Arthritis Research & Therapy

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		Research article Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis Zhongying Zhang, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Takashi Yurube, Minoru Doita, Masahiro Kurosaka, Kotaro Nishida Arthritis Research & Therapy 2011, 13:R200 (8 December 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Identification of urinary metabolites that distinguish membranous lupus nephritis from proliferative lupus nephritis and focal segmental glomerulosclerosis Lindsey E Romick-Rosendale, Hermine I Brunner, Michael R Bennett, Rina Mina, Shannen Nelson, Michelle Petri, Adnan Kiani, Prasad Devarajan, Michael A Kennedy Arthritis Research & Therapy 2011, 13:R199 (7 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury Robert A Mooney, Erik R Sampson, Jaclyn Lerea, Randy N Rosier, Michael J Zuscik Arthritis Research & Therapy 2011, 13:R198 (7 December 2011) Abstract \| Full text \| PDF \| PubMed
		Research article A_2Aand A₃adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release Katia Varani, Melissa Padovan, Fabrizio Vincenzi, Martina Targa, Francesco Trotta, Marcello Govoni, Pier Borea Arthritis Research & Therapy 2011, 13:R197 (6 December 2011) Abstract \| Full text \| PDF \| PubMed
		Research article NLRP3 E311K mutation in a large family with Muckle-Wells syndrome - description of a heterogeneous phenotype and response to treatment Jasmin B Kuemmerle-Deschner, Peter Lohse, Ina Koetter, Guenther E Dannecker, Fabian Reess, Katharina Ummenhofer, Silvia Koch, Nikolay Tzaribachev, Anja Bialkowski, Susanne M Benseler Arthritis Research & Therapy 2011, 13:R196 (6 December 2011) Abstract \| Full text \| PDF \| PubMed
		Editorial T cells as key players for bone destruction in gouty arthritis? Ulrike Harre, Anja Derer, Christine Schorn, Georg Schett, Martin Herrmann Arthritis Research & Therapy 2011, 13:135 (2 December 2011) Abstract \| Full text \| PDF \| PubMed
		Editorial Beyond cognitive-behavioral therapy for fibromyalgia: addressing stress by emotional exposure, processing, and resolution Mark A Lumley Arthritis Research & Therapy 2011, 13:136 (1 December 2011) Abstract \| Full text \| PDF \| PubMed
		Research article The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA Parawee Suwannalai, Annemiek Willemze, Linda van Toorn, Gerrie Stoeken-Rijsbergen, Nivine Levarht, Jan Drijfhout, Tom W J Huizinga, Rene E M Toes, Leendert A Trouw Arthritis Research & Therapy 2011, 13:R195 (30 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Proteomic analysis of saliva: a unique tool to distinguish primary Sjögren's syndrome from secondary Sjögren's syndrome and other sicca syndromes Chiara Baldini, Laura Giusti, Federica Ciregia, Ylenia Da Valle, Camillo Giacomelli, Elena Donadio, Francesca Sernissi, Laura Bazzichi, Gino Giannaccini, Stefano Bombardieri, Antonio Lucacchini Arthritis Research & Therapy 2011, 13:R194 (25 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Follistatin-like protein 1: a serum biochemical marker reflecting the severity of joint damage in patients with osteoarthritis Yuji Wang, Dawei Li, Nanwei Xu, Weijian Tao, Ruixia Zhu, Rongbin Sun, Weiwei Fan, Ping Zhang, Tianhua Dong, Long Yu Arthritis Research & Therapy 2011, 13:R193 (25 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Serum levels of follistatin-like protein 1 (FSTL1) may reflect the severity of joint damage and have potential for monitoring disease course and treatment efficacy in osteoarthritis patients.
		Editorial Central pain contributions in osteoarthritis: next steps for improving recognition and treatment? Kelli Allen Arthritis Research & Therapy 2011, 13:133 (25 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats Guo-Xin Ni, Li-Qiong Zhan, Mei-Qin Gao, Lei Lei, Yue-Zhu Zhou, Yan-Xia Pan Arthritis Research & Therapy 2011, 13:R192 (24 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Why radiography should no longer be considered a surrogate outcome measure for longitudinal assessment of cartilage in knee osteoarthritis Ali Guermazi, Frank W Roemer, Deborah Burstein, Daichi Hayashi Arthritis Research & Therapy 2011, 13:247 (24 November 2011) Abstract \| Full text \| PDF \| PubMed
		Editorial Multiplex, megaplex, index, and complex: the present and future of laboratory diagnostics in rheumatology Mark H Wener Arthritis Research & Therapy 2011, 13:134 (24 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Detection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and pro-inflammatory role of citrullinated BiP in collagen-induced arthritis Hirofumi Shoda, Keishi Fujio, Mihoko Shibuya, Tomohisa Okamura, Shuji Sumitomo, Akiko Okamoto, Tetsuji Sawada, Kazuhiko Yamamoto Arthritis Research & Therapy 2011, 13:R191 (22 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Cardiac autonomic impairment and chronotropic incompetence in fibromyalgia Roberta da Cunha Ribeiro, Hamilton Roschel, Guilherme Artioli, Thalita Dassouki, Luiz Perandini, Ana Calich, Ana de Sá Pinto, Fernanda Lima, Eloísa Bonfá, Bruno Gualano Arthritis Research & Therapy 2011, 13:R190 (18 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Fibromyalgia patients may suffer from chronotropic incompetence and delayed heart rate recovery, both of which are indicative of cardiac autonomic impairment and higher risk of cardiovascular events and mortality.
		Research article Primary care physicians' perspectives towards managing rheumatoid arthritis: room for improvement Katie L Garneau, Maura D Iversen, Hsun Tsao, Daniel H Solomon Arthritis Research & Therapy 2011, 13:R189 (18 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Rheumatoid arthritis patients in the US may not be receiving optimal care, as primary care physicians are uncomfortable prescribing disease-modifying anti-rheumatic drugs and report that their patients have difficulty accessing rheumatologists.
		Research article Ultrasound in the evaluation of enthesitis: status and perspectives Frédérique Gandjbakhch, Lene Terslev, Fredrick Joshua, Richard J Wakefield, Esperanza Naredo, Maria D'Agostino, OMERACT Ultrasound Task Force Arthritis Research & Therapy 2011, 13:R188 (17 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Interleukin-1, tumor necrosis factor-alpha, and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration Katherine M Riera, Nicole E Rothfusz, Rebecca E Wilusz, JB Weinberg, Farshid Guilak, Amy L McNulty Arthritis Research & Therapy 2011, 13:R187 (16 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population Hua Zhong, Xiao-lan Li, Ming Li, Li-xia Hao, Rong-wei Chen, Kun Xiang, Xue-bin Qi, Runlin Z Ma, Bing Su Arthritis Research & Therapy 2011, 13:R186 (16 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Nocturnal heart rate variability parameters as potential fibromyalgia biomarker: correlation with symptoms severity Claudia Lerma, Aline Martinez, Natllely Ruiz, Angelica Vargas, Oscar Infante, Manuel Martinez-Lavin Arthritis Research & Therapy 2011, 13:R185 (16 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Nocturnal heart rate variability parameters indicative of sympathetic predominance are significantly different in fibromyalgia patients compared to healthy individuals, and correlate with several symptoms including pain severity.
		Research article Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways Anna Koskinen, Sami Juslin, Riina Nieminen, Teemu Moilanen, Katriina Vuolteenaho, Eeva Moilanen Arthritis Research & Therapy 2011, 13:R184 (11 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Increased incidence of pregnancy complications in women who later develop scleroderma: a case control study Linda van Wyk, Jacolien van der Marel, Annemie JM Schuerwegh, Anne A Schouffoer, Alexandre E Voskuyl, Tom WJ Huizinga, Diana W Bianchi, Sicco A Scherjon Arthritis Research & Therapy 2011, 13:R183 (4 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Women who developed systemic sclerosis after pregnancy were more likely to have had a pregnancy history of hypertension or a fetus with intra-uterine growth restriction.
		Review Imaging in gout - What can we learn from MRI, CT, DECT and US? Fiona M McQueen, Anthony Doyle, Nicola Dalbeth Arthritis Research & Therapy 2011, 13:246 (4 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Lymphotoxin-beta receptor blockade reduces CXCL13 in lacrimal glands and improves corneal integrity in the NOD model of Sjögren's syndrome Roy A Fava, Susan M Kennedy, Sheryl G Wood, Anne I Bolstad, Jadwiga Bienkowska, Adrian Papandile, John A Kelly, Clio P Mavragani, Margaret Gatumu, Kathrine Skarstein, Jeffrey L Browning Arthritis Research & Therapy 2011, 13:R182 (1 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Blockade of lymphotoxin-beta receptor pathways increased tear-fluid secretion and significantly improved ocular surface integrity score in a mouse model of Sjoegren's syndrome, suggesting this may have therapeutic potential.

	All
		Research article Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis Zhongying Zhang, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Takashi Yurube, Minoru Doita, Masahiro Kurosaka, Kotaro Nishida Arthritis Research & Therapy 2011, 13:R200 (8 December 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Identification of urinary metabolites that distinguish membranous lupus nephritis from proliferative lupus nephritis and focal segmental glomerulosclerosis Lindsey E Romick-Rosendale, Hermine I Brunner, Michael R Bennett, Rina Mina, Shannen Nelson, Michelle Petri, Adnan Kiani, Prasad Devarajan, Michael A Kennedy Arthritis Research & Therapy 2011, 13:R199 (7 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury Robert A Mooney, Erik R Sampson, Jaclyn Lerea, Randy N Rosier, Michael J Zuscik Arthritis Research & Therapy 2011, 13:R198 (7 December 2011) Abstract \| Full text \| PDF \| PubMed
		Research article A_2Aand A₃adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release Katia Varani, Melissa Padovan, Fabrizio Vincenzi, Martina Targa, Francesco Trotta, Marcello Govoni, Pier Borea Arthritis Research & Therapy 2011, 13:R197 (6 December 2011) Abstract \| Full text \| PDF \| PubMed
		Research article NLRP3 E311K mutation in a large family with Muckle-Wells syndrome - description of a heterogeneous phenotype and response to treatment Jasmin B Kuemmerle-Deschner, Peter Lohse, Ina Koetter, Guenther E Dannecker, Fabian Reess, Katharina Ummenhofer, Silvia Koch, Nikolay Tzaribachev, Anja Bialkowski, Susanne M Benseler Arthritis Research & Therapy 2011, 13:R196 (6 December 2011) Abstract \| Full text \| PDF \| PubMed
		Editorial T cells as key players for bone destruction in gouty arthritis? Ulrike Harre, Anja Derer, Christine Schorn, Georg Schett, Martin Herrmann Arthritis Research & Therapy 2011, 13:135 (2 December 2011) Abstract \| Full text \| PDF \| PubMed
		Editorial Beyond cognitive-behavioral therapy for fibromyalgia: addressing stress by emotional exposure, processing, and resolution Mark A Lumley Arthritis Research & Therapy 2011, 13:136 (1 December 2011) Abstract \| Full text \| PDF \| PubMed
		Research article The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA Parawee Suwannalai, Annemiek Willemze, Linda van Toorn, Gerrie Stoeken-Rijsbergen, Nivine Levarht, Jan Drijfhout, Tom W J Huizinga, Rene E M Toes, Leendert A Trouw Arthritis Research & Therapy 2011, 13:R195 (30 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Proteomic analysis of saliva: a unique tool to distinguish primary Sjögren's syndrome from secondary Sjögren's syndrome and other sicca syndromes Chiara Baldini, Laura Giusti, Federica Ciregia, Ylenia Da Valle, Camillo Giacomelli, Elena Donadio, Francesca Sernissi, Laura Bazzichi, Gino Giannaccini, Stefano Bombardieri, Antonio Lucacchini Arthritis Research & Therapy 2011, 13:R194 (25 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Follistatin-like protein 1: a serum biochemical marker reflecting the severity of joint damage in patients with osteoarthritis Yuji Wang, Dawei Li, Nanwei Xu, Weijian Tao, Ruixia Zhu, Rongbin Sun, Weiwei Fan, Ping Zhang, Tianhua Dong, Long Yu Arthritis Research & Therapy 2011, 13:R193 (25 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Serum levels of follistatin-like protein 1 (FSTL1) may reflect the severity of joint damage and have potential for monitoring disease course and treatment efficacy in osteoarthritis patients.
		Editorial Central pain contributions in osteoarthritis: next steps for improving recognition and treatment? Kelli Allen Arthritis Research & Therapy 2011, 13:133 (25 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats Guo-Xin Ni, Li-Qiong Zhan, Mei-Qin Gao, Lei Lei, Yue-Zhu Zhou, Yan-Xia Pan Arthritis Research & Therapy 2011, 13:R192 (24 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Why radiography should no longer be considered a surrogate outcome measure for longitudinal assessment of cartilage in knee osteoarthritis Ali Guermazi, Frank W Roemer, Deborah Burstein, Daichi Hayashi Arthritis Research & Therapy 2011, 13:247 (24 November 2011) Abstract \| Full text \| PDF \| PubMed
		Editorial Multiplex, megaplex, index, and complex: the present and future of laboratory diagnostics in rheumatology Mark H Wener Arthritis Research & Therapy 2011, 13:134 (24 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Detection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and pro-inflammatory role of citrullinated BiP in collagen-induced arthritis Hirofumi Shoda, Keishi Fujio, Mihoko Shibuya, Tomohisa Okamura, Shuji Sumitomo, Akiko Okamoto, Tetsuji Sawada, Kazuhiko Yamamoto Arthritis Research & Therapy 2011, 13:R191 (22 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Cardiac autonomic impairment and chronotropic incompetence in fibromyalgia Roberta da Cunha Ribeiro, Hamilton Roschel, Guilherme Artioli, Thalita Dassouki, Luiz Perandini, Ana Calich, Ana de Sá Pinto, Fernanda Lima, Eloísa Bonfá, Bruno Gualano Arthritis Research & Therapy 2011, 13:R190 (18 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Fibromyalgia patients may suffer from chronotropic incompetence and delayed heart rate recovery, both of which are indicative of cardiac autonomic impairment and higher risk of cardiovascular events and mortality.
		Research article Primary care physicians' perspectives towards managing rheumatoid arthritis: room for improvement Katie L Garneau, Maura D Iversen, Hsun Tsao, Daniel H Solomon Arthritis Research & Therapy 2011, 13:R189 (18 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Rheumatoid arthritis patients in the US may not be receiving optimal care, as primary care physicians are uncomfortable prescribing disease-modifying anti-rheumatic drugs and report that their patients have difficulty accessing rheumatologists.
		Research article Ultrasound in the evaluation of enthesitis: status and perspectives Frédérique Gandjbakhch, Lene Terslev, Fredrick Joshua, Richard J Wakefield, Esperanza Naredo, Maria D'Agostino, OMERACT Ultrasound Task Force Arthritis Research & Therapy 2011, 13:R188 (17 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Interleukin-1, tumor necrosis factor-alpha, and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration Katherine M Riera, Nicole E Rothfusz, Rebecca E Wilusz, JB Weinberg, Farshid Guilak, Amy L McNulty Arthritis Research & Therapy 2011, 13:R187 (16 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population Hua Zhong, Xiao-lan Li, Ming Li, Li-xia Hao, Rong-wei Chen, Kun Xiang, Xue-bin Qi, Runlin Z Ma, Bing Su Arthritis Research & Therapy 2011, 13:R186 (16 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Nocturnal heart rate variability parameters as potential fibromyalgia biomarker: correlation with symptoms severity Claudia Lerma, Aline Martinez, Natllely Ruiz, Angelica Vargas, Oscar Infante, Manuel Martinez-Lavin Arthritis Research & Therapy 2011, 13:R185 (16 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Nocturnal heart rate variability parameters indicative of sympathetic predominance are significantly different in fibromyalgia patients compared to healthy individuals, and correlate with several symptoms including pain severity.
		Research article Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways Anna Koskinen, Sami Juslin, Riina Nieminen, Teemu Moilanen, Katriina Vuolteenaho, Eeva Moilanen Arthritis Research & Therapy 2011, 13:R184 (11 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Increased incidence of pregnancy complications in women who later develop scleroderma: a case control study Linda van Wyk, Jacolien van der Marel, Annemie JM Schuerwegh, Anne A Schouffoer, Alexandre E Voskuyl, Tom WJ Huizinga, Diana W Bianchi, Sicco A Scherjon Arthritis Research & Therapy 2011, 13:R183 (4 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Women who developed systemic sclerosis after pregnancy were more likely to have had a pregnancy history of hypertension or a fetus with intra-uterine growth restriction.
		Review Imaging in gout - What can we learn from MRI, CT, DECT and US? Fiona M McQueen, Anthony Doyle, Nicola Dalbeth Arthritis Research & Therapy 2011, 13:246 (4 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Lymphotoxin-beta receptor blockade reduces CXCL13 in lacrimal glands and improves corneal integrity in the NOD model of Sjögren's syndrome Roy A Fava, Susan M Kennedy, Sheryl G Wood, Anne I Bolstad, Jadwiga Bienkowska, Adrian Papandile, John A Kelly, Clio P Mavragani, Margaret Gatumu, Kathrine Skarstein, Jeffrey L Browning Arthritis Research & Therapy 2011, 13:R182 (1 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Blockade of lymphotoxin-beta receptor pathways increased tear-fluid secretion and significantly improved ocular surface integrity score in a mouse model of Sjoegren's syndrome, suggesting this may have therapeutic potential.