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Research article   Open Access

High-density lipoprotein cholesterol subfractions HDL2 and HDL3 are reduced in women with rheumatoid arthritis and may augment the cardiovascular risk of women with RA: a cross-sectional study

Elke Arts, Jaap Fransen, Heidi Lemmers, Anton Stalenhoef, Leo Joosten, Piet van Riel, Calin D Popa Arthritis Research & Therapy 2012, 14:R116 (14 May 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Body mass index influences the response to infliximab in ankylosing spondylitis

Sébastien Ottaviani, Yannick Allanore, Florence Tubach, Marine Forien, Anaïs Gardette, Blandine Pasquet, Elisabeth Palazzo, Marine Meunier, Gilles Hayem, Chantal Job-Deslandre, André Kahan, Olivier Meyer, Philippe Dieudé Arthritis Research & Therapy 2012, 14:R115 (14 May 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Elevated levels of fibrinogen-derived endogenous citrullinated peptides in synovial fluid of rheumatoid arthritis patients

Reinout Raijmakers, Joyce JBC van Beers, Mahmoud El-Azzouny, Natasja FC Visser, Borut Božič, Ger JM Pruijn, Albert JR Heck Arthritis Research & Therapy 2012, 14:R114 (14 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage

Valeria M Dejica, John S Mort, Sheila Laverty, John Antoniou, David J Zukor, Michael Tanzer, A Robin Poole Arthritis Research & Therapy 2012, 14:R113 (14 May 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Low-dose oral prednisone improves clinical and ultrasonographic remission rates in early rheumatoid arthritis: results of a 12-month open-label randomised study

Carlomaurizio Montecucco, Monica Todoerti, Garifallia Sakellariou, Carlo Scirè, Roberto Caporali Arthritis Research & Therapy 2012, 14:R112 (14 May 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Resistin in idiopathic inflammatory myopathies

Mária Filková, Hana Hulejová, Klára Kuncová, Lenka Pleštilová, Lucie Cerezo, Heřman Mann, Martin Klein, Josef Zámečník, Steffen Gay, Jiří Vencovský, Ladislav Šenolt Arthritis Research & Therapy 2012, 14:R111 (11 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Mycophenolic acid counteracts B cell proliferation and plasmablast formation in patients with systemic lupus erythematosus

Sebastian Eickenberg, Eva Mickholz, Elisabeth Jung, Jerzy-Roch Nofer, Herrmann Pavenstädt, Annett M Jacobi Arthritis Research & Therapy 2012, 14:R110 (9 May 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Long-term stability of anti-cyclic citrullinated peptide antibody status in patients with early inflammatory polyarthritis

Marian L Burr, Sebastien Viatte, Marwan Bukhari, Darren Plant, Deborah P Symmons, Wendy Thomson, Anne Barton Arthritis Research & Therapy 2012, 14:R109 (9 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Editorial   Free Highly Accessed

Nothing lasts forever - a critical look at sustained remission

Daniel Aletaha Arthritis Research & Therapy 2012, 14:116 (9 May 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Osteoporosis in ankylosing spondylitis - prevalence, risk factors and methods of assessment

Eva Klingberg, Mattias Lorentzon, Dan Mellström, Mats Geijer, Jan Göthlin, Elisabet Hilme, Martin Hedberg, Hans Carlsten, Helena Forsblad-d'Elia Arthritis Research & Therapy 2012, 14:R108 (8 May 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Characterization of inhibitory T cells induced by an analog of type II collagen in an HLA-DR1 humanized mouse model of autoimmune arthritis

Masaru Kimata, David L Cullins, Monica L Brown, David D Brand, Edward F Rosloniec, Linda K Myers, John M Stuart, Andrew H Kang Arthritis Research & Therapy 2012, 14:R107 (8 May 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Efficacy of an immunotoxin to folate receptor beta in the intra-articular treatment of antigen-induced arthritis

Taku Nagai, Akira Kyo, Kazuhisa Hasui, Sonshin Takao, Takami Matsuyama Arthritis Research & Therapy 2012, 14:R106 (2 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells

Akihiko Hiyama, Fumiyuki Arai, Daisuke Sakai, Katsuya Yokoyama, Joji Mochida Arthritis Research & Therapy 2012, 14:R105 (2 May 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis

Amanda S Rohrbach, Saskia Hemmers, Sanja Arandjelovic, Maripat Corr, Kerri A Mowen Arthritis Research & Therapy 2012, 14:R104 (2 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

New insights into the role and mechanism of macrophage migration inhibitory factor in steroid-resistant patients with systemic lupus erythematosus

Fang-Fang Wang, Li-An Zhu, Yu-Qiong Zou, Hui Zheng, Alisa Wilson, Cheng-De Yang, Nan Shen, Daniel J Wallace, Michael H Weisman, Shun-Le Chen, Liang-Jing Lu Arthritis Research & Therapy 2012, 14:R103 (2 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Macrophage migration inhibitory factor (MIF) may play a role in the mechanism of steroid resistance in systemic lupus erythematosus by affecting the NF-κB/IκB signaling cascade, and is a potential therapeutic target.

Research article   Open Access Highly Accessed

Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behçet's disease

Sunao Sugita, Yuko Kawazoe, Ayano Imai, Yukiko Yamada, Shintaro Horie, Manabu Mochizuki Arthritis Research & Therapy 2012, 14:R99 (1 May 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker?

Katja Lakota, Jun Wei, Mary Carns, Monique Hinchcliff, Jungwha Lee, Michael L Whitfield, Snezna Sodin-Semrl, John Varga Arthritis Research & Therapy 2012, 14:R102 (1 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Sensory and sympathetic nerve fibers undergo sprouting and neuroma formation in the painful arthritic joint of geriatric mice

Juan M Jimenez-Andrade, Patrick W Mantyh Arthritis Research & Therapy 2012, 14:R101 (1 May 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Anti-type II collagen antibodies are associated with early radiographic destruction in rheumatoid arthritis

Mohammed Mullazehi, Marius C Wick, Lars Klareskog, Ronald van Vollenhoven, Johan Rönnelid Arthritis Research & Therapy 2012, 14:R100 (1 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

The effect of three years of TNF alpha blocking therapy on markers of bone turnover and their predictive value for treatment discontinuation in patients with ankylosing spondylitis: a prospective longitudinal observational cohort study

Suzanne Arends, Anneke Spoorenberg, Pieternella M Houtman, Martha K Leijsma, Reinhard Bos, Cees GM Kallenberg, Henk Groen, Elisabeth Brouwer, Eveline van der Veer Arthritis Research & Therapy 2012, 14:R98 (30 April 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis

Angela Ceribelli, Micaela Fredi, Mara Taraborelli, Ilaria Cavazzana, Franco Franceschini, Marzia Quinzanini, Angela Tincani, Steven J Ross, Jason YF Chan, Brad A Pauley, Edward KL Chan, Minoru Satoh Arthritis Research & Therapy 2012, 14:R97 (30 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model

Misato Hashizume, Hiroto Yoshida, Keisuke Tanaka, Miho Suzuki, Isao Matsumoto, Takayuki Sumida, Masahiko Mihara Arthritis Research & Therapy 2012, 14:R96 (30 April 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Interleukin-6 (IL-6) reduced the efficacy of methotrexate in a mouse arthritis model by inhibiting the expression of the reduced folate transporter SLC19A1, which is important for the uptake of methotrexate into cells.

Review   Free

Progress in treatment of ANCA-associated vasculitis

Rona M Smith, Rachel B Jones, David RW Jayne Arthritis Research & Therapy 2012, 14:210 (30 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

The interferon type I signature towards prediction of non-response to rituximab in rheumatoid arthritis patients

Hennie G Raterman, Saskia Vosslamber, Sander de Ridder, Michael T Nurmohamed, Willem F Lems, Maarten Boers, Mark van de Wiel, Ben AC Dijkmans, Cornelis L Verweij, Alexandre E Voskuyl Arthritis Research & Therapy 2012, 14:R95 (27 April 2012)

Abstract | Full text | PDF | PubMed | F1000 Biology

Research article   Open Access

Bias in effect size of systemic lupus erythematosus susceptibility loci across Europe: a case-control study

Elisa Alonso-Perez, Marian Suarez-Gestal, Manuel Calaza, Gian Sebastiani, Rudolf Pullmann, Chryssa Papasteriades, Attila Kovacs, Fotini N Skopouli, Marc Bijl, Ana Suarez, Maurizio Marchini, Sergio Migliaresi, Patricia Carreira, Josep Ordi-Ros, Torsten Witte, Sarka Ruzickova, Maria Santos, Nadia Barizzone, Francisco J Blanco, Bernard R Lauwerys, Juan J Gomez-Reino, Antonio Gonzalez, the European Consortium of SLE DNA Collections Arthritis Research & Therapy 2012, 14:R94 (27 April 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Synovial cytokine expression in psoriatic arthritis and associations with lymphoid neogenesis and clinical features

Raquel Celis, Núria Planell, José L Fernández-Sueiro, Raimon Sanmartí, Julio Ramírez, Isidoro González-Álvaro, José L Pablos, Juan D Cañete Arthritis Research & Therapy 2012, 14:R93 (27 April 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

The renal urate transporter SLC17A1 locus: confirmation of association with gout

Jade E Hollis-Moffatt, Amanda J Phipps-Green, Brett Chapman, Gregory T Jones, Andre van Rij, Peter J Gow, Andrew A Harrison, John Highton, Peter B Jones, Grant W Montgomery, Lisa K Stamp, Nicola Dalbeth, Tony R Merriman Arthritis Research & Therapy 2012, 14:R92 (27 April 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Thrombin induces heme oxygenase-1 expression in human synovial fibroblasts through protease-activated receptor signaling pathways

Ju-Fang Liu, Sheng-Mou Hou, Chun-Hao Tsai, Chun-Yin Huang, Wei-Hung Yang, Chih-Hsin Tang Arthritis Research & Therapy 2012, 14:R91 (27 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Review   Free

Role of non-immune mechanisms of muscle damage in idiopathic inflammatory myopathies

William Coley, Sree Rayavarapu, Kanneboyina Nagaraju Arthritis Research & Therapy 2012, 14:209 (27 April 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Statins accelerate the onset of collagen type II-induced arthritis in mice

Rob J Vandebriel, Hilda JI De Jong, Eric R Gremmer, Olaf H Klungel, Jan-Willem Tervaert, Wout Slob, Jan Willem Van Der Laan, Henk Van Loveren Arthritis Research & Therapy 2012, 14:R90 (26 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Smoking interacts with HLA-DRB1 shared epitope in the development of anti-citrullinated protein antibody-positive rheumatoid arthritis: results from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA)

Chun Too, Abqariyah Yahya, Shahnaz Murad, Jasbir Dhaliwal, Per Larsson, Nor Muhamad, Nor Abdullah, Amal Mustafa, Lars Klareskog, Lars Alfredsson, Leonid Padyukov, Camilla Bengtsson, MyEIRA study group Arthritis Research & Therapy 2012, 14:R89 (26 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Review   Free

Congenital heart block: evidence for a pathogenic role of maternal autoantibodies

Aurélie Ambrosi, Marie Wahren-Herlenius Arthritis Research & Therapy 2012, 14:208 (26 April 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Suppression of endothelial cell activity by inhibition of TNFα

Qiang Shu, Mohammad A Amin, Jeffrey H Ruth, Phillip L Campbell, Alisa E Koch Arthritis Research & Therapy 2012, 14:R88 (25 April 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast-like synoviocytes

Kenji Ikuta, Yuko Waguri-Nagaya, Kae Kikuchi, Takaya Yamagami, Masahiro Nozaki, Mineyoshi Aoyama, Kiyofumi Asai, Takanobu Otsuka Arthritis Research & Therapy 2012, 14:R87 (25 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Serum BAFF and APRIL levels in patients with IgG4-related disease and their clinical significance

Kazuhiro Kiyama, Daisuke Kawabata, Yuji Hosono, Koji Kitagori, Naoichiro Yukawa, Hajime Yoshifuji, Koichiro Omura, Takao Fujii, Tsuneyo Mimori Arthritis Research & Therapy 2012, 14:R86 (24 April 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis

Lara Bossini-Castillo, Carmen P Simeon, Lorenzo Beretta, Jasper C Broen, Madelon C Vonk, Raquel Ríos-Fernández, Gerard Espinosa, Patricia Carreira, María T Camps, Maria J Castillo, Miguel A González-Gay, Emma Beltrán, María Carmen Freire, Javier Narváez, Carlos Tolosa, Torsten Witte, Alexander Kreuter, Annemie J Schuerwegh, Anna-Maria Hoffmann-Vold, Roger Hesselstrand, Claudio Lunardi, Jacob M van Laar, Meng Chee, Ariane Herrick, Bobby PC Koeleman, Christopher P Denton, Carmen Fonseca, Timothy RDJ Radstake, Javier Martin, the Spanish Scleroderma Group et al. Arthritis Research & Therapy 2012, 14:R85 (24 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Review   Free Highly Accessed

MRI and X-ray in axial spondyloarthritis: the relationship between inflammatory and structural changes

Walter P Maksymowych Arthritis Research & Therapy 2012, 14:207 (19 April 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Identification of low-frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization

Beate Böhm, Harald Burkhardt, Steffen Uebe, Maria Apel, Frank Behrens, André Reis, Ulrike Hüffmeier Arthritis Research & Therapy 2012, 14:R84 (18 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Risk of end-stage renal disease associated with gout: a nationwide population study

Kuang-Hui Yu, Chang-Fu Kuo, Shue-Fen Luo, Lai-Chu See, I-Jun Chou, Hsiao-Chun Chang, Meng-Jiun Chiou Arthritis Research & Therapy 2012, 14:R83 (18 April 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Bone morphogenetic protein-2-induced Wnt/β-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes

Ioanna Papathanasiou, Konstantinos N Malizos, Aspasia Tsezou Arthritis Research & Therapy 2012, 14:R82 (18 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study

Ying Chen, Peter T Dawes, Jon C Packham, Derek L Mattey Arthritis Research & Therapy 2012, 14:R81 (18 April 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Antagonist-mediated down-regulation of toll-like receptors increases the prevalence of human papillomavirus infection in systemic lupus erythematosus

Shui-Lian Yu, Paul KS Chan, Chun-Kwok Wong, Cheuk-Chun Szeto, Suzanne C Ho, Karine So, May MY Yu, So-Fan Yim, Tak-Hong Cheung, Martin CS Wong, Jo LK Cheung, Apple CM Yeung, Edmund K Li, Lai-Shan Tam Arthritis Research & Therapy 2012, 14:R80 (18 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Autoantibodies to transcription intermediary factor (TIF)1β associated with dermatomyositis

Minoru Satoh, Jason YF Chan, Steven J Ross, Yi Li, Yoshioki Yamasaki, Hidehiro Yamada, Monica Vazquez-del Mercado, Marcelo H Petri, Luis J Jara, Miguel A Saavedra, Claudia Cruz-Reyes, Eric S Sobel, Westley H Reeves, Angela Ceribelli, Edward KL Chan Arthritis Research & Therapy 2012, 14:R79 (18 April 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis

Kyle D Allen, Brian A Mata, Mostafa A Gabr, Janet L Huebner, Samuel B Adams, Virginia B Kraus, Daniel O Schmitt, Lori A Setton Arthritis Research & Therapy 2012, 14:R78 (17 April 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Circulating and synovial antibody profiling of juvenile arthritis patients by nucleic acid programmable protein arrays

David S Gibson, Ji Qiu, Eliseo A Mendoza, Kristi Barker, Madeleine E Rooney, Joshua LaBaer Arthritis Research & Therapy 2012, 14:R77 (17 April 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Estradiol ameliorates arthritis and protects against systemic bone loss in Staphylococcus aureus infection in mice

Inger Gjertsson, Marie K Lagerquist, Erik Kristiansson, Hans Carlsten, Catharina Lindholm Arthritis Research & Therapy 2012, 14:R76 (16 April 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4

Jing Li, Jingang Huang, Liming Dai, Degang Yu, Qian Chen, Xiaoling Zhang, Kerong Dai Arthritis Research & Therapy 2012, 14:R75 (16 April 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The microRNA miR-146a may reduce cellular response to transforming growth factor-beta through targeted inhibition of Smad4 in cartilage, thus increasing vascular endothelial growth factor levels, and increasing chondrocyte apoptosis.

Research article   Open Access

Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis

Carmen A Ambarus, Troy Noordenbos, Maria JH de Hair, Paul P Tak, Dominique LP Baeten Arthritis Research & Therapy 2012, 14:R74 (11 April 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Increased frequency of CCR4+ and CCR6+ memory T-cells including CCR7+CD45RAmed very early memory cells in granulomatosis with polyangiitis (Wegener's)

Ursula Fagin, Silke Pitann, Wolfgang L Gross, Peter Lamprecht Arthritis Research & Therapy 2012, 14:R73 (10 April 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Induction of superficial zone protein (SZP)/lubricin/PRG 4 in muscle-derived mesenchymal stem/progenitor cells by transforming growth factor-β1 and bone morphogenetic protein-7

José A Andrades, Shirley C Motaung, Pedro Jiménez-Palomo, Silvia Claros, José M López-Puerta, José Becerra, Thomas M Schmid, A Hari Reddi Arthritis Research & Therapy 2012, 14:R72 (10 April 2012)

Abstract | Full text | PDF | PubMed

Correction   Free

Correction: FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development

Rizwanul Haque, Fengyang Lei, Xiaofang Xiong, Yuzhang Wu, Jianxun Song Arthritis Research & Therapy 2012, 14:401 (10 April 2012)

Abstract | Full text | PDF | PubMed

Editorial   Free Highly Accessed

Knotting the NETs: Analyzing histone modifications in neutrophil extracellular traps

Indira Neeli, Marko Radic Arthritis Research & Therapy 2012, 14:115 (6 April 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Bone formation rather than inflammation reflects Ankylosing Spondylitis activity on PET-CT: a pilot study

Stefan TG Bruijnen, Mignon AC van der Weijden, Joannes P Klein, Otto S Hoekstra, Ronald Boellaard, J Christiaan van Denderen, Ben AC Dijkmans, Alexandre E Voskuyl, Irene E van der Horst-Bruinsma, Conny J van der Laken Arthritis Research & Therapy 2012, 14:R71 (2 April 2012)

Abstract | Full text | PDF | PubMed

Review   Free

Placebo analgesia: cognitive influences on therapeutic outcome

Alison Watson, Andrea Power, Christopher Brown, Wael El-Deredy, Anthony Jones Arthritis Research & Therapy 2012, 14:206 (30 March 2012)

Abstract | Full text | PDF | PubMed

Editorial   Free Highly Accessed

What is the future of CCR5 antagonists in rheumatoid arthritis?

Tsutomu Takeuchi, Hideto Kameda Arthritis Research & Therapy 2012, 14:114 (30 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Replication study confirms the association between UBAC2 and Behçet's disease in two independent Chinese sets of patients and controls

Shengping Hou, Qinmeng Shu, Zhengxuan Jiang, Yuanyuan Chen, Fuzhen Li, Feilan Chen, Aize Kijlstra, Peizeng Yang Arthritis Research & Therapy 2012, 14:R70 (29 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Egr-1 contributes to IL-1-mediated down-regulation of peroxisome proliferator-activated receptor γ expression in human osteoarthritic chondrocytes

Sarah-Salwa Nebbaki, Fatima El Mansouri, Hassan Afif, Mohit Kapoor, Mohamed Benderdour, Nicolas Duval, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Hassan Fahmi Arthritis Research & Therapy 2012, 14:R69 (28 March 2012)

Abstract | Full text | PDF | PubMed

Editorial   Free Highly Accessed

Meryl Streep and the problems of clinical trials

David A Isenberg Arthritis Research & Therapy 2012, 14:113 (23 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Sustained rheumatoid arthritis remission is uncommon in clinical practice

Femke HM Prince, Vivian P Bykerk, Nancy A Shadick, Bing Lu, Jing Cui, Michelle Frits, Christine K Iannaccone, Michael E Weinblatt, Daniel H Solomon Arthritis Research & Therapy 2012, 14:R68 (19 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In clinical practice only a minority of patients with rheumatoid arthritis (RA) are in sustained remission, suggesting strict monitoring is required even once remission is reached.

Research article   Open Access Highly Accessed

Obesity and carotid atherosclerosis in African black and Caucasian women with established rheumatoid arthritis: a cross-sectional study

Ahmed Solomon, Gavin R Norton, Angela J Woodiwiss, Patrick H Dessein Arthritis Research & Therapy 2012, 14:R67 (19 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Effect of pregnancy on serum cytokines in SLE patients

Andrea Doria, Maurizio Cutolo, Anna Ghirardello, Margherita Zen, Danilo Villalta, Angela Tincani, Leonardo Punzi, Luca Iaccarino, Michelle Petri Arthritis Research & Therapy 2012, 14:R66 (14 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Functional role of IL-22 in psoriatic arthritis

Anupam Mitra, Smriti K Raychaudhuri, Siba P Raychaudhuri Arthritis Research & Therapy 2012, 14:R65 (14 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

TLR2 ligation induces the production of IL-23/IL-17 via IL-6, STAT3 and NF-kB pathway in patients with primary Sjogren's syndrome

Seung-Ki Kwok, Mi-La Cho, Yang-Mi Her, Hye-Joa Oh, Mi-Kyung Park, Seon-Yeong Lee, Yun Woo, Ji Ju, Kyung-Su Park, Ho-Youn Kim, Sung-Hwan Park Arthritis Research & Therapy 2012, 14:R64 (14 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Clinical features of symptomatic patellofemoral joint osteoarthritis

George Peat, Rachel C Duncan, Laurence RJ Wood, Elaine Thomas, Sara Muller Arthritis Research & Therapy 2012, 14:R63 (14 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

TNFα modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts

Alison M Connor, Nizar Mahomed, Rajiv Gandhi, Edward C Keystone, Stuart A Berger Arthritis Research & Therapy 2012, 14:R62 (14 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Value of self-performed joint counts in rheumatoid arthritis patients near remission

Helga Radner, Johannes Grisar, Josef S Smolen, Tanja Stamm, Daniel Aletaha Arthritis Res Ther 2012, 14:R61 (14 March 2012)

Abstract | Full text | PDF | PubMed

Editorial   Free Highly Accessed

HMGB1: a smoking gun in lupus nephritis?

David S Pisetsky Arthritis Research & Therapy 2012, 14:112 (14 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Cytokines profiling by multiplex analysis in experimental arthritis: which pathophysiological relevance for articular versus systemic mediators?

Joseph Paquet, Jean-Christophe Goebel, Camille Delaunay, Astrid Pinzano, Laurent Grossin, Christel Cournil-Henrionnet, Pierre Gillet, Patrick Netter, Jean-Yves Jouzeau, David Moulin Arthritis Research & Therapy 2012, 14:R60 (13 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Inhibition of inflammation but not ankylosis by glucocorticoids in mice: further evidence for the entheseal stress hypothesis

Kirsten Braem, Christophe M Deroose, Frank P Luyten, Rik J Lories Arthritis Research & Therapy 2012, 14:R59 (12 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Characterization of synovial angiogenesis in osteoarthritis patients and its modulation by chondroitin sulfate

Cécile Lambert, Marianne Mathy-Hartert, Jean-Emile Dubuc, Eulàlia Montell, Josep Vergés, Carine Munaut, Agnès Noël, Yves Henrotin Arthritis Research & Therapy 2012, 14:R58 (12 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Induction of long-term B-cell depletion in refractory rheumatoid arthritis patients preferentially affects autoreactive more than protective humoral immunity

YK Onno Teng, Gillian Wheater, Vanessa E Hogan, Philip Stocks, EW Nivine Levarht, Tom WJ Huizinga, Rene EM Toes, Jacob M van Laar Arthritis Research & Therapy 2012, 14:R57 (12 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Editorial   Free

Implication of new atherosclerotic carotid plaques in the cardiovascular outcome of patients with rheumatoid arthritis

Miguel A González-Gay, Carlos González-Juanatey Arthritis Research & Therapy 2012, 14:105 (12 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

The independent association between parathyroid hormone levels and hyperuricemia: a national population study

Janet Y Hui, Jee Woong J Choi, David B Mount, Yanyan Zhu, Yuqing Zhang, Hyon K Choi Arthritis Research & Therapy 2012, 14:R56 (10 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

A systematic critical review on MRI in spondyloarthritis

Bodil Arnbak, Charlotte Leboeuf-Yde, Tue Jensen Arthritis Research & Therapy 2012, 14:R55 (9 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

The anti-CD74 humanized monoclonal antibody, milatuzumab, which targets the invariant chain of MHC II complexes, alters B-cell proliferation, migration, and adhesion molecule expression

Daniela Frölich, Daniela Blaβfeld, Karin Reiter, Claudia Giesecke, Capucine Daridon, Henrik E Mei, Gerd R Burmester, David M Goldenberg, Abdulagabar Salama, Thomas Dörner Arthritis Research & Therapy 2012, 14:R54 (9 March 2012)

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Is IL-6 an appropriate target to treat spondyloarthritis patients refractory to anti-TNF therapy? a multicentre retrospective observational study

Fernando Lekpa, Cécile Poulain, Daniel Wendling, Martin Soubrier, Michel De Bandt, Jean Berthelot, Philippe Gaudin, Eric Toussirot, Philippe Goupille, Thao Pham, Jérémie Sellam, Rémy Bruckert, Muriel Paul, Valérie Farrenq, Pascal Claudepierre, the Club Rhumatismes et Inflammation Arthritis Research & Therapy 2012, 14:R53 (9 March 2012)

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Moving instead of asking? Performance-based tests and BASFI-questionnaire measure different aspects of physical function in ankylosing spondylitis

Salima FE van Weely, J Christiaan van Denderen, Martijn PM Steultjens, Marike van der Leeden, Michael T Nurmohamed, Joost Dekker, Ben AC Dijkmans, Irene E van der Horst-Bruinsma Arthritis Research & Therapy 2012, 14:R52 (8 March 2012)

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Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration

Takashi Yurube, Toru Takada, Teppei Suzuki, Kenichiro Kakutani, Koichiro Maeno, Minoru Doita, Masahiro Kurosaka, Kotaro Nishida Arthritis Research & Therapy 2012, 14:R51 (6 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Clinical significance of antibodies to Ro52/TRIM21 in systemic sclerosis

Marie Hudson, Janet Pope, Michael Mahler, Solène Tatibouet, Russell Steele, Murray Baron, Canadian Scleroderma Research Group (CSRG), Marvin J Fritzler Arthritis Research & Therapy 2012, 14:R50 (6 March 2012)

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Altered responsiveness to TGF-β results in reduced Papss2 expression and alterations in the biomechanical properties of mouse articular cartilage

Girish Ramaswamy, Philip Sohn, Alan Eberhardt, Rosa Serra Arthritis Research & Therapy 2012, 14:R49 (6 March 2012)

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Research article   Open Access

Serum level of soluble CX3CL1/fractalkine is elevated in patients with polymyositis and dermatomyositis, which is correlated with disease activity

Fumihito Suzuki, Tetsuo Kubota, Yasunari Miyazaki, Kinya Ishikawa, Masashi Ebisawa, Shunsei Hirohata, Takashi Ogura, Hidehiro Mizusawa, Toshio Imai, Nobuyuki Miyasaka, Toshihiro Nanki Arthritis Research & Therapy 2012, 14:R48 (6 March 2012)

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Research article   Open Access

Dutch translation and cross-cultural adaptation of the PROMIS® physical function item bank and cognitive pre-test in Dutch arthritis patients

Martijn AH Oude Voshaar, Peter M ten Klooster, Erik Taal, Eswar Krishnan, Mart AFJ van de Laar Arthritis Research & Therapy 2012, 14:R47 (5 March 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The Patient-Reported Outcomes Measurement Information System (PROMIS) physical function item bank translated into Dutch is semantically and conceptually equivalent to the original, with all items comprehended by patients as intended.

Research article   Open Access

Risk factors for cardiovascular mortality in patients with systemic lupus erythematosus, a prospective cohort study

Johanna T Gustafsson, Julia F Simard, Iva Gunnarsson, Kerstin Elvin, Ingrid E Lundberg, Lars-Olof Hansson, Anders Larsson, Elisabet Svenungsson Arthritis Research & Therapy 2012, 14:R46 (5 March 2012)

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Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes

Chiyoko Sekine, Akemi Koyanagi, Noriko Koyama, Katsuto Hozumi, Shigeru Chiba, Hideo Yagita Arthritis Research & Therapy 2012, 14:R45 (5 March 2012)

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Research article   Open Access

Predictors of new atherosclerotic carotid plaque development in patients with rheumatoid arthritis: a longitudinal study

Evangelia Zampeli, Athanase Protogerou, Kimon Stamatelopoulos, Kalliopi Fragiadaki, Christina G Katsiari, Katerina Kyrkou, Christos M Papamichael, Myron Mavrikakis, Peter Nightingale, George D Kitas, Petros P Sfikakis Arthritis Research & Therapy 2012, 14:R44 (5 March 2012)

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Research article   Open Access

Hypogalactosylation of serum N-glycans fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis

Altan Ercan, Jing Cui, Melissa M Hazen, Franak Batliwalla, Louise Royle, Pauline M Rudd, Jonathan S Coblyn, Nancy Shadick, Michael E Weinblatt, Peter Gregersen, David M Lee, Peter A Nigrovic Arthritis Research & Therapy 2012, 14:R43 (5 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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Plasma proteins take their toll on the joint in osteoarthritis

Steven R Goldring, Carla R Scanzello Arthritis Research & Therapy 2012, 14:111 (5 March 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

The lp13.3 genomic region -rs599839- is associated with endothelial dysfunction in patients with rheumatoid arthritis

Raquel López-Mejías, Carlos González-Juanatey, Mercedes García-Bermúdez, Santos Castañeda, José A Miranda-Filloy, Ricardo Blanco, Javier Llorca, Javier Martín, Miguel A González-Gay Arthritis Research & Therapy 2012, 14:R42 (1 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Review   Free

Taking responsibility for the early assessment and treatment of patients with musculoskeletal pain: a review and critical analysis

Nadine E Foster, Jan Hartvigsen, Peter R Croft Arthritis Research & Therapy 2012, 14:205 (29 February 2012)

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Clinical examination or whole-body magnetic resonance imaging: the Holy Grail of spondyloarthritis imaging

Winston J Rennie Arthritis Research & Therapy 2012, 14:110 (29 February 2012)

Abstract | Full text | PDF | PubMed

Editorial   Free

Role of environmental factors in autoantibody production - importance of a detailed analysis in a small cohort

Minoru Satoh, Angela Ceribelli, Edward KL Chan Arthritis Research & Therapy 2012, 14:109 (29 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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Inhibiting citrullination in rheumatoid arthritis: taking fuel from the fire

Benjamin AC Fisher, Patrick J Venables Arthritis Research & Therapy 2012, 14:108 (29 February 2012)

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Research article   Open Access

Usage of skin care products and risk of rheumatoid arthritis: results from the Swedish EIRA study

Berit M Sverdrup, Henrik Källberg, Lars Klareskog, Lars Alfredsson, Epidemiological Investigation of Rheumatoid Arthritis Study Group Arthritis Research & Therapy 2012, 14:R41 (28 February 2012)

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Research article   Open Access

Local delivery of AAV2-CTLA4IgG decreases sialadenitis and improves gland function in the C57BL/6.NOD-Aec1Aec2 mouse model of Sjögren's syndrome

Hongen Yin, Cuong Q Nguyen, Yuval Samuni, Toshimitsu Uede, Ammon B Peck, John A Chiorini Arthritis Research & Therapy 2012, 14:R40 (27 February 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Myocardial citrullination in rheumatoid arthritis: a correlative histopathologic study

Jon T Giles, Justyna Fert-Bober, Jin Park, Clifton O Bingham, Felipe Andrade, Karen Fox-Talbot, Dimitrios Pappas, Antony Rosen, Jennifer van Eyk, Joan M Bathon, Marc K Halushka Arthritis Research & Therapy 2012, 14:R39 (24 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Editorial   Free

The BRIC-GARN Meeting 2011: of mice and men

David S Pisetsky Arthritis Research & Therapy 2012, 14:107 (24 February 2012)

Abstract | Full text | PDF | PubMed

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How does BAFF activate B cells in patients with autoimmune diseases?

Xavier Mariette Arthritis Research & Therapy 2012, 14:106 (24 February 2012)

Abstract | Full text | PDF | PubMed

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Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-Terminal kinase pathway

Sang-il Lee, David L Boyle, Andres Berdeja, Gary S Firestein Arthritis Research & Therapy 2012, 14:R38 (21 February 2012)

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Abatacept versus other biologics in methotrexate inadequate responders with rheumatoid arthritis: you like tomato and I like tomahto... let's call the whole thing off

Yusuf Yazici Arthritis Research & Therapy 2012, 14:104 (21 February 2012)

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Contributions of mass spectrometry-based proteomics to defining cellular mechanisms and diagnostic markers for systemic lupus erythematosus

Erik A Korte, Patrick M Gaffney, David W Powell Arthritis Research & Therapy 2012, 14:204 (20 February 2012)

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