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Research article   Open Access

A novel in vitro bovine cartilage punch model for assessing the regeneration of focal cartilage defects with biocompatible bacterial nanocellulose

David Pretzel, Stefanie Linss, Hannes Ahrem, Michaela Endres, Christian Kaps, Dieter Klemm, Raimund W. Kinne Arthritis Research & Therapy 2013, 15:R59 (14 May 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

In vitro bovine cartilage punch model is a novel tool developed to evaluate potential bio-materials for use in cartilage regeneration and repair.

Research article   Open Access

Adenosine A2A receptors promote collagen production by a Fli1- and CTGF-mediated mechanism

Edwin SL Chan, Hailing Liu, Patricia Fernandez, Alex Luna, Miguel Perez-Aso, Andreea M Bujor, Maria Trojanowska, Bruce N Cronstein Arthritis Research & Therapy 2013, 15:R58 (11 May 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Adenosine promotion of dermal fibrosis in conditions such as scleroderma is mediated by the transcription factor Fli1 and growth factor CTFG, highlighting potential targets for future anti-fibrotic therapies.

Correction   Free

Correction: TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β- induced rat osteoarthritis chondrocytes in vitro

Jun Qin, Liang Shang, An-song Ping, Jing Li, Xiao-jun Li, Hong Yu, Jacques Magdalou, Liao-bin Chen, Hui Wang Arthritis Research & Therapy 2013, 15:407 (10 May 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Editorial   Free

A complicated liaison: IL-33 and IL-33R in arthritis pathogenesis

Thomas Kamradt, Sebastian Drube Arthritis Research & Therapy 2013, 15:115 (2 May 2013)

Abstract | Full text | PDF | PubMed

Commentary   Subscription

What can rheumatologists learn from translational cancer therapy?

Jonathan P Sherlock, Andrew D Filer, John D Isaacs, Christopher D Buckley Arthritis Research & Therapy 2013, 15:114 (1 May 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

MMP-2 mediates local degradation and remodeling of collagen by annulus fibrosus cells of the intervertebral disc

Anshu Rastogi, Hyunchul Kim, Julianne D Twomey, Adam H Hsieh Arthritis Research & Therapy 2013, 15:R57 (27 April 2013)

Abstract | Provisional PDF | PubMed

Research article   Open Access Highly Accessed

Cigarette smoking and smoking cessation in relation to risk of rheumatoid arthritis in women

Daniela Di Giuseppe, Nicola Orsini, Lars Alfredsson, Johan Askling, Alicja Wolk Arthritis Research & Therapy 2013, 15:R56 (22 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Smoking only a few cigarettes a day more than doubles the risk of developing rheumatoid arthritis and although this risk will lower with time after smoking cessation, it can remain elevated 15 years later.

Research article   Open Access

Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis

Jérôme Avouac, Maeva Vallucci, Vanessa Smith, Patricia Senet, Barbara Ruiz, Alberto Sulli, Carmen Pizzorni, Camille Frances, Gilles Chiocchia, Maurizio Cutolo, Yannick Allanore Arthritis Research & Therapy 2013, 15:R55 (19 April 2013)

Abstract | Provisional PDF | PubMed

Research article   Open Access Highly Accessed

Open label study of escalating doses of oral treprostinil diethanolamine in patients with systemic sclerosis and digital ischemia: pharmacokinetics and correlation with digital perfusion

Ami A Shah, Elena Schiopu, Laura K Hummers, Michael Wade, Kristine Phillips, Cynthia Anderson, Robert Wise, Francesco Boin, James R Seibold, Fredrick Wigley, Kristan D Rollins Arthritis Research & Therapy 2013, 15:R54 (18 April 2013)

Abstract | Provisional PDF | PubMed

Research article   Open Access

Shear stress modulates macrophage-induced urokinase plasminogen activator expression in human chondrocytes

Chih-Chang Yeh, Shun-Fu Chang, Ting-Ying Huang, Hsin-I Chang, Hsing-Chun Kuo, Yi-Chien Wu, Ching-Hsiang Hsieh, Chung-Sheng Shi, Cheng-Nan Chen Arthritis Research & Therapy 2013, 15:R53 (18 April 2013)

Abstract | Provisional PDF | PubMed

Research article   Open Access

Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGFbeta1) gene in knee and hip osteoarthritis

Stella G Muthuri, Sally Doherty, Weiya Zhang, Rose A Maciewicz, Kenneth Muir, Michael Doherty Arthritis Research & Therapy 2013, 15:R52 (18 April 2013)

Abstract | Provisional PDF | PubMed

Research article   Open Access Highly Accessed

Anti-inflammatory properties of a dual PPARgamma/alpha agonist muraglitazar in in vitro and in vivo models

Erja-Leena Paukkeri, Tiina Leppanen, Mira Lindholm, Mun Fei Yam, Mohd. Zaini Asmawi, Anne Kolmonen, Paula H Aulaskari, Eeva Moilanen Arthritis Research & Therapy 2013, 15:R51 (17 April 2013)

Abstract | Provisional PDF | PubMed

Research article   Open Access Highly Accessed

Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay

Michael Mahler, Cristina Gascon, Sima Patel, Angela Ceribelli, Marvin J Fritzler, Andreas Swart, Edward KL Chan, Minoru Satoh Arthritis Research & Therapy 2013, 15:R50 (12 April 2013)

Abstract | Full text | PDF | PubMed

Review   Subscription Highly Accessed

microRNA-mediated regulation of innate immune response in rheumatic diseases

Xiaobing Luo, Koustubh Ranade, Ronel Talker, Bahija Jallal, Nan Shen, Yihong Yao Arthritis Research & Therapy 2013, 15:210 (9 April 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

The granulocyte colony stimulating factor pathway regulates autoantibody production in a murine induced model of systemic lupus erythematosus

Margareta Lantow, Ramya Sivakumar, Leilani Zeumer, Clive Wasserfall, Ying-Yi Zheng, Mark A Atkinson, Laurence Morel Arthritis Research & Therapy 2013, 15:R49 (8 April 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

B6.Sle2c2 mice are resistant to lupus due to a mutation in the granulocyte colony stimulating factor pathway, suggesting autoantibody production is inhibited by reduced neutrophil activation.

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Adult and juvenile dermatomyositis: are the distinct clinical features explained by our current understanding of serological subgroups and pathogenic mechanisms?

Sarah L Tansley, Neil J McHugh, Lucy R Wedderburn Arthritis Research & Therapy 2013, 15:211 (8 April 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Implications in the difference of anti-Mi-2 and -p155/140 autoantibody prevalence in two dermatomyositis cohorts from Mexico City and Guadalajara

Marcelo H Petri, Minoru Satoh, Beatriz T Martin-Marquez, Raul Vargas-Ramírez, Luis J Jara, Miguel A Saavedra, Claudia Cruz-Gonzalez, Lilia Andrade-Ortega, Olga Vera-Lastra, Mario Salazar-Páramo, Rosa E Prieto-Parra, Laura Gonzalez-Lopez, Jorge I Gamez-Nava, Hermes U Ramírez-Sánchez, Jason YF Chan, Steven J Ross, Edward KL Chan, Mónica Mercado Arthritis Research & Therapy 2013, 15:R48 (4 April 2013)

Abstract | Provisional PDF | PubMed

Letter   Free

Response to 'Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis' - authors' reply

Qin Shi, Jamilah Abusarah, Ghayath Baroudi, Julio C Fernandes, Hassan Fahmi, Mohamed Benderdour Arthritis Research & Therapy 2013, 15:406 (3 April 2013)

Abstract | Full text | PDF | PubMed

Letter   Free

Response to 'Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis'

Di Wang, Shanshan Hu, Wei Wei Arthritis Research & Therapy 2013, 15:405 (3 April 2013)

Abstract | Full text | PDF | PubMed

Review   Subscription

Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases?

Udo Oppermann Arthritis Research & Therapy 2013, 15:209 (3 April 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Germline deletion of β2 microglobulin or CD1d reduces anti-phospholipid antibody, but increases autoantibodies against non-phospholipid antigens in the NZB/W F1 model of lupus

Ram Singh, Jun-Qi Yang, Peter J Kim, Ramesh C Halder Arthritis Research & Therapy 2013, 15:R47 (27 March 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Exercise training in childhood-onset systemic lupus erythematosus: a controlled randomized trial

Danilo ML Prado, Fabiana B Benatti, Ana L de Sá-Pinto, Ana P Hayashi, Bruno Gualano, Rosa MR Pereira, Adriana ME Sallum, Eloisa Bonfá, Clovis A Silva, Hamilton Roschel Arthritis Research & Therapy 2013, 15:R46 (26 March 2013)

Abstract | Provisional PDF | PubMed

Editorial   Free

Canonical Wnt signaling and caveolae play a role in intervertebral disc degeneration; the continuing saga of the mysterious notochordal cell

Mark Erwin Arthritis Research & Therapy 2013, 15:113 (22 March 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Possible rheumatoid arthritis subtypes in terms of rheumatoid factor, depression, diagnostic delay and emotional expression: an exploratory case-control study

Taavi Tillmann, Rajeev Krishnadas, Jonathan Cavanagh, KV Petrides Arthritis Research & Therapy 2013, 15:R45 (21 March 2013)

Abstract | Full text | PDF | PubMed

Review   Subscription Highly Accessed

Cortical remodeling during menopause, rheumatoid arthritis, glucocorticoid and bisphosphonate therapy

Daniel Aeberli, Georg Schett Arthritis Research & Therapy 2013, 15:208 (21 March 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Monitoring cartilage loss in the hands and wrists in rheumatoid arthritis with magnetic resonance imaging in a multi-center clinical trial: IMPRESS (NCT00425932)

Charles G Peterfy, Ewa Olech, Julie C DiCarlo, Joan T Merrill, Peter J Countryman, Norman B Gaylis Arthritis Research & Therapy 2013, 15:R44 (20 March 2013)

Abstract | Provisional PDF | PubMed

Editorial   Free Highly Accessed

Mesenchymal stem cell therapy in osteoarthritis: advanced tissue repair or intervention with smouldering synovial activation?

Peter LEM van Lent, Wim B van den Berg Arthritis Research & Therapy 2013, 15:112 (20 March 2013)

Abstract | Full text | PDF | PubMed

Editorial   Free Highly Accessed

Cardiovascular risk management in rheumatoid arthritis: are we still waiting for the first step?

Mike JL Peters, Michael T Nurmohamed Arthritis Research & Therapy 2013, 15:111 (19 March 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Treatment of rheumatoid arthritis in the Medicare Current Beneficiary Survey

Daniel H Solomon, Edward Yelin, Jeffrey N Katz, Bing Lu, Tamara Shaykevich, John Z Ayanian Arthritis Research & Therapy 2013, 15:R43 (18 March 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Medicare patients with rheumatoid arthritis are less likely to receive disease-modifying anti-rheumatic drug (DMARD) treatment if they are not seeing a rheumatologist, have a lower income, or are older.

Research article   Open Access Highly Accessed

Association between alcohol consumption and symptom severity and quality of life in patients with fibromyalgia

Chul H Kim, Ann Vincent, Daniel J Clauw, Connie A Luedtke, Jeffrey M Thompson, Terry D Schneekloth, Terry H Oh Arthritis Research & Therapy 2013, 15:R42 (15 March 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Low to moderate alcohol consumption lessens symptom severity and betters quality of life for fibromyalgia patients when compared to no alcohol consumption.

Review   Subscription Highly Accessed

Perspectives on epigenetic-based immune intervention for rheumatic diseases

Steven G Gray Arthritis Research & Therapy 2013, 15:207 (14 March 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Vitamin K-dependent proteins GAS6 and Protein S and TAM receptors in patients of systemic lupus erythematosus: correlation with common genetic variants and disease activity

Pedro Recarte-Pelz, Dolors Tàssies, Gerard Espinosa, Begoña Hurtado, Núria Sala, Ricard Cervera, Joan Reverter, Pablo de Frutos Arthritis Research & Therapy 2013, 15:R41 (12 March 2013)

Abstract | Full text | PDF | PubMed

Letter   Free Highly Accessed

Further evaluation of a claims-based algorithm to determine the effectiveness of biologics for rheumatoid arthritis using commercial claims data

Jeffrey R Curtis, Benjamin Chastek, Laura Becker, David J Harrison, David Collier, Huifeng Yun, George J Joseph Arthritis Research & Therapy 2013, 15:404 (8 March 2013)

Abstract | Full text | PDF | PubMed

Letter   Free

Response to 'Statins accelerate the onset of collagen type II-induced arthritis in mice'-authors' reply

Rob J Vandebriel, Hilda JI De Jong, Eric R Gremmer, Olaf H Klungel, Jan-Willem Tervaert, Wout Slob, Jan W Van Der Laan, Henk Van Loveren Arthritis Research & Therapy 2013, 15:403 (8 March 2013)

Abstract | Full text | PDF | PubMed

Letter   Free

Response to 'Statins accelerate the onset of collagen type II-induced arthritis in mice'

Sylvain Mathieu, Sylvain Palat, Bruno Pereira, Jean-Louis Kemeny, Geoffroy Marceau, Claude Dubray, Martin Soubrier Arthritis Research & Therapy 2013, 15:402 (8 March 2013)

Abstract | Full text | PDF | PubMed

Editorial   Free

Osteopontin - a biomarker for organ damage in paediatric lupus?

Tracy A Briggs Arthritis Research & Therapy 2013, 15:110 (8 March 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Functional neuronal network activity differs with cognitive dysfunction in childhood-onset systemic lupus erythematosus

Mark W DiFrancesco, Darren R Gitelman, Marisa S Klein-Gitelman, Anna Carmela P Sagcal-Gironella, Frank Zelko, Dean Beebe, Todd Parrish, Jessica Hummel, Jun Ying, Hermine I Brunner Arthritis Research & Therapy 2013, 15:R40 (7 March 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Functional MRI (fMRI) detection of differential neuronal network activation could be a candidate imaging biomarker for neurocognitive dysfunction (NCD) in childhood-onset systemic lupus erythematosus.

Correction   Free

Correction: Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease 13 - identification of a new biglycan cleavage site

Jordi Monfort, Ginette Tardif, Pascal Reboul, François Mineau, Peter Roughley, Jean-Pierre Pelletier, Johanne Martel-Pelletier Arthritis Research & Therapy 2013, 15:401 (5 March 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Involvement of TLR7 MyD88-dependent signaling pathway in the pathogenesis of adult-onset Still's disease

Der-Yuan Chen, Chi-Chen Lin, Yi-Ming Chen, Joung-Liang Lan, Wei-Ting Hung, Hsin-Hua Chen, Kuo-Lung Lai, Chia-Wei Hsieh Arthritis Research & Therapy 2013, 15:R39 (4 March 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

The severity of experimental arthritis is independent of IL-36 receptor signaling

Céline Lamacchia, Gaby Palmer, Emiliana Rodriguez, Praxedis Martin, Solenne Vigne, Christian A Seemayer, Dominique Talabot-Ayer, Jennifer E Towne, Cem Gabay Arthritis Research & Therapy 2013, 15:R38 (1 March 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Evaluation of the novel folate receptor ligand [18F]fluoro-PEG-folate for macrophage targeting in a rat model of arthritis

Yoony YJ Gent, Karin Weijers, Carla FM Molthoff, Albert D Windhorst, Marc C Huisman, Desirée EC Smith, Sumith A Kularatne, Gerrit Jansen, Philip S Low, Adriaan A Lammertsma, Conny J van der Laken Arthritis Research & Therapy 2013, 15:R37 (1 March 2013)

Abstract | Full text | PDF | PubMed

Editorial   Free Highly Accessed

Kidney disease in lupus is not always 'lupus nephritis'

Hans-Joachim Anders, Jan J Weening Arthritis Research & Therapy 2013, 15:108 (1 March 2013)

Abstract | Full text | PDF | PubMed

Commentary   Subscription

Enhancing the reporting and transparency of rheumatology research: a guide to reporting guidelines

Robin Christensen, Henning Bliddal, Marius Henriksen Arthritis Research & Therapy 2013, 15:109 (28 February 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Urinary CD8+ T-cell counts discriminate between active and inactive lupus nephritis

Sebastian Dolff, Wayel H Abdulahad, Suzanne Arends, Marcory CRF van Dijk, Pieter C Limburg, Cees GM Kallenberg, Marc Bijl Arthritis Research & Therapy 2013, 15:R36 (27 February 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

CD4+Foxp3+ regulatory T cells prolong drug-induced disease remission in (NZBxNZW) F1 lupus mice

Olivia Weigert, Caroline von Spee, Reinmar Undeutsch, Lutz Kloke, Jens Y Humrich, Gabriela Riemekasten Arthritis Research & Therapy 2013, 15:R35 (27 February 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Exercise and obesity in fibromyalgia: beneficial roles of IGF-1 and resistin?

Jan L Bjersing, Malin Erlandsson, Maria I Bokarewa, Kaisa Mannerkorpi Arthritis Research & Therapy 2013, 15:R34 (27 February 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

The schedule of administration of canakinumab in cryopyrin associated periodic syndrome is driven by the phenotype severity rather than the age

Roberta Caorsi, Loredana Lepore, Francesco Zulian, Maria Alessio, Achille Stabile, Antonella Insalaco, Martina Finetti, Antonella Battagliese, Giorgia Martini, Chiara Bibalo, Alberto Martini, Marco Gattorno Arthritis Research & Therapy 2013, 15:R33 (26 February 2013)

Abstract | Full text | PDF | PubMed

Editorial   Free

To target or not to target APRIL in systemic lupus erythematosus: that is the question!

Jacques Morel, Michael Hahne Arthritis Research & Therapy 2013, 15:107 (25 February 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Periodic knee injections of collagen tripeptide delay cartilage degeneration in rabbit experimental osteoarthritis

Takuya Naraoka, Yasuyuki Ishibashi, Eiichi Tsuda, Yuji Yamamoto, Tomomi Kusumi, Satoshi Toh Arthritis Research & Therapy 2013, 15:R32 (22 February 2013)

Abstract | Full text | PDF | PubMed

Review   Subscription

CD154: the atherosclerotic risk factor in rheumatoid arthritis?

Ghada S Hassan, Daniel Yacoub, Nada Alaaeddine, Amal Nadiri, Yahye Merhi, Walid Mourad Arthritis Research & Therapy 2013, 15:206 (22 February 2013)

Abstract | Full text | PDF | PubMed

Review   Subscription Highly Accessed

The role of the circadian clock in rheumatoid arthritis

Julie E Gibbs, David W Ray Arthritis Research & Therapy 2013, 15:205 (21 February 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

IL-17-mediated Bcl-2 expression regulates survival of fibroblast-like synoviocytes in rheumatoid arthritis through STAT3 activation

Seon-Yeong Lee, Seung-Ki Kwok, Hye-Jin Son, Jun-Geol Ryu, Eun-Kyung Kim, Hye-Jwa Oh, Mi-La Cho, Ji Ju, Sung-Hwan Park, Ho-Youn Kim Arthritis Research & Therapy 2013, 15:R31 (20 February 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Clinical characteristics in subjects with NLRP3 V198M diagnosed at a single UK center and a review of the literature

Dorota M Rowczenio, Hadija Trojer, Tonia Russell, Anna Baginska, Thirusha Lane, Nicola M Stewart, Julian D Gillmore, Philip N Hawkins, Patricia Woo, Bozena Mikoluc, Helen J Lachmann Arthritis Research & Therapy 2013, 15:R30 (19 February 2013)

Abstract | Full text | PDF | PubMed

Editorial   Free

The butterfly rash of lupus: An example of aposematism?

David S Pisetsky Arthritis Research & Therapy 2013, 15:106 (19 February 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Cellular and extracellular matrix changes in anterior cruciate ligaments during human knee aging and osteoarthritis

Akihiko Hasegawa, Hiroyuki Nakahara, Mitsuo Kinoshita, Hiroshi Asahara, James Koziol, Martin K Lotz Arthritis Research & Therapy 2013, 15:R29 (14 February 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes

Tetsuya Matsukawa, Tadahiro Sakai, Tomo Yonezawa, Hideki Hiraiwa, Takashi Hamada, Motoshige Nakashima, Yohei Ono, Shinya Ishizuka, Hiroyuki Nakahara, Martin K Lotz, Hiroshi Asahara, Naoki Ishiguro Arthritis Research & Therapy 2013, 15:R28 (13 February 2013)

Abstract | Full text | PDF | PubMed | F1000 Biology

Research article   Open Access

Joint damage in rheumatoid arthritis: assessment of a new scoring method

Alexander Pfeil, Peter Oelzner, Klaus Bornholdt, Andreas Hansch, Gabriele Lehmann, Diane M Renz, Gunter Wolf, Joachim Böttcher Arthritis Research & Therapy 2013, 15:R27 (13 February 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes

Jung-Yoon Choe, Ki-Yeun Park, Sung-Hoon Park, Sang-Il Lee, Seong-Kyu Kim Arthritis Research & Therapy 2013, 15:R26 (13 February 2013)

Abstract | Full text | PDF | PubMed

Review   Subscription Highly Accessed

Dendritic cells and the promise of antigen-specific therapy in rheumatoid arthritis

Ranjeny Thomas Arthritis Research & Therapy 2013, 15:204 (4 February 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Rilonacept in the treatment of acute gouty arthritis: a randomized, controlled clinical trial using indomethacin as the active comparator

Robert A Terkeltaub, H Ralph Schumacher, John D Carter, Herbert SB Baraf, Robert R Evans, Jian Wang, Shirletta King-Davis, Steven P Weinstein Arthritis Research & Therapy 2013, 15:R25 (1 February 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Treatment with indomethacin alone in patients with acute gout flare is more effective than treatment with rilonacept and no greater pain relief is provided when used in combination with rilonacept. 

Review   Subscription

Implantable sensor technology: measuring bone and joint biomechanics of daily life in vivo

Darryl D D'Lima, Benjamin J Fregly, Clifford W Colwell Arthritis Research & Therapy 2013, 15:203 (31 January 2013)

Abstract | Full text | PDF | PubMed

Editorial   Free

Adult-onset immunodeficiency - why is it important in rheumatology?

Hans-Hartmut Peter Arthritis Research & Therapy 2012, 15:105 (30 January 2013)

Abstract | Full text | PDF

Research article   Open Access

Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation

Rowan S Hardy, Claudia Hülso, Yingling Liu, Sylvia J Gasparini, Colette Fong-Yee, Jinwen Tu, Shihani Stoner, Paul M Stewart, Karim Raza, Mark S Cooper, Markus J Seibel, Hong Zhou Arthritis Research & Therapy 2013, 15:R24 (29 January 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

Lucas A Smolders, Björn P Meij, David Onis, Frank M Riemers, Niklas Bergknut, Richard Wubbolts, Guy CM Grinwis, Martin Houweling, Marian JA Groot Koerkamp, Dik van Leenen, Frank CP Holstege, Herman AW Hazewinkel, Laura B Creemers, Louis C Penning, Marianna A Tryfonidou Arthritis Research & Therapy 2013, 15:R23 (29 January 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model

Giovanna Desando, Carola Cavallo, Federica Sartoni, Lucia Martini, Annapaola Parrilli, Francesca Veronesi, Milena Fini, Roberto Giardino, Andrea Facchini, Brunella Grigolo Arthritis Research & Therapy 2013, 15:R22 (29 January 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Adipose derived stromal cells (ASC) promote repair of cartilage and inhibit progression of osteoarthritis (OA) in an experimental rabbit model, highlighting ASC therapy as a potential tool to treat OA.

Review   Subscription

Dissecting complex epigenetic alterations in human lupus

Dipak R Patel, Bruce C Richardson Arthritis Research & Therapy 2012, 15:201 (29 January 2013)

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Research article   Open Access

High prevalence of spondyloarthritis and ankylosing spondylitis among familial Mediterranean fever patients and their first-degree relatives: further evidence for the connection

Servet Akar, Ozgul Soysal, Ali Balci, Dilek Solmaz, Vedat Gerdan, Fatos Onen, Mehmet Tunca, Nurullah Akkoc Arthritis Research & Therapy 2013, 15:R21 (28 January 2013)

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Editorial   Free

Tools for monitoring remission in rheumatoid arthritis: any will do, let's just pick one and start measuring

Yusuf Yazici, Ismail Simsek Arthritis Research & Therapy 2013, 15:104 (28 January 2013)

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Research article   Open Access

A rheumatoid factor paradox: inhibition of rituximab effector function

Jonathan D Jones, Irene Shyu, Marianna M Newkirk, William FC Rigby Arthritis Research & Therapy 2013, 15:R20 (25 January 2013)

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MicroRNA control in the development of systemic autoimmunity

Ruozhen Hu, Ryan M O'Connell Arthritis Research & Therapy 2013, 15:202 (25 January 2013)

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Editorial   Free Highly Accessed

IgG4-related disease: why high IgG4 and fibrosis?

Takao Koike Arthritis Research & Therapy 2013, 15:103 (25 January 2013)

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CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts

Chun-Han Hou, Chih-Hsin Tang, Chin-Jung Hsu, Sheng-Mon Hou, Ju-Fang Liu Arthritis Research & Therapy 2013, 15:R19 (23 January 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Plasma levels of osteopontin identify patients at risk for organ damage in systemic lupus erythematosus

Ornella J Rullo, Jennifer MP Woo, Miriam F Parsa, Alice DC Hoftman, Paul Maranian, David A Elashoff, Timothy B Niewold, Jennifer M Grossman, Bevra H Hahn, Maureen McMahon, Deborah K McCurdy, Betty P Tsao Arthritis Research & Therapy 2013, 15:R18 (23 January 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Impaired beta cell function is present in nondiabetic rheumatoid arthritis patients

Iván Ferraz-Amaro, Jose A García-Dopico, Lilian Medina-Vega, Miguel A González-Gay, Federico Díaz-González Arthritis Research & Therapy 2013, 15:R17 (22 January 2013)

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Research article   Open Access

Anti-cyclic citrullinated peptide antibody titer predicts time to rheumatoid arthritis onset in patients with undifferentiated arthritis: results from a 2-year prospective study

Nicola Bizzaro, Elena Bartoloni, Gabriella Morozzi, Stefania Manganelli, Valeria Riccieri, Paola Sabatini, Matteo Filippini, Marilina Tampoia, Antonella Afeltra, Giandomenico Sebastiani, Claudia Alpini, Vittorio Bini, Onelia Bistoni, Alessia Alunno, Roberto Gerli, the Forum Interdisciplinare per la Ricerca nelle Malattie Autoimmuni (FIRMA Group) Arthritis Research & Therapy 2013, 15:R16 (22 January 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Editorial   Free

Lots of autoantibodies equal lupus?

Martin Aringer, Edward Vital Arthritis Research & Therapy 2013, 15:102 (22 January 2013)

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Research article   Open Access

Expression of regulatory receptors on γδ T Cells and their cytokine production in Behcet's disease

Gunes Parlakgul, Ekin Guney, Burak Erer, Zeki Kılıcaslan, Haner Direskeneli, Ahmet Gul, Guher Saruhan-Direskeneli Arthritis Research & Therapy 2013, 15:R15 (21 January 2013)

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Editorial   Free

(Auto)immunity to cartilage matrix proteins - a time bomb?

Raimund W Kinne Arthritis Research & Therapy 2012, 15:101 (21 January 2013)

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Research article   Open Access

Scoring radiographic progression in ankylosing spondylitis: should we use the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) or the Radiographic Ankylosing Spondylitis Spinal Score (RASSS)?

Sofia Ramiro, Astrid van Tubergen, Carmen Stolwijk, Robert Landewé, Filip van de Bosch, Maxime Dougados, Désirée van der Heijde Arthritis Research & Therapy 2013, 15:R14 (17 January 2013)

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Research article   Open Access

Disease severity in K/BxN serum transfer-induced arthritis is not affected by IL-33 deficiency

Praxedis Martin, Dominique Talabot-Ayer, Christian Seemayer, Solenne Vigne, Céline Lamacchia, Emiliana Rodriguez, Axel Finckh, Dirk E Smith, Cem Gabay, Gaby Palmer Arthritis Research & Therapy 2013, 15:R13 (16 January 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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The spectrum of renal thrombotic microangiopathy in lupus nephritis

Di Song, Li-hua Wu, Feng-mei Wang, Xiao-wei Yang, Di Zhu, Min Chen, Feng Yu, Gang Liu, Ming-hui Zhao Arthritis Research & Therapy 2013, 15:R12 (15 January 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Association of the AIRE gene with susceptibility to rheumatoid arthritis in a European population: a case control study

José-Raúl García-Lozano, Belén Torres-Agrela, Marco-Antonio Montes-Cano, Lourdes Ortiz-Fernández, Marta Conde-Jaldón, María Teruel, Alicia García, Antonio Núñez-Roldán, Javier Martín, María-Francisca González-Escribano Arthritis Research & Therapy 2013, 15:R11 (15 January 2013)

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Research article   Open Access

Estradiol promotes the development of a fibrotic phenotype and is increased in the serum of patients with systemic sclerosis

Keiko Aida-Yasuoka, Christine Peoples, Hidekata Yasuoka, Pamela Hershberger, Katelynn Thiel, Jane A Cauley, Thomas A Medsger, Carol A Feghali-Bostwick Arthritis Research & Therapy 2013, 15:R10 (10 January 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Predictors of Chikungunya rheumatism: a prognostic survey ancillary to the TELECHIK cohort study

Patrick Gérardin, Adrian Fianu, Alain Michault, Corinne Mussard, Karim Boussaïd, Olivier Rollot, Philippe Grivard, Somar Kassab, Eric Bouquillard, Gianandrea Borgherini, Bernard-Alex Gaüzère, Denis Malvy, Gérard Bréart, François Favier Arthritis Research & Therapy 2013, 15:R9 (9 January 2013)

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Research article   Open Access

Prognostic impact of coronary microcirculation abnormalities in systemic sclerosis: a prospective study to evaluate the role of non-invasive tests

Alessandra Vacca, Roberta Montisci, Pietro Garau, Paolo Siotto, Matteo Piga, Alberto Cauli, Massimo Ruscazio, Luigi Meloni, Sabino Iliceto, Alessandro Mathieu Arthritis Research & Therapy 2013, 15:R8 (9 January 2013)

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Research article   Open Access

Atherosclerotic cardiovascular disease and dermatomyositis: an analysis of the Nationwide Inpatient Sample survey

Eleni Linos, David Fiorentino, Bharathi Lingala, Eswar Krishnan, Lorinda Chung Arthritis Research & Therapy 2013, 15:R7 (8 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Patients suffering from both dermatomyositis and an atherosclerotic cardiovascular disease (CVD) are twice as likely to die during inpatient stay compared to controls with CVD, and dermatomyositis patients without CVD.

Research article   Open Access

Patient-level pooled analysis of adjudicated gastrointestinal outcomes in celecoxib clinical trials: meta-analysis of 51,000 patients enrolled in 52 randomized trials

Andrew Moore, Geoffrey Makinson, Chunming Li Arthritis Research & Therapy 2013, 15:R6 (8 January 2013)

Abstract | Full text | PDF | PubMed | F1000 Biology

Research article   Open Access Highly Accessed

MMP13 is a critical target gene during the progression of osteoarthritis

Meina Wang, Erik R Sampson, Hongting Jin, Jia Li, Qiao H Ke, Hee-Jeong Im, Di Chen Arthritis Research & Therapy 2013, 15:R5 (8 January 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Role of ultrasonography in diagnosing early rheumatoid arthritis and remission of rheumatoid arthritis - a systematic review of the literature

David F Ten Cate, Jolanda J Luime, Nanno Swen, Andreas H Gerards, Mike H De Jager, Natalja M Basoski, Johanna MW Hazes, Cees J Haagsma, Johannes WG Jacobs Arthritis Research & Therapy 2013, 15:R4 (8 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Ultrasonography has added value to clinical examination in diagnosing early rheumatoid arthritis and assessing remission, which could facilitate the provision of earlier and more effective treatments.

Research article   Open Access

OPN gene polymorphisms influence the risk of knee OA and OPN levels in synovial fluid in a Chinese population

Yongqing Jiang, Meng Yao, Qingpeng Liu, Changwei Zhou Arthritis Research & Therapy 2013, 15:R3 (5 January 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Low-field magnetic resonance imaging study on carpal arthritis in systemic sclerosis - low-grade erosive arthritis of carpal bones is an unexpected and frequent disease manifestation

Elif Akbayrak, Robert Dinser, Ulf Müller-Ladner, Ingo H Tarner Arthritis Research & Therapy 2013, 15:R2 (4 January 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Persistence of antibody response 1.5 years after vaccination using 7-valent pneumococcal conjugate vaccine in patients with arthritis treated with different antirheumatic drugs

Meliha Crnkic Kapetanovic, Tore Saxne, Lennart Truedsson, Pierre Geborek Arthritis Research & Therapy 2013, 15:R1 (4 January 2013)

Abstract | Full text | PDF | PubMed | F1000 Biology

Editorial   Free

Lupus nephritis - alarmins may sound the alarm?

Tianfu Wu, Chandra Mohan Arthritis Research & Therapy 2012, 14:129 (31 December 2012)

Abstract | Full text | PDF | PubMed

Review   Subscription

T cells in myositis

Vivianne Malmström, Paulius Venalis, Inka Albrecht Arthritis Research & Therapy 2012, 14:230 (28 December 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor

Lara Bossini-Castillo, Carmen P Simeon, Lorenzo Beretta, Jasper Broen, Madelon C Vonk, José Callejas, Patricia Carreira, Luis Rodríguez-Rodríguez, Rosa García-Portales, Miguel A González-Gay, Ivan Castellví, María Camps, Carlos Tolosa, Esther Vicente-Rabaneda, María Egurbide, the Spanish Scleroderma Group, Annemie J Schuerwegh, Roger Hesselstrand, Claudio Lunardi, Jacob M van Laar, Paul Shiels, Ariane Herrick, Jane Worthington, Christopher Denton, Timothy RDJ Radstake, Carmen Fonseca, Javier Martin Arthritis Research & Therapy 2012, 14:R273 (27 December 2012)

Abstract | Full text | PDF | PubMed

Review   Subscription

Inflammatory lesions in the bone marrow of rheumatoid arthritis patients: a morphological perspective

Serena Bugatti, Antonio Manzo, Roberto Caporali, Carlomaurizio Montecucco Arthritis Research & Therapy 2012, 14:229 (27 December 2012)

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Editorial   Free Highly Accessed

Imaging joints for calcium pyrophosphate crystal deposition: a knock to the knees

Robert Terkeltaub Arthritis Research & Therapy 2012, 14:128 (27 December 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Ghrelin and adipokines as circulating markers of disease activity in patients with Takayasu arteritis

Hatice Yilmaz, Vedat Gerdan, Didem Kozaci, Dilek Solmaz, Servet Akar, Gercek Can, Aytac Gulcu, Yigit Goktay, Ismail Sari, Merih Birlik, Nurullah Akkoc, Fatos Onen Arthritis Research & Therapy 2012, 14:R272 (21 December 2012)

Abstract | Full text | PDF | PubMed

Editorial   Free

Can measuring urinary biomarkers improve the management of lupus nephritis?

Anisur Rahman Arthritis Research & Therapy 2012, 14:127 (19 December 2012)

Abstract | Full text | PDF | PubMed

Editorial   Free

Rheumatology meets radiology in the hot soup of Gutta

Tim L Jansen Arthritis Research & Therapy 2012, 14:126 (19 December 2012)

Abstract | Full text | PDF | PubMed

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