Figure 2.

Sequence of pathological events leading to the development of SSc. ECM, extracellular matrix; IL, interleukin; PDGF, platelet-derived growth factor; SMC, smooth muscle cell; SSc, systemic sclerosis; TGF, transforming growth factor.

Abraham and Distler Arthritis Research & Therapy 2007 9(Suppl 2):S2   doi:10.1186/ar2186