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Comparative analysis of collagen type II-specific immune responses during development of collagen-induced arthritis in two B10 mouse strains
Tsvetelina Batsalova, Ingrid Lindh, Johan Bäcklund, Balik Dzhambazov, Rikard Holmdahl Arthritis Research & Therapy 2012, 14:R237 (1 November 2012)
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Noninvasive optical characterization of muscle blood flow, oxygenation, and metabolism in women with fibromyalgia
Yu Shang, Katelyn Gurley, Brock Symons, Douglas Long, Ratchakrit Srikuea, Leslie J Crofford, Charlotte A Peterson, Guoqiang Yu Arthritis Research & Therapy 2012, 14:R236 (1 November 2012)
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Y27, a novel derivative of 4-hydroxyquinoline-3-formamide, prevents the development of murine systemic lupus erythematosus-like diseases in MRL/lpr autoimmune mice and BDF1 hybrid mice
Zhi-Yong Xiao, Shao-Hui Chen, Jun-Ping Cheng, Wen-Xia Zhou, Yong-Xiang Zhang, Ri-Fang Yang, Liu-Hong Yun Arthritis Research & Therapy 2012, 14:R235 (1 November 2012)
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Deletion of interferon-γ delays onset and severity of dacryoadenitis in CD25KO mice
Flavia SA Pelegrino, Eugene A Volpe, Niral B Gandhi, De-Quan Li, Stephen C Pflugfelder, Cintia S de Paiva Arthritis Research & Therapy 2012, 14:R234 (1 November 2012)
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New insight into the functions of the interleukin-17 receptor adaptor protein Act1 in psoriatic arthritis
Matthew S Doyle, Emily S Collins, Oliver M FitzGerald, Stephen R Pennington Arthritis Research & Therapy 2012, 14:226 (31 October 2012)
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Muscle-fiber transdifferentiation in an experimental model of respiratory chain myopathy
Nils Venhoff, Dirk Lebrecht, Dietmar Pfeifer, Ana C Venhoff, Emmanuel Bissé, Janbernd Kirschner, Ulrich A Walker Arthritis Research & Therapy 2012, 14:R233 (29 October 2012)
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Leflunomide increases the risk of silent liver fibrosis in patients with rheumatoid arthritis receiving methotrexate
Sang-Won Lee, Hee-Jin Park, Beom Kim, Kwang-Hyub Han, Soo-Kon Lee, Seung Kim, Yong-Beom Park Arthritis Research & Therapy 2012, 14:R232 (29 October 2012)
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Editor’s summary
Cumulative dose of leflunomide correlated closely with the presence of silent liver fibrosis in rheumatoid arthritis patients treated with methotrexate.
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Sulforaphane has opposing effects on TNF-alpha stimulated and unstimulated synoviocytes
Athanassios Fragoulis, Jendrik Laufs, Susanna Müller, Ulf Soppa, Stephanie Siegl, Lucy Reiss, Mersedeh Tohidnezhad, Christian Rosen, Klaus Tenbrock, Deike Varoga, Sebastian Lippross, Thomas Pufe, Christoph Wruck Arthritis Research & Therapy 2012, 14:R220 (27 October 2012)
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Changes in pain catastrophizing predict later changes in fibromyalgia clinical and experimental pain report: cross-lagged panel analyses of dispositional and situational catastrophizing
Claudia M Campbell, Lea McCauley, Sara C Bounds, Vani A Mathur, Lora Conn, Mpepera Simango, Robert R Edwards, Kevin R Fontaine Arthritis Research & Therapy 2012, 14:R231 (25 October 2012)
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Double-blind, placebo-controlled randomized trial with adalimumab for treatment of juvenile onset ankylosing spondylitis (JoAS): significant short term improvement
Gerd Horneff, Sigrid Fitter, Ivan Foeldvari, Kirsten Minden, Jasmin Kuemmerle-Deschner, Nicolay Tzaribacev, Angelika Thon, Michael Borte, Gerd Ganser, Rolf Trauzeddel, Hans-Iko Huppertz Arthritis Research & Therapy 2012, 14:R230 (24 October 2012)
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Editor’s summary
A double-blind randomized trial found adalimumab treatment was significantly superior to placebo in the treatment of juvenile onset ankylosing spondylitis (AS), being well tolerated and highly effective.
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The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy
Feng Fang, Lei Liu, Yang Yang, Zenshiro Tamaki, Jun Wei, Roberta G Marangoni, Swati Bhattacharyya, Ross S Summer, Boping Ye, John Varga Arthritis Research & Therapy 2012, 14:R229 (23 October 2012)
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Editor’s summary
Activation of the adiponectin pathway has potent antifibrotic effects in normal and scleroderma fibroblasts, and is a potential therapeutic target to control fibrosis in scleroderma and other chronic fibrosing conditions.
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Interleukin-29 modulates proinflammatory cytokine production in synovial inflammation of rheumatoid arthritis
Fang Wang, Lingxiao Xu, Xiaoke Feng, Dunming Guo, Wenfeng Tan, Miaojia Zhang Arthritis Research & Therapy 2012, 14:R228 (19 October 2012)
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Th17 expansion in granulomatosis with polyangiitis (Wegener's): the role of disease activity, immune regulation and therapy
Benjamin Wilde, Marielle Thewissen, Jan Damoiseaux, Marc Hilhorst, Pieter van Paassen, Oliver Witzke, Jan Cohen Tervaert Arthritis Research & Therapy 2012, 14:R227 (18 October 2012)
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Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis
Rowan Hardy, Maria Juarez, Amy Naylor, Jinwen Tu, Elizabeth H Rabbitt, Andrew Filer, Paul M Stewart, Christopher D Buckley, Karim Raza, Mark S Cooper Arthritis Research & Therapy 2012, 14:R226 (18 October 2012)
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Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2
Joachim Pircher, Monika Merkle, Markus Wörnle, Andrea Ribeiro, Thomas Czermak, Yvonn Stampnik, Hanna Mannell, Markus Niemeyer, Volker Vielhauer, Florian Krötz Arthritis Research & Therapy 2012, 14:R225 (18 October 2012)
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Osteogenesis and osteoclast inhibition in rheumatoid arthritis patients treated with bisphosphonates alone or in combination with pitavastatin over an 18-month follow-up after more than 4 years of treatment with bisphosphonates
Masakazu Nagashima, Hiroshi Takahashi, Kenichi Shimane, Yuichi Nagase, Koichi Wauke Arthritis Research & Therapy 2012, 14:R224 (18 October 2012)
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Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis
Qin Shi, Jamilah Abusarah, Ghayath Baroudi, Julio C Fernandes, Hassan Fahmi, Mohamed Benderdour Arthritis Research & Therapy 2012, 14:R223 (18 October 2012)
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Periodontitis in established rheumatoid arthritis patients: a cross-sectional clinical, microbiological and serological study
Menke Smit, Johanna Westra, Arjan Vissink, Berber Doornbos-van der Meer, Elisabeth Brouwer, Arie van Winkelhoff Arthritis Research & Therapy 2012, 14:R222 (17 October 2012)
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Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation
Benjamin Terrier, Nicolas Derian, Yoland Schoindre, Wahiba Chaara, Guillaume Geri, Noël Zahr, Kubéraka Mariampillai, Michelle Rosenzwajg, Wassila Carpentier, Lucile Musset, Jean-Charles Piette, Adrien Six, David Klatzmann, David Saadoun, Cacoub Patrice, Nathalie Costedoat-Chalumeau Arthritis Research & Therapy 2012, 14:R221 (17 October 2012)
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Editor’s summary
Vitamin D supplementation in systemic lupus erythematosus (SLE) patients caused a reduction in B memory cells and effector T cells, and an increase in Tregs, suggesting vitamin D provides beneficial immunological effects for SLE.
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Aberrant cytokine pattern of the nasal mucosa in granulomatosis with polyangiitis
Janet Wohlers, Katrin Breucker, Rainer Podschun, Jürgen Hedderich, Peter Lamprecht, Petra Ambrosch, Martin Laudien Arthritis Research & Therapy 2012, 14:R203 (17 October 2012)
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Does digital X-ray radiogrammetry have a role in identifying patients at increased risk for joint destruction in early rheumatoid arthritis?
Kristina Forslind, Johan Kälvesten, Ingiäld Hafström, Björn Svensson, for the BARFOT Study Group Arthritis Research & Therapy 2012, 14:R219 (15 October 2012)
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Editor’s summary
Change in bone mineral density measured by digital X-ray radiogrammetry (DXR) in the first year of rheumatoid arthritis is associated with progression of radiographic joint damage over a number of years.
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Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity
Aditya K Panda, Jyoti R Parida, Rina Tripathy, Sarit S Pattanaik, Balachandran Ravindran, Bidyut K Das Arthritis Research & Therapy 2012, 14:R218 (15 October 2012)
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A randomized, double-blind, multicenter, placebo-controlled phase III trial to evaluate the efficacy and safety of pregabalin in Japanese patients with fibromyalgia
Hiroyoshi Ohta, Hiroshi Oka, Chie Usui, Masayuki Ohkura, Makoto Suzuki, Kusuki Nishioka Arthritis Research & Therapy 2012, 14:R217 (12 October 2012)
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Low sclerostin levels: a predictive marker of persistent inflammation in ankylosing spondylitis during anti-tumor necrosis factor therapy?
Carla GS Saad, Ana CM Ribeiro, Julio CB Moraes, Liliam Takayama, Celio R Goncalves, Marcelo B Rodrigues, Ricardo M de Oliveira, Clovis A Silva, Eloisa Bonfa, Rosa MR Pereira Arthritis Research & Therapy 2012, 14:R216 (12 October 2012)
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Editor’s summary
Persistent low serum levels of the Wnt inhibitor sclerostin are associated with continuous inflammation in patients with ankylosing spondylitis being treated with anti-TNF therapy.
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Sleep disturbances are associated with increased pain, disease activity, depression, and anxiety in ankylosing spondylitis: a case-control study
Yan Li, Shengli Zhang, Jian Zhu, Xuna Du, Feng Huang Arthritis Research & Therapy 2012, 14:R215 (11 October 2012)
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