Table 1

Some proangiogenic mediators involved in the pathogenesis of rheumatoid arthritis

Type of molecule

Molecule


Growth factors

Fibroblast growth factor (FGF)-2

Transforming growth factor (TGF)-β

Hepatocyte growth factor (HGF)

Vascular endothelial growth factors (VEGF, VEGF-C, and VEGF-D)

Cytokines

Tumour necrosis factor (TNF)-α

Platelet activating factor (PAF)

Angiopoietin (Ang)-1, Ang-2

Chemokines

Interleukin (IL)-8

Epithelial neutrophil activating peptide (ENA)-78

Growth related gene product (GRO)-α

Stromal cell derived factor (SDF)-1

Fractalkine

Other mediators

Endothelin (ET)-1


Koch and Distler Arthritis Research & Therapy 2007 9(Suppl 2):S3   doi:10.1186/ar2187