Arthritis Research & Therapy

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		Research article Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis Rowan Hardy, Maria Juarez, Amy Naylor, Jinwen Tu, Elizabeth H Rabbitt, Andrew Filer, Paul M Stewart, Christopher D Buckley, Karim Raza, Mark S Cooper Arthritis Research & Therapy 2012, 14:R226 (18 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2 Joachim Pircher, Monika Merkle, Markus Wörnle, Andrea Ribeiro, Thomas Czermak, Yvonn Stampnik, Hanna Mannell, Markus Niemeyer, Volker Vielhauer, Florian Krötz Arthritis Research & Therapy 2012, 14:R225 (18 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Osteogenesis and osteoclast inhibition in rheumatoid arthritis patients treated with bisphosphonates alone or in combination with pitavastatin over an 18-month follow-up after more than 4 years of treatment with bisphosphonates Masakazu Nagashima, Hiroshi Takahashi, Kenichi Shimane, Yuichi Nagase, Koichi Wauke Arthritis Research & Therapy 2012, 14:R224 (18 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis Qin Shi, Jamilah Abusarah, Ghayath Baroudi, Julio C Fernandes, Hassan Fahmi, Mohamed Benderdour Arthritis Research & Therapy 2012, 14:R223 (18 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Periodontitis in established rheumatoid arthritis patients: a cross-sectional clinical, microbiological and serological study Menke Smit, Johanna Westra, Arjan Vissink, Berber Doornbos-van der Meer, Elisabeth Brouwer, Arie van Winkelhoff Arthritis Research & Therapy 2012, 14:R222 (17 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation Benjamin Terrier, Nicolas Derian, Yoland Schoindre, Wahiba Chaara, Guillaume Geri, Noël Zahr, Kubéraka Mariampillai, Michelle Rosenzwajg, Wassila Carpentier, Lucile Musset, Jean-Charles Piette, Adrien Six, David Klatzmann, David Saadoun, Cacoub Patrice, Nathalie Costedoat-Chalumeau Arthritis Research & Therapy 2012, 14:R221 (17 October 2012) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology \| Editor’s summary Vitamin D supplementation in systemic lupus erythematosus (SLE) patients caused a reduction in B memory cells and effector T cells, and an increase in Tregs, suggesting vitamin D provides beneficial immunological effects for SLE.
		Research article Aberrant cytokine pattern of the nasal mucosa in granulomatosis with polyangiitis Janet Wohlers, Katrin Breucker, Rainer Podschun, Jürgen Hedderich, Peter Lamprecht, Petra Ambrosch, Martin Laudien Arthritis Research & Therapy 2012, 14:R203 (17 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Does digital X-ray radiogrammetry have a role in identifying patients at increased risk for joint destruction in early rheumatoid arthritis? Kristina Forslind, Johan Kälvesten, Ingiäld Hafström, Björn Svensson, for the BARFOT Study Group Arthritis Research & Therapy 2012, 14:R219 (15 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Change in bone mineral density measured by digital X-ray radiogrammetry (DXR) in the first year of rheumatoid arthritis is associated with progression of radiographic joint damage over a number of years.
		Research article Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity Aditya K Panda, Jyoti R Parida, Rina Tripathy, Sarit S Pattanaik, Balachandran Ravindran, Bidyut K Das Arthritis Research & Therapy 2012, 14:R218 (15 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article A randomized, double-blind, multicenter, placebo-controlled phase III trial to evaluate the efficacy and safety of pregabalin in Japanese patients with fibromyalgia Hiroyoshi Ohta, Hiroshi Oka, Chie Usui, Masayuki Ohkura, Makoto Suzuki, Kusuki Nishioka Arthritis Research & Therapy 2012, 14:R217 (12 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Low sclerostin levels: a predictive marker of persistent inflammation in ankylosing spondylitis during anti-tumor necrosis factor therapy? Carla GS Saad, Ana CM Ribeiro, Julio CB Moraes, Liliam Takayama, Celio R Goncalves, Marcelo B Rodrigues, Ricardo M de Oliveira, Clovis A Silva, Eloisa Bonfa, Rosa MR Pereira Arthritis Research & Therapy 2012, 14:R216 (12 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Persistent low serum levels of the Wnt inhibitor sclerostin are associated with continuous inflammation in patients with ankylosing spondylitis being treated with anti-TNF therapy.
		Research article Sleep disturbances are associated with increased pain, disease activity, depression, and anxiety in ankylosing spondylitis: a case-control study Yan Li, Shengli Zhang, Jian Zhu, Xuna Du, Feng Huang Arthritis Research & Therapy 2012, 14:R215 (11 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort Darren Plant, Ibrahim Ibrahim, Mark Lunt, Stephen Eyre, Edward Flynn, Kimme L Hyrich, Ann W Morgan, Anthony G Wilson, John D Isaacs, BRAGGGSS, Anne Barton Arthritis Research & Therapy 2012, 14:R214 (7 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Predictors of mortality in connective tissue disease-associated pulmonary arterial hypertension: a cohort study Gene-Siew Ngian, Wendy Stevens, David Prior, Eli Gabbay, Janet Roddy, Ai Tran, Robert Minson, Catherine Hill, Ken Chow, Joanne Sahhar, Susanna Proudman, Mandana Nikpour Arthritis Research & Therapy 2012, 14:R213 (5 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Biomechanical factors and physical examination findings in osteoarthritis of the knee: associations with tissue abnormalities assessed by conventional radiography and high-resolution 3.0 Tesla magnetic resonance imaging Jesper Knoop, Joost Dekker, Jan-Paul Klein, Marike van der Leeden, Martin van der Esch, Dick Reiding, Ramon E Voorneman, Martijn Gerritsen, Leo D Roorda, Martijn PM Steultjens, Willem F Lems Arthritis Research & Therapy 2012, 14:R212 (5 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Hepatic steatosis, carotid plaques and achieving MDA in psoriatic arthritis patients starting TNF-α blockers treatment: a prospective study Matteo Nicola Dario Di Minno, Rosario Peluso, Salvatore Iervolino, Roberta Lupoli, Anna Russolillo, Giovanni Tarantino, Raffaele Scarpa Arthritis Research & Therapy 2012, 14:R211 (4 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article TLR4-mediated IL-12 production enhances IFN-γ and IL-1β production, which inhibits TGF-β production and promotes antibody-induced joint inflammation Hye Kim, Doo Chung Arthritis Research & Therapy 2012, 14:R210 (4 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Impaired skeletal muscle microcirculation in systemic sclerosis Sasan Partovi, Anja-Carina Schulte, Markus Aschwanden, Daniel Staub, Daniela Benz, Stephan Imfeld, Björn Jacobi, Pavel Broz, Kurt A Jäger, Martin Takes, Rolf W Huegli, Deniz Bilecen, Ulrich A Walker Arthritis Research & Therapy 2012, 14:R209 (4 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis Marina G Kazantseva, John Highton, Lisa K Stamp, Paul A Hessian Arthritis Research & Therapy 2012, 14:R208 (4 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Functional relationship between high mobility group A1 (HMGA1) protein and insulin-like growth factor-binding protein 3 (IGFBP-3) in human chondrocytes Giorgio Gasparini, Marco De Gori, Francesco Paonessa, Eusebio Chiefari, Antonio Brunetti, Olimpio Galasso Arthritis Research & Therapy 2012, 14:R207 (4 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Targeting tumour necrosis factor alleviates signs and symptoms of inflammatory osteoarthritis of the knee Walter P Maksymowych, Anthony S Russell, Peter Chiu, Alex Yan, Niall Jones, Tracey Clare, Robert GW Lambert Arthritis Research & Therapy 2012, 14:R206 (4 October 2012) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology
		Research article Chondrocalcinosis is common in the absence of knee involvement Abhishek Abhishek, Sally Doherty, Rose Maciewicz, Kenneth Muir, Weiya Zhang, Michael Doherty Arthritis Research & Therapy 2012, 14:R205 (4 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Association of circulating levels of MMP-8 with mortality from respiratory disease in patients with rheumatoid arthritis Derek L Mattey, Nicola B Nixon, Peter T Dawes Arthritis Research & Therapy 2012, 14:R204 (2 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Secretome analysis of chondroitin sulfate-treated chondrocytes reveals anti-angiogenic, anti-inflammatory and anti-catabolic properties Valentina Calamia, Lucía Lourido, Patricia Fernández-Puente, Jesús Mateos, Beatriz Rocha, Eulalia Montell, Josep Vergés, Cristina Ruiz-Romero, Francisco J Blanco Arthritis Research & Therapy 2012, 14:R202 (2 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Validation of a multiplex chip-based assay for the detection of autoantibodies against citrullinated peptides Monika Hansson, Linda Mathsson, Thomas Schlederer, Lena Israelsson, Per Matsson, Leonor Nogueira, Per-Johan Jakobsson, Karin Lundberg, Vivianne Malmström, Guy Serre, Rikard Holmdahl, Mats Nystrand, Lars Klareskog, Johan Rönnelid Arthritis Research & Therapy 2012, 14:R201 (1 October 2012) Abstract \| Full text \| PDF \| PubMed

	All
		Research article Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis Rowan Hardy, Maria Juarez, Amy Naylor, Jinwen Tu, Elizabeth H Rabbitt, Andrew Filer, Paul M Stewart, Christopher D Buckley, Karim Raza, Mark S Cooper Arthritis Research & Therapy 2012, 14:R226 (18 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2 Joachim Pircher, Monika Merkle, Markus Wörnle, Andrea Ribeiro, Thomas Czermak, Yvonn Stampnik, Hanna Mannell, Markus Niemeyer, Volker Vielhauer, Florian Krötz Arthritis Research & Therapy 2012, 14:R225 (18 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Osteogenesis and osteoclast inhibition in rheumatoid arthritis patients treated with bisphosphonates alone or in combination with pitavastatin over an 18-month follow-up after more than 4 years of treatment with bisphosphonates Masakazu Nagashima, Hiroshi Takahashi, Kenichi Shimane, Yuichi Nagase, Koichi Wauke Arthritis Research & Therapy 2012, 14:R224 (18 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis Qin Shi, Jamilah Abusarah, Ghayath Baroudi, Julio C Fernandes, Hassan Fahmi, Mohamed Benderdour Arthritis Research & Therapy 2012, 14:R223 (18 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Periodontitis in established rheumatoid arthritis patients: a cross-sectional clinical, microbiological and serological study Menke Smit, Johanna Westra, Arjan Vissink, Berber Doornbos-van der Meer, Elisabeth Brouwer, Arie van Winkelhoff Arthritis Research & Therapy 2012, 14:R222 (17 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation Benjamin Terrier, Nicolas Derian, Yoland Schoindre, Wahiba Chaara, Guillaume Geri, Noël Zahr, Kubéraka Mariampillai, Michelle Rosenzwajg, Wassila Carpentier, Lucile Musset, Jean-Charles Piette, Adrien Six, David Klatzmann, David Saadoun, Cacoub Patrice, Nathalie Costedoat-Chalumeau Arthritis Research & Therapy 2012, 14:R221 (17 October 2012) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology \| Editor’s summary Vitamin D supplementation in systemic lupus erythematosus (SLE) patients caused a reduction in B memory cells and effector T cells, and an increase in Tregs, suggesting vitamin D provides beneficial immunological effects for SLE.
		Research article Aberrant cytokine pattern of the nasal mucosa in granulomatosis with polyangiitis Janet Wohlers, Katrin Breucker, Rainer Podschun, Jürgen Hedderich, Peter Lamprecht, Petra Ambrosch, Martin Laudien Arthritis Research & Therapy 2012, 14:R203 (17 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Does digital X-ray radiogrammetry have a role in identifying patients at increased risk for joint destruction in early rheumatoid arthritis? Kristina Forslind, Johan Kälvesten, Ingiäld Hafström, Björn Svensson, for the BARFOT Study Group Arthritis Research & Therapy 2012, 14:R219 (15 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Change in bone mineral density measured by digital X-ray radiogrammetry (DXR) in the first year of rheumatoid arthritis is associated with progression of radiographic joint damage over a number of years.
		Research article Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity Aditya K Panda, Jyoti R Parida, Rina Tripathy, Sarit S Pattanaik, Balachandran Ravindran, Bidyut K Das Arthritis Research & Therapy 2012, 14:R218 (15 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article A randomized, double-blind, multicenter, placebo-controlled phase III trial to evaluate the efficacy and safety of pregabalin in Japanese patients with fibromyalgia Hiroyoshi Ohta, Hiroshi Oka, Chie Usui, Masayuki Ohkura, Makoto Suzuki, Kusuki Nishioka Arthritis Research & Therapy 2012, 14:R217 (12 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Low sclerostin levels: a predictive marker of persistent inflammation in ankylosing spondylitis during anti-tumor necrosis factor therapy? Carla GS Saad, Ana CM Ribeiro, Julio CB Moraes, Liliam Takayama, Celio R Goncalves, Marcelo B Rodrigues, Ricardo M de Oliveira, Clovis A Silva, Eloisa Bonfa, Rosa MR Pereira Arthritis Research & Therapy 2012, 14:R216 (12 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Persistent low serum levels of the Wnt inhibitor sclerostin are associated with continuous inflammation in patients with ankylosing spondylitis being treated with anti-TNF therapy.
		Research article Sleep disturbances are associated with increased pain, disease activity, depression, and anxiety in ankylosing spondylitis: a case-control study Yan Li, Shengli Zhang, Jian Zhu, Xuna Du, Feng Huang Arthritis Research & Therapy 2012, 14:R215 (11 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort Darren Plant, Ibrahim Ibrahim, Mark Lunt, Stephen Eyre, Edward Flynn, Kimme L Hyrich, Ann W Morgan, Anthony G Wilson, John D Isaacs, BRAGGGSS, Anne Barton Arthritis Research & Therapy 2012, 14:R214 (7 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Predictors of mortality in connective tissue disease-associated pulmonary arterial hypertension: a cohort study Gene-Siew Ngian, Wendy Stevens, David Prior, Eli Gabbay, Janet Roddy, Ai Tran, Robert Minson, Catherine Hill, Ken Chow, Joanne Sahhar, Susanna Proudman, Mandana Nikpour Arthritis Research & Therapy 2012, 14:R213 (5 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Biomechanical factors and physical examination findings in osteoarthritis of the knee: associations with tissue abnormalities assessed by conventional radiography and high-resolution 3.0 Tesla magnetic resonance imaging Jesper Knoop, Joost Dekker, Jan-Paul Klein, Marike van der Leeden, Martin van der Esch, Dick Reiding, Ramon E Voorneman, Martijn Gerritsen, Leo D Roorda, Martijn PM Steultjens, Willem F Lems Arthritis Research & Therapy 2012, 14:R212 (5 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Hepatic steatosis, carotid plaques and achieving MDA in psoriatic arthritis patients starting TNF-α blockers treatment: a prospective study Matteo Nicola Dario Di Minno, Rosario Peluso, Salvatore Iervolino, Roberta Lupoli, Anna Russolillo, Giovanni Tarantino, Raffaele Scarpa Arthritis Research & Therapy 2012, 14:R211 (4 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article TLR4-mediated IL-12 production enhances IFN-γ and IL-1β production, which inhibits TGF-β production and promotes antibody-induced joint inflammation Hye Kim, Doo Chung Arthritis Research & Therapy 2012, 14:R210 (4 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Impaired skeletal muscle microcirculation in systemic sclerosis Sasan Partovi, Anja-Carina Schulte, Markus Aschwanden, Daniel Staub, Daniela Benz, Stephan Imfeld, Björn Jacobi, Pavel Broz, Kurt A Jäger, Martin Takes, Rolf W Huegli, Deniz Bilecen, Ulrich A Walker Arthritis Research & Therapy 2012, 14:R209 (4 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis Marina G Kazantseva, John Highton, Lisa K Stamp, Paul A Hessian Arthritis Research & Therapy 2012, 14:R208 (4 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Functional relationship between high mobility group A1 (HMGA1) protein and insulin-like growth factor-binding protein 3 (IGFBP-3) in human chondrocytes Giorgio Gasparini, Marco De Gori, Francesco Paonessa, Eusebio Chiefari, Antonio Brunetti, Olimpio Galasso Arthritis Research & Therapy 2012, 14:R207 (4 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Targeting tumour necrosis factor alleviates signs and symptoms of inflammatory osteoarthritis of the knee Walter P Maksymowych, Anthony S Russell, Peter Chiu, Alex Yan, Niall Jones, Tracey Clare, Robert GW Lambert Arthritis Research & Therapy 2012, 14:R206 (4 October 2012) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology
		Research article Chondrocalcinosis is common in the absence of knee involvement Abhishek Abhishek, Sally Doherty, Rose Maciewicz, Kenneth Muir, Weiya Zhang, Michael Doherty Arthritis Research & Therapy 2012, 14:R205 (4 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Association of circulating levels of MMP-8 with mortality from respiratory disease in patients with rheumatoid arthritis Derek L Mattey, Nicola B Nixon, Peter T Dawes Arthritis Research & Therapy 2012, 14:R204 (2 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Secretome analysis of chondroitin sulfate-treated chondrocytes reveals anti-angiogenic, anti-inflammatory and anti-catabolic properties Valentina Calamia, Lucía Lourido, Patricia Fernández-Puente, Jesús Mateos, Beatriz Rocha, Eulalia Montell, Josep Vergés, Cristina Ruiz-Romero, Francisco J Blanco Arthritis Research & Therapy 2012, 14:R202 (2 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Validation of a multiplex chip-based assay for the detection of autoantibodies against citrullinated peptides Monika Hansson, Linda Mathsson, Thomas Schlederer, Lena Israelsson, Per Matsson, Leonor Nogueira, Per-Johan Jakobsson, Karin Lundberg, Vivianne Malmström, Guy Serre, Rikard Holmdahl, Mats Nystrand, Lars Klareskog, Johan Rönnelid Arthritis Research & Therapy 2012, 14:R201 (1 October 2012) Abstract \| Full text \| PDF \| PubMed