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Research article   Open Access Highly Accessed

The neuropeptide neuromedin U promotes autoantibody-mediated arthritis

Sindhuja M Rao, Jennifer L Auger, Philippe Gaillard, Ralph Weissleder, Etsuko Wada, Richard Torres, Masayasu Kojima, Christophe Benoist, Diane Mathis, Bryce A Binstadt Arthritis Research & Therapy 2012, 14:R29 (7 February 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Neuromedin U (NMU), a neuropeptide produced by bone-marrow-derived cells, promotes autoantibody-mediated arthritis in mice, suggesting NMU may be a potential therapeutic target in inflammatory arthritis.

Research article   Open Access

Low copy number of the FCGR3B gene and rheumatoid arthritis: a case-control study and meta-analysis

Scott W Graf, Sue Lester, Johannes C Nossent, Catherine L Hill, Susanna M Proudman, Anita Lee, Maureen Rischmueller Arthritis Research & Therapy 2012, 14:R28 (7 February 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Takayasu's arteritis is associated with HLA-B*52, but not with HLA-B*51, in Turkey

Ziver Sahin, Muge Bıcakcıgil, Kenan Aksu, Sevil Kamali, Servet Akar, Fatos Onen, Omer Karadag, Zeynep Ozbalkan, Askin Ates, Huseyin TE Ozer, Vuslat Yilmaz, Emire Seyahi, Mehmet A Ozturk, Ayse Cefle, Veli Cobankara, A Mesut Onat, Ercan Tunc, Nursen Düzgün, Sibel Z Aydin, Neslihan Yilmaz, İzzet Fresko, Yasar Karaaslan, Sedat Kiraz, Nurullah Akkoc, Murat Inanc, Gokhan Keser, F Aytul Uyar, Haner Direskeneli, Güher Saruhan-Direskeneli, the Turkish Takayasu Study Group et al. Arthritis Research & Therapy 2012, 14:R27 (6 February 2012)

Abstract | Full text | PDF | PubMed

Editorial   Free

Pre-disease pregnancy complications and systemic sclerosis: pathogenic or pre-clinical?

Eliza Chakravarty Arthritis Research & Therapy 2012, 14:102 (6 February 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

An in vivo investigation of the initiation and progression of subchondral cysts in a rodent model of secondary osteoarthritis

David D McErlain, Veronica Ulici, Mark Darling, Joseph S Gati, Vasek Pitelka, Frank Beier, David W Holdsworth Arthritis Research & Therapy 2012, 14:R26 (3 February 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies

Chih Liu, Stephanie Tangsombatvisit, Jacob M Rosenberg, Gil Mandelbaum, Emily C Gillespie, Or P Gozani, Ash A Alizadeh, Paul J Utz Arthritis Research & Therapy 2012, 14:R25 (2 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

A profile of immune response to herpesvirus is associated with radiographic joint damage in rheumatoid arthritis

John M Davis, Keith L Knutson, John A Skinner, Michael A Strausbauch, Cynthia S Crowson, Terry M Therneau, Peter J Wettstein, Eric L Matteson, Sherine E Gabriel Arthritis Research & Therapy 2012, 14:R24 (31 January 2012)

Abstract | Full text | PDF | PubMed

Review   Free Highly Accessed

Therapy of lupus nephritis: lessons learned from clinical research and daily care of patients

Frédéric A Houssiau Arthritis Research & Therapy 2012, 14:202 (31 January 2012)

Abstract | Full text | PDF | PubMed | F1000 Biology

Research article   Open Access

Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes

Raghunatha R Yammani, Richard F Loeser Arthritis Research & Therapy 2012, 14:R23 (30 January 2012)

Abstract | Full text | PDF | PubMed

Review   Free Highly Accessed

Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis?

Yves Henrotin, Ali Mobasheri, Marc Marty Arthritis Research & Therapy 2012, 14:201 (30 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Predictors of survival in a cohort of patients with polymyositis and dermatomyositis: effect of corticosteroids, methotrexate and azathioprine

Elena Schiopu, Kristine Phillips, Paul M MacDonald, Leslie J Crofford, Emily C Somers Arthritis Research & Therapy 2012, 14:R22 (27 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

A randomised controlled trial of a self-management education program for osteoarthritis of the knee delivered by health care professionals

Sophie Coleman, N Kathryn Briffa, Graeme Carroll, Charles Inderjeeth, Nicola Cook, Jean McQuade Arthritis Research & Therapy 2012, 14:R21 (27 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Local administration of glucocorticoids decreases synovial citrullination in rheumatoid arthritis

Dimitrios Makrygiannakis, Shankar Revu, Marianne Engström, Erik af Klint, Anthony P Nicholas, Ger JM Pruijn, Anca I Catrina Arthritis Research & Therapy 2012, 14:R20 (27 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Glucocorticoid reduced levels of protein citrullination and the enzyme peptidylargininedeiminase 4 (PAD4) in the joints of patients with rheumatoid arthritis, and this was matched by a decrease in visible signs of inflammation.

Research article   Open Access

Restrictive pulmonary function is more prevalent in patients with ankylosing spondylitis than in matched population controls and is associated with impaired spinal mobility: a comparative study

Gunnhild Berdal, Silje Halvorsen, Désirée van der Heijde, Morten Mowe, Hanne Dagfinrud Arthritis Research & Therapy 2012, 14:R19 (25 January 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Reduced spinal mobility is associated with restrictive pulmonary function in patients with ankylosing spondylitis, emphasizing the importance of maintaining spinal flexibility in the management of the disease.

Research article   Open Access

Neutralization of IL-17 ameliorates uveitis but damages photoreceptors in a murine model of spondyloarthritis

Jelena M Kezic, Tibor T Glant, James T Rosenbaum, Holly L Rosenzweig Arthritis Research & Therapy 2012, 14:R18 (23 January 2012)

Abstract | Full text | PDF | PubMed | F1000 Biology

Research article   Open Access

Effect of in utero exposure to diethylstilbestrol on lumbar and femoral bone, articular cartilage, and the intervertebral disc in male and female adult mice progeny with and without swimming exercise

Sora Rowas, Rami Haddad, Rahul Gawri, Abdul Al Ma'awi, Lorraine E Chalifour, John Antoniou, Fackson Mwale Arthritis Research & Therapy 2012, 14:R17 (23 January 2012)

Abstract | Full text | PDF | PubMed

Editorial   Free Highly Accessed

Autoimmunity induced by human cytomegalovirus in patients with systemic lupus erythematosus

Cecilia Söderberg-Nauclér Arthritis Research & Therapy 2012, 14:101 (23 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Tight regulation of wingless-type signaling in the articular cartilage - subchondral bone biomechanical unit: transcriptomics in Frzb-knockout mice

Liesbet Lodewyckx, Frédéric Cailotto, Sarah Thysen, Frank P Luyten, Rik J Lories Arthritis Research & Therapy 2012, 14:R16 (20 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Serum COMP-C3b complexes in rheumatic diseases and relation to anti-TNF-α treatment

Kaisa E Happonen, Tore Saxne, Pierre Geborek, Maria Andersson, Anders A Bengtsson, Roger Hesselstrand, Dick Heinegård, Anna M Blom Arthritis Research & Therapy 2012, 14:R15 (20 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis

Seung-Jun Hwang, Bongkun Choi, Soon-Suk Kang, Jae-Ho Chang, Yong-Gil Kim, Yeon-Ho Chung, Dong Sohn, Min So, Chang-Keun Lee, William H Robinson, Eun-Ju Chang Arthritis Research & Therapy 2012, 14:R14 (20 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

A longitudinal study of the association between dietary factors, serum lipids, and bone marrow lesions of the knee

Dawn Doré, Jonathon de Hoog, Graham Giles, Changhai Ding, Flavia Cicuttini, Graeme Jones Arthritis Research & Therapy 2012, 14:R13 (18 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

The distribution pattern of critically short telomeres in human osteoarthritic knees

Maria Harbo, Laila Bendix, Anne-Christine Bay-Jensen, Jesper Graakjaer, Kent Søe, Thomas L Andersen, Per Kjaersgaard-Andersen, Steen Koelvraa, Jean-Marie Delaisse Arthritis Research & Therapy 2012, 14:R12 (18 January 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

An increase in the number of cells with ultra short telomeres is associated with increased severity of osteoarthritis, proximity to the most damaged section of the joint, and with senescence.

Research article   Open Access

A 4-trifluoromethyl analogue of celecoxib inhibits arthritis by suppressing innate immune cell activation

Asako Chiba, Miho Mizuno, Chiharu Tomi, Ryohsuke Tajima, Iraide Alloza, Alessandra di Penta, Takashi Yamamura, Koen Vandenbroeck, Sachiko Miyake Arthritis Research & Therapy 2012, 14:R9 (17 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Identification and evaluation of novel synovial tissue biomarkers in rheumatoid arthritis by laser scanning cytometry

Christiane Fueldner, Anja Mittag, Jens Knauer, Maria Biskop, Pierre Hepp, Roger Scholz, Ulf Wagner, Ulrich Sack, Frank Emmrich, Attila Tárnok, Joerg Lehmann Arthritis Research & Therapy 2012, 14:R8 (17 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Maraviroc, a chemokine receptor-5 antagonist, fails to demonstrate efficacy in the treatment of patients with rheumatoid arthritis in a randomized, double-blind placebo-controlled trial

Dona L Fleishaker, Juan A Garcia Meijide, Andriy Petrov, Michael Kohen, Xin Wang, Sujatha Menon, Thomas C Stock, Charles A Mebus, James M Goodrich, Howard B Mayer, Bernhardt G Zeiher Arthritis Research & Therapy 2012, 14:R11 (17 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Hyperuricemia and untreated gout are poor prognostic markers among those with a recent acute myocardial infarction

Eswar Krishnan, Bhavik J Pandya, Bharathi Lingala, Ali Hariri, Omar Dabbous Arthritis Research & Therapy 2012, 14:R10 (17 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

Dong Sohn, Jeremy Sokolove, Orr Sharpe, Jennifer C Erhart, Piyanka E Chandra, Lauren J Lahey, Tamsin M Lindstrom, Inyong Hwang, Katherine A Boyer, Thomas P Andriacchi, William H Robinson Arthritis Research & Therapy 2012, 14:R7 (8 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Safety, pharmacokinetics, and biologic activity of pateclizumab, a novel monoclonal antibody targeting lymphotoxin α: results of a phase I randomized, placebo-controlled trial

Brinda Emu, Diana Luca, Carolyn Offutt, Jane L Grogan, Bernadette Rojkovich, Marna B Williams, Meina T Tang, Jim Xiao, June H Lee, John C Davis Arthritis Research & Therapy 2012, 14:R6 (8 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis

Niklas Schuelert, Jason J McDougall Arthritis Research & Therapy 2012, 14:R5 (7 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Association between being African-American, serum urate levels and the risk of developing hyperuricemia: findings from the Coronary Artery Risk Development in Young Adults cohort

Angelo L Gaffo, David R Jacobs, Cora E Lewis, Ted R Mikuls, Kenneth G Saag Arthritis Research & Therapy 2012, 14:R4 (6 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Anterior chest wall inflammation by whole-body magnetic resonance imaging in patients with spondyloarthritis: lack of association between clinical and imaging findings in a cross-sectional study

Ulrich Weber, Robert GW Lambert, Kaspar Rufibach, Walter P Maksymowych, Juerg Hodler, Anna Zejden, Stefan Duewell, Rudolf O Kissling, Paul L Filipow, Anne G Jurik Arthritis Research & Therapy 2012, 14:R3 (6 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

No association was found between clinical and imaging findings in a study using whole body magnetic resonance imaging to assess anterior chest wall inflammation in patients with spondyloarthritis.

Research article   Open Access

International cohort study of 73 anti-Ku-positive patients: association of p70/p80 anti-Ku antibodies with joint/bone features and differentiation of disease populations by using principal-components analysis

Katja Lakota, Gerhard G Thallinger, Snezna Sodin-Semrl, Blaz Rozman, Ales Ambrozic, Matija Tomsic, Sonja Praprotnik, Sasa Cucnik, Katjusa Mrak-Poljsak, Angela Ceribelli, Ilaria Cavazzana, Franco Franceschini, Jiri Vencovsky, Laszlo Czirják, Cecilia Varjú, Gunther Steiner, Martin Aringer, Bojana Stamenkovic, Oliver Distler, Marco Matucci-Cerinic, Tanja Kveder Arthritis Research & Therapy 2012, 14:R2 (6 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Tumor necrosis factor α release in peripheral blood mononuclear cells of cutaneous lupus and dermatomyositis patients

Adam S Nabatian, Muhammad M Bashir, Maria Wysocka, Meena Sharma, Victoria P Werth Arthritis Research & Therapy 2012, 14:R1 (4 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration

W Erwin, Diana Islam, Robert D Inman, Michael G Fehlings, Florence WL Tsui Arthritis Research & Therapy 2011, 13:R215 (29 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Epidemiologic study of clinically amyopathic dermatomyositis and anti-melanoma differentiation-associated gene 5 antibodies in central Japan

Yoshinao Muro, Kazumitsu Sugiura, Kei Hoshino, Masashi Akiyama, Koji Tamakoshi Arthritis Research & Therapy 2011, 13:R214 (22 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Correlation of antinuclear antibody and anti-double-stranded DNA antibody with clinical response to infliximab in patients with rheumatoid arthritis: a retrospective clinical study

Naoichiro Yukawa, Takao Fujii, Seiko Kondo-Ishikawa, Hajime Yoshifuji, Daisuke Kawabata, Takaki Nojima, Koichiro Ohmura, Takashi Usui, Tsuneyo Mimori Arthritis Research & Therapy 2011, 13:R213 (22 December 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The antinuclear antibodies (ANA) titer before starting treatment may predict clinical response to infliximab, while increased ANA titers or development of anti-ds-DNA antibodies after infliximab treatment may be useful markers of no response.

Research article   Open Access

IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis

Jian Tao, Masahito Kamanaka, Jianlei Hao, Zhifang Hao, Xi Jiang, Joe E Craft, Richard A Flavell, Zhenzhou Wu, Zhangyong Hong, Liqing Zhao, Zhinan Yin Arthritis Research & Therapy 2011, 13:R212 (22 December 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Prevalence, correlates and clinical usefulness of antibodies to RNA polymerase III in systemic sclerosis: a cross-sectional analysis of data from an Australian cohort

Mandana Nikpour, Pravin Hissaria, Jillian Byron, Joanne Sahhar, Maree Micallef, William Paspaliaris, Janet Roddy, Peter Nash, Alan Sturgess, Susanna Proudman, Wendy Stevens Arthritis Research & Therapy 2011, 13:R211 (22 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Review   Free

Type I interferon pathway in adult and juvenile dermatomyositis

Emily C Baechler, Hatice Bilgic, Ann M Reed Arthritis Research & Therapy 2011, 13:249 (22 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Application of in vivo micro-computed tomography in the temporal characterisation of subchondral bone architecture in a rat model of low-dose monosodium iodoacetate-induced osteoarthritis

Geetha Mohan, Egon Perilli, Julia S Kuliwaba, Julia M Humphries, Ian H Parkinson, Nicola L Fazzalari Arthritis Research & Therapy 2011, 13:R210 (21 December 2011)

Abstract | Full text | PDF | PubMed

Review   Free Highly Accessed

Mechanisms of tissue injury in lupus nephritis

Tamara K Nowling, Gary S Gilkeson Arthritis Research & Therapy 2011, 13:250 (21 December 2011)

Abstract | Full text | PDF | PubMed

Editorial   Free

The 2011 ACR Meeting: what's new in the Windy City

David S Pisetsky Arthritis Research & Therapy 2011, 13:138 (21 December 2011)

Abstract | Full text | PDF | PubMed

Editorial   Free

IL-21 and Sjögren's syndrome

R Hal Scofield Arthritis Research & Therapy 2011, 13:137 (19 December 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Decreased influenza-specific B cell responses in rheumatoid arthritis patients treated with anti-tumor necrosis factor

James J Kobie, Bo Zheng, Peter Bryk, Michael Barnes, Christopher T Ritchlin, Darren A Tabechian, Allen P Anandarajah, R Looney, Ralf G Thiele, Jennifer H Anolik, Andreea Coca, Chungwen Wei, Alexander F Rosenberg, Changyong Feng, John J Treanor, F Eun-Hyung Lee, Ignacio Sanz Arthritis Research & Therapy 2011, 13:R209 (16 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects

Paul Eggleton, Edwin Bremer, Joanna M Tarr, Marco de Bruyn, Wijnand Helfrich, Alexandra Kendall, Richard C Haigh, Nick J Viner, Paul G Winyard Arthritis Research & Therapy 2011, 13:R208 (15 December 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Regenerative potential of human muscle stem cells in chronic inflammation

Bouke J Duijnisveld, Anne Bigot, Karel GM Beenakker, Débora M Portilho, Vered Raz, Huub JL van der Heide, Cornelis PJ Visser, Soraya Chaouch, Kamel Mamchaoui, Rudi GJ Westendorp, Vincent Mouly, Gillian S Butler-Browne, Rob GHH Nelissen, Andrea B Maier Arthritis Research & Therapy 2011, 13:R207 (15 December 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus

Andreas Jönsen, Sara C Nilsson, Emma Ahlqvist, Elisabet Svenungsson, Iva Gunnarsson, Karin G Eriksson, Anders Bengtsson, Agneta Zickert, Maija-Leena Eloranta, Lennart Truedsson, Lars Rönnblom, Gunnel Nordmark, Gunnar Sturfelt, Anna M Blom Arthritis Research & Therapy 2011, 13:R206 (15 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Advanced glycation endproducts are increased in rheumatoid arthritis patients with controlled disease

Lodewijk de Groot, Helmy Hinkema, Johanna Westra, Andries J Smit, Cees GM Kallenberg, Marc Bijl, Marcel D Posthumus Arthritis Research & Therapy 2011, 13:R205 (14 December 2011)

Abstract | Full text | PDF | PubMed

Review   Free

Imaging modalities in hand osteoarthritis - status and perspectives of conventional radiography, magnetic resonance imaging, and ultrasonography

Ida K Haugen, Pernille Bøyesen Arthritis Research & Therapy 2011, 13:248 (13 December 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Abatacept with methotrexate versus other biologic agents in treatment of patients with active rheumatoid arthritis despite methotrexate: a network meta-analysis

Patricia Guyot, Peter Taylor, Robin Christensen, Louisa Pericleous, Coralie Poncet, Maximilian Lebmeier, Pieter Drost, Gert Bergman Arthritis Research & Therapy 2011, 13:R204 (12 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Abatacept in combination with methotrexate (MTX) is superior to placebo and comparable to other biologic agents in the treatment of patients with rheumatoid arthritis who have inadequate response to MTX alone.

Research article   Open Access

Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis

Rhian S Thomas, Alan R Clarke, Victor C Duance, Emma J Blain Arthritis Research & Therapy 2011, 13:R203 (9 December 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Sustained remission of symptoms and improved health-related quality of life in patients with cryopyrin-associated periodic syndrome treated with canakinumab: results of a double-blind placebo-controlled randomized withdrawal study

Isabelle Koné-Paut, Helen J Lachmann, Jasmin B Kuemmerle-Deschner, Eric Hachulla, Kieron S Leslie, Richard Mouy, Alberto Ferreira, Karine Lheritier, Neha Patel, Ralph Preiss, Philip N Hawkins, on behalf of the Canakinumab in CAPS Study Group Arthritis Research & Therapy 2011, 13:R202 (9 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration

Nan Hu, Johanna Westra, Abraham Rutgers, Berber Doornbos-Van der Meer, Minke G Huitema, Coen A Stegeman, Wayel H Abdulahad, Simon C Satchell, Peter W Mathieson, Peter Heeringa, Cees G M Kallenberg Arthritis Research & Therapy 2011, 13:R201 (8 December 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis

Zhongying Zhang, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Takashi Yurube, Minoru Doita, Masahiro Kurosaka, Kotaro Nishida Arthritis Research & Therapy 2011, 13:R200 (8 December 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Identification of urinary metabolites that distinguish membranous lupus nephritis from proliferative lupus nephritis and focal segmental glomerulosclerosis

Lindsey E Romick-Rosendale, Hermine I Brunner, Michael R Bennett, Rina Mina, Shannen Nelson, Michelle Petri, Adnan Kiani, Prasad Devarajan, Michael A Kennedy Arthritis Research & Therapy 2011, 13:R199 (7 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury

Robert A Mooney, Erik R Sampson, Jaclyn Lerea, Randy N Rosier, Michael J Zuscik Arthritis Research & Therapy 2011, 13:R198 (7 December 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access

A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release

Katia Varani, Melissa Padovan, Fabrizio Vincenzi, Martina Targa, Francesco Trotta, Marcello Govoni, Pier Borea Arthritis Research & Therapy 2011, 13:R197 (6 December 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access

NLRP3 E311K mutation in a large family with Muckle-Wells syndrome - description of a heterogeneous phenotype and response to treatment

Jasmin B Kuemmerle-Deschner, Peter Lohse, Ina Koetter, Guenther E Dannecker, Fabian Reess, Katharina Ummenhofer, Silvia Koch, Nikolay Tzaribachev, Anja Bialkowski, Susanne M Benseler Arthritis Research & Therapy 2011, 13:R196 (6 December 2011)

Abstract | Full text | PDF | PubMed

Editorial   Free

T cells as key players for bone destruction in gouty arthritis?

Ulrike Harre, Anja Derer, Christine Schorn, Georg Schett, Martin Herrmann Arthritis Research & Therapy 2011, 13:135 (2 December 2011)

Abstract | Full text | PDF | PubMed

Editorial   Free Highly Accessed

Beyond cognitive-behavioral therapy for fibromyalgia: addressing stress by emotional exposure, processing, and resolution

Mark A Lumley Arthritis Research & Therapy 2011, 13:136 (1 December 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access

The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA

Parawee Suwannalai, Annemiek Willemze, Linda van Toorn, Gerrie Stoeken-Rijsbergen, Nivine Levarht, Jan Drijfhout, Tom W J Huizinga, Rene E M Toes, Leendert A Trouw Arthritis Research & Therapy 2011, 13:R195 (30 November 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Proteomic analysis of saliva: a unique tool to distinguish primary Sjögren's syndrome from secondary Sjögren's syndrome and other sicca syndromes

Chiara Baldini, Laura Giusti, Federica Ciregia, Ylenia Da Valle, Camillo Giacomelli, Elena Donadio, Francesca Sernissi, Laura Bazzichi, Gino Giannaccini, Stefano Bombardieri, Antonio Lucacchini Arthritis Research & Therapy 2011, 13:R194 (25 November 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Follistatin-like protein 1: a serum biochemical marker reflecting the severity of joint damage in patients with osteoarthritis

Yuji Wang, Dawei Li, Nanwei Xu, Weijian Tao, Ruixia Zhu, Rongbin Sun, Weiwei Fan, Ping Zhang, Tianhua Dong, Long Yu Arthritis Research & Therapy 2011, 13:R193 (25 November 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Serum levels of follistatin-like protein 1 (FSTL1) may reflect the severity of joint damage and have potential for monitoring disease course and treatment efficacy in osteoarthritis patients.

Editorial   Free Highly Accessed

Central pain contributions in osteoarthritis: next steps for improving recognition and treatment?

Kelli Allen Arthritis Research & Therapy 2011, 13:133 (25 November 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats

Guo-Xin Ni, Li-Qiong Zhan, Mei-Qin Gao, Lei Lei, Yue-Zhu Zhou, Yan-Xia Pan Arthritis Research & Therapy 2011, 13:R192 (24 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Review   Free

Why radiography should no longer be considered a surrogate outcome measure for longitudinal assessment of cartilage in knee osteoarthritis

Ali Guermazi, Frank W Roemer, Deborah Burstein, Daichi Hayashi Arthritis Research & Therapy 2011, 13:247 (24 November 2011)

Abstract | Full text | PDF | PubMed

Editorial   Free

Multiplex, megaplex, index, and complex: the present and future of laboratory diagnostics in rheumatology

Mark H Wener Arthritis Research & Therapy 2011, 13:134 (24 November 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Detection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and pro-inflammatory role of citrullinated BiP in collagen-induced arthritis

Hirofumi Shoda, Keishi Fujio, Mihoko Shibuya, Tomohisa Okamura, Shuji Sumitomo, Akiko Okamoto, Tetsuji Sawada, Kazuhiko Yamamoto Arthritis Research & Therapy 2011, 13:R191 (22 November 2011)

Abstract | Full text | PDF | PubMed

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Cardiac autonomic impairment and chronotropic incompetence in fibromyalgia

Roberta da Cunha Ribeiro, Hamilton Roschel, Guilherme Artioli, Thalita Dassouki, Luiz Perandini, Ana Calich, Ana de Sá Pinto, Fernanda Lima, Eloísa Bonfá, Bruno Gualano Arthritis Research & Therapy 2011, 13:R190 (18 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Fibromyalgia patients may suffer from chronotropic incompetence and delayed heart rate recovery, both of which are indicative of cardiac autonomic impairment and higher risk of cardiovascular events and mortality.

Research article   Open Access Highly Accessed

Primary care physicians' perspectives towards managing rheumatoid arthritis: room for improvement

Katie L Garneau, Maura D Iversen, Hsun Tsao, Daniel H Solomon Arthritis Research & Therapy 2011, 13:R189 (18 November 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Rheumatoid arthritis patients in the US may not be receiving optimal care, as primary care physicians are uncomfortable prescribing disease-modifying anti-rheumatic drugs and report that their patients have difficulty accessing rheumatologists.

Research article   Open Access Highly Accessed

Ultrasound in the evaluation of enthesitis: status and perspectives

Frédérique Gandjbakhch, Lene Terslev, Fredrick Joshua, Richard J Wakefield, Esperanza Naredo, Maria D'Agostino, OMERACT Ultrasound Task Force Arthritis Research & Therapy 2011, 13:R188 (17 November 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Interleukin-1, tumor necrosis factor-alpha, and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration

Katherine M Riera, Nicole E Rothfusz, Rebecca E Wilusz, JB Weinberg, Farshid Guilak, Amy L McNulty Arthritis Research & Therapy 2011, 13:R187 (16 November 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population

Hua Zhong, Xiao-lan Li, Ming Li, Li-xia Hao, Rong-wei Chen, Kun Xiang, Xue-bin Qi, Runlin Z Ma, Bing Su Arthritis Research & Therapy 2011, 13:R186 (16 November 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Nocturnal heart rate variability parameters as potential fibromyalgia biomarker: correlation with symptoms severity

Claudia Lerma, Aline Martinez, Natllely Ruiz, Angelica Vargas, Oscar Infante, Manuel Martinez-Lavin Arthritis Research & Therapy 2011, 13:R185 (16 November 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Nocturnal heart rate variability parameters indicative of sympathetic predominance are significantly different in fibromyalgia patients compared to healthy individuals, and correlate with several symptoms including pain severity.

Research article   Open Access Highly Accessed

Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways

Anna Koskinen, Sami Juslin, Riina Nieminen, Teemu Moilanen, Katriina Vuolteenaho, Eeva Moilanen Arthritis Research & Therapy 2011, 13:R184 (11 November 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Increased incidence of pregnancy complications in women who later develop scleroderma: a case control study

Linda van Wyk, Jacolien van der Marel, Annemie JM Schuerwegh, Anne A Schouffoer, Alexandre E Voskuyl, Tom WJ Huizinga, Diana W Bianchi, Sicco A Scherjon Arthritis Research & Therapy 2011, 13:R183 (4 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Women who developed systemic sclerosis after pregnancy were more likely to have had a pregnancy history of hypertension or a fetus with intra-uterine growth restriction.

Review   Free

Imaging in gout - What can we learn from MRI, CT, DECT and US?

Fiona M McQueen, Anthony Doyle, Nicola Dalbeth Arthritis Research & Therapy 2011, 13:246 (4 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Lymphotoxin-beta receptor blockade reduces CXCL13 in lacrimal glands and improves corneal integrity in the NOD model of Sjögren's syndrome

Roy A Fava, Susan M Kennedy, Sheryl G Wood, Anne I Bolstad, Jadwiga Bienkowska, Adrian Papandile, John A Kelly, Clio P Mavragani, Margaret Gatumu, Kathrine Skarstein, Jeffrey L Browning Arthritis Research & Therapy 2011, 13:R182 (1 November 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Blockade of lymphotoxin-beta receptor pathways increased tear-fluid secretion and significantly improved ocular surface integrity score in a mouse model of Sjoegren's syndrome, suggesting this may have therapeutic potential.

Research article   Open Access

Plasma proteomic profiles from disease-discordant monozygotic twins suggest that molecular pathways are shared in multiple systemic autoimmune diseases*

Terrance P O'Hanlon, Zhuoyan Li, Lu Gan, Mark F Gourley, Lisa G Rider, Frederick W Miller Arthritis Research & Therapy 2011, 13:R181 (1 November 2011)

Abstract | Full text | PDF | PubMed

Review   Free

The role of epigenetic variation in the pathogenesis of systemic lupus erythematosus

Travis Hughes, Amr H Sawalha Arthritis Research & Therapy 2011, 13:245 (31 October 2011)

Abstract | Full text | PDF | PubMed

Editorial   Free Highly Accessed

Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis

Xinhua Yu, Saleh M Ibrahim Arthritis Research & Therapy 2011, 13:132 (31 October 2011)

Abstract | Full text | PDF | PubMed

Review   Free

Integrins and their ligands in rheumatoid arthritis

Torsten Lowin, Rainer H Straub Arthritis Research & Therapy 2011, 13:244 (28 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Can anti-cyclic citrullinated peptide antibody-negative RA be subdivided into clinical subphenotypes?

Diederik PC De Rooy, Annemiek Willemze, Bart Mertens, Tom WJ Huizinga, Annette HM Van der Helm-van Mil Arthritis Research & Therapy 2011, 13:R180 (27 October 2011)

Abstract | Full text | PDF | PubMed

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Mechanisms of B cell autoimmunity in SLE

Thomas Dörner, Claudia Giesecke, Peter E Lipsky Arthritis Research & Therapy 2011, 13:243 (27 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Impact of interleukin-21 in the pathogenesis of primary Sjogren's syndrome: increased serum levels of interleukin-21 and its expression in the labial salivary glands

Kwi Kang, Hyun-Ok Kim, Seung-Ki Kwok, Ji Ju, Kyung-Su Park, Dong-Il Sun, Joo Jhun, Hye Oh, Sung-Hwan Park, Ho-Youn Kim Arthritis Research & Therapy 2011, 13:R179 (26 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

The soluble biomarker calprotectin (a S100 protein) is associated to ultrasonographic synovitis scores and is sensitive to change in patients with rheumatoid arthritis treated with adalimumab

Hilde Hammer, Magne K Fagerhol, Tale Wien, Tore K Kvien Arthritis Research & Therapy 2011, 13:R178 (26 October 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access

MTRX1011A, a humanized anti-CD4 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a Phase I randomized, double-blind, placebo-controlled study incorporating pharmacodynamic biomarker assessments

Heleen Scheerens, Zheng Su, Bryan Irving, Michael J Townsend, Yanan Zheng, Eric Stefanich, Vishala Chindalore, Clifton O Bingham, John C Davis Arthritis Research & Therapy 2011, 13:R177 (26 October 2011)

Abstract | Full text | PDF | PubMed

Editorial   Free Highly Accessed

Pus: the Rodney Dangerfield of immunology

David S Pisetsky Arthritis Research & Therapy 2011, 13:131 (26 October 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Quantification of the whole-body burden of radiographic osteoarthritis using factor analysis

Amanda E Nelson, Robert F DeVellis, Jordan B Renner, Todd A Schwartz, Philip G Conaghan, Virginia B Kraus, Joanne M Jordan Arthritis Research & Therapy 2011, 13:R176 (25 October 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Soluble receptor activator of nuclear factor κB ligand/osteoprotegerin ratio is increased in systemic lupus erythematosus patients

Diana Carmona-Fernandes, Maria Santos, Inês Perpétuo, João Fonseca, Helena Canhão Arthritis Research & Therapy 2011, 13:R175 (25 October 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

The use, safety, and effectiveness of herpes zoster vaccination in individuals with inflammatory and autoimmune diseases: a longitudinal observational study

Jie Zhang, Elizabeth Delzell, Fenglong Xie, John W Baddley, Claire Spettell, Raechele M Mcmahan, Joaquim Fernandes, Lang Chen, Kevin Winthrop, Jeffrey R Curtis Arthritis Research & Therapy 2011, 13:R174 (24 October 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Effectiveness of cognitive behaviour therapy for the treatment of catastrophisation in patients with fibromyalgia: a randomised controlled trial

Marta Alda, Juan V Luciano, Eva Andrés, Antoni Serrano-Blanco, Baltasar Rodero, Yolanda del Hoyo, Miquel Roca, Sergio Moreno, Rosa Magallón, Javier García-Campayo Arthritis Research & Therapy 2011, 13:R173 (23 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Cognitive behaviour therapy (CBT) should be included in standard treatment of fibromyalgia, as a clinical trial shows it improves outcomes including pain catastrophising, pain acceptance, function and quality of life.

Research article   Open Access

Frequency of disease-associated and other nuclear autoantibodies in patients of the German network for systemic scleroderma: correlation with characteristic clinical features

Rudolf Mierau, Pia Moinzadeh, Gabriela Riemekasten, Inga Melchers, Michael Meurer, Frank Reichenberger, Michael Buslau, Margitta Worm, Norbert Blank, Rüdiger Hein, Ulf Müller-Ladner, Annegret Kuhn, Cord Sunderkötter, Aaron Juche, Christiane Pfeiffer, Christoph Fiehn, Michael Sticherling, Percy Lehmann, Rudolf Stadler, Eckhard Schulze-Lohoff, Cornelia Seitz, Ivan Foeldvari, Thomas Krieg, Ekkehard Genth, Nicolas Hunzelmann Arthritis Research & Therapy 2011, 13:R172 (21 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

An organ culture system to model early degenerative changes of the intervertebral disc

Ravi K Ponnappan, Dessislava Z Markova, Paul JD Antonio, Hallie B Murray, Alexander R Vaccaro, Irving M Shapiro, D Greg Anderson, Todd J Albert, Makarand V Risbud Arthritis Research & Therapy 2011, 13:R171 (21 October 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Regulatory mechanisms for the production of BAFF and IL-6 are impaired in monocytes of patients of primary Sjögren's syndrome

Keiko Yoshimoto, Maiko Tanaka, Masako Kojima, Yumiko Setoyama, Hideto Kameda, Katsuya Suzuki, Kensei Tsuzaka, Yoko Ogawa, Kazuo Tsubota, Tohru Abe, Tsutomu Takeuchi Arthritis Research & Therapy 2011, 13:R170 (21 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Associations of educational attainment, occupation and community poverty with knee osteoarthritis in the Johnston County (North Carolina) osteoarthritis project

Leigh F Callahan, Rebecca J Cleveland, Jack Shreffler, Todd A Schwartz, Britta Schoster, Randy Randolph, Jordan B Renner, Joanne M Jordan Arthritis Research & Therapy 2011, 13:R169 (19 October 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Low levels of educational attainment and living in a community with a high poverty rate are independently associated with knee osteoarthritis in a rural community in the south-eastern United States.

Editorial   Free

Declining needs for total joint replacements for rheumatoid arthritis

Nasim A Khan, Tuulikki Sokka Arthritis Research & Therapy 2011, 13:130 (19 October 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Minocycline and doxycycline therapy in community patients with rheumatoid arthritis: prescribing patterns, patient-level determinants of use, and patient-reported side effects

Christopher J Smith, Harlan Sayles, Ted R Mikuls, Kaleb Michaud Arthritis Research & Therapy 2011, 13:R168 (18 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Although the drugs are generally well-tolerated, rheumatologists mostly prescribe minocycline or doxycycline in patients with long-standing rheumatoid arthritis (RA) where other treatments have failed, and not as a primary treatment option.

Research article   Open Access

A five-year prospective study of fatigue in primary Sjögren's syndrome

Karstein Haldorsen, Ingvar Bjelland, Anne Bolstad, Roland Jonsson, Johan Brun Arthritis Research & Therapy 2011, 13:R167 (13 October 2011)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis: association with interstitial lung disease

Marie-Elise Truchetet, Nicolò C Brembilla, Elisa Montanari, Yannick Allanore, Carlo Chizzolini Arthritis Research & Therapy 2011, 13:R166 (13 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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