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This article is part of the supplement: Advances in systemic sclerosis and related fibrotic and vascular conditions

Review

Clinical trials and basic research: defining mechanisms and improving treatment in connective tissue disease

Lewis J Rubin1 email, Carol M Black2, Christopher P Denton2 and James R Seibold3

1Division of Pulmonary and Critical Care Medicine, University of California San Diego, Campus Point Drive, La Jolla, California 92037-7381, USA

2Centre for Rheumatology, Royal Free and University College Medical School, Rowland Hill Street, London, NW3 2PF, UK

3University of Michigan Scleroderma Program, East Medical Center Drive, Ann Arbor, Michigan 48109-0358, USA

author email corresponding author email

Arthritis Research & Therapy 2007, 9(Suppl 2):S10doi:10.1186/ar2194

Published: 15 August 2007

Abstract

Despite advances in elucidating the pathogenic factors responsible for its development, systemic sclerosis remains complex and poorly understood, and treatment options are limited. Multidisciplinary collaborative efforts are needed to better characterize clinical and prognostic parameters and to design and implement large-scale clinical trials in well defined populations with therapies that target potential disease modulators.


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