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Lymphotoxin-beta receptor blockade reduces CXCL13 in lacrimal glands and improves corneal integrity in the NOD model of Sjögren's syndrome
Roy A Fava, Susan M Kennedy, Sheryl G Wood, Anne I Bolstad, Jadwiga Bienkowska, Adrian Papandile, John A Kelly, Clio P Mavragani, Margaret Gatumu, Kathrine Skarstein, Jeffrey L Browning Arthritis Research & Therapy 2011, 13:R182 (1 November 2011)
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Editor’s summary
Blockade of lymphotoxin-beta receptor pathways increased tear-fluid secretion and significantly improved ocular surface integrity score in a mouse model of Sjoegren's syndrome, suggesting this may have therapeutic potential.
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Plasma proteomic profiles from disease-discordant monozygotic twins suggest that molecular pathways are shared in multiple systemic autoimmune diseases*
Terrance P O'Hanlon, Zhuoyan Li, Lu Gan, Mark F Gourley, Lisa G Rider, Frederick W Miller Arthritis Research & Therapy 2011, 13:R181 (1 November 2011)
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The role of epigenetic variation in the pathogenesis of systemic lupus erythematosus
Travis Hughes, Amr H Sawalha Arthritis Research & Therapy 2011, 13:245 (31 October 2011)
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Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis
Xinhua Yu, Saleh M Ibrahim Arthritis Research & Therapy 2011, 13:132 (31 October 2011)
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Integrins and their ligands in rheumatoid arthritis
Torsten Lowin, Rainer H Straub Arthritis Research & Therapy 2011, 13:244 (28 October 2011)
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Can anti-cyclic citrullinated peptide antibody-negative RA be subdivided into clinical subphenotypes?
Diederik PC De Rooy, Annemiek Willemze, Bart Mertens, Tom WJ Huizinga, Annette HM Van der Helm-van Mil Arthritis Research & Therapy 2011, 13:R180 (27 October 2011)
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Mechanisms of B cell autoimmunity in SLE
Thomas Dörner, Claudia Giesecke, Peter E Lipsky Arthritis Research & Therapy 2011, 13:243 (27 October 2011)
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Impact of interleukin-21 in the pathogenesis of primary Sjogren's syndrome: increased serum levels of interleukin-21 and its expression in the labial salivary glands
Kwi Kang, Hyun-Ok Kim, Seung-Ki Kwok, Ji Ju, Kyung-Su Park, Dong-Il Sun, Joo Jhun, Hye Oh, Sung-Hwan Park, Ho-Youn Kim Arthritis Research & Therapy 2011, 13:R179 (26 October 2011)
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The soluble biomarker calprotectin (a S100 protein) is associated to ultrasonographic synovitis scores and is sensitive to change in patients with rheumatoid arthritis treated with adalimumab
Hilde Hammer, Magne K Fagerhol, Tale Wien, Tore K Kvien Arthritis Research & Therapy 2011, 13:R178 (26 October 2011)
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MTRX1011A, a humanized anti-CD4 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a Phase I randomized, double-blind, placebo-controlled study incorporating pharmacodynamic biomarker assessments
Heleen Scheerens, Zheng Su, Bryan Irving, Michael J Townsend, Yanan Zheng, Eric Stefanich, Vishala Chindalore, Clifton O Bingham, John C Davis Arthritis Research & Therapy 2011, 13:R177 (26 October 2011)
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Pus: the Rodney Dangerfield of immunology
David S Pisetsky Arthritis Research & Therapy 2011, 13:131 (26 October 2011)
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Quantification of the whole-body burden of radiographic osteoarthritis using factor analysis
Amanda E Nelson, Robert F DeVellis, Jordan B Renner, Todd A Schwartz, Philip G Conaghan, Virginia B Kraus, Joanne M Jordan Arthritis Research & Therapy 2011, 13:R176 (25 October 2011)
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Soluble receptor activator of nuclear factor κB ligand/osteoprotegerin ratio is increased in systemic lupus erythematosus patients
Diana Carmona-Fernandes, Maria Santos, Inês Perpétuo, João Fonseca, Helena Canhão Arthritis Research & Therapy 2011, 13:R175 (25 October 2011)
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The use, safety, and effectiveness of herpes zoster vaccination in individuals with inflammatory and autoimmune diseases: a longitudinal observational study
Jie Zhang, Elizabeth Delzell, Fenglong Xie, John W Baddley, Claire Spettell, Raechele M Mcmahan, Joaquim Fernandes, Lang Chen, Kevin Winthrop, Jeffrey R Curtis Arthritis Research & Therapy 2011, 13:R174 (24 October 2011)
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Effectiveness of cognitive behaviour therapy for the treatment of catastrophisation in patients with fibromyalgia: a randomised controlled trial
Marta Alda, Juan V Luciano, Eva Andrés, Antoni Serrano-Blanco, Baltasar Rodero, Yolanda del Hoyo, Miquel Roca, Sergio Moreno, Rosa Magallón, Javier García-Campayo Arthritis Research & Therapy 2011, 13:R173 (23 October 2011)
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Editor’s summary
Cognitive behaviour therapy (CBT) should be included in standard treatment of fibromyalgia, as a clinical trial shows it improves outcomes including pain catastrophising, pain acceptance, function and quality of life.
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Frequency of disease-associated and other nuclear autoantibodies in patients of the German network for systemic scleroderma: correlation with characteristic clinical features
Rudolf Mierau, Pia Moinzadeh, Gabriela Riemekasten, Inga Melchers, Michael Meurer, Frank Reichenberger, Michael Buslau, Margitta Worm, Norbert Blank, Rüdiger Hein, Ulf Müller-Ladner, Annegret Kuhn, Cord Sunderkötter, Aaron Juche, Christiane Pfeiffer, Christoph Fiehn, Michael Sticherling, Percy Lehmann, Rudolf Stadler, Eckhard Schulze-Lohoff, Cornelia Seitz, Ivan Foeldvari, Thomas Krieg, Ekkehard Genth, Nicolas Hunzelmann Arthritis Research & Therapy 2011, 13:R172 (21 October 2011)
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An organ culture system to model early degenerative changes of the intervertebral disc
Ravi K Ponnappan, Dessislava Z Markova, Paul JD Antonio, Hallie B Murray, Alexander R Vaccaro, Irving M Shapiro, D Greg Anderson, Todd J Albert, Makarand V Risbud Arthritis Research & Therapy 2011, 13:R171 (21 October 2011)
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Regulatory mechanisms for the production of BAFF and IL-6 are impaired in monocytes of patients of primary Sjögren's syndrome
Keiko Yoshimoto, Maiko Tanaka, Masako Kojima, Yumiko Setoyama, Hideto Kameda, Katsuya Suzuki, Kensei Tsuzaka, Yoko Ogawa, Kazuo Tsubota, Tohru Abe, Tsutomu Takeuchi Arthritis Research & Therapy 2011, 13:R170 (21 October 2011)
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Associations of educational attainment, occupation and community poverty with knee osteoarthritis in the Johnston County (North Carolina) osteoarthritis project
Leigh F Callahan, Rebecca J Cleveland, Jack Shreffler, Todd A Schwartz, Britta Schoster, Randy Randolph, Jordan B Renner, Joanne M Jordan Arthritis Research & Therapy 2011, 13:R169 (19 October 2011)
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Low levels of educational attainment and living in a community with a high poverty rate are independently associated with knee osteoarthritis in a rural community in the south-eastern United States.
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Declining needs for total joint replacements for rheumatoid arthritis
Nasim A Khan, Tuulikki Sokka Arthritis Research & Therapy 2011, 13:130 (19 October 2011)
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Minocycline and doxycycline therapy in community patients with rheumatoid arthritis: prescribing patterns, patient-level determinants of use, and patient-reported side effects
Christopher J Smith, Harlan Sayles, Ted R Mikuls, Kaleb Michaud Arthritis Research & Therapy 2011, 13:R168 (18 October 2011)
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Editor’s summary
Although the drugs are generally well-tolerated, rheumatologists mostly prescribe minocycline or doxycycline in patients with long-standing rheumatoid arthritis (RA) where other treatments have failed, and not as a primary treatment option.
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A five-year prospective study of fatigue in primary Sjögren's syndrome
Karstein Haldorsen, Ingvar Bjelland, Anne Bolstad, Roland Jonsson, Johan Brun Arthritis Research & Therapy 2011, 13:R167 (13 October 2011)
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Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis: association with interstitial lung disease
Marie-Elise Truchetet, Nicolò C Brembilla, Elisa Montanari, Yannick Allanore, Carlo Chizzolini Arthritis Research & Therapy 2011, 13:R166 (13 October 2011)
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The rat intervertebral disk degeneration pain model: relationships between biological and structural alterations and pain
Jae-Sung Kim, Jeffrey S Kroin, Xin Li, Howard S An, Asokumar Buvanendran, Dongyao Yan, Kenneth J Tuman, Andre J van Wijnen, Di Chen, Hee-Jeong Im Arthritis Research & Therapy 2011, 13:R165 (13 October 2011)
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Bone destruction by receptor activator of nuclear factor κB ligand-expressing T cells in chronic gouty arthritis
Sung-Ji Lee, Kwang-Il Nam, Hye-Mi Jin, Young-Nan Cho, Song-Eun Lee, Tae-Jong Kim, Shin-Seok Lee, Seung-Jung Kee, Keun-Bae Lee, Nacksung Kim, Yong-Wook Park Arthritis Research & Therapy 2011, 13:R164 (13 October 2011)
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