Arthritis Research & Therapy

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		Research article Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1β in chondrocyte/agarose constructs Manoj Ramachandran, Prim Achan, Donald M Salter, Dan L Bader, Tina T Chowdhury Arthritis Research & Therapy 2011, 13:R145 (13 September 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Ossification process involving the human thoracic ligamentum flavum: role of transcription factors Kenzo Uchida, Takafumi Yayama, Hong-Xin Cai, Hideaki Nakajima, Daisuke Sugita, Alexander Guerrero, Shigeru Kobayashi, Ai Yoshida, Ke-Bing Chen, Hisatoshi Baba Arthritis Research & Therapy 2011, 13:R144 (13 September 2011) Abstract \| Full text \| PDF \| PubMed
		Research article The gene expression profile of preclinical autoimmune arthritis and its modulation by a tolerogenic disease-protective antigenic challenge Hua Yu, Changwan Lu, Ming T Tan, Kamal D Moudgil Arthritis Research & Therapy 2011, 13:R143 (13 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Dupuytren's: a systems biology disease Samrina Rehman, Royston Goodacre, Philip J Day, Ardeshir Bayat, Hans V Westerhoff Arthritis Research & Therapy 2011, 13:238 (12 September 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines Yihong CS Lu, Christopher H Evans, Alan J Grodzinsky Arthritis Research & Therapy 2011, 13:R142 (2 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Short term treatment of damaged cartilage with glucocorticoids can reduce long term degenerative changes; results from this in vitro study may offer hope for prevention of osteoarthritis after joint injury.
		Research article Integrated safety in tocilizumab clinical trials Michael H Schiff, Joel M Kremer, Angelika Jahreis, Emma Vernon, John D Isaacs, Ronald F van Vollenhoven Arthritis Research & Therapy 2011, 13:R141 (1 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Constitutive expression of cathepsin K in the human intervertebral disc: new insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor-κB ligand Helen E Gruber, Jane A Ingram, Gretchen L Hoelscher, Natalia Zinchenko, H James Norton, Edward N Hanley Arthritis Research & Therapy 2011, 13:R140 (31 August 2011) Abstract \| Full text \| PDF \| PubMed
		Research article The association between systemic glucocorticoid therapy and the risk of infection in patients with rheumatoid arthritis: systematic review and meta-analyses William G Dixon, Samy Suissa, Marie Hudson Arthritis Research & Therapy 2011, 13:R139 (31 August 2011) Abstract \| Full text \| PDF \| PubMed
		Research article CD23⁺/CD21^hiB-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice Jie Li, Quan Zhou, Ronald W Wood, Igor Kuzin, Andrea Bottaro, Christopher T Ritchlin, Lianping Xing, Edward M Schwarz Arthritis Research & Therapy 2011, 13:R138 (31 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Editorial More than just B-cell inhibition Eric M Ruderman, Richard M Pope Arthritis Research & Therapy 2011, 13:125 (30 August 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Kinematic and dynamic gait compensations in a rat model of lumbar radiculopathy and the effects of tumor necrosis factor-alpha antagonism Kyle D Allen, Mohammed F Shamji, Brian A Mata, Mostafa A Gabr, S Michael Sinclair, Daniel O Schmitt, William J Richardson, Lori A Setton Arthritis Research & Therapy 2011, 13:R137 (26 August 2011) Abstract \| Full text \| PDF \| PubMed
		Research article High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts Heidi Wähämaa, Hanna Schierbeck, Hulda S Hreggvidsdottir, Karin Palmblad, Anne-Charlotte Aveberger, Ulf Andersson, Helena Harris Arthritis Research & Therapy 2011, 13:R136 (26 August 2011) Abstract \| Full text \| PDF \| PubMed
		Review Cardiovascular disease in systemic sclerosis - an emerging association? Gene-Siew Ngian, Joanne Sahhar, Ian P Wicks, Sharon Van Doornum Arthritis Research & Therapy 2011, 13:237 (26 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Editorial Desperately looking for the right target in osteoarthritis: the anti-IL-1 strategy Xavier Chevalier, Thierry Conrozier, Pascal Richette Arthritis Research & Therapy 2011, 13:124 (26 August 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Subgroups of older adults with osteoarthritis based upon differing comorbid symptom presentations and potential underlying pain mechanisms Susan L Murphy, Angela K Lyden, Kristine Phillips, Daniel J Clauw, David A Williams Arthritis Research & Therapy 2011, 13:R135 (24 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Meeting report 7th meeting of the global arthritis research network Matthias Brock, Michelle Trenkmann, Maria Filkova, Hossein Hemmatazad, Emmanuel Karouzakis, Fabienne Niederer, Kerstin Klein, Steffen Gay Arthritis Research & Therapy 2011, 13:303 (23 August 2011) Abstract \| Full text \| PDF \| PubMed
		Review T-helper cells as new players in ANCA-associated vasculitides Wayel H Abdulahad, Peter Lamprecht, Cees GM Kallenberg Arthritis Research & Therapy 2011, 13:236 (23 August 2011) Abstract \| Full text \| PDF \| PubMed
		Review Immunopathologic differences of Sjögren's syndrome versus sicca syndrome in HCV and HIV infection Claudio Vitali Arthritis Research & Therapy 2011, 13:233 (19 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Editorial Challenges in understanding Sjögren's syndrome - improved insights into the pathogenesis generate hope for innovative therapies? Thomas Dörner Arthritis Research & Therapy 2011, 13:123 (19 August 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Utility of a simplified ultrasound assessment to assess interstitial pulmonary fibrosis in connective tissue disorders - preliminary results Marwin Gutierrez, Fausto Salaffi, Marina Carotti, Marika Tardella, Carlos Pineda, Chiara Bertolazzi, Elisabetta Bichisecchi, Emilio Filippucci, Walter Grassi Arthritis Research & Therapy 2011, 13:R134 (18 August 2011) Abstract \| Full text \| PDF \| PubMed
		Letter Response to 'Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study' Kazuki Yoshida, Kazuo Matsui, Hiroto Nakano, Hideto Oshikawa, Masako Utsunomiya, Tatsuo Kobayashi, Makiko Kimura, Gautam A Deshpande, Mitsumasa Kishimoto Arthritis Research & Therapy 2011, 13:405 (18 August 2011) Abstract \| Full text \| PDF \| PubMed
		Research article CCR5Δ32 variant and cardiovascular disease in patients with rheumatoid arthritis: a cohort study Luis Rodríguez-Rodríguez, Carlos González-Juanatey, Mercedes García-Bermúdez, Tomas R Vázquez-Rodríguez, Jose A Miranda-Filloy, Benjamin Fernández-Gutiérrez, Javier Llorca, Javier Martin, Miguel A González-Gay Arthritis Research & Therapy 2011, 13:R133 (16 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Autophagy in rat annulus fibrosus cells: evidence and possible implications Chao Shen, Jun Yan, Lei-Sheng Jiang, Li-Yang Dai Arthritis Research & Therapy 2011, 13:R132 (16 August 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Cardiovascular events in early RA are a result of inflammatory burden and traditional risk factors: a five year prospective study Lena Innala, Bozena Möller, Lotta Ljung, Staffan Magnusson, Torgny Smedby, Anna Södergren, Marie-Louise Öhman, Solbritt Rantapää-Dahlqvist, Solveig Wållberg-Jonsson Arthritis Research & Therapy 2011, 13:R131 (15 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The occurrence of heart disease in patients with rheumatoid arthritis (RA) is potentiated by disease-related inflammation as well as traditional risk factors, which may have implications for cardioprotective strategies in RA.
		Editorial A new weapon against an old target Christoph Fiehn Arthritis Research & Therapy 2011, 13:122 (12 August 2011) Abstract \| Full text \| PDF \| PubMed

	All
		Research article Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1β in chondrocyte/agarose constructs Manoj Ramachandran, Prim Achan, Donald M Salter, Dan L Bader, Tina T Chowdhury Arthritis Research & Therapy 2011, 13:R145 (13 September 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Ossification process involving the human thoracic ligamentum flavum: role of transcription factors Kenzo Uchida, Takafumi Yayama, Hong-Xin Cai, Hideaki Nakajima, Daisuke Sugita, Alexander Guerrero, Shigeru Kobayashi, Ai Yoshida, Ke-Bing Chen, Hisatoshi Baba Arthritis Research & Therapy 2011, 13:R144 (13 September 2011) Abstract \| Full text \| PDF \| PubMed
		Research article The gene expression profile of preclinical autoimmune arthritis and its modulation by a tolerogenic disease-protective antigenic challenge Hua Yu, Changwan Lu, Ming T Tan, Kamal D Moudgil Arthritis Research & Therapy 2011, 13:R143 (13 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Dupuytren's: a systems biology disease Samrina Rehman, Royston Goodacre, Philip J Day, Ardeshir Bayat, Hans V Westerhoff Arthritis Research & Therapy 2011, 13:238 (12 September 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines Yihong CS Lu, Christopher H Evans, Alan J Grodzinsky Arthritis Research & Therapy 2011, 13:R142 (2 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Short term treatment of damaged cartilage with glucocorticoids can reduce long term degenerative changes; results from this in vitro study may offer hope for prevention of osteoarthritis after joint injury.
		Research article Integrated safety in tocilizumab clinical trials Michael H Schiff, Joel M Kremer, Angelika Jahreis, Emma Vernon, John D Isaacs, Ronald F van Vollenhoven Arthritis Research & Therapy 2011, 13:R141 (1 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Constitutive expression of cathepsin K in the human intervertebral disc: new insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor-κB ligand Helen E Gruber, Jane A Ingram, Gretchen L Hoelscher, Natalia Zinchenko, H James Norton, Edward N Hanley Arthritis Research & Therapy 2011, 13:R140 (31 August 2011) Abstract \| Full text \| PDF \| PubMed
		Research article The association between systemic glucocorticoid therapy and the risk of infection in patients with rheumatoid arthritis: systematic review and meta-analyses William G Dixon, Samy Suissa, Marie Hudson Arthritis Research & Therapy 2011, 13:R139 (31 August 2011) Abstract \| Full text \| PDF \| PubMed
		Research article CD23⁺/CD21^hiB-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice Jie Li, Quan Zhou, Ronald W Wood, Igor Kuzin, Andrea Bottaro, Christopher T Ritchlin, Lianping Xing, Edward M Schwarz Arthritis Research & Therapy 2011, 13:R138 (31 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Editorial More than just B-cell inhibition Eric M Ruderman, Richard M Pope Arthritis Research & Therapy 2011, 13:125 (30 August 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Kinematic and dynamic gait compensations in a rat model of lumbar radiculopathy and the effects of tumor necrosis factor-alpha antagonism Kyle D Allen, Mohammed F Shamji, Brian A Mata, Mostafa A Gabr, S Michael Sinclair, Daniel O Schmitt, William J Richardson, Lori A Setton Arthritis Research & Therapy 2011, 13:R137 (26 August 2011) Abstract \| Full text \| PDF \| PubMed
		Research article High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts Heidi Wähämaa, Hanna Schierbeck, Hulda S Hreggvidsdottir, Karin Palmblad, Anne-Charlotte Aveberger, Ulf Andersson, Helena Harris Arthritis Research & Therapy 2011, 13:R136 (26 August 2011) Abstract \| Full text \| PDF \| PubMed
		Review Cardiovascular disease in systemic sclerosis - an emerging association? Gene-Siew Ngian, Joanne Sahhar, Ian P Wicks, Sharon Van Doornum Arthritis Research & Therapy 2011, 13:237 (26 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Editorial Desperately looking for the right target in osteoarthritis: the anti-IL-1 strategy Xavier Chevalier, Thierry Conrozier, Pascal Richette Arthritis Research & Therapy 2011, 13:124 (26 August 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Subgroups of older adults with osteoarthritis based upon differing comorbid symptom presentations and potential underlying pain mechanisms Susan L Murphy, Angela K Lyden, Kristine Phillips, Daniel J Clauw, David A Williams Arthritis Research & Therapy 2011, 13:R135 (24 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Meeting report 7th meeting of the global arthritis research network Matthias Brock, Michelle Trenkmann, Maria Filkova, Hossein Hemmatazad, Emmanuel Karouzakis, Fabienne Niederer, Kerstin Klein, Steffen Gay Arthritis Research & Therapy 2011, 13:303 (23 August 2011) Abstract \| Full text \| PDF \| PubMed
		Review T-helper cells as new players in ANCA-associated vasculitides Wayel H Abdulahad, Peter Lamprecht, Cees GM Kallenberg Arthritis Research & Therapy 2011, 13:236 (23 August 2011) Abstract \| Full text \| PDF \| PubMed
		Review Immunopathologic differences of Sjögren's syndrome versus sicca syndrome in HCV and HIV infection Claudio Vitali Arthritis Research & Therapy 2011, 13:233 (19 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Editorial Challenges in understanding Sjögren's syndrome - improved insights into the pathogenesis generate hope for innovative therapies? Thomas Dörner Arthritis Research & Therapy 2011, 13:123 (19 August 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Utility of a simplified ultrasound assessment to assess interstitial pulmonary fibrosis in connective tissue disorders - preliminary results Marwin Gutierrez, Fausto Salaffi, Marina Carotti, Marika Tardella, Carlos Pineda, Chiara Bertolazzi, Elisabetta Bichisecchi, Emilio Filippucci, Walter Grassi Arthritis Research & Therapy 2011, 13:R134 (18 August 2011) Abstract \| Full text \| PDF \| PubMed
		Letter Response to 'Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study' Kazuki Yoshida, Kazuo Matsui, Hiroto Nakano, Hideto Oshikawa, Masako Utsunomiya, Tatsuo Kobayashi, Makiko Kimura, Gautam A Deshpande, Mitsumasa Kishimoto Arthritis Research & Therapy 2011, 13:405 (18 August 2011) Abstract \| Full text \| PDF \| PubMed
		Research article CCR5Δ32 variant and cardiovascular disease in patients with rheumatoid arthritis: a cohort study Luis Rodríguez-Rodríguez, Carlos González-Juanatey, Mercedes García-Bermúdez, Tomas R Vázquez-Rodríguez, Jose A Miranda-Filloy, Benjamin Fernández-Gutiérrez, Javier Llorca, Javier Martin, Miguel A González-Gay Arthritis Research & Therapy 2011, 13:R133 (16 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Autophagy in rat annulus fibrosus cells: evidence and possible implications Chao Shen, Jun Yan, Lei-Sheng Jiang, Li-Yang Dai Arthritis Research & Therapy 2011, 13:R132 (16 August 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Cardiovascular events in early RA are a result of inflammatory burden and traditional risk factors: a five year prospective study Lena Innala, Bozena Möller, Lotta Ljung, Staffan Magnusson, Torgny Smedby, Anna Södergren, Marie-Louise Öhman, Solbritt Rantapää-Dahlqvist, Solveig Wållberg-Jonsson Arthritis Research & Therapy 2011, 13:R131 (15 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The occurrence of heart disease in patients with rheumatoid arthritis (RA) is potentiated by disease-related inflammation as well as traditional risk factors, which may have implications for cardioprotective strategies in RA.
		Editorial A new weapon against an old target Christoph Fiehn Arthritis Research & Therapy 2011, 13:122 (12 August 2011) Abstract \| Full text \| PDF \| PubMed