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Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis
Zhongying Zhang, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Takashi Yurube, Minoru Doita, Masahiro Kurosaka, Kotaro Nishida Arthritis Research & Therapy 2011, 13:R200 (8 December 2011)
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Identification of urinary metabolites that distinguish membranous lupus nephritis from proliferative lupus nephritis and focal segmental glomerulosclerosis
Lindsey E Romick-Rosendale, Hermine I Brunner, Michael R Bennett, Rina Mina, Shannen Nelson, Michelle Petri, Adnan Kiani, Prasad Devarajan, Michael A Kennedy Arthritis Research & Therapy 2011, 13:R199 (7 December 2011)
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High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury
Robert A Mooney, Erik R Sampson, Jaclyn Lerea, Randy N Rosier, Michael J Zuscik Arthritis Research & Therapy 2011, 13:R198 (7 December 2011)
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A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release
Katia Varani, Melissa Padovan, Fabrizio Vincenzi, Martina Targa, Francesco Trotta, Marcello Govoni, Pier Borea Arthritis Research & Therapy 2011, 13:R197 (6 December 2011)
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NLRP3 E311K mutation in a large family with Muckle-Wells syndrome - description of a heterogeneous phenotype and response to treatment
Jasmin B Kuemmerle-Deschner, Peter Lohse, Ina Koetter, Guenther E Dannecker, Fabian Reess, Katharina Ummenhofer, Silvia Koch, Nikolay Tzaribachev, Anja Bialkowski, Susanne M Benseler Arthritis Research & Therapy 2011, 13:R196 (6 December 2011)
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T cells as key players for bone destruction in gouty arthritis?
Ulrike Harre, Anja Derer, Christine Schorn, Georg Schett, Martin Herrmann Arthritis Research & Therapy 2011, 13:135 (2 December 2011)
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Beyond cognitive-behavioral therapy for fibromyalgia: addressing stress by emotional exposure, processing, and resolution
Mark A Lumley Arthritis Research & Therapy 2011, 13:136 (1 December 2011)
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The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA
Parawee Suwannalai, Annemiek Willemze, Linda van Toorn, Gerrie Stoeken-Rijsbergen, Nivine Levarht, Jan Drijfhout, Tom W J Huizinga, Rene E M Toes, Leendert A Trouw Arthritis Research & Therapy 2011, 13:R195 (30 November 2011)
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Proteomic analysis of saliva: a unique tool to distinguish primary Sjögren's syndrome from secondary Sjögren's syndrome and other sicca syndromes
Chiara Baldini, Laura Giusti, Federica Ciregia, Ylenia Da Valle, Camillo Giacomelli, Elena Donadio, Francesca Sernissi, Laura Bazzichi, Gino Giannaccini, Stefano Bombardieri, Antonio Lucacchini Arthritis Research & Therapy 2011, 13:R194 (25 November 2011)
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Follistatin-like protein 1: a serum biochemical marker reflecting the severity of joint damage in patients with osteoarthritis
Yuji Wang, Dawei Li, Nanwei Xu, Weijian Tao, Ruixia Zhu, Rongbin Sun, Weiwei Fan, Ping Zhang, Tianhua Dong, Long Yu Arthritis Research & Therapy 2011, 13:R193 (25 November 2011)
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Editor’s summary
Serum levels of follistatin-like protein 1 (FSTL1) may reflect the severity of joint damage and have potential for monitoring disease course and treatment efficacy in osteoarthritis patients.
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Central pain contributions in osteoarthritis: next steps for improving recognition and treatment?
Kelli Allen Arthritis Research & Therapy 2011, 13:133 (25 November 2011)
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Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats
Guo-Xin Ni, Li-Qiong Zhan, Mei-Qin Gao, Lei Lei, Yue-Zhu Zhou, Yan-Xia Pan Arthritis Research & Therapy 2011, 13:R192 (24 November 2011)
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Why radiography should no longer be considered a surrogate outcome measure for longitudinal assessment of cartilage in knee osteoarthritis
Ali Guermazi, Frank W Roemer, Deborah Burstein, Daichi Hayashi Arthritis Research & Therapy 2011, 13:247 (24 November 2011)
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Multiplex, megaplex, index, and complex: the present and future of laboratory diagnostics in rheumatology
Mark H Wener Arthritis Research & Therapy 2011, 13:134 (24 November 2011)
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Detection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and pro-inflammatory role of citrullinated BiP in collagen-induced arthritis
Hirofumi Shoda, Keishi Fujio, Mihoko Shibuya, Tomohisa Okamura, Shuji Sumitomo, Akiko Okamoto, Tetsuji Sawada, Kazuhiko Yamamoto Arthritis Research & Therapy 2011, 13:R191 (22 November 2011)
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Cardiac autonomic impairment and chronotropic incompetence in fibromyalgia
Roberta da Cunha Ribeiro, Hamilton Roschel, Guilherme Artioli, Thalita Dassouki, Luiz Perandini, Ana Calich, Ana de Sá Pinto, Fernanda Lima, Eloísa Bonfá, Bruno Gualano Arthritis Research & Therapy 2011, 13:R190 (18 November 2011)
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Editor’s summary
Fibromyalgia patients may suffer from chronotropic incompetence and delayed heart rate recovery, both of which are indicative of cardiac autonomic impairment and higher risk of cardiovascular events and mortality.
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Primary care physicians' perspectives towards managing rheumatoid arthritis: room for improvement
Katie L Garneau, Maura D Iversen, Hsun Tsao, Daniel H Solomon Arthritis Research & Therapy 2011, 13:R189 (18 November 2011)
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Rheumatoid arthritis patients in the US may not be receiving optimal care, as primary care physicians are uncomfortable prescribing disease-modifying anti-rheumatic drugs and report that their patients have difficulty accessing rheumatologists.
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Ultrasound in the evaluation of enthesitis: status and perspectives
Frédérique Gandjbakhch, Lene Terslev, Fredrick Joshua, Richard J Wakefield, Esperanza Naredo, Maria D'Agostino, OMERACT Ultrasound Task Force Arthritis Research & Therapy 2011, 13:R188 (17 November 2011)
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Interleukin-1, tumor necrosis factor-alpha, and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration
Katherine M Riera, Nicole E Rothfusz, Rebecca E Wilusz, JB Weinberg, Farshid Guilak, Amy L McNulty Arthritis Research & Therapy 2011, 13:R187 (16 November 2011)
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Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population
Hua Zhong, Xiao-lan Li, Ming Li, Li-xia Hao, Rong-wei Chen, Kun Xiang, Xue-bin Qi, Runlin Z Ma, Bing Su Arthritis Research & Therapy 2011, 13:R186 (16 November 2011)
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Nocturnal heart rate variability parameters as potential fibromyalgia biomarker: correlation with symptoms severity
Claudia Lerma, Aline Martinez, Natllely Ruiz, Angelica Vargas, Oscar Infante, Manuel Martinez-Lavin Arthritis Research & Therapy 2011, 13:R185 (16 November 2011)
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Editor’s summary
Nocturnal heart rate variability parameters indicative of sympathetic predominance are significantly different in fibromyalgia patients compared to healthy individuals, and correlate with several symptoms including pain severity.
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Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways
Anna Koskinen, Sami Juslin, Riina Nieminen, Teemu Moilanen, Katriina Vuolteenaho, Eeva Moilanen Arthritis Research & Therapy 2011, 13:R184 (11 November 2011)
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Increased incidence of pregnancy complications in women who later develop scleroderma: a case control study
Linda van Wyk, Jacolien van der Marel, Annemie JM Schuerwegh, Anne A Schouffoer, Alexandre E Voskuyl, Tom WJ Huizinga, Diana W Bianchi, Sicco A Scherjon Arthritis Research & Therapy 2011, 13:R183 (4 November 2011)
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Editor’s summary
Women who developed systemic sclerosis after pregnancy were more likely to have had a pregnancy history of hypertension or a fetus with intra-uterine growth restriction.
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Imaging in gout - What can we learn from MRI, CT, DECT and US?
Fiona M McQueen, Anthony Doyle, Nicola Dalbeth Arthritis Research & Therapy 2011, 13:246 (4 November 2011)
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Lymphotoxin-beta receptor blockade reduces CXCL13 in lacrimal glands and improves corneal integrity in the NOD model of Sjögren's syndrome
Roy A Fava, Susan M Kennedy, Sheryl G Wood, Anne I Bolstad, Jadwiga Bienkowska, Adrian Papandile, John A Kelly, Clio P Mavragani, Margaret Gatumu, Kathrine Skarstein, Jeffrey L Browning Arthritis Research & Therapy 2011, 13:R182 (1 November 2011)
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Blockade of lymphotoxin-beta receptor pathways increased tear-fluid secretion and significantly improved ocular surface integrity score in a mouse model of Sjoegren's syndrome, suggesting this may have therapeutic potential.
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Plasma proteomic profiles from disease-discordant monozygotic twins suggest that molecular pathways are shared in multiple systemic autoimmune diseases*
Terrance P O'Hanlon, Zhuoyan Li, Lu Gan, Mark F Gourley, Lisa G Rider, Frederick W Miller Arthritis Research & Therapy 2011, 13:R181 (1 November 2011)
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The role of epigenetic variation in the pathogenesis of systemic lupus erythematosus
Travis Hughes, Amr H Sawalha Arthritis Research & Therapy 2011, 13:245 (31 October 2011)
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Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis
Xinhua Yu, Saleh M Ibrahim Arthritis Research & Therapy 2011, 13:132 (31 October 2011)
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Integrins and their ligands in rheumatoid arthritis
Torsten Lowin, Rainer H Straub Arthritis Research & Therapy 2011, 13:244 (28 October 2011)
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Can anti-cyclic citrullinated peptide antibody-negative RA be subdivided into clinical subphenotypes?
Diederik PC De Rooy, Annemiek Willemze, Bart Mertens, Tom WJ Huizinga, Annette HM Van der Helm-van Mil Arthritis Research & Therapy 2011, 13:R180 (27 October 2011)
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Mechanisms of B cell autoimmunity in SLE
Thomas Dörner, Claudia Giesecke, Peter E Lipsky Arthritis Research & Therapy 2011, 13:243 (27 October 2011)
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Impact of interleukin-21 in the pathogenesis of primary Sjogren's syndrome: increased serum levels of interleukin-21 and its expression in the labial salivary glands
Kwi Kang, Hyun-Ok Kim, Seung-Ki Kwok, Ji Ju, Kyung-Su Park, Dong-Il Sun, Joo Jhun, Hye Oh, Sung-Hwan Park, Ho-Youn Kim Arthritis Research & Therapy 2011, 13:R179 (26 October 2011)
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The soluble biomarker calprotectin (a S100 protein) is associated to ultrasonographic synovitis scores and is sensitive to change in patients with rheumatoid arthritis treated with adalimumab
Hilde Hammer, Magne K Fagerhol, Tale Wien, Tore K Kvien Arthritis Research & Therapy 2011, 13:R178 (26 October 2011)
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MTRX1011A, a humanized anti-CD4 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a Phase I randomized, double-blind, placebo-controlled study incorporating pharmacodynamic biomarker assessments
Heleen Scheerens, Zheng Su, Bryan Irving, Michael J Townsend, Yanan Zheng, Eric Stefanich, Vishala Chindalore, Clifton O Bingham, John C Davis Arthritis Research & Therapy 2011, 13:R177 (26 October 2011)
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Pus: the Rodney Dangerfield of immunology
David S Pisetsky Arthritis Research & Therapy 2011, 13:131 (26 October 2011)
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Quantification of the whole-body burden of radiographic osteoarthritis using factor analysis
Amanda E Nelson, Robert F DeVellis, Jordan B Renner, Todd A Schwartz, Philip G Conaghan, Virginia B Kraus, Joanne M Jordan Arthritis Research & Therapy 2011, 13:R176 (25 October 2011)
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Soluble receptor activator of nuclear factor κB ligand/osteoprotegerin ratio is increased in systemic lupus erythematosus patients
Diana Carmona-Fernandes, Maria Santos, Inês Perpétuo, João Fonseca, Helena Canhão Arthritis Research & Therapy 2011, 13:R175 (25 October 2011)
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The use, safety, and effectiveness of herpes zoster vaccination in individuals with inflammatory and autoimmune diseases: a longitudinal observational study
Jie Zhang, Elizabeth Delzell, Fenglong Xie, John W Baddley, Claire Spettell, Raechele M Mcmahan, Joaquim Fernandes, Lang Chen, Kevin Winthrop, Jeffrey R Curtis Arthritis Research & Therapy 2011, 13:R174 (24 October 2011)
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Effectiveness of cognitive behaviour therapy for the treatment of catastrophisation in patients with fibromyalgia: a randomised controlled trial
Marta Alda, Juan V Luciano, Eva Andrés, Antoni Serrano-Blanco, Baltasar Rodero, Yolanda del Hoyo, Miquel Roca, Sergio Moreno, Rosa Magallón, Javier García-Campayo Arthritis Research & Therapy 2011, 13:R173 (23 October 2011)
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Editor’s summary
Cognitive behaviour therapy (CBT) should be included in standard treatment of fibromyalgia, as a clinical trial shows it improves outcomes including pain catastrophising, pain acceptance, function and quality of life.
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Frequency of disease-associated and other nuclear autoantibodies in patients of the German network for systemic scleroderma: correlation with characteristic clinical features
Rudolf Mierau, Pia Moinzadeh, Gabriela Riemekasten, Inga Melchers, Michael Meurer, Frank Reichenberger, Michael Buslau, Margitta Worm, Norbert Blank, Rüdiger Hein, Ulf Müller-Ladner, Annegret Kuhn, Cord Sunderkötter, Aaron Juche, Christiane Pfeiffer, Christoph Fiehn, Michael Sticherling, Percy Lehmann, Rudolf Stadler, Eckhard Schulze-Lohoff, Cornelia Seitz, Ivan Foeldvari, Thomas Krieg, Ekkehard Genth, Nicolas Hunzelmann Arthritis Research & Therapy 2011, 13:R172 (21 October 2011)
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An organ culture system to model early degenerative changes of the intervertebral disc
Ravi K Ponnappan, Dessislava Z Markova, Paul JD Antonio, Hallie B Murray, Alexander R Vaccaro, Irving M Shapiro, D Greg Anderson, Todd J Albert, Makarand V Risbud Arthritis Research & Therapy 2011, 13:R171 (21 October 2011)
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Regulatory mechanisms for the production of BAFF and IL-6 are impaired in monocytes of patients of primary Sjögren's syndrome
Keiko Yoshimoto, Maiko Tanaka, Masako Kojima, Yumiko Setoyama, Hideto Kameda, Katsuya Suzuki, Kensei Tsuzaka, Yoko Ogawa, Kazuo Tsubota, Tohru Abe, Tsutomu Takeuchi Arthritis Research & Therapy 2011, 13:R170 (21 October 2011)
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Associations of educational attainment, occupation and community poverty with knee osteoarthritis in the Johnston County (North Carolina) osteoarthritis project
Leigh F Callahan, Rebecca J Cleveland, Jack Shreffler, Todd A Schwartz, Britta Schoster, Randy Randolph, Jordan B Renner, Joanne M Jordan Arthritis Research & Therapy 2011, 13:R169 (19 October 2011)
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Low levels of educational attainment and living in a community with a high poverty rate are independently associated with knee osteoarthritis in a rural community in the south-eastern United States.
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Declining needs for total joint replacements for rheumatoid arthritis
Nasim A Khan, Tuulikki Sokka Arthritis Research & Therapy 2011, 13:130 (19 October 2011)
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Minocycline and doxycycline therapy in community patients with rheumatoid arthritis: prescribing patterns, patient-level determinants of use, and patient-reported side effects
Christopher J Smith, Harlan Sayles, Ted R Mikuls, Kaleb Michaud Arthritis Research & Therapy 2011, 13:R168 (18 October 2011)
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Editor’s summary
Although the drugs are generally well-tolerated, rheumatologists mostly prescribe minocycline or doxycycline in patients with long-standing rheumatoid arthritis (RA) where other treatments have failed, and not as a primary treatment option.
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A five-year prospective study of fatigue in primary Sjögren's syndrome
Karstein Haldorsen, Ingvar Bjelland, Anne Bolstad, Roland Jonsson, Johan Brun Arthritis Research & Therapy 2011, 13:R167 (13 October 2011)
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Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis: association with interstitial lung disease
Marie-Elise Truchetet, Nicolò C Brembilla, Elisa Montanari, Yannick Allanore, Carlo Chizzolini Arthritis Research & Therapy 2011, 13:R166 (13 October 2011)
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The rat intervertebral disk degeneration pain model: relationships between biological and structural alterations and pain
Jae-Sung Kim, Jeffrey S Kroin, Xin Li, Howard S An, Asokumar Buvanendran, Dongyao Yan, Kenneth J Tuman, Andre J van Wijnen, Di Chen, Hee-Jeong Im Arthritis Research & Therapy 2011, 13:R165 (13 October 2011)
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Bone destruction by receptor activator of nuclear factor κB ligand-expressing T cells in chronic gouty arthritis
Sung-Ji Lee, Kwang-Il Nam, Hye-Mi Jin, Young-Nan Cho, Song-Eun Lee, Tae-Jong Kim, Shin-Seok Lee, Seung-Jung Kee, Keun-Bae Lee, Nacksung Kim, Yong-Wook Park Arthritis Research & Therapy 2011, 13:R164 (13 October 2011)
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Aberrant axial mineralization precedes spinal ankylosis: a molecular imaging study in ank/ank mice
Facundo Las Heras, Ralph S DaCosta, Kenneth PH Pritzker, Nigil Haroon, George Netchev, Hing Wo Tsui, Basil Chiu, W Mark Erwin, Florence WL Tsui, Robert D Inman Arthritis Research & Therapy 2011, 13:R163 (12 October 2011)
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