Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience
1 CHRU de Tours, Université François Rabelais, INSERM, Centre d'investigation clinique 202, Tours, France
2 University Hospital, Créteil, France
Arthritis Research & Therapy 2007, 9:110 doi:10.1186/ar2324
See related research article by Le Maitre et al., http://arthritis-research.com/content/9/4/R77Published: 21 November 2007
IL-1 plays a key role in disc degeneration and could be a valid target for inhibiting this process. IL-1 receptor antagonist (IL-1ra) might be a good candidate to inhibit IL-1 activity. However, many questions need to be addressed before contemplating therapy in humans. IL-1 blockade is also a great challenge in osteoarthritis and results from animal models suggest that IL-1ra may have beneficial effects. The clinical benefit of a local injection of IL-1ra in knee osteoarthritis may be limited by the antagonist's short half-life. Further studies with longer-lasting antagonists are needed to explore this new therapeutic approach.