellido, Laura Lugo, Jorge A Roman-Blas, Santos Castañeda, Jose R Caeiro, Sonia Dapia, Emilio Calvo, Raquel Largo, Gabriel Herrero-Beaumont Arthritis Research & Therapy 2010, 12:R152 (2 August 2010)
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New developments in osteoarthritis. Sex differences in magnetic resonance imaging-based biomarkers and in those of joint metabolism
Mehrnaz Maleki-Fischbach, Joanne M Jordan Arthritis Research & Therapy 2010, 12:212 (30 July 2010)
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Efficacy assessed in follow-ups of clinical trials: methodological conundrum
Robert BM Landewé Arthritis Research & Therapy 2010, 12:132 (30 July 2010)
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Exercise-induced changes in interleukin-10 in patients with knee osteoarthritis: new perspectives?
Willem F Lems, Debby den Uyl Arthritis Research & Therapy 2010, 12:131 (29 July 2010)
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Osteoarthritis and a high-fat diet: the full 'OA syndrome' in a small animal model
Peter M van der Kraan Arthritis Research & Therapy 2010, 12:130 (28 July 2010)
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Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus
Silvia N Kariuki, Beverly S Franek, Akaash A Kumar, Jasmine Arrington, Rachel A Mikolaitis, Tammy O Utset, Meenakshi Jolly, Mary K Crow, Andrew D Skol, Timothy B Niewold Arthritis Research & Therapy 2010, 12:R151 (26 July 2010)
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Increased expression of costimulatory markers CD134 and CD80 on interleukin-17 producing T cells in patients with systemic lupus erythematosus
Sebastian Dolff, Daniel Quandt, Benjamin Wilde, Thorsten Feldkamp, Fan Hua, Xin Cai, Christof Specker, Andreas Kribben, Cees GM Kallenberg, Oliver Witzke Arthritis Research & Therapy 2010, 12:R150 (23 July 2010)
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Bcl-xL affects the development of functional CD4 Tregs
Amir Sharabi, Edna Mozes Arthritis Research & Therapy 2010, 12:405 (23 July 2010)
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Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis
Sindhu T Mohanty, Lucksy Kottam, Alessandra Gambardella, Martin J Nicklin, Les Coulton, David Hughes, Anthony G Wilson, Peter I Croucher, Ilaria Bellantuono Arthritis Research & Therapy 2010, 12:R149 (22 July 2010)
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Synovial effusion and synovial fluid biomarkers in psoriatic arthritis to assess intraarticular tumor necrosis factor-α blockade in the knee joint
Ugo Fiocco, Paolo Sfriso, Francesca Oliviero, Pascale Roux-Lombard, Elena Scagliori, Luisella Cozzi, Francesca Lunardi, Fiorella Calabrese, Maristella Vezzù, Serena Dainese, Beatrice Molena, Anna Scanu, Roberto Nardacchione, Leopoldo Rubaltelli, Jean Michel Dayer, Leonardo Punzi Arthritis Research & Therapy 2010, 12:R148 (19 July 2010)
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Liposomal encapsulation enhances and prolongs the anti-inflammatory effects of water-soluble dexamethasone phosphate in experimental adjuvant arthritis
Rebecca Anderson, Angels Franch, Margarida Castell, Francisco J Perez-Cano, Rolf Bräuer, Dirk Pohlers, Mieczyslaw Gajda, Alexandros P Siskos, Theodora Katsila, Constantin Tamvakopoulos, Una Rauchhaus, Steffen Panzner, Raimund W Kinne Arthritis Research & Therapy 2010, 12:R147 (19 July 2010)
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TAM receptor ligands in lupus: Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus
Chang-Hee Suh, Brendan Hilliard, Sophia Li, Joan T Merrill, Philip L Cohen Arthritis Research & Therapy 2010, 12:R146 (16 July 2010)
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Risk factors for total joint arthroplasty infection in patients receiving tumor necrosis factor α-blockers: a case-control study
Mélanie Gilson, Laure Gossec, Xavier Mariette, Dalenda Gherissi, Marie-Hélène Guyot, Jean-Marie Berthelot, Daniel Wendling, Christian Michelet, Pierre Dellamonica, Florence Tubach, Maxime Dougados, Dominique Salmon Arthritis Research & Therapy 2010, 12:R145 (16 July 2010)
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The delivery of evidence-based preventive care for older Americans with arthritis
Jeffrey R Curtis, Tarun Arora, Pongthorn Narongroeknawin, Allison Taylor, Clifton O Bingham, Jack Cush, Kenneth G Saag, Monika Safford, Elizabeth Delzell Arthritis Research & Therapy 2010, 12:R144 (16 July 2010)
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Rare incidence of methotrexate-specific lesions in liver biopsy of patients with arthritis and elevated liver enzymes
Emilie Quintin, Jean-Yves Scoazec, Hubert Marotte, Pierre Miossec Arthritis Research & Therapy 2010, 12:R143 (16 July 2010)
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Maintenance of cytomegalovirus-specific CD4pos T-cell response in rheumatoid arthritis patients receiving anti-tumor necrosis factor treatments
Jean-Luc Davignon, Jean-Frédéric Boyer, Bénédicte Jamard, Delphine Nigon, Arnaud Constantin, Alain Cantagrel Arthritis Research & Therapy 2010, 12:R142 (15 July 2010)
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Effect of duloxetine in patients with fibromyalgia: tiredness subgroups
Laurence A Bradley, Robert Bennett, Irwin J Russell, Madelaine M Wohlreich, Amy S Chappell, Fujun Wang, Deborah N D'Souza, Harvey Moldofsky Arthritis Research & Therapy 2010, 12:R141 (14 July 2010)
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Editor’s summary
Duloxetine efficacy on measures of pain and functional ability does not vary according to patients' fatigue levels, finds an analysis of four randomised controlled trials.
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Remission makes its way to rheumatology
Tuulikki Sokka, Heidi Mäkinen Arthritis Research & Therapy 2010, 12:129 (14 July 2010)
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Differential effects of locally and systemically administered soluble glycoprotein 130 on pain and inflammation in experimental arthritis
Michael K Boettger, Johannes Leuchtweis, Diana Kümmel, Mieczyslaw Gajda, Rolf Bräuer, Hans-Georg Schaible Arthritis Research & Therapy 2010, 12:R140 (13 July 2010)
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Editor’s summary
Locally administered soluble glycoprotein 130 attenuates arthritic pain modulated by interleukin-6 signalling pathways and is effective in preventing joint destruction in an experimental model of arthritis.
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Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women?
Sharon L Brennan, Flavia M Cicuttini, Julie A Pasco, Margaret J Henry, Yuanyuan Wang, Mark A Kotowicz, Geoff C Nicholson, Anita E Wluka Arthritis Research & Therapy 2010, 12:R139 (13 July 2010)
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Editor’s summary
Female weight gain during early adulthood is associated with increased prevalence of bone marrow lesions and detrimental effects on cartilage, which may increase the risk of developing knee osteoarthritis.
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Pharmacoproteomic study of the effects of chondroitin and glucosamine sulfate on human articular chondrocytes
Valentina Calamia, Cristina Ruiz-Romero, Beatriz Rocha, Patricia Fernández-Puente, Jesús Mateos, Eulàlia Montell, Josep Vergés, Francisco J Blanco Arthritis Research & Therapy 2010, 12:R138 (13 July 2010)
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Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus
Ou Jin, Sushma Kavikondala, Mo-Yin Mok, Lingyun Sun, Jieruo Gu, Rong Fu, Albert Chan, Joseph Yeung, Yingjie Nie, Chak-Sing Lau Arthritis Research & Therapy 2010, 12:R137 (9 July 2010)
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Editor’s summary
Plasmacytoid dendritic cells are less capable of inducing regulatory T cell differentiation and lack toll like receptor-9 recruitment in systemic lupus erythematosus (SLE) patients compared with controls, suggesting a potential pathologic role in SLE.
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Modulation of collagen-induced arthritis by adenovirus-mediated intra-articular expression of modified collagen type II
Bo Tang, David L Cullins, Jing Zhou, Janice A Zawaski, Hyelee Park, David D Brand, Karen A Hasty, M Waleed Gaber, John M Stuart, Andrew H Kang, Linda K Myers Arthritis Research & Therapy 2010, 12:R136 (8 July 2010)
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Innate immunity triggers IL-32 expression by fibroblast-like synoviocytes in rheumatoid arthritis
Ghada Alsaleh, Laetitia Sparsa, Emmanuel Chatelus, Mathieu Ehlinger, Jacques-Eric Gottenberg, Dominique Wachsmann, Jean Sibilia Arthritis Research & Therapy 2010, 12:R135 (8 July 2010)
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Editor’s summary
Interleukin-32 expression by fibroblast-like synoviocytes is tightly regulated by innate immunity in rheumatoid arthritis (RA), highlighting it as a potential therapeutic target in RA.
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Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate
Nicolas Fayed, Javier Garcia-Campayo, Rosa Magallón, Helena Andrés-Bergareche, Juan V Luciano, Eva Andres, Julián Beltrán Arthritis Research & Therapy 2010, 12:R134 (7 July 2010)
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Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis
Tomoko Kawabata, Keiichiro Nishida, Koji Takasugi, Hiroko Ogawa, Kenei Sada, Yasutaka Kadota, Junko Inagaki, Satoshi Hirohata, Yoshifumi Ninomiya, Hirofumi Makino Arthritis Research & Therapy 2010, 12:R133 (7 July 2010)
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Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins
Katleen Van Steendam, Kelly Tilleman, Marlies De Ceuleneer, Filip De Keyser, Dirk Elewaut, Dieter Deforce Arthritis Research & Therapy 2010, 12:R132 (7 July 2010)
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Gene expression profiling in circulating endothelial cells from systemic sclerosis patients shows an altered control of apoptosis and angiogenesis that is modified by iloprost infusion
Elisa Tinazzi, Marzia Dolcino, Antonio Puccetti, Antonella Rigo, Ruggero Beri, Maria Valenti, Roberto Corrocher, Claudio Lunardi Arthritis Research & Therapy 2010, 12:R131 (7 July 2010)
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Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice
Timothy M Griffin, Beverley Fermor, Janet L Huebner, Virginia B Kraus, Ramona M Rodriguiz, William C Wetsel, Li Cao, Lori A Setton, Farshid Guilak Arthritis Research & Therapy 2010, 12:R130 (6 July 2010)
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Effects of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis
Chun K Wong, Da P Chen, Lai S Tam, Edmund K Li, Yi B Yin, Christopher WK Lam Arthritis Research & Therapy 2010, 12:R129 (6 July 2010)
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Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis
Nobuyo Higashi-Kuwata, Masatoshi Jinnin, Takamitsu Makino, Satoshi Fukushima, Yuji Inoue, Faith C Muchemwa, Yuji Yonemura, Yoshihiro Komohara, Motohiro Takeya, Hiroaki Mitsuya, Hironobu Ihn Arthritis Research & Therapy 2010, 12:R128 (5 July 2010)
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Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment
Constanze Buhrmann, Ali Mobasheri, Ulrike Matis, Mehdi Shakibaei Arthritis Research & Therapy 2010, 12:R127 (1 July 2010)
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Editor’s summary
Curcumin, a naturally-occurring nuclear factor-KB inhibitor, protects mesenchymal stem cells (MSCs) from the harmful effects of pro-inflammatory cytokines, thereby establishing a suitable microenvironment for MSCs to undergo chondrogenesis.
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Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial
Ida C Helmark, Ulla R Mikkelsen, Jens Børglum, Anders Rothe, Marie CH Petersen, Ove Andersen, Henning Langberg, Michael Kjaer Arthritis Research & Therapy 2010, 12:R126 (1 July 2010)
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Editor’s summary
A single bout of mechanical joint loading increases intraarticular and peri-synovial concentrations of interleukin-10 in females with knee osteoarthritis, suggesting exercise enhances the chondroprotective anti-inflammatory cytokine response.
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Variability over time and correlates of cholesterol and blood pressure in systemic lupus erythematosus: a longitudinal cohort study
Mandana Nikpour, Dafna D Gladman, Dominique Ibanez, Paula J Harvey, Murray B Urowitz Arthritis Research & Therapy 2010, 12:R125 (30 June 2010)
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Functional significance of nerve growth factor and its receptor (TrkA) in inflammatory arthritis
Smriti K Raychaudhuri, Siba P Raychaudhuri Arthritis Research & Therapy 2010, 12:404 (28 June 2010)
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New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options
Martin K Lotz Arthritis Research & Therapy 2010, 12:211 (28 June 2010)
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Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and sysemic lupus erythematosus
György Nagy, Agnes Koncz, Tiffany Telarico, David Fernandez, Barbara Érsek, Edit Buzás, András Perl Arthritis Research & Therapy 2010, 12:210 (28 June 2010)
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Angiotensin-converting enzyme 2 autoantibodies: further evidence for a role of the renin-angiotensin system in inflammation
Mark C Chappell Arthritis Research & Therapy 2010, 12:128 (28 June 2010)
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New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model
Mohammad Amin Kerachian, Denis Cournoyer, Edward J Harvey, Terry Y Chow, Louis R Bégin, Ayoub Nahal, Chantal Séguin Arthritis Research & Therapy 2010, 12:R124 (25 June 2010)
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The use of glucocorticoids in rheumatoid arthritis - no 'rational' approach yet
Sonali P Desai, Daniel H Solomon Arthritis Research & Therapy 2010, 12:127 (25 June 2010)
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Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis
Claas H Hinze, Ndate Fall, Sherry Thornton, Jun Q Mo, Bruce J Aronow, Gerlinde Layh-Schmitt, Thomas A Griffin, Susan D Thompson, Robert A Colbert, David N Glass, Michael G Barnes, Alexei A Grom Arthritis Research & Therapy 2010, 12:R123 (24 June 2010)
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Early combination disease-modifying antirheumatic drug therapy and tight disease control improve long-term radiologic outcome in patients with early rheumatoid arthritis: the 11-year results of the Finnish Rheumatoid Arthritis Combination Therapy trial
Vappu Rantalaiho, Markku Korpela, Leena Laasonen, Hannu Kautiainen, Salme Järvenpää, Pekka Hannonen, Marjatta Leirisalo-Repo, Harri Blåfield, Kari Puolakka, Anna Karjalainen, Timo Möttönen, the FIN-RACo Trial Group Arthritis Research & Therapy 2010, 12:R122 (24 June 2010)
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