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Canakinumab (ACZ885, a fully human IgG1 anti-IL-1β mAb) induces sustained remission in pediatric patients with cryopyrin-associated periodic syndrome (CAPS)
Jasmin B Kuemmerle-Deschner, Eduardo Ramos, Norbert Blank, Joachim Roesler, Sandra D Felix, Thomas Jung, Kirstin Stricker, Abhijit Chakraborty, Stacey Tannenbaum, Andrew M Wright, Christiane Rordorf Arthritis Research & Therapy 2011, 13:R34 (28 February 2011)
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Managing pregnancy in inflammatory rheumatological diseases
Varsha Jain, Caroline Gordon Arthritis Research & Therapy 2011, 13:206 (25 February 2011)
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Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures
Sinéad Nic An Ultaigh, Tajvur P Saber, Jennifer McCormick, Mary Connolly, Jerome Dellacasagrande, Brian Keogh, William McCormack, Mary Reilly, Luke A O'Neill, Peter McGuirk, Ursula Fearon, Douglas J Veale Arthritis Research & Therapy 2011, 13:R33 (23 February 2011)
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Editor’s summary
A novel monoclonal antibody that inhibits Toll-like receptor 2 significantly decreased spontaneous cytokine production from rheumatoid arthritis (RA) synovial tissue explant cultures, with an inhibitory effect comparable to adalimumab.
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Validation of rheumatoid arthritis diagnoses in health care utilization data
Seo Young Kim, Amber Servi, Jennifer M Polinski, Helen Mogun, Michael E Weinblatt, Jeffrey N Katz, Daniel H Solomon Arthritis Research & Therapy 2011, 13:R32 (23 February 2011)
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Early changes in bone mineral density measured by digital X-ray radiogrammetry predict up to 20 years radiological outcome in rheumatoid arthritis
Meliha C Kapetanovic, Elisabet Lindqvist, Jakob Algulin, Kjell Jonsson, Tore Saxne, Kerstin Eberhardt, Pierre Geborek Arthritis Research & Therapy 2011, 13:R31 (23 February 2011)
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Editor’s summary
Rheumatoid arthritis patients with marked bone mineral density (BMD) loss early in the disease course had significantly worse progression of joint damage during the 20-year follow-up period of this cohort study.
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Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden
Catharina Eriksson, Heidi Kokkonen, Martin Johansson, Göran Hallmans, Göran Wadell, Solbritt Rantapää-Dahlqvist Arthritis Research & Therapy 2011, 13:R30 (22 February 2011)
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Reduced immunomodulation potential of bone marrow-derived mesenchymal stem cells induced CCR4+CCR6+ Th/Treg cell subset imbalance in ankylosing spondylitis
Yanfeng Wu, Mingliang Ren, Rui Yang, Xinjun Liang, Yuanchen Ma, Yong Tang, Lin Huang, Jichao Ye, Keng Chen, Peng Wang, Huiyong Shen Arthritis Research & Therapy 2011, 13:R29 (21 February 2011)
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Effects of rehabilitative interventions on pain, function and physical impairments in people with hand osteoarthritis: a systematic review
Liuzhen Ye, Leonid Kalichman, Alicia Spittle, Fiona Dobson, Kim Bennell Arthritis Research & Therapy 2011, 13:R28 (18 February 2011)
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Editor’s summary
Rehabilitative interventions such as exercise, splints, laser therapy and massage can improve pain, hand function, grip strength and range of motion in individuals with hand osteoarthritis.
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Association of the D repeat polymorphism in the ASPN gene with developmental dysplasia of the hip: a case-control study in Han Chinese
Dongquan Shi, Jin Dai, Pengsheng Zhu, Jianghui Qin, Lunqing Zhu, Hongtao Zhu, Baocheng Zhao, Xusheng Qiu, Zhihong Xu, Dongyang Chen, Long Yi, Shiro Ikegawa, Qing Jiang Arthritis Research & Therapy 2011, 13:R27 (17 February 2011)
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Evaluating the efficacy of sequential biologic therapies for rheumatoid arthritis patients with an inadequate response to tumor necrosis factor-α inhibitors
Regina Rendas-Baum, Gene V Wallenstein, Tamas Koncz, Mark Kosinski, Min Yang, John Bradley, Samuel H Zwillich Arthritis Research & Therapy 2011, 13:R25 (16 February 2011)
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Nordic walking in fibromyalgia: a means of promoting fitness that is easy for busy clinicians to recommend
Kim Jones Arthritis Research & Therapy 2011, 13:103 (16 February 2011)
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Tumor necrosis factor-alpha promotes survival in methotrexate-exposed macrophages by an NF-kappaB-dependent pathway
Susan ZY Lo, James H Steer, David A Joyce Arthritis Research & Therapy 2011, 13:R24 (15 February 2011)
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Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta
Catherine Baugé, Olivier Cauvard, Sylvain Leclercq, Philippe Galéra, Karim Boumédiene Arthritis Research & Therapy 2011, 13:R23 (15 February 2011)
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Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis
Muneaki Ishijima, Taiji Watari, Kiyohito Naito, Haruka Kaneko, Ippei Futami, Kaori Yoshimura-Ishida, Akihito Tomonaga, Hideyo Yamaguchi, Tetsuro Yamamoto, Isao Nagaoka, Hisashi Kurosawa, Robin A Poole, Kazuo Kaneko Arthritis Research & Therapy 2011, 13:R22 (14 February 2011)
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Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients
Stefan Bittner, Nicole Bobak, Martin Feuchtenberger, Alexander M Herrmann, Kerstin Göbel, Raimund W Kinne, Anker J Hansen, Thomas Budde, Christoph Kleinschnitz, Oliver Frey, Hans-Peter Tony, Heinz Wiendl, Sven G Meuth Arthritis Research & Therapy 2011, 13:R21 (11 February 2011)
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Anti-dsDNA-NcX ELISA: dsDNA-loaded nucleosomes improve diagnosis and monitoring of disease activity in systemic lupus erythematosus
Robert Biesen, Cornelia Dähnrich, Anke Rosemann, Fidan Barkhudarova, Thomas Rose, Olga Jakob, Anne Bruns, Marina Backhaus, Winfried Stöcker, Gerd-Rüdiger Burmester, Wolfgang Schlumberger, Karl Egerer, Falk Hiepe Arthritis Research & Therapy 2011, 13:R26 (10 February 2011)
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Diagnostic value and clinical laboratory associations of antibodies against recombinant ribosomal P0, P1 and P2 proteins and their native heterocomplex in a Caucasian cohort with systemic lupus erythematosus
Fidan Barkhudarova, Cornelia Dähnrich, Anke Rosemann, Udo Schneider, Winfried Stöcker, Gerd-Rüdiger Burmester, Karl Egerer, Wolfgang Schlumberger, Falk Hiepe, Robert Biesen Arthritis Research & Therapy 2011, 13:R20 (10 February 2011)
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Diagnostic properties of metabolic perturbations in rheumatoid arthritis
Rasmus K Madsen, Torbjörn Lundstedt, Jon Gabrielsson, Carl-Johan Sennbro, Gerd-Marie Alenius, Thomas Moritz, Solbritt Rantapää-Dahlqvist, Johan Trygg Arthritis Research & Therapy 2011, 13:R19 (8 February 2011)
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Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis
Bradley J Rabquer, Pei-Suen Tsou, Yong Hou, Eshwar Thirunavukkarasu, G Kenneth Haines, Ann J Impens, Kristine Phillips, Bashar Kahaleh, James R Seibold, Alisa E Koch Arthritis Research & Therapy 2011, 13:R18 (8 February 2011)
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Follistatin-like protein 1 is elevated in systemic autoimmune diseases and correlated with disease activity in patients with rheumatoid arthritis
Dawei Li, Yuji Wang, Nanwei Xu, Qianghua Wei, Min Wu, Xiaofeng Li, Ping Zheng, Sai Sun, Yuli Jin, Gailian Zhang, Ruomin Liao, Ping Zhang Arthritis Research & Therapy 2011, 13:R17 (8 February 2011)
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Bone mineral density and body composition in postmenopausal women with psoriasis and psoriatic arthritis
Paulo G Pedreira, Marcelo M Pinheiro, Vera L Szejnfeld Arthritis Research & Therapy 2011, 13:R16 (7 February 2011)
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A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis
Susan K Wallis, Laura A Cooney, Judith L Endres, Min Jie Lee, Jennifer Ryu, Emily C Somers, David A Fox Arthritis Research & Therapy 2011, 13:R15 (4 February 2011)
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Dual role of interleukin-17 in pannus growth and osteoclastogenesis in rheumatoid arthritis
Hiroshi Ito, Hidehiro Yamada, Toshiko N Shibata, Hirofumi Mitomi, So Nomoto, Shoichi Ozaki Arthritis Research & Therapy 2011, 13:R14 (4 February 2011)
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Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis
Heidi Kokkonen, Mohammed Mullazehi, Ewa Berglin, Göran Hallmans, Göran Wadell, Johan Rönnelid, Solbritt Rantapää-Dahlqvist Arthritis Research & Therapy 2011, 13:R13 (3 February 2011)
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Molecular targets of natural health products in arthritis
Sarah Khalifé, Muhammad Zafarullah Arthritis Research & Therapy 2011, 13:102 (3 February 2011)
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Promise and pitfalls of the Immunochip
Adrian Cortes, Matthew A Brown Arthritis Research & Therapy 2011, 13:101 (1 February 2011)
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Anti-class a scavenger receptor autoantibodies from systemic lupus erythematosus patients impair phagocytic clearance of apoptotic cells by macrophages in vitro
Xiao-wei Chen, Yan Shen, Chuan-yin Sun, Feng-xia Wu, Yi Chen, Cheng-de Yang Arthritis Research & Therapy 2011, 13:R9 (31 January 2011)
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Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis
Anne Hinks, Paul Martin, Edward Flynn, Steve Eyre, Jon Packham, Childhood Arthritis Prospective Study (CAPS), BSPAR study group, Anne Barton, Jane Worthington, Wendy Thomson Arthritis Research & Therapy 2011, 13:R12 (31 January 2011)
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Single-nucleotide polymorphisms and haplotype of CYP2E1 gene associated with systemic lupus erythematosus in Chinese population
Ling-hong Liao, Hao Zhang, Man-Po Lai, Shun-Le Chen, Madeline Wu, Nan Shen Arthritis Research & Therapy 2011, 13:R11 (31 January 2011)
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Mannose-binding lectin does not explain the course and outcome of pregnancy in rheumatoid arthritis
Fleur E van de Geijn, Yaël A de Man, Manfred Wuhrer, Sten P Willemsen, André M Deelder, Johanna MW Hazes, Radboud JEM Dolhain Arthritis Research & Therapy 2011, 13:R10 (31 January 2011)
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A window on disease pathogenesis and potential therapeutic strategies: molecular imaging for arthritis
Luke L Gompels, Ewa M Paleolog Arthritis Research & Therapy 2011, 13:201 (31 January 2011)
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The involvement of interleukin-1 and interleukin-4 in the response of human annulus fibrosus cells to cyclic tensile strain: an altered mechanotransduction pathway with degeneration
Hamish TJ Gilbert, Judith A Hoyland, Anthony J Freemont, Sarah J Millward-Sadler Arthritis Research & Therapy 2011, 13:R8 (28 January 2011)
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Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy - a single centre, open-label study
Eliza K Pontifex, Danielle M Gerlag, Martina Gogarty, Marjolein Vinkenoog, Adrian Gibbs, Ilse Burgman, Ursula Fearon, Barry Bresnihan, Paul Tak, Robin G Gibney, Douglas J Veale, Oliver FitzGerald Arthritis Research & Therapy 2011, 13:R7 (27 January 2011)
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mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis
Matthew R McCann, Roxana Monemdjou, Parisa Ghassemi-Kakroodi, Hassan Fahmi, Gemma Perez, Shangxi Liu, Xu Shi-wen, Sunil K Parapuram, Fumiaki Kojima, Christopher P Denton, David J Abraham, Johanne Martel-Pelletier, Leslie J Crofford, Andrew Leask, Mohit Kapoor Arthritis Research & Therapy 2011, 13:R6 (25 January 2011)
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Response to: Comparison of laser Doppler imaging, fingertip lacticemy test, and nailfold capillaroscopy for assessment of digital microcirculation in systemic sclerosis - authors' reply
Marcelo JU Correa, Luis EC Andrade, Cristiane Kayser Arthritis Research & Therapy 2011, 13:302 (24 January 2011)
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Response to: Comparison of laser Doppler imaging, fingertip lacticemy test, and nailfold capillaroscopy for assessment of digital microcirculation in systemic sclerosis
Alberto Sulli, Vanessa Smith, Maurizio Cutolo Arthritis Research & Therapy 2011, 13:301 (24 January 2011)
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(Sub)clinical cardiovascular disease is associated with increased bone loss and fracture risk; a systematic review of the association between cardiovascular disease and osteoporosis
Debby den Uyl, Mike T Nurmohamed, Lilian HD van Tuyl, Hennie G Raterman, Willem F Lems Arthritis Research & Therapy 2011, 13:R5 (17 January 2011)
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Individuals with subclinical cardiovascular disease are at greater risk of bone loss and subsequent fractures, suggesting the need for bone density screening in patients with this disease.
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Joint and tendon subclinical involvement suggestive of gouty arthritis in asymptomatic hyperuricemia: an ultrasound controlled study
Carlos Pineda, Luis M Amezcua-Guerra, Carla Solano, Pedro Rodriguez-Henríquez, Cristina Hernández-Díaz, Angelica Vargas, Fritz Hofmann, Marwin Gutiérrez Arthritis Research & Therapy 2011, 13:R4 (17 January 2011)
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Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts
Sandeep K Agarwal, Minghua Wu, Christopher K Livingston, Donald H Parks, Maureen D Mayes, Frank C Arnett, Filemon K Tan Arthritis Research & Therapy 2011, 13:R3 (11 January 2011)
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Salivary glands of primary Sjögren's syndrome patients express factors vital for plasma cell survival
Ewa A Szyszko, Karl A Brokstad, Gunnvor Øijordsbakken, Malin V Jonsson, Roland Jonsson, Kathrine Skarstein Arthritis Research & Therapy 2011, 13:R2 (7 January 2011)
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Validating English- and Spanish-language patient-reported outcome measures in underserved patients with rheumatic disease
Gwenyth R Wallen, Kimberly R Middleton, Migdalia V Rivera-Goba, Barbara B Mittleman Arthritis Research & Therapy 2011, 13:R1 (5 January 2011)
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Adiponectin is a potential catabolic mediator in osteoarthritis cartilage
Eun Kang, Yun Lee, Tae Kim, Chong Chang, Jin-Haeng Chung, Kichul Shin, Eun Lee, Eun Lee, Yeong Song Arthritis Research & Therapy 2010, 12:R231 (31 December 2010)
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Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis
Staffan Larsson, Martin Englund, André Struglics, L Stefan Lohmander Arthritis Research & Therapy 2010, 12:R230 (31 December 2010)
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Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254)
Jonathan B Catterall, Thomas V Stabler, Carl R Flannery, Virginia B Kraus Arthritis Research & Therapy 2010, 12:R229 (31 December 2010)
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Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin21-157
Vivian Berg, Baldur Sveinbjörnsson, Signy Bendiksen, Jan Brox, Khaled Meknas, Yngve Figenschau Arthritis Research & Therapy 2010, 12:R228 (30 December 2010)
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RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1
Ming Zhao, Xiaoyan Wu, Qing Zhang, Shuangyan Luo, Gongping Liang, Yuwen Su, Yixin Tan, Qianjin Lu Arthritis Research & Therapy 2010, 12:R227 (30 December 2010)
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The incidence of hip, forearm, humeral, ankle, and vertebral fragility fractures in Italy: results from a 3-year multicenter study
Umberto Tarantino, Antonio Capone, Marco Planta, Michele D'Arienzo, Giulia Letizia Mauro, Angelo Impagliazzo, Alessandro Formica, Francesco Pallotta, Vittorio Patella, Antonio Spinarelli, Ugo Pazzaglia, Guido Zarattini, Mauro Roselli, Giuseppina Montanari, Giuseppe Sessa, Marco Privitera, Cesare Verdoia, Costantino Corradini, Maurizio Feola, Antonio Padolino, Luca Saturnino, Alessandro Scialdoni, Cecilia Rao, Giovanni Iolascon, Maria Luisa Brandi, Prisco Piscitelli Arthritis Research & Therapy 2010, 12:R226 (29 December 2010)
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Marked disability and high use of nonsteroidal antiinflammatory drugs associated with knee osteoarthritis in rural China: a cross-sectional population-based survey
Jianhao Lin, Marlene Fransen, Xiaozheng Kang, Hu Li, Yan Ke, Zhiqiang Wang, Yuqing Zhang, Steve Su Arthritis Research & Therapy 2010, 12:R225 (29 December 2010)
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Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model
Samuel García, Jerónimo Forteza, Carlos López-Otin, Juan J Gómez-Reino, Antonio González, Carmen Conde Arthritis Research & Therapy 2010, 12:R224 (29 December 2010)
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Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults
Dawn Dore, Stephen Quinn, Changhai Ding, Tania Winzenberg, Guangju Zhai, Flavia Cicuttini, Graeme Jones Arthritis Research & Therapy 2010, 12:R223 (29 December 2010)
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