Arthritis Research & Therapy

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		Research article Characterization of inhibitory T cells induced by an analog of type II collagen in an HLA-DR1 humanized mouse model of autoimmune arthritis Masaru Kimata, David L Cullins, Monica L Brown, David D Brand, Edward F Rosloniec, Linda K Myers, John M Stuart, Andrew H Kang Arthritis Research & Therapy 2012, 14:R107 (8 May 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Efficacy of an immunotoxin to folate receptor beta in the intra-articular treatment of antigen-induced arthritis Taku Nagai, Akira Kyo, Kazuhisa Hasui, Sonshin Takao, Takami Matsuyama Arthritis Research & Therapy 2012, 14:R106 (2 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells Akihiko Hiyama, Fumiyuki Arai, Daisuke Sakai, Katsuya Yokoyama, Joji Mochida Arthritis Research & Therapy 2012, 14:R105 (2 May 2012) Abstract \| Full text \| PDF \| PubMed
		Research article PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis Amanda S Rohrbach, Saskia Hemmers, Sanja Arandjelovic, Maripat Corr, Kerri A Mowen Arthritis Research & Therapy 2012, 14:R104 (2 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article New insights into the role and mechanism of macrophage migration inhibitory factor in steroid-resistant patients with systemic lupus erythematosus Fang-Fang Wang, Li-An Zhu, Yu-Qiong Zou, Hui Zheng, Alisa Wilson, Cheng-De Yang, Nan Shen, Daniel J Wallace, Michael H Weisman, Shun-Le Chen, Liang-Jing Lu Arthritis Research & Therapy 2012, 14:R103 (2 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Macrophage migration inhibitory factor (MIF) may play a role in the mechanism of steroid resistance in systemic lupus erythematosus by affecting the NF-κB/IκB signaling cascade, and is a potential therapeutic target.
		Research article Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behçet's disease Sunao Sugita, Yuko Kawazoe, Ayano Imai, Yukiko Yamada, Shintaro Horie, Manabu Mochizuki Arthritis Research & Therapy 2012, 14:R99 (1 May 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker? Katja Lakota, Jun Wei, Mary Carns, Monique Hinchcliff, Jungwha Lee, Michael L Whitfield, Snezna Sodin-Semrl, John Varga Arthritis Research & Therapy 2012, 14:R102 (1 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Sensory and sympathetic nerve fibers undergo sprouting and neuroma formation in the painful arthritic joint of geriatric mice Juan M Jimenez-Andrade, Patrick W Mantyh Arthritis Research & Therapy 2012, 14:R101 (1 May 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Anti-type II collagen antibodies are associated with early radiographic destruction in rheumatoid arthritis Mohammed Mullazehi, Marius C Wick, Lars Klareskog, Ronald van Vollenhoven, Johan Rönnelid Arthritis Research & Therapy 2012, 14:R100 (1 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article The effect of three years of TNF alpha blocking therapy on markers of bone turnover and their predictive value for treatment discontinuation in patients with ankylosing spondylitis: a prospective longitudinal observational cohort study Suzanne Arends, Anneke Spoorenberg, Pieternella M Houtman, Martha K Leijsma, Reinhard Bos, Cees GM Kallenberg, Henk Groen, Elisabeth Brouwer, Eveline van der Veer Arthritis Research & Therapy 2012, 14:R98 (30 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis Angela Ceribelli, Micaela Fredi, Mara Taraborelli, Ilaria Cavazzana, Franco Franceschini, Marzia Quinzanini, Angela Tincani, Steven J Ross, Jason YF Chan, Brad A Pauley, Edward KL Chan, Minoru Satoh Arthritis Research & Therapy 2012, 14:R97 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model Misato Hashizume, Hiroto Yoshida, Keisuke Tanaka, Miho Suzuki, Isao Matsumoto, Takayuki Sumida, Masahiko Mihara Arthritis Research & Therapy 2012, 14:R96 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Interleukin-6 (IL-6) reduced the efficacy of methotrexate in a mouse arthritis model by inhibiting the expression of the reduced folate transporter SLC19A1, which is important for the uptake of methotrexate into cells.
		Review Progress in treatment of ANCA-associated vasculitis Rona M Smith, Rachel B Jones, David RW Jayne Arthritis Research & Therapy 2012, 14:210 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article The interferon type I signature towards prediction of non-response to rituximab in rheumatoid arthritis patients Hennie G Raterman, Saskia Vosslamber, Sander de Ridder, Michael T Nurmohamed, Willem F Lems, Maarten Boers, Mark van de Wiel, Ben AC Dijkmans, Cornelis L Verweij, Alexandre E Voskuyl Arthritis Research & Therapy 2012, 14:R95 (27 April 2012) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology
		Research article Bias in effect size of systemic lupus erythematosus susceptibility loci across Europe: a case-control study Elisa Alonso-Perez, Marian Suarez-Gestal, Manuel Calaza, Gian Sebastiani, Rudolf Pullmann, Chryssa Papasteriades, Attila Kovacs, Fotini N Skopouli, Marc Bijl, Ana Suarez, Maurizio Marchini, Sergio Migliaresi, Patricia Carreira, Josep Ordi-Ros, Torsten Witte, Sarka Ruzickova, Maria Santos, Nadia Barizzone, Francisco J Blanco, Bernard R Lauwerys, Juan J Gomez-Reino, Antonio Gonzalez, the European Consortium of SLE DNA Collections Arthritis Research & Therapy 2012, 14:R94 (27 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Synovial cytokine expression in psoriatic arthritis and associations with lymphoid neogenesis and clinical features Raquel Celis, Núria Planell, José L Fernández-Sueiro, Raimon Sanmartí, Julio Ramírez, Isidoro González-Álvaro, José L Pablos, Juan D Cañete Arthritis Research & Therapy 2012, 14:R93 (27 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article The renal urate transporter SLC17A1 locus: confirmation of association with gout Jade E Hollis-Moffatt, Amanda J Phipps-Green, Brett Chapman, Gregory T Jones, Andre van Rij, Peter J Gow, Andrew A Harrison, John Highton, Peter B Jones, Grant W Montgomery, Lisa K Stamp, Nicola Dalbeth, Tony R Merriman Arthritis Research & Therapy 2012, 14:R92 (27 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Thrombin induces heme oxygenase-1 expression in human synovial fibroblasts through protease-activated receptor signaling pathways Ju-Fang Liu, Sheng-Mou Hou, Chun-Hao Tsai, Chun-Yin Huang, Wei-Hung Yang, Chih-Hsin Tang Arthritis Research & Therapy 2012, 14:R91 (27 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Role of non-immune mechanisms of muscle damage in idiopathic inflammatory myopathies William Coley, Sree Rayavarapu, Kanneboyina Nagaraju Arthritis Research & Therapy 2012, 14:209 (27 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Statins accelerate the onset of collagen type II-induced arthritis in mice Rob J Vandebriel, Hilda JI De Jong, Eric R Gremmer, Olaf H Klungel, Jan-Willem Tervaert, Wout Slob, Jan Willem Van Der Laan, Henk Van Loveren Arthritis Research & Therapy 2012, 14:R90 (26 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Smoking interacts with HLA-DRB1 shared epitope in the development of anti-citrullinated protein antibody-positive rheumatoid arthritis: results from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA) Chun Too, Abqariyah Yahya, Shahnaz Murad, Jasbir Dhaliwal, Per Larsson, Nor Muhamad, Nor Abdullah, Amal Mustafa, Lars Klareskog, Lars Alfredsson, Leonid Padyukov, Camilla Bengtsson, MyEIRA study group Arthritis Research & Therapy 2012, 14:R89 (26 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Congenital heart block: evidence for a pathogenic role of maternal autoantibodies Aurélie Ambrosi, Marie Wahren-Herlenius Arthritis Research & Therapy 2012, 14:208 (26 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Suppression of endothelial cell activity by inhibition of TNFα Qiang Shu, Mohammad A Amin, Jeffrey H Ruth, Phillip L Campbell, Alisa E Koch Arthritis Research & Therapy 2012, 14:R88 (25 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast-like synoviocytes Kenji Ikuta, Yuko Waguri-Nagaya, Kae Kikuchi, Takaya Yamagami, Masahiro Nozaki, Mineyoshi Aoyama, Kiyofumi Asai, Takanobu Otsuka Arthritis Research & Therapy 2012, 14:R87 (25 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Serum BAFF and APRIL levels in patients with IgG4-related disease and their clinical significance Kazuhiro Kiyama, Daisuke Kawabata, Yuji Hosono, Koji Kitagori, Naoichiro Yukawa, Hajime Yoshifuji, Koichiro Omura, Takao Fujii, Tsuneyo Mimori Arthritis Research & Therapy 2012, 14:R86 (24 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis Lara Bossini-Castillo, Carmen P Simeon, Lorenzo Beretta, Jasper C Broen, Madelon C Vonk, Raquel Ríos-Fernández, Gerard Espinosa, Patricia Carreira, María T Camps, Maria J Castillo, Miguel A González-Gay, Emma Beltrán, María Carmen Freire, Javier Narváez, Carlos Tolosa, Torsten Witte, Alexander Kreuter, Annemie J Schuerwegh, Anna-Maria Hoffmann-Vold, Roger Hesselstrand, Claudio Lunardi, Jacob M van Laar, Meng Chee, Ariane Herrick, Bobby PC Koeleman, Christopher P Denton, Carmen Fonseca, Timothy RDJ Radstake, Javier Martin, the Spanish Scleroderma Group et al. Arthritis Research & Therapy 2012, 14:R85 (24 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review MRI and X-ray in axial spondyloarthritis: the relationship between inflammatory and structural changes Walter P Maksymowych Arthritis Research & Therapy 2012, 14:207 (19 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Identification of low-frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization Beate Böhm, Harald Burkhardt, Steffen Uebe, Maria Apel, Frank Behrens, André Reis, Ulrike Hüffmeier Arthritis Research & Therapy 2012, 14:R84 (18 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Risk of end-stage renal disease associated with gout: a nationwide population study Kuang-Hui Yu, Chang-Fu Kuo, Shue-Fen Luo, Lai-Chu See, I-Jun Chou, Hsiao-Chun Chang, Meng-Jiun Chiou Arthritis Research & Therapy 2012, 14:R83 (18 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Bone morphogenetic protein-2-induced Wnt/β-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes Ioanna Papathanasiou, Konstantinos N Malizos, Aspasia Tsezou Arthritis Research & Therapy 2012, 14:R82 (18 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study Ying Chen, Peter T Dawes, Jon C Packham, Derek L Mattey Arthritis Research & Therapy 2012, 14:R81 (18 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Antagonist-mediated down-regulation of toll-like receptors increases the prevalence of human papillomavirus infection in systemic lupus erythematosus Shui-Lian Yu, Paul KS Chan, Chun-Kwok Wong, Cheuk-Chun Szeto, Suzanne C Ho, Karine So, May MY Yu, So-Fan Yim, Tak-Hong Cheung, Martin CS Wong, Jo LK Cheung, Apple CM Yeung, Edmund K Li, Lai-Shan Tam Arthritis Research & Therapy 2012, 14:R80 (18 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Autoantibodies to transcription intermediary factor (TIF)1β associated with dermatomyositis Minoru Satoh, Jason YF Chan, Steven J Ross, Yi Li, Yoshioki Yamasaki, Hidehiro Yamada, Monica Vazquez-del Mercado, Marcelo H Petri, Luis J Jara, Miguel A Saavedra, Claudia Cruz-Reyes, Eric S Sobel, Westley H Reeves, Angela Ceribelli, Edward KL Chan Arthritis Research & Therapy 2012, 14:R79 (18 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis Kyle D Allen, Brian A Mata, Mostafa A Gabr, Janet L Huebner, Samuel B Adams, Virginia B Kraus, Daniel O Schmitt, Lori A Setton Arthritis Research & Therapy 2012, 14:R78 (17 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Circulating and synovial antibody profiling of juvenile arthritis patients by nucleic acid programmable protein arrays David S Gibson, Ji Qiu, Eliseo A Mendoza, Kristi Barker, Madeleine E Rooney, Joshua LaBaer Arthritis Research & Therapy 2012, 14:R77 (17 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Estradiol ameliorates arthritis and protects against systemic bone loss in Staphylococcus aureus infection in mice Inger Gjertsson, Marie K Lagerquist, Erik Kristiansson, Hans Carlsten, Catharina Lindholm Arthritis Research & Therapy 2012, 14:R76 (16 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4 Jing Li, Jingang Huang, Liming Dai, Degang Yu, Qian Chen, Xiaoling Zhang, Kerong Dai Arthritis Research & Therapy 2012, 14:R75 (16 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The microRNA miR-146a may reduce cellular response to transforming growth factor-beta through targeted inhibition of Smad4 in cartilage, thus increasing vascular endothelial growth factor levels, and increasing chondrocyte apoptosis.
		Research article Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis Carmen A Ambarus, Troy Noordenbos, Maria JH de Hair, Paul P Tak, Dominique LP Baeten Arthritis Research & Therapy 2012, 14:R74 (11 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Increased frequency of CCR4+ and CCR6+ memory T-cells including CCR7+CD45RA^medvery early memory cells in granulomatosis with polyangiitis (Wegener's) Ursula Fagin, Silke Pitann, Wolfgang L Gross, Peter Lamprecht Arthritis Research & Therapy 2012, 14:R73 (10 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Induction of superficial zone protein (SZP)/lubricin/PRG 4 in muscle-derived mesenchymal stem/progenitor cells by transforming growth factor-β1 and bone morphogenetic protein-7 José A Andrades, Shirley C Motaung, Pedro Jiménez-Palomo, Silvia Claros, José M López-Puerta, José Becerra, Thomas M Schmid, A Hari Reddi Arthritis Research & Therapy 2012, 14:R72 (10 April 2012) Abstract \| Full text \| PDF \| PubMed
		Correction Correction: FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development Rizwanul Haque, Fengyang Lei, Xiaofang Xiong, Yuzhang Wu, Jianxun Song Arthritis Research & Therapy 2012, 14:401 (10 April 2012) Abstract \| Full text \| PDF \| PubMed
		Editorial Knotting the NETs: Analyzing histone modifications in neutrophil extracellular traps Indira Neeli, Marko Radic Arthritis Research & Therapy 2012, 14:115 (6 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Bone formation rather than inflammation reflects Ankylosing Spondylitis activity on PET-CT: a pilot study Stefan TG Bruijnen, Mignon AC van der Weijden, Joannes P Klein, Otto S Hoekstra, Ronald Boellaard, J Christiaan van Denderen, Ben AC Dijkmans, Alexandre E Voskuyl, Irene E van der Horst-Bruinsma, Conny J van der Laken Arthritis Research & Therapy 2012, 14:R71 (2 April 2012) Abstract \| Full text \| PDF \| PubMed
		Review Placebo analgesia: cognitive influences on therapeutic outcome Alison Watson, Andrea Power, Christopher Brown, Wael El-Deredy, Anthony Jones Arthritis Research & Therapy 2012, 14:206 (30 March 2012) Abstract \| Full text \| PDF \| PubMed
		Editorial What is the future of CCR5 antagonists in rheumatoid arthritis? Tsutomu Takeuchi, Hideto Kameda Arthritis Research & Therapy 2012, 14:114 (30 March 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Replication study confirms the association between UBAC2 and Behçet's disease in two independent Chinese sets of patients and controls Shengping Hou, Qinmeng Shu, Zhengxuan Jiang, Yuanyuan Chen, Fuzhen Li, Feilan Chen, Aize Kijlstra, Peizeng Yang Arthritis Research & Therapy 2012, 14:R70 (29 March 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Egr-1 contributes to IL-1-mediated down-regulation of peroxisome proliferator-activated receptor γ expression in human osteoarthritic chondrocytes Sarah-Salwa Nebbaki, Fatima El Mansouri, Hassan Afif, Mohit Kapoor, Mohamed Benderdour, Nicolas Duval, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Hassan Fahmi Arthritis Research & Therapy 2012, 14:R69 (28 March 2012) Abstract \| Full text \| PDF \| PubMed
		Editorial Meryl Streep and the problems of clinical trials David A Isenberg Arthritis Research & Therapy 2012, 14:113 (23 March 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Sustained rheumatoid arthritis remission is uncommon in clinical practice Femke HM Prince, Vivian P Bykerk, Nancy A Shadick, Bing Lu, Jing Cui, Michelle Frits, Christine K Iannaccone, Michael E Weinblatt, Daniel H Solomon Arthritis Research & Therapy 2012, 14:R68 (19 March 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In clinical practice only a minority of patients with rheumatoid arthritis (RA) are in sustained remission, suggesting strict monitoring is required even once remission is reached.
		Research article Obesity and carotid atherosclerosis in African black and Caucasian women with established rheumatoid arthritis: a cross-sectional study Ahmed Solomon, Gavin R Norton, Angela J Woodiwiss, Patrick H Dessein Arthritis Research & Therapy 2012, 14:R67 (19 March 2012) Abstract \| Full text \| PDF \| PubMed

	All
		Research article Characterization of inhibitory T cells induced by an analog of type II collagen in an HLA-DR1 humanized mouse model of autoimmune arthritis Masaru Kimata, David L Cullins, Monica L Brown, David D Brand, Edward F Rosloniec, Linda K Myers, John M Stuart, Andrew H Kang Arthritis Research & Therapy 2012, 14:R107 (8 May 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Efficacy of an immunotoxin to folate receptor beta in the intra-articular treatment of antigen-induced arthritis Taku Nagai, Akira Kyo, Kazuhisa Hasui, Sonshin Takao, Takami Matsuyama Arthritis Research & Therapy 2012, 14:R106 (2 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells Akihiko Hiyama, Fumiyuki Arai, Daisuke Sakai, Katsuya Yokoyama, Joji Mochida Arthritis Research & Therapy 2012, 14:R105 (2 May 2012) Abstract \| Full text \| PDF \| PubMed
		Research article PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis Amanda S Rohrbach, Saskia Hemmers, Sanja Arandjelovic, Maripat Corr, Kerri A Mowen Arthritis Research & Therapy 2012, 14:R104 (2 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article New insights into the role and mechanism of macrophage migration inhibitory factor in steroid-resistant patients with systemic lupus erythematosus Fang-Fang Wang, Li-An Zhu, Yu-Qiong Zou, Hui Zheng, Alisa Wilson, Cheng-De Yang, Nan Shen, Daniel J Wallace, Michael H Weisman, Shun-Le Chen, Liang-Jing Lu Arthritis Research & Therapy 2012, 14:R103 (2 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Macrophage migration inhibitory factor (MIF) may play a role in the mechanism of steroid resistance in systemic lupus erythematosus by affecting the NF-κB/IκB signaling cascade, and is a potential therapeutic target.
		Research article Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behçet's disease Sunao Sugita, Yuko Kawazoe, Ayano Imai, Yukiko Yamada, Shintaro Horie, Manabu Mochizuki Arthritis Research & Therapy 2012, 14:R99 (1 May 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker? Katja Lakota, Jun Wei, Mary Carns, Monique Hinchcliff, Jungwha Lee, Michael L Whitfield, Snezna Sodin-Semrl, John Varga Arthritis Research & Therapy 2012, 14:R102 (1 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Sensory and sympathetic nerve fibers undergo sprouting and neuroma formation in the painful arthritic joint of geriatric mice Juan M Jimenez-Andrade, Patrick W Mantyh Arthritis Research & Therapy 2012, 14:R101 (1 May 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Anti-type II collagen antibodies are associated with early radiographic destruction in rheumatoid arthritis Mohammed Mullazehi, Marius C Wick, Lars Klareskog, Ronald van Vollenhoven, Johan Rönnelid Arthritis Research & Therapy 2012, 14:R100 (1 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article The effect of three years of TNF alpha blocking therapy on markers of bone turnover and their predictive value for treatment discontinuation in patients with ankylosing spondylitis: a prospective longitudinal observational cohort study Suzanne Arends, Anneke Spoorenberg, Pieternella M Houtman, Martha K Leijsma, Reinhard Bos, Cees GM Kallenberg, Henk Groen, Elisabeth Brouwer, Eveline van der Veer Arthritis Research & Therapy 2012, 14:R98 (30 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis Angela Ceribelli, Micaela Fredi, Mara Taraborelli, Ilaria Cavazzana, Franco Franceschini, Marzia Quinzanini, Angela Tincani, Steven J Ross, Jason YF Chan, Brad A Pauley, Edward KL Chan, Minoru Satoh Arthritis Research & Therapy 2012, 14:R97 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model Misato Hashizume, Hiroto Yoshida, Keisuke Tanaka, Miho Suzuki, Isao Matsumoto, Takayuki Sumida, Masahiko Mihara Arthritis Research & Therapy 2012, 14:R96 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Interleukin-6 (IL-6) reduced the efficacy of methotrexate in a mouse arthritis model by inhibiting the expression of the reduced folate transporter SLC19A1, which is important for the uptake of methotrexate into cells.
		Review Progress in treatment of ANCA-associated vasculitis Rona M Smith, Rachel B Jones, David RW Jayne Arthritis Research & Therapy 2012, 14:210 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article The interferon type I signature towards prediction of non-response to rituximab in rheumatoid arthritis patients Hennie G Raterman, Saskia Vosslamber, Sander de Ridder, Michael T Nurmohamed, Willem F Lems, Maarten Boers, Mark van de Wiel, Ben AC Dijkmans, Cornelis L Verweij, Alexandre E Voskuyl Arthritis Research & Therapy 2012, 14:R95 (27 April 2012) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology
		Research article Bias in effect size of systemic lupus erythematosus susceptibility loci across Europe: a case-control study Elisa Alonso-Perez, Marian Suarez-Gestal, Manuel Calaza, Gian Sebastiani, Rudolf Pullmann, Chryssa Papasteriades, Attila Kovacs, Fotini N Skopouli, Marc Bijl, Ana Suarez, Maurizio Marchini, Sergio Migliaresi, Patricia Carreira, Josep Ordi-Ros, Torsten Witte, Sarka Ruzickova, Maria Santos, Nadia Barizzone, Francisco J Blanco, Bernard R Lauwerys, Juan J Gomez-Reino, Antonio Gonzalez, the European Consortium of SLE DNA Collections Arthritis Research & Therapy 2012, 14:R94 (27 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Synovial cytokine expression in psoriatic arthritis and associations with lymphoid neogenesis and clinical features Raquel Celis, Núria Planell, José L Fernández-Sueiro, Raimon Sanmartí, Julio Ramírez, Isidoro González-Álvaro, José L Pablos, Juan D Cañete Arthritis Research & Therapy 2012, 14:R93 (27 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article The renal urate transporter SLC17A1 locus: confirmation of association with gout Jade E Hollis-Moffatt, Amanda J Phipps-Green, Brett Chapman, Gregory T Jones, Andre van Rij, Peter J Gow, Andrew A Harrison, John Highton, Peter B Jones, Grant W Montgomery, Lisa K Stamp, Nicola Dalbeth, Tony R Merriman Arthritis Research & Therapy 2012, 14:R92 (27 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Thrombin induces heme oxygenase-1 expression in human synovial fibroblasts through protease-activated receptor signaling pathways Ju-Fang Liu, Sheng-Mou Hou, Chun-Hao Tsai, Chun-Yin Huang, Wei-Hung Yang, Chih-Hsin Tang Arthritis Research & Therapy 2012, 14:R91 (27 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Role of non-immune mechanisms of muscle damage in idiopathic inflammatory myopathies William Coley, Sree Rayavarapu, Kanneboyina Nagaraju Arthritis Research & Therapy 2012, 14:209 (27 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Statins accelerate the onset of collagen type II-induced arthritis in mice Rob J Vandebriel, Hilda JI De Jong, Eric R Gremmer, Olaf H Klungel, Jan-Willem Tervaert, Wout Slob, Jan Willem Van Der Laan, Henk Van Loveren Arthritis Research & Therapy 2012, 14:R90 (26 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Smoking interacts with HLA-DRB1 shared epitope in the development of anti-citrullinated protein antibody-positive rheumatoid arthritis: results from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA) Chun Too, Abqariyah Yahya, Shahnaz Murad, Jasbir Dhaliwal, Per Larsson, Nor Muhamad, Nor Abdullah, Amal Mustafa, Lars Klareskog, Lars Alfredsson, Leonid Padyukov, Camilla Bengtsson, MyEIRA study group Arthritis Research & Therapy 2012, 14:R89 (26 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Congenital heart block: evidence for a pathogenic role of maternal autoantibodies Aurélie Ambrosi, Marie Wahren-Herlenius Arthritis Research & Therapy 2012, 14:208 (26 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Suppression of endothelial cell activity by inhibition of TNFα Qiang Shu, Mohammad A Amin, Jeffrey H Ruth, Phillip L Campbell, Alisa E Koch Arthritis Research & Therapy 2012, 14:R88 (25 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast-like synoviocytes Kenji Ikuta, Yuko Waguri-Nagaya, Kae Kikuchi, Takaya Yamagami, Masahiro Nozaki, Mineyoshi Aoyama, Kiyofumi Asai, Takanobu Otsuka Arthritis Research & Therapy 2012, 14:R87 (25 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Serum BAFF and APRIL levels in patients with IgG4-related disease and their clinical significance Kazuhiro Kiyama, Daisuke Kawabata, Yuji Hosono, Koji Kitagori, Naoichiro Yukawa, Hajime Yoshifuji, Koichiro Omura, Takao Fujii, Tsuneyo Mimori Arthritis Research & Therapy 2012, 14:R86 (24 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis Lara Bossini-Castillo, Carmen P Simeon, Lorenzo Beretta, Jasper C Broen, Madelon C Vonk, Raquel Ríos-Fernández, Gerard Espinosa, Patricia Carreira, María T Camps, Maria J Castillo, Miguel A González-Gay, Emma Beltrán, María Carmen Freire, Javier Narváez, Carlos Tolosa, Torsten Witte, Alexander Kreuter, Annemie J Schuerwegh, Anna-Maria Hoffmann-Vold, Roger Hesselstrand, Claudio Lunardi, Jacob M van Laar, Meng Chee, Ariane Herrick, Bobby PC Koeleman, Christopher P Denton, Carmen Fonseca, Timothy RDJ Radstake, Javier Martin, the Spanish Scleroderma Group et al. Arthritis Research & Therapy 2012, 14:R85 (24 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review MRI and X-ray in axial spondyloarthritis: the relationship between inflammatory and structural changes Walter P Maksymowych Arthritis Research & Therapy 2012, 14:207 (19 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Identification of low-frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization Beate Böhm, Harald Burkhardt, Steffen Uebe, Maria Apel, Frank Behrens, André Reis, Ulrike Hüffmeier Arthritis Research & Therapy 2012, 14:R84 (18 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Risk of end-stage renal disease associated with gout: a nationwide population study Kuang-Hui Yu, Chang-Fu Kuo, Shue-Fen Luo, Lai-Chu See, I-Jun Chou, Hsiao-Chun Chang, Meng-Jiun Chiou Arthritis Research & Therapy 2012, 14:R83 (18 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Bone morphogenetic protein-2-induced Wnt/β-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes Ioanna Papathanasiou, Konstantinos N Malizos, Aspasia Tsezou Arthritis Research & Therapy 2012, 14:R82 (18 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study Ying Chen, Peter T Dawes, Jon C Packham, Derek L Mattey Arthritis Research & Therapy 2012, 14:R81 (18 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Antagonist-mediated down-regulation of toll-like receptors increases the prevalence of human papillomavirus infection in systemic lupus erythematosus Shui-Lian Yu, Paul KS Chan, Chun-Kwok Wong, Cheuk-Chun Szeto, Suzanne C Ho, Karine So, May MY Yu, So-Fan Yim, Tak-Hong Cheung, Martin CS Wong, Jo LK Cheung, Apple CM Yeung, Edmund K Li, Lai-Shan Tam Arthritis Research & Therapy 2012, 14:R80 (18 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Autoantibodies to transcription intermediary factor (TIF)1β associated with dermatomyositis Minoru Satoh, Jason YF Chan, Steven J Ross, Yi Li, Yoshioki Yamasaki, Hidehiro Yamada, Monica Vazquez-del Mercado, Marcelo H Petri, Luis J Jara, Miguel A Saavedra, Claudia Cruz-Reyes, Eric S Sobel, Westley H Reeves, Angela Ceribelli, Edward KL Chan Arthritis Research & Therapy 2012, 14:R79 (18 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis Kyle D Allen, Brian A Mata, Mostafa A Gabr, Janet L Huebner, Samuel B Adams, Virginia B Kraus, Daniel O Schmitt, Lori A Setton Arthritis Research & Therapy 2012, 14:R78 (17 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Circulating and synovial antibody profiling of juvenile arthritis patients by nucleic acid programmable protein arrays David S Gibson, Ji Qiu, Eliseo A Mendoza, Kristi Barker, Madeleine E Rooney, Joshua LaBaer Arthritis Research & Therapy 2012, 14:R77 (17 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Estradiol ameliorates arthritis and protects against systemic bone loss in Staphylococcus aureus infection in mice Inger Gjertsson, Marie K Lagerquist, Erik Kristiansson, Hans Carlsten, Catharina Lindholm Arthritis Research & Therapy 2012, 14:R76 (16 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4 Jing Li, Jingang Huang, Liming Dai, Degang Yu, Qian Chen, Xiaoling Zhang, Kerong Dai Arthritis Research & Therapy 2012, 14:R75 (16 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The microRNA miR-146a may reduce cellular response to transforming growth factor-beta through targeted inhibition of Smad4 in cartilage, thus increasing vascular endothelial growth factor levels, and increasing chondrocyte apoptosis.
		Research article Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis Carmen A Ambarus, Troy Noordenbos, Maria JH de Hair, Paul P Tak, Dominique LP Baeten Arthritis Research & Therapy 2012, 14:R74 (11 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Increased frequency of CCR4+ and CCR6+ memory T-cells including CCR7+CD45RA^medvery early memory cells in granulomatosis with polyangiitis (Wegener's) Ursula Fagin, Silke Pitann, Wolfgang L Gross, Peter Lamprecht Arthritis Research & Therapy 2012, 14:R73 (10 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Induction of superficial zone protein (SZP)/lubricin/PRG 4 in muscle-derived mesenchymal stem/progenitor cells by transforming growth factor-β1 and bone morphogenetic protein-7 José A Andrades, Shirley C Motaung, Pedro Jiménez-Palomo, Silvia Claros, José M López-Puerta, José Becerra, Thomas M Schmid, A Hari Reddi Arthritis Research & Therapy 2012, 14:R72 (10 April 2012) Abstract \| Full text \| PDF \| PubMed
		Correction Correction: FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development Rizwanul Haque, Fengyang Lei, Xiaofang Xiong, Yuzhang Wu, Jianxun Song Arthritis Research & Therapy 2012, 14:401 (10 April 2012) Abstract \| Full text \| PDF \| PubMed
		Editorial Knotting the NETs: Analyzing histone modifications in neutrophil extracellular traps Indira Neeli, Marko Radic Arthritis Research & Therapy 2012, 14:115 (6 April 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Bone formation rather than inflammation reflects Ankylosing Spondylitis activity on PET-CT: a pilot study Stefan TG Bruijnen, Mignon AC van der Weijden, Joannes P Klein, Otto S Hoekstra, Ronald Boellaard, J Christiaan van Denderen, Ben AC Dijkmans, Alexandre E Voskuyl, Irene E van der Horst-Bruinsma, Conny J van der Laken Arthritis Research & Therapy 2012, 14:R71 (2 April 2012) Abstract \| Full text \| PDF \| PubMed
		Review Placebo analgesia: cognitive influences on therapeutic outcome Alison Watson, Andrea Power, Christopher Brown, Wael El-Deredy, Anthony Jones Arthritis Research & Therapy 2012, 14:206 (30 March 2012) Abstract \| Full text \| PDF \| PubMed
		Editorial What is the future of CCR5 antagonists in rheumatoid arthritis? Tsutomu Takeuchi, Hideto Kameda Arthritis Research & Therapy 2012, 14:114 (30 March 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Replication study confirms the association between UBAC2 and Behçet's disease in two independent Chinese sets of patients and controls Shengping Hou, Qinmeng Shu, Zhengxuan Jiang, Yuanyuan Chen, Fuzhen Li, Feilan Chen, Aize Kijlstra, Peizeng Yang Arthritis Research & Therapy 2012, 14:R70 (29 March 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Egr-1 contributes to IL-1-mediated down-regulation of peroxisome proliferator-activated receptor γ expression in human osteoarthritic chondrocytes Sarah-Salwa Nebbaki, Fatima El Mansouri, Hassan Afif, Mohit Kapoor, Mohamed Benderdour, Nicolas Duval, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Hassan Fahmi Arthritis Research & Therapy 2012, 14:R69 (28 March 2012) Abstract \| Full text \| PDF \| PubMed
		Editorial Meryl Streep and the problems of clinical trials David A Isenberg Arthritis Research & Therapy 2012, 14:113 (23 March 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Sustained rheumatoid arthritis remission is uncommon in clinical practice Femke HM Prince, Vivian P Bykerk, Nancy A Shadick, Bing Lu, Jing Cui, Michelle Frits, Christine K Iannaccone, Michael E Weinblatt, Daniel H Solomon Arthritis Research & Therapy 2012, 14:R68 (19 March 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In clinical practice only a minority of patients with rheumatoid arthritis (RA) are in sustained remission, suggesting strict monitoring is required even once remission is reached.
		Research article Obesity and carotid atherosclerosis in African black and Caucasian women with established rheumatoid arthritis: a cross-sectional study Ahmed Solomon, Gavin R Norton, Angela J Woodiwiss, Patrick H Dessein Arthritis Research & Therapy 2012, 14:R67 (19 March 2012) Abstract \| Full text \| PDF \| PubMed