Table 1

Clinical features associated with systemic sclerosis autoantibodies

Antibodies


ACA

Th/To

U1RNP

U3RNP

Topo

Pol III


Patient characteristics

Female

MCTD

African American

Disease subtype

Limited

Limited

Limited

Diffuse

Diffuse

Diffuse

Joint/skin involvement

↓ Joint

↓ Joint

↑ Joint

↑↑ Skin

Muscle involvement

Calcinosis

Acroosteolysis

DUs

Yes

Yes

PAH ± PF

PAH

PAH

PAH

PAH + PF

PF

↓↓ PF

Renal crisis

Yes

Yes


ACA, anticentromere antibodies; DU, digital ulcer; MCTD, mixed connective tissue disease; PAH, pulmonary arterial hypertension; PF, pulmonary fibrosis; Pol III, polymerase III; Topo, topoisomerase; U1RNP, U1 ribonuclear protein; U3RNP, U3 ribonuclear protein.

Matucci-Cerinic et al. Arthritis Research & Therapy 2007 9(Suppl 2):S7   doi:10.1186/ar2191