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Characteristics of all reported singleton pregnanciesa |
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| Mother ever diagnosed with SLE |
Mother never diagnosed with SLE |
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| Pregnancies conceived before mother's SLE diagnosis |
Pregnancies conceived after mother's SLE diagnosis |
All pregnancies conceived by mothers ever diagnosed with SLE |
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|
|
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| Total number of pregnancies |
274 (100%) |
78 (100%) |
352 (100%) |
667 (100%) |
| Mean (standard deviation) maternal age at conception |
25.0 (5.5) |
30.1 (5.6) |
25.6 (5.8) |
26.3 (6.1) |
| Pregnancy type |
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| Live birth |
224/274 (81.8%) |
33/78 (42.3%) |
257/352 (73.0%) |
553/667 (82.9) |
| Foetal death |
47/274 (17.2%) |
43/78 (55.1%) |
90/352 (25.6%) |
109/667 (16.3%) |
| First-trimester miscarriage (0–12 weeks)b |
28/274 (10.2%) |
34/78 (43.6%) |
62/352 (17.6%) |
90/667 (13.4%) |
| Mid-trimester miscarriage (13–23 weeks)b |
3/259 (1.2%) |
4/49 (8.2%) |
7/315 (2.2%) |
9/605 (1.5%) |
| Miscarriage missing gestation |
3/274 (1.1%) |
1/78 (1.3%) |
4/352 (1.1%) |
1/667 (0.1%) |
| Stillbirth (≥ 24 weeks)c |
13/237 (5.5%) |
4/37 (10.8%) |
17/274 (6.2%) |
9/562 (1.6%) |
| Ectopic pregnancy |
3/274 (1.1%) |
2/78 (2.6%) |
5/352 (1.4%) |
5/667 (0.7%) |
| Reported gestation of live births (completed weeks) |
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| All pregnancies ending in live birth |
224 (100%) |
33 (100%) |
257 (100%) |
553 (100%) |
| < 24 weeks |
5 (2.2%) |
3 (9.1%) |
8 (3.1%) |
20 (3.6%) |
| 24–31 weeks |
2 (0.9%) |
3 (9.1%) |
5 (2.0%) |
2 (0.4%) |
| 32–36 weeks |
5 (2.2%) |
1 (3.0%) |
6 (2.3%) |
4 (0.7%) |
| All preterm (< 37 weeks) |
12 (5.4%) |
7 (21.2%) |
19 (7.4%) |
26 (4.7%) |
| 37–42 weeks |
212 (94.6%) |
26 (78.8%) |
238 (92.6%) |
526 (95.1%) |
| 42–46 weeks |
0 (0%) |
0 (0%) |
0 |
1 (0.2%) |
| Reported gestation of foetal deaths (completed weeks) |
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| All pregnancies ending in foetal deathb |
47 (100%) |
43 (100%) |
90 (100%) |
109 (100%) |
| < 8 weeks |
17 (36.2%) |
25 (58.1%) |
42 (46.7%) |
63 (57.8%) |
| 8–12 weeks |
11 (23.4%) |
9 (20.9%) |
20 (22.2%) |
28 (25.7%) |
| 13–15 weeks |
2 (4.3%) |
0 (0%) |
2 (2.2%) |
4 (3.7%) |
| 16–23 weeks |
1 (2.1%) |
4 (9.3%) |
5 (5.6%) |
5 (4.6%) |
| 24–36 weeks |
6 (12.7%) |
4 (9.3%) |
10 (11.1%) |
4 (3.7%) |
| ≥ 37 weeks |
7 (14.9%) |
0 (0%) |
7 (7.7%) |
3 (2.8%) |
| Missing gestation category |
3 (6.4%) |
1 (2.3%) |
4 (4.4%) |
2 (1.8%) |
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aTwin pregnancies excluded. bFour pregnancies ending in miscarriage have the gestational age missing (three conceived prior to systemic lupus erythematosus (SLE) diagnosis; one conceived after SLE diagnosis). cOne woman without SLE had missing stillbirth gestation. | ||||
Molokhia et al. Arthritis Research & Therapy 2007 9:R124 doi:10.1186/ar2332 |
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