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Research article   Open Access Highly Accessed

Suboptimal cardiovascular risk factor identification and management in patients with rheumatoid arthritis: a cohort analysis

Shailey S Desai, James D Myles, Mariana J Kaplan Arthritis Research & Therapy 2012, 14:R270 (13 December 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Autoantibody-mediated arthritis in the absence of C3 and activating Fcγ receptors: C5 is activated by the coagulation cascade

Jennifer L Auger, Stefanie Haasken, Bryce A Binstadt Arthritis Research & Therapy 2012, 14:R269 (13 December 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Silencing of microRNA-101 prevents IL-1β-induced extracellular matrix degradation in chondrocytes

Linghui Dai, Xin Zhang, Xiaoqing Hu, Chunyan Zhou, Yingfang Ao Arthritis Research & Therapy 2012, 14:R268 (10 December 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

The effect of Link N on differentiation of human bone marrow-derived mesenchymal stem cells

John Antoniou, Hong Wang, Abdulrahman M Alaseem, Lisbet Haglund, Peter J Roughley, Fackson Mwale Arthritis Research & Therapy 2012, 14:R267 (10 December 2012)

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Research article   Open Access Highly Accessed

Citrullinated fibronectin inhibits apoptosis and promotes the secretion of pro-inflammatory cytokines in fibroblast-like synoviocytes in rheumatoid arthritis

Lieying Fan, Qiang Wang, Rongqing Liu, Ming Zong, Dongyi He, Hui Zhang, Yuanyuan Ding, Jianwei Ma Arthritis Research & Therapy 2012, 14:R266 (10 December 2012)

Abstract | Full text | PDF | PubMed | F1000 Biology

Research article   Open Access Highly Accessed

Efficacy and safety of lenalidomide for refractory cutaneous lupus erythematosus

Josefina Cortés-Hernández, Gabriela Ávila, Miquel Vilardell-Tarrés, Josep Ordi-Ros Arthritis Research & Therapy 2012, 14:R265 (7 December 2012)

Abstract | Full text | PDF | PubMed | F1000 Biology |  Editor’s summary

Lenalidomide, a thalidomide derivative, is effective and safe for the treatment of refractory cutaneous lupus erythematosus in patients recruited to a phase II clinical study.

Research article   Open Access

Meta-analysis identified the TNFA -308G > A promoter polymorphism as a risk factor for disease severity in patients with rheumatoid arthritis

Erik JM Toonen, Pilar Barrera, Jaap Fransen, Arjan PM de Brouwer, Agnes M Eijsbouts, Pierre Miossec, Hubert Marotte, Hans Scheffer, Piet LCM van Riel, Barbara Franke, Marieke JH Coenen Arthritis Research & Therapy 2012, 14:R264 (7 December 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Disease activity and cognition in rheumatoid arthritis: an open label pilot study

Graham Raftery, Jiabao He, Ruth Pearce, Daniel Birchall, Julia L Newton, Andrew M Blamire, John D Isaacs Arthritis Research & Therapy 2012, 14:R263 (4 December 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model

Anika I Tsuchida, Michiel Beekhuizen, Marijn Rutgers, Gerjo JVM van Osch, Joris EJ Bekkers, Arjan GJ Bot, Bernd Geurts, Wouter JA Dhert, Daniel BF Saris, Laura B Creemers Arthritis Research & Therapy 2012, 14:R262 (3 December 2012)

Abstract | Full text | PDF | PubMed

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An update on the hyper-IgE syndromes

Patrick FK Yong, Alexandra F Freeman, Karin R Engelhardt, Steven Holland, Jennifer M Puck, Bodo Grimbacher Arthritis Research & Therapy 2012, 14:228 (30 November 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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Biologic adjuvants for fracture healing

Mandeep S Virk, Jay R Lieberman Arthritis Research & Therapy 2012, 14:225 (30 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Markers of intestinal inflammation in patients with ankylosing spondylitis: a pilot study

Franziska G Matzkies, Stephan R Targan, Dror Berel, Carol J Landers, John D Reveille, Dermot PB McGovern, Michael H Weisman Arthritis Research & Therapy 2012, 14:R261 (29 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Raised circulating tenascin-C in rheumatoid arthritis

Theresa H Page, Peter J Charles, Anna M Piccinini, Vicky Nicolaidou, Peter C Taylor, Kim S Midwood Arthritis Research & Therapy 2012, 14:R260 (29 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Interleukin-32-induced thymic stromal lymphopoietin plays a critical role in macrophage differentiation through the activation of caspase-1 in vitro

Hyun-Ja Jeong, Sun-Young Nam, Hyun-A Oh, Na-Ra Han, Young-Sick Kim, Phil-Dong Moon, Seung-Youp Shin, Min-Ho Kim, Hyung-Min Kim Arthritis Research & Therapy 2012, 14:R259 (28 November 2012)

Abstract | Full text | PDF | PubMed

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The role of inflammation, the autonomic nervous system and classical cardiovascular disease risk factors on subendocardial viability ratio in patients with RA: a cross-sectional and longitudinal study

Aamer Sandoo, Athanassios D Protogerou, James Hodson, Jacqueline P Smith, Evi Zampeli, Petros P Sfikakis, George D Kitas Arthritis Research & Therapy 2012, 14:R258 (28 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Association of a BMP5 microsatellite with knee osteoarthritis: case-control study

Cristina Rodriguez-Fontenla, Andrew Carr, Juan J Gomez-Reino, Aspasia Tsezou, John Loughlin, Antonio Gonzalez Arthritis Research & Therapy 2012, 14:R257 (27 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Intensity-dependent effect of treadmill running on lubricin metabolism of rat articular cartilage

Guo-Xin Ni, Lei Lei, Yue-Zhu Zhou Arthritis Research & Therapy 2012, 14:R256 (24 November 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

High-intensity running in rats lowers lubricin content of joints and increases damage to cartilage while lower intensity running increases lubricin levels and improves joint fitness.

Research article   Open Access Highly Accessed

A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis

Rui Liu, Qian Wu, Dinglei Su, Nan Che, Haifeng Chen, Linyu Geng, Jinyun Chen, Wanjun Chen, Xia Li, Lingyun Sun Arthritis Research & Therapy 2012, 14:R255 (23 November 2012)

Abstract | Full text | PDF | PubMed

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Adherence to a treat-to-target strategy in early rheumatoid arthritis: results of the DREAM remission induction cohort

Marloes Vermeer, Hillechiena H Kuper, Hein J Bernelot Moens, Monique Hoekstra, Marcel D Posthumus, Piet LCM van Riel, Mart AFJ van de Laar Arthritis Research & Therapy 2012, 14:R254 (23 November 2012)

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Excessive bone formation in a mouse model of ankylosing spondylitis is associated with decreases in Wnt pathway inhibitors

Katelin R Haynes, Allison R Pettit, Ran Duan, Hsu-Wen Tseng, Tibor T Glant, Matthew A Brown, Gethin P Thomas Arthritis Research & Therapy 2012, 14:R253 (22 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

APRIL, a proliferation-inducing ligand, as a potential marker of lupus nephritis

Worapot Treamtrakanpon, Pornpen Tantivitayakul, Thitima Benjachat, Poorichaya Somparn, Wipawee Kittikowit, Somchai Eiam-ong, Asada Leelahavanichkul, Nattiya Hirankarn, Yingyos Avihingsanon Arthritis Research & Therapy 2012, 14:R252 (21 November 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Reverse regulation of soluble receptor for advanced glycation end products and proinflammatory factor resistin and S100A12 in Kawasaki disease

Yanqi Qi, Fangqi Gong, Qing Zhang, Chunhong Xie, Wei Wang, Songling Fu Arthritis Research & Therapy 2012, 14:R251 (21 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis

Chun Too, Shahnaz Murad, Jasbir Dhaliwal, Per Larsson, Xia Jiang, Bo Ding, Lars Alfredsson, Lars Klareskog, Leonid Padyukov Arthritis Research & Therapy 2012, 14:R250 (19 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Matrix to predict rapid radiographic progression of early rheumatoid arthritis patients from the community treated with methotrexate or leflunomide: results from the ESPOIR cohort

Bruno Fautrel, Benjamin Granger, Bernard Combe, Alain Saraux, Francis Guillemin, Xavier Le Loet Arthritis Research & Therapy 2012, 14:R249 (19 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Predictors of use of pain medications for persistent knee pain after primary Total Knee Arthroplasty: a cohort study using an institutional joint registry

Jasvinder A Singh, David G Lewallen Arthritis Research & Therapy 2012, 14:R248 (16 November 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Patients that have had primary Total Knee Arthroplasty (TKA) are more likely to continue using pain medication if they are female, of a younger age, or suffering from depression or anxiety.

Research article   Open Access Highly Accessed

Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3

Marije Oosting, Kathrin Buffen, Subbarao RK Malireddi, Patrick Sturm, Ineke Verschueren, Marije I Koenders, Frank L van de Veerdonk, Jos WM van der Meer, Mihai G Netea, Thirumala-Devi Kanneganti, Leo AB Joosten Arthritis Research & Therapy 2012, 14:R247 (13 November 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

An early murine Lyme arthritis model using intra-articular injection of live B.burgdorferi demonstrates that induction of Lyme arthritis is strongly dependent on IL-1β production, suggesting IL-1 may be a future therapeutic target.

Research article   Open Access Highly Accessed

IL-32 and IL-17 interact and have the potential to aggravate osteoclastogenesis in rheumatoid arthritis

Young-Mee Moon, Bo-Young Yoon, Yang-Mi Her, Hye-Joa Oh, Jae-Seon Lee, Kyoung-Woon Kim, Seon-Yeong Lee, Yun-Ju Woo, Kyung-Su Park, Sung-Hwan Park, Ho-Youn Kim, Mi-La Cho Arthritis Research & Therapy 2012, 14:R246 (13 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

The immunoreceptor tyrosine-based activation motif (ITAM) -related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints

Tania N Crotti, Anak ASSK Dharmapatni, Ekram Alias, Andrew CW Zannettino, Malcolm D Smith, David R Haynes Arthritis Research & Therapy 2012, 14:R245 (12 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Serum progranulin levels are elevated in patients with systemic lupus erythematosus, reflecting disease activity

Atsushi Tanaka, Hiroshi Tsukamoto, Hiroki Mitoma, Chikako Kiyohara, Naoyasu Ueda, Masahiro Ayano, Shun-ichiro Ohta, Yasushi Inoue, Yojirou Arinobu, Hiroaki Niiro, Takahiko Horiuchi, Koichi Akashi Arthritis Research & Therapy 2012, 14:R244 (11 November 2012)

Abstract | Full text | PDF | PubMed

Review   Free Highly Accessed

Epigenetic contributions in the development of rheumatoid arthritis

Kerstin Klein, Caroline Ospelt, Steffen Gay Arthritis Research & Therapy 2012, 14:227 (9 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus

Jack Hutcheson, Kamala Vanarsa, Anna Bashmakov, Simer Grewal, Deena Sajitharan, Betty Y Chang, Joseph J Buggy, Xin J Zhou, Yong Du, Anne B Satterthwaite, Chandra Mohan Arthritis Research & Therapy 2012, 14:R243 (8 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro

Jun Qin, Liang Shang, An-song Ping, Jing Li, Xiao-jun Li, Hong Yu, Jacques Magdalou, Liao-bin Chen, Hui Wang Arthritis Research & Therapy 2012, 14:R242 (7 November 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Effect of autologous platelet-rich plasma-releasate on intervertebral disc degeneration in the rabbit anular puncture model: a preclinical study

Shuji Obata, Koji Akeda, Takao Imanishi, Koichi Masuda, Won Bae, Ryo Morimoto, Yumiko Asanuma, Yuichi Kasai, Atsumasa Uchida, Akihiro Sudo Arthritis Research & Therapy 2012, 14:R241 (5 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Citrullination of fibronectin modulates synovial fibroblast behavior

Miriam A Shelef, David A Bennin, Deane F Mosher, Anna Huttenlocher Arthritis Research & Therapy 2012, 14:R240 (5 November 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Altered behaviour of synovial fibroblasts on citrullinated fibronectin suggests interaction of synovial fibroblasts with the citrullinated matrix may play an important role in the pathophysiology of rheumatoid arthritis (RA).

Research article   Open Access

Investigation of Caucasian rheumatoid arthritis susceptibility loci in African patients with the same disease

Sebastien Viatte, Edward Flynn, Mark Lunt, Joanne Barnes, Madeleine Singwe-Ngandeu, Sylvette Bas, Anne Barton, Cem Gabay Arthritis Research & Therapy 2012, 14:R239 (3 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Systems analysis of primary Sjögren's syndrome pathogenesis in salivary glands identifies shared pathways in human and a mouse model

Steve Horvath, Abu NM Nazmul-Hossain, Rodney PE Pollard, Frans GM Kroese, Arjan Vissink, Cees GM Kallenberg, Fred KL Spijkervet, Hendrika Bootsma, Sara A Michie, Sven U Gorr, Ammon B Peck, Chaochao Cai, Hui Zhou, David TW Wong Arthritis Research & Therapy 2012, 14:R238 (1 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Comparative analysis of collagen type II-specific immune responses during development of collagen-induced arthritis in two B10 mouse strains

Tsvetelina Batsalova, Ingrid Lindh, Johan Bäcklund, Balik Dzhambazov, Rikard Holmdahl Arthritis Research & Therapy 2012, 14:R237 (1 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Noninvasive optical characterization of muscle blood flow, oxygenation, and metabolism in women with fibromyalgia

Yu Shang, Katelyn Gurley, Brock Symons, Douglas Long, Ratchakrit Srikuea, Leslie J Crofford, Charlotte A Peterson, Guoqiang Yu Arthritis Research & Therapy 2012, 14:R236 (1 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Y27, a novel derivative of 4-hydroxyquinoline-3-formamide, prevents the development of murine systemic lupus erythematosus-like diseases in MRL/lpr autoimmune mice and BDF1 hybrid mice

Zhi-Yong Xiao, Shao-Hui Chen, Jun-Ping Cheng, Wen-Xia Zhou, Yong-Xiang Zhang, Ri-Fang Yang, Liu-Hong Yun Arthritis Research & Therapy 2012, 14:R235 (1 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Deletion of interferon-γ delays onset and severity of dacryoadenitis in CD25KO mice

Flavia SA Pelegrino, Eugene A Volpe, Niral B Gandhi, De-Quan Li, Stephen C Pflugfelder, Cintia S de Paiva Arthritis Research & Therapy 2012, 14:R234 (1 November 2012)

Abstract | Full text | PDF | PubMed

Review   Free

New insight into the functions of the interleukin-17 receptor adaptor protein Act1 in psoriatic arthritis

Matthew S Doyle, Emily S Collins, Oliver M FitzGerald, Stephen R Pennington Arthritis Research & Therapy 2012, 14:226 (31 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Muscle-fiber transdifferentiation in an experimental model of respiratory chain myopathy

Nils Venhoff, Dirk Lebrecht, Dietmar Pfeifer, Ana C Venhoff, Emmanuel Bissé, Janbernd Kirschner, Ulrich A Walker Arthritis Research & Therapy 2012, 14:R233 (29 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Leflunomide increases the risk of silent liver fibrosis in patients with rheumatoid arthritis receiving methotrexate

Sang-Won Lee, Hee-Jin Park, Beom Kim, Kwang-Hyub Han, Soo-Kon Lee, Seung Kim, Yong-Beom Park Arthritis Research & Therapy 2012, 14:R232 (29 October 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Cumulative dose of leflunomide correlated closely with the presence of silent liver fibrosis in rheumatoid arthritis patients treated with methotrexate.

Research article   Open Access Highly Accessed

Sulforaphane has opposing effects on TNF-alpha stimulated and unstimulated synoviocytes

Athanassios Fragoulis, Jendrik Laufs, Susanna Müller, Ulf Soppa, Stephanie Siegl, Lucy Reiss, Mersedeh Tohidnezhad, Christian Rosen, Klaus Tenbrock, Deike Varoga, Sebastian Lippross, Thomas Pufe, Christoph Wruck Arthritis Research & Therapy 2012, 14:R220 (27 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Changes in pain catastrophizing predict later changes in fibromyalgia clinical and experimental pain report: cross-lagged panel analyses of dispositional and situational catastrophizing

Claudia M Campbell, Lea McCauley, Sara C Bounds, Vani A Mathur, Lora Conn, Mpepera Simango, Robert R Edwards, Kevin R Fontaine Arthritis Research & Therapy 2012, 14:R231 (25 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Double-blind, placebo-controlled randomized trial with adalimumab for treatment of juvenile onset ankylosing spondylitis (JoAS): significant short term improvement

Gerd Horneff, Sigrid Fitter, Ivan Foeldvari, Kirsten Minden, Jasmin Kuemmerle-Deschner, Nicolay Tzaribacev, Angelika Thon, Michael Borte, Gerd Ganser, Rolf Trauzeddel, Hans-Iko Huppertz Arthritis Research & Therapy 2012, 14:R230 (24 October 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A double-blind randomized trial found adalimumab treatment was significantly superior to placebo in the treatment of juvenile onset ankylosing spondylitis (AS), being well tolerated and highly effective.

Research article   Open Access Highly Accessed

The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy

Feng Fang, Lei Liu, Yang Yang, Zenshiro Tamaki, Jun Wei, Roberta G Marangoni, Swati Bhattacharyya, Ross S Summer, Boping Ye, John Varga Arthritis Research & Therapy 2012, 14:R229 (23 October 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Activation of the adiponectin pathway has potent antifibrotic effects in normal and scleroderma fibroblasts, and is a potential therapeutic target to control fibrosis in scleroderma and other chronic fibrosing conditions.

Research article   Open Access Highly Accessed

Interleukin-29 modulates proinflammatory cytokine production in synovial inflammation of rheumatoid arthritis

Fang Wang, Lingxiao Xu, Xiaoke Feng, Dunming Guo, Wenfeng Tan, Miaojia Zhang Arthritis Research & Therapy 2012, 14:R228 (19 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Th17 expansion in granulomatosis with polyangiitis (Wegener's): the role of disease activity, immune regulation and therapy

Benjamin Wilde, Marielle Thewissen, Jan Damoiseaux, Marc Hilhorst, Pieter van Paassen, Oliver Witzke, Jan Cohen Tervaert Arthritis Research & Therapy 2012, 14:R227 (18 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis

Rowan Hardy, Maria Juarez, Amy Naylor, Jinwen Tu, Elizabeth H Rabbitt, Andrew Filer, Paul M Stewart, Christopher D Buckley, Karim Raza, Mark S Cooper Arthritis Research & Therapy 2012, 14:R226 (18 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2

Joachim Pircher, Monika Merkle, Markus Wörnle, Andrea Ribeiro, Thomas Czermak, Yvonn Stampnik, Hanna Mannell, Markus Niemeyer, Volker Vielhauer, Florian Krötz Arthritis Research & Therapy 2012, 14:R225 (18 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Osteogenesis and osteoclast inhibition in rheumatoid arthritis patients treated with bisphosphonates alone or in combination with pitavastatin over an 18-month follow-up after more than 4 years of treatment with bisphosphonates

Masakazu Nagashima, Hiroshi Takahashi, Kenichi Shimane, Yuichi Nagase, Koichi Wauke Arthritis Research & Therapy 2012, 14:R224 (18 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis

Qin Shi, Jamilah Abusarah, Ghayath Baroudi, Julio C Fernandes, Hassan Fahmi, Mohamed Benderdour Arthritis Research & Therapy 2012, 14:R223 (18 October 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Periodontitis in established rheumatoid arthritis patients: a cross-sectional clinical, microbiological and serological study

Menke Smit, Johanna Westra, Arjan Vissink, Berber Doornbos-van der Meer, Elisabeth Brouwer, Arie van Winkelhoff Arthritis Research & Therapy 2012, 14:R222 (17 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation

Benjamin Terrier, Nicolas Derian, Yoland Schoindre, Wahiba Chaara, Guillaume Geri, Noël Zahr, Kubéraka Mariampillai, Michelle Rosenzwajg, Wassila Carpentier, Lucile Musset, Jean-Charles Piette, Adrien Six, David Klatzmann, David Saadoun, Cacoub Patrice, Nathalie Costedoat-Chalumeau Arthritis Research & Therapy 2012, 14:R221 (17 October 2012)

Abstract | Full text | PDF | PubMed | F1000 Biology |  Editor’s summary

Vitamin D supplementation in systemic lupus erythematosus (SLE) patients caused a reduction in B memory cells and effector T cells, and an increase in Tregs, suggesting vitamin D provides beneficial immunological effects for SLE.

Research article   Open Access

Aberrant cytokine pattern of the nasal mucosa in granulomatosis with polyangiitis

Janet Wohlers, Katrin Breucker, Rainer Podschun, Jürgen Hedderich, Peter Lamprecht, Petra Ambrosch, Martin Laudien Arthritis Research & Therapy 2012, 14:R203 (17 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Does digital X-ray radiogrammetry have a role in identifying patients at increased risk for joint destruction in early rheumatoid arthritis?

Kristina Forslind, Johan Kälvesten, Ingiäld Hafström, Björn Svensson, for the BARFOT Study Group Arthritis Research & Therapy 2012, 14:R219 (15 October 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Change in bone mineral density measured by digital X-ray radiogrammetry (DXR) in the first year of rheumatoid arthritis is associated with progression of radiographic joint damage over a number of years.

Research article   Open Access Highly Accessed

Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity

Aditya K Panda, Jyoti R Parida, Rina Tripathy, Sarit S Pattanaik, Balachandran Ravindran, Bidyut K Das Arthritis Research & Therapy 2012, 14:R218 (15 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

A randomized, double-blind, multicenter, placebo-controlled phase III trial to evaluate the efficacy and safety of pregabalin in Japanese patients with fibromyalgia

Hiroyoshi Ohta, Hiroshi Oka, Chie Usui, Masayuki Ohkura, Makoto Suzuki, Kusuki Nishioka Arthritis Research & Therapy 2012, 14:R217 (12 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Low sclerostin levels: a predictive marker of persistent inflammation in ankylosing spondylitis during anti-tumor necrosis factor therapy?

Carla GS Saad, Ana CM Ribeiro, Julio CB Moraes, Liliam Takayama, Celio R Goncalves, Marcelo B Rodrigues, Ricardo M de Oliveira, Clovis A Silva, Eloisa Bonfa, Rosa MR Pereira Arthritis Research & Therapy 2012, 14:R216 (12 October 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Persistent low serum levels of the Wnt inhibitor sclerostin are associated with continuous inflammation in patients with ankylosing spondylitis being treated with anti-TNF therapy.

Research article   Open Access

Sleep disturbances are associated with increased pain, disease activity, depression, and anxiety in ankylosing spondylitis: a case-control study

Yan Li, Shengli Zhang, Jian Zhu, Xuna Du, Feng Huang Arthritis Research & Therapy 2012, 14:R215 (11 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort

Darren Plant, Ibrahim Ibrahim, Mark Lunt, Stephen Eyre, Edward Flynn, Kimme L Hyrich, Ann W Morgan, Anthony G Wilson, John D Isaacs, BRAGGGSS, Anne Barton Arthritis Research & Therapy 2012, 14:R214 (7 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Predictors of mortality in connective tissue disease-associated pulmonary arterial hypertension: a cohort study

Gene-Siew Ngian, Wendy Stevens, David Prior, Eli Gabbay, Janet Roddy, Ai Tran, Robert Minson, Catherine Hill, Ken Chow, Joanne Sahhar, Susanna Proudman, Mandana Nikpour Arthritis Research & Therapy 2012, 14:R213 (5 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Biomechanical factors and physical examination findings in osteoarthritis of the knee: associations with tissue abnormalities assessed by conventional radiography and high-resolution 3.0 Tesla magnetic resonance imaging

Jesper Knoop, Joost Dekker, Jan-Paul Klein, Marike van der Leeden, Martin van der Esch, Dick Reiding, Ramon E Voorneman, Martijn Gerritsen, Leo D Roorda, Martijn PM Steultjens, Willem F Lems Arthritis Research & Therapy 2012, 14:R212 (5 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Hepatic steatosis, carotid plaques and achieving MDA in psoriatic arthritis patients starting TNF-α blockers treatment: a prospective study

Matteo Nicola Dario Di Minno, Rosario Peluso, Salvatore Iervolino, Roberta Lupoli, Anna Russolillo, Giovanni Tarantino, Raffaele Scarpa Arthritis Research & Therapy 2012, 14:R211 (4 October 2012)

Abstract | Full text | PDF | PubMed

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TLR4-mediated IL-12 production enhances IFN-γ and IL-1β production, which inhibits TGF-β production and promotes antibody-induced joint inflammation

Hye Kim, Doo Chung Arthritis Research & Therapy 2012, 14:R210 (4 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Impaired skeletal muscle microcirculation in systemic sclerosis

Sasan Partovi, Anja-Carina Schulte, Markus Aschwanden, Daniel Staub, Daniela Benz, Stephan Imfeld, Björn Jacobi, Pavel Broz, Kurt A Jäger, Martin Takes, Rolf W Huegli, Deniz Bilecen, Ulrich A Walker Arthritis Research & Therapy 2012, 14:R209 (4 October 2012)

Abstract | Full text | PDF | PubMed

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Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis

Marina G Kazantseva, John Highton, Lisa K Stamp, Paul A Hessian Arthritis Research & Therapy 2012, 14:R208 (4 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Functional relationship between high mobility group A1 (HMGA1) protein and insulin-like growth factor-binding protein 3 (IGFBP-3) in human chondrocytes

Giorgio Gasparini, Marco De Gori, Francesco Paonessa, Eusebio Chiefari, Antonio Brunetti, Olimpio Galasso Arthritis Research & Therapy 2012, 14:R207 (4 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Targeting tumour necrosis factor alleviates signs and symptoms of inflammatory osteoarthritis of the knee

Walter P Maksymowych, Anthony S Russell, Peter Chiu, Alex Yan, Niall Jones, Tracey Clare, Robert GW Lambert Arthritis Research & Therapy 2012, 14:R206 (4 October 2012)

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Research article   Open Access

Chondrocalcinosis is common in the absence of knee involvement

Abhishek Abhishek, Sally Doherty, Rose Maciewicz, Kenneth Muir, Weiya Zhang, Michael Doherty Arthritis Research & Therapy 2012, 14:R205 (4 October 2012)

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Research article   Open Access

Association of circulating levels of MMP-8 with mortality from respiratory disease in patients with rheumatoid arthritis

Derek L Mattey, Nicola B Nixon, Peter T Dawes Arthritis Research & Therapy 2012, 14:R204 (2 October 2012)

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Research article   Open Access

Secretome analysis of chondroitin sulfate-treated chondrocytes reveals anti-angiogenic, anti-inflammatory and anti-catabolic properties

Valentina Calamia, Lucía Lourido, Patricia Fernández-Puente, Jesús Mateos, Beatriz Rocha, Eulalia Montell, Josep Vergés, Cristina Ruiz-Romero, Francisco J Blanco Arthritis Research & Therapy 2012, 14:R202 (2 October 2012)

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Validation of a multiplex chip-based assay for the detection of autoantibodies against citrullinated peptides

Monika Hansson, Linda Mathsson, Thomas Schlederer, Lena Israelsson, Per Matsson, Leonor Nogueira, Per-Johan Jakobsson, Karin Lundberg, Vivianne Malmström, Guy Serre, Rikard Holmdahl, Mats Nystrand, Lars Klareskog, Johan Rönnelid Arthritis Research & Therapy 2012, 14:R201 (1 October 2012)

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Bone marrow edema and osteitis in rheumatoid arthritis: the imaging perspective

Fiona M McQueen Arthritis Research & Therapy 2012, 14:224 (28 September 2012)

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Editorial   Free Highly Accessed

4th International Forum on Rheumatoid Arthritis: Great Times Near the Great Wall

David S Pisetsky Arthritis Research & Therapy 2012, 14:125 (27 September 2012)

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Research article   Open Access

Expression of IL-20 in synovium and lesional skin of patients with psoriatic arthritis: differential response to alefacept treatment

Maria C Lebre, Christina L Jonckheere, Maarten C Kraan, Arno WR van Kuijk, Jan D Bos, Menno de Rie, Danielle M Gerlag, Paul P Tak Arthritis Research & Therapy 2012, 14:R200 (24 September 2012)

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Common variable immunodeficiency - an update

Ulrich Salzer, Klaus Warnatz, Hans Peter Arthritis Research & Therapy 2012, 14:223 (24 September 2012)

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Editorial   Free

Ways forward to identify new ACPA targets in RA

A Jimmy Ytterberg, Vivianne Malmström Arthritis Research & Therapy 2012, 14:124 (24 September 2012)

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Research article   Open Access

Granulocyte-macrophage colony-stimulating factor is a key mediator in experimental osteoarthritis pain and disease development

Andrew D Cook, Jarrad Pobjoy, Stefan Steidl, Manuela Dürr, Emma L Braine, Amanda L Turner, Derek C Lacey, John A Hamilton Arthritis Research & Therapy 2012, 14:R199 (20 September 2012)

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Ultrasound of metacarpophalangeal joints is a sensitive and reliable endpoint for drug therapies in rheumatoid arthritis: results of a randomized, two-center placebo-controlled study

Matthew W Seymour, Stephen Kelly, Chan R Beals, Marie-Pierre Malice, James A Bolognese, Bernard J Dardzinski, Amy S Cheng, Corinne E Cummings, Steven S Smugar, Catherine McClinton, Amy Fox, William M Dooley, Constantino Pitzalis, Peter C Taylor Arthritis Research & Therapy 2012, 14:R198 (12 September 2012)

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Letter   Free

Response to 'Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4' - authors' reply

Dong Sohn, Jeremy Sokolove, Orr Sharpe, Jennifer C Erhart, Piyanka E Chandra, Lauren J Lahey, Tamsin M Lindstrom, Inyong Hwang, Katherine A Boyer, Thomas P Andriacchi, William H Robinson Arthritis Research & Therapy 2012, 14:406 (12 September 2012)

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Letter   Free

Response to 'Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4'

Francesca Oliviero, Anna Scanu, Jean-Michel Dayer, Ugo Fiocco, Paolo Sfriso, Leonardo Punzi Arthritis Research & Therapy 2012, 14:405 (12 September 2012)

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Matrilin-3 Induction of IL-1 receptor antagonist Is required for up-regulating collagen II and aggrecan and down-regulating ADAMTS-5 gene expression

Chathuraka T Jayasuriya, Mary B Goldring, Richard Terek, Qian Chen Arthritis Research & Therapy 2012, 14:R197 (11 September 2012)

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Letter   Free

Response to 'Fragment of tegument protein pp65 of human cytomegalovirus induces autoantibodies in BALB/c mice'

Gn Kim, Think-You Kim Arthritis Research & Therapy 2012, 14:404 (10 September 2012)

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Review   Free

Idiopathic CD4 lymphocytopenia: a case of missing, wandering or ineffective T cells

Dimitrios Zonios, Virginia Sheikh, Irini Sereti Arthritis Research & Therapy 2012, 14:222 (31 August 2012)

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Inhibitory function of parathyroid hormone-related protein on chondrocyte hypertrophy: the implication for articular cartilage repair

Wei Zhang, Jialin Chen, Shufang Zhang, Hong Ouyang Arthritis Research & Therapy 2012, 14:221 (31 August 2012)

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Atypical subtrochanteric femoral shaft fractures: role for mechanics and bone quality

Marjolein CH van der Meulen, Adele L Boskey Arthritis Research & Therapy 2012, 14:220 (29 August 2012)

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Research article   Open Access

Antinociceptive interaction of (±)-CPP and propentofylline in monoarthritic rats

Francisco Morales, Luis Constandil, Teresa Pelissier, Alejandro Hernández, Claudio Laurido Arthritis Research & Therapy 2012, 14:R196 (24 August 2012)

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Research article   Open Access

In vitro glucocorticoid sensitivity is associated with clinical glucocorticoid therapy outcome in rheumatoid arthritis

Rogier AM Quax, Jan W Koper, Pascal HP de Jong, Ramona van Heerebeek, Angelique E Weel, Anne M Huisman, Derkjen van Zeben, Frank H de Jong, Steven WJ Lamberts, Johanna MW Hazes, Richard A Feelders Arthritis Research & Therapy 2012, 14:R195 (24 August 2012)

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Research article   Open Access

Angiotensin II induces skin fibrosis: a novel mouse model of dermal fibrosis

Lukasz Stawski, Rong Han, Andreea M Bujor, Maria Trojanowska Arthritis Research & Therapy 2012, 14:R194 (22 August 2012)

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Research article   Open Access

Anemia and the onset of gout in a population-based cohort of adults: Atherosclerosis Risk in Communities study

Mara A McAdams-DeMarco, Janet W Maynard, Josef Coresh, Alan N Baer Arthritis Research & Therapy 2012, 14:R193 (20 August 2012)

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Research article   Open Access

Fully recombinant IgG2a Fc multimers (stradomers) effectively treat collagen-induced arthritis and prevent idiopathic thrombocytopenic purpura in mice

Ajay Jain, Henrik S Olsen, Ravi Vyzasatya, Erin Burch, Yukimi Sakoda, Emmanuel Y Mérigeon, Ling Cai, Changwan Lu, Ming Tan, Koji Tamada, Dan Schulze, David S Block, Scott E Strome Arthritis Research & Therapy 2012, 14:R192 (20 August 2012)

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Research article   Open Access

Cartilage oligomeric matrix protein specific antibodies are pathogenic

Hui Geng, Kutty Nandakumar, Anna Pramhed, Anders Aspberg, Ragnar Mattsson, Rikard Holmdahl Arthritis Research & Therapy 2012, 14:R191 (20 August 2012)

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Early menopause and severity of rheumatoid arthritis in women older than 45 years

Mitra Pikwer, Jan-Åke Nilsson, Ulf Bergström, Lennart TH Jacobsson, Carl Turesson Arthritis Research & Therapy 2012, 14:R190 (17 August 2012)

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Research article   Open Access

Fractional clearance of urate: validation of measurement in spot-urine samples in healthy subjects and gouty patients

Diluk RW Kannangara, Sheena N Ramasamy, Praveen L Indraratna, Sophie L Stocker, Garry G Graham, Graham Jones, Ian Portek, Kenneth M Williams, Richard O Day Arthritis Research & Therapy 2012, 14:R189 (17 August 2012)

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Early systemic sclerosis: short-term disease evolution and factors predicting the development of new manifestations of organ involvement

Gabriele Valentini, Serena Vettori, Giovanna Cuomo, Michele Iudici, Virginia D'Abrosca, Domenico Capocotta, Gianmattia Del Genio, Carlo Santoriello, Domenico Cozzolino Arthritis Research & Therapy 2012, 14:R188 (17 August 2012)

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Atorvastatin inhibits osteoclastogenesis by decreasing the expression of RANKL in the synoviocytes of rheumatoid arthritis

Jeong Kim, Eun Lee, Eun Lee, Yun Lee, Hyun Yoo, Jiyong Choi, Yeong Song Arthritis Research & Therapy 2012, 14:R187 (17 August 2012)

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Research article   Open Access

Activity of the neuroendocrine axes in patients with polymyalgia rheumatica before and after TNF-α blocking etanercept treatment

Frederik Kreiner, Henrik Galbo Arthritis Research & Therapy 2012, 14:R186 (15 August 2012)

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Research article   Open Access

Factor H autoantibodies and deletion of Complement Factor H-Related protein-1 in rheumatic diseases in comparison to atypical hemolytic uremic syndrome

Anna Foltyn Zadura, Peter F Zipfel, Maria I Bokarewa, Gunnar Sturfelt, Andreas Jönsen, Sara C Nilsson, Andreas Hillarp, Tore Saxne, Leendert A Trouw, Anna M Blom Arthritis Research & Therapy 2012, 14:R185 (15 August 2012)

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