|
Some antiangiogenic and proangiogenic mediators in systemic sclerosis |
|
| Type of mediator |
Molecule |
|
|
|
| Antiangiogenic |
Endostatin (normal in some studies) |
| Platelet factor (PF)4 |
|
| Thrombospondin |
|
| Interleukin (IL)-4 |
|
| Proangiogenic |
Soluble vascular cell adhesion molecule (sVCAM)-1 |
| Soluble E-selectin (sE-selectin; normal in some studies) |
|
| E-selectin |
|
| Soluble P-selectin (sP-selectin) |
|
| P-selectin |
|
| Soluble intercellular adhesion molecule (sICAM)-1/ICAM-1 |
|
| CD44 |
|
| Vascular endothelial growth factor (VEGF) |
|
| Vascular endothelial growth factor receptors (VEGFRs; VEGFR1 and VEGFR2) |
|
| IL-8 |
|
| Monocyte chemoattractant protein (MCP)-1/CC chemokine ligand (CCL)2 and CCR2 (receptor for MCP-1) |
|
| Macrophage inflammatory protein (MIP)-1α/CCL3 |
|
| Fractalkine/CX3 chemokine ligand (CX3CL)1 and CX3 chemokine receptor (CX3CR)1 (receptor for fractalkine) |
|
| β-Thromboglobulin |
|
| Tumour necrosis factor (TNF)-α |
|
| Endothelin (ET)-1 |
|
Koch and Distler Arthritis Research & Therapy 2007 9(Suppl 2):S3 doi:10.1186/ar2187 |
|