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This article is part of the supplement: Basic science, rationale, background and future of denosumab: a RANK ligand inhibitor

Review

Aseptic loosening of total joint replacements: mechanisms underlying osteolysis and potential therapies

Yousef Abu-Amer*, Isra Darwech and John C Clohisy

Arthritis Research & Therapy 2007, 9(Suppl 1):S6  doi:10.1186/ar2170

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