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This article is part of the supplement: 6th Global Arthritis Research Network (GARN) Meeting

Poster presentation

Arthritis induced by systemic autoimmunity against glucose-6-phosphate isomerase in normal mice

T Kamradt1, L Bruns1, O Frey1, L Morawietz2, D Schubert3 and A Taubner1

Author Affiliations

1 Department of Immunology, Medical School, Friedrich-Schiller-Universität, Jena, Germany

2 Department of Pathology, University Hospital Charité, Berlin, Germany

3 German Center for Arthritis Research, Berlin, Germany

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Arthritis Research & Therapy 2007, 9(Suppl 3):P12  doi:10.1186/ar2238


The electronic version of this article is the complete one and can be found online at: http://arthritis-research.com/content/9/S3/P12


Published:19 October 2007

© 2007 BioMed Central Ltd

Poster presentation

The antigens that trigger the pathogenic immune response in rheumatoid arthritis remain unknown. Until recently it was assumed that joint-specific antigens were the targets of arthritogenic T lymphocytes and B lymphocytes in rheumatoid arthritis. Consequently, murine models of arthritis are induced by immunization with either joint-specific antigens such as type II collagen or microbial products such as streptococcal cell wall. In the K/BxN T-cell receptor transgenic mouse model, arthritis is caused by a systemic autoimmune response to the ubiquitously expressed glycolytic enzyme glucose-6-phosphate isomerase (G6PI). More recently it was shown that G6PI immunization induces severe symmetrical peripheral polyarthritis in genetically unaltered DBA/I or SJL mice [1,2]. T cells are indispensable for both the induction and the effector phase of G6PI-induced arthritis. Arthritis is cured by depletion of CD4 cells. In contrast, antibodies and FcγR effector cells are necessary but not sufficient for G6PI-induced arthritis in genetically unaltered mice [1]. Both the induction and effector phase of arthritis induced by a systemic autoimmune response can be dissected and preventive and therapeutic strategies evaluated in this model.

References

  1. Schubert D, Maier B, Morawietz L, Krenn V, Kamradt T: Immunization with glucose-6-phosphate isomerase induces T-cell dependent peripheral polyarthritis in genetically unaltered mice.

    J Immunol 2004, 172:4503-4509. PubMed Abstract | Publisher Full Text OpenURL

  2. Bockermann R, Schubert D, Kamradt T, Holmdahl R: Induction of a B cell dependent chronic arthritis with glucose 6 phosphate isomerase.

    Arthritis Res Therapy 2005, 7:R1316-R1324. BioMed Central Full Text OpenURL