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Safety, pharmacokinetics, and biologic activity of pateclizumab, a novel monoclonal antibody targeting lymphotoxin α: results of a phase I randomized, placebo-controlled trial
Brinda Emu, Diana Luca, Carolyn Offutt, Jane L Grogan, Bernadette Rojkovich, Marna B Williams, Meina T Tang, Jim Xiao, June H Lee, John C Davis Arthritis Research & Therapy 2012, 14:R6 (8 January 2012)
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Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis
Niklas Schuelert, Jason J McDougall Arthritis Research & Therapy 2012, 14:R5 (7 January 2012)
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Association between being African-American, serum urate levels and the risk of developing hyperuricemia: findings from the Coronary Artery Risk Development in Young Adults cohort
Angelo L Gaffo, David R Jacobs, Cora E Lewis, Ted R Mikuls, Kenneth G Saag Arthritis Research & Therapy 2012, 14:R4 (6 January 2012)
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Anterior chest wall inflammation by whole-body magnetic resonance imaging in patients with spondyloarthritis: lack of association between clinical and imaging findings in a cross-sectional study
Ulrich Weber, Robert GW Lambert, Kaspar Rufibach, Walter P Maksymowych, Juerg Hodler, Anna Zejden, Stefan Duewell, Rudolf O Kissling, Paul L Filipow, Anne G Jurik Arthritis Research & Therapy 2012, 14:R3 (6 January 2012)
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Editor’s summary
No association was found between clinical and imaging findings in a study using whole body magnetic resonance imaging to assess anterior chest wall inflammation in patients with spondyloarthritis.
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International cohort study of 73 anti-Ku-positive patients: association of p70/p80 anti-Ku antibodies with joint/bone features and differentiation of disease populations by using principal-components analysis
Katja Lakota, Gerhard G Thallinger, Snezna Sodin-Semrl, Blaz Rozman, Ales Ambrozic, Matija Tomsic, Sonja Praprotnik, Sasa Cucnik, Katjusa Mrak-Poljsak, Angela Ceribelli, Ilaria Cavazzana, Franco Franceschini, Jiri Vencovsky, Laszlo Czirják, Cecilia Varjú, Gunther Steiner, Martin Aringer, Bojana Stamenkovic, Oliver Distler, Marco Matucci-Cerinic, Tanja Kveder Arthritis Research & Therapy 2012, 14:R2 (6 January 2012)
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Tumor necrosis factor α release in peripheral blood mononuclear cells of cutaneous lupus and dermatomyositis patients
Adam S Nabatian, Muhammad M Bashir, Maria Wysocka, Meena Sharma, Victoria P Werth Arthritis Research & Therapy 2012, 14:R1 (4 January 2012)
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Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration
W Erwin, Diana Islam, Robert D Inman, Michael G Fehlings, Florence WL Tsui Arthritis Research & Therapy 2011, 13:R215 (29 December 2011)
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Epidemiologic study of clinically amyopathic dermatomyositis and anti-melanoma differentiation-associated gene 5 antibodies in central Japan
Yoshinao Muro, Kazumitsu Sugiura, Kei Hoshino, Masashi Akiyama, Koji Tamakoshi Arthritis Research & Therapy 2011, 13:R214 (22 December 2011)
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Correlation of antinuclear antibody and anti-double-stranded DNA antibody with clinical response to infliximab in patients with rheumatoid arthritis: a retrospective clinical study
Naoichiro Yukawa, Takao Fujii, Seiko Kondo-Ishikawa, Hajime Yoshifuji, Daisuke Kawabata, Takaki Nojima, Koichiro Ohmura, Takashi Usui, Tsuneyo Mimori Arthritis Research & Therapy 2011, 13:R213 (22 December 2011)
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Editor’s summary
The antinuclear antibodies (ANA) titer before starting treatment may predict clinical response to infliximab, while increased ANA titers or development of anti-ds-DNA antibodies after infliximab treatment may be useful markers of no response.
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IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis
Jian Tao, Masahito Kamanaka, Jianlei Hao, Zhifang Hao, Xi Jiang, Joe E Craft, Richard A Flavell, Zhenzhou Wu, Zhangyong Hong, Liqing Zhao, Zhinan Yin Arthritis Research & Therapy 2011, 13:R212 (22 December 2011)
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Prevalence, correlates and clinical usefulness of antibodies to RNA polymerase III in systemic sclerosis: a cross-sectional analysis of data from an Australian cohort
Mandana Nikpour, Pravin Hissaria, Jillian Byron, Joanne Sahhar, Maree Micallef, William Paspaliaris, Janet Roddy, Peter Nash, Alan Sturgess, Susanna Proudman, Wendy Stevens Arthritis Research & Therapy 2011, 13:R211 (22 December 2011)
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Type I interferon pathway in adult and juvenile dermatomyositis
Emily C Baechler, Hatice Bilgic, Ann M Reed Arthritis Research & Therapy 2011, 13:249 (22 December 2011)
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Application of in vivo micro-computed tomography in the temporal characterisation of subchondral bone architecture in a rat model of low-dose monosodium iodoacetate-induced osteoarthritis
Geetha Mohan, Egon Perilli, Julia S Kuliwaba, Julia M Humphries, Ian H Parkinson, Nicola L Fazzalari Arthritis Research & Therapy 2011, 13:R210 (21 December 2011)
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Mechanisms of tissue injury in lupus nephritis
Tamara K Nowling, Gary S Gilkeson Arthritis Research & Therapy 2011, 13:250 (21 December 2011)
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The 2011 ACR Meeting: what's new in the Windy City
David S Pisetsky Arthritis Research & Therapy 2011, 13:138 (21 December 2011)
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IL-21 and Sjögren's syndrome
R Hal Scofield Arthritis Research & Therapy 2011, 13:137 (19 December 2011)
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Decreased influenza-specific B cell responses in rheumatoid arthritis patients treated with anti-tumor necrosis factor
James J Kobie, Bo Zheng, Peter Bryk, Michael Barnes, Christopher T Ritchlin, Darren A Tabechian, Allen P Anandarajah, R Looney, Ralf G Thiele, Jennifer H Anolik, Andreea Coca, Chungwen Wei, Alexander F Rosenberg, Changyong Feng, John J Treanor, F Eun-Hyung Lee, Ignacio Sanz Arthritis Research & Therapy 2011, 13:R209 (16 December 2011)
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Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects
Paul Eggleton, Edwin Bremer, Joanna M Tarr, Marco de Bruyn, Wijnand Helfrich, Alexandra Kendall, Richard C Haigh, Nick J Viner, Paul G Winyard Arthritis Research & Therapy 2011, 13:R208 (15 December 2011)
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Regenerative potential of human muscle stem cells in chronic inflammation
Bouke J Duijnisveld, Anne Bigot, Karel GM Beenakker, Débora M Portilho, Vered Raz, Huub JL van der Heide, Cornelis PJ Visser, Soraya Chaouch, Kamel Mamchaoui, Rudi GJ Westendorp, Vincent Mouly, Gillian S Butler-Browne, Rob GHH Nelissen, Andrea B Maier Arthritis Research & Therapy 2011, 13:R207 (15 December 2011)
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Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus
Andreas Jönsen, Sara C Nilsson, Emma Ahlqvist, Elisabet Svenungsson, Iva Gunnarsson, Karin G Eriksson, Anders Bengtsson, Agneta Zickert, Maija-Leena Eloranta, Lennart Truedsson, Lars Rönnblom, Gunnel Nordmark, Gunnar Sturfelt, Anna M Blom Arthritis Research & Therapy 2011, 13:R206 (15 December 2011)
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Advanced glycation endproducts are increased in rheumatoid arthritis patients with controlled disease
Lodewijk de Groot, Helmy Hinkema, Johanna Westra, Andries J Smit, Cees GM Kallenberg, Marc Bijl, Marcel D Posthumus Arthritis Research & Therapy 2011, 13:R205 (14 December 2011)
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Imaging modalities in hand osteoarthritis - status and perspectives of conventional radiography, magnetic resonance imaging, and ultrasonography
Ida K Haugen, Pernille Bøyesen Arthritis Research & Therapy 2011, 13:248 (13 December 2011)
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Abatacept with methotrexate versus other biologic agents in treatment of patients with active rheumatoid arthritis despite methotrexate: a network meta-analysis
Patricia Guyot, Peter Taylor, Robin Christensen, Louisa Pericleous, Coralie Poncet, Maximilian Lebmeier, Pieter Drost, Gert Bergman Arthritis Research & Therapy 2011, 13:R204 (12 December 2011)
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Editor’s summary
Abatacept in combination with methotrexate (MTX) is superior to placebo and comparable to other biologic agents in the treatment of patients with rheumatoid arthritis who have inadequate response to MTX alone.
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Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis
Rhian S Thomas, Alan R Clarke, Victor C Duance, Emma J Blain Arthritis Research & Therapy 2011, 13:R203 (9 December 2011)
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Sustained remission of symptoms and improved health-related quality of life in patients with cryopyrin-associated periodic syndrome treated with canakinumab: results of a double-blind placebo-controlled randomized withdrawal study
Isabelle Koné-Paut, Helen J Lachmann, Jasmin B Kuemmerle-Deschner, Eric Hachulla, Kieron S Leslie, Richard Mouy, Alberto Ferreira, Karine Lheritier, Neha Patel, Ralph Preiss, Philip N Hawkins, on behalf of the Canakinumab in CAPS Study Group Arthritis Research & Therapy 2011, 13:R202 (9 December 2011)
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