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Volume 9 Issue 6
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Comment |
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Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience
Philippe Goupille, Denis Mulleman, Xavier Chevalier Arthritis Research & Therapy 2007, 9:110 (21 November 2007)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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The quest for the Holy Grail: a disease-modifying osteoarthritis drug
Francis Berenbaum Arthritis Research & Therapy 2007, 9:111 (10 December 2007)
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Review |
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Toll-like receptors and innate immune responses in systemic lupus erythematosus
Robert Lafyatis, Ann Marshak-Rothstein Arthritis Research & Therapy 2007, 9:222 (29 November 2007)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts
Ulf Müller-Ladner, Caroline Ospelt, Steffen Gay, Oliver Distler, Thomas Pap Arthritis Research & Therapy 2007, 9:223 (20 December 2007)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Cells of the synovium in rheumatoid arthritis. Macrophages
Raimund W Kinne, Bruno Stuhlmüller, Gerd-R Burmester Arthritis Research & Therapy 2007, 9:224 (21 December 2007)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Research |
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Mycophenolate sodium treatment in patients with primary Sjögren syndrome: a pilot trial
Peter Willeke, Bernhard Schlüter, Heidemarie Becker, Heiko Schotte, Wolfram Domschke, Markus Gaubitz Arthritis Research & Therapy 2007, 9:R115 (6 November 2007)
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Atherosclerotic disease is increased in recent-onset rheumatoid arthritis: a critical role for inflammation
Suad Hannawi, Brian Haluska, Thomas H Marwick, Ranjeny Thomas Arthritis Research & Therapy 2007, 9:R116 (6 November 2007)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Early rheumatoid arthritis patients show increased atherosclerotic burden compared to controls; inflammation may promote the development of atherosclerotic disease well before the first symptoms of joint disease appear.
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Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study
Steeve Tat, Jean-Pierre Pelletier, Josep Vergés, Daniel Lajeunesse, Eulàlia Montell, Hassan Fahmi, Martin Lavigne, Johanne Martel-Pelletier Arthritis Research & Therapy 2007, 9:R117 (9 November 2007)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
A combination of glucosamine sulphate and chondroitin sulphate markedly reduces the resorptive activity of subchondral bone osteoblasts, suggesting a positive effect on early bone structural changes in osteoarthritis.
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Increased lymphangiogenesis in joints of mice with inflammatory arthritis
Qian Zhang, Yan Lu, Steven T Proulx, Ruolin Guo, Zhenqiang Yao, Edward M Schwarz, Brendan F Boyce, Lianping Xing Arthritis Research & Therapy 2007, 9:R118 (12 November 2007)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Ultrasonography, magnetic resonance imaging, radiography, and clinical assessment of inflammatory and destructive changes in fingers and toes of patients with psoriatic arthritis
Charlotte Wiell, Marcin Szkudlarek, Maria Hasselquist, Jakob M Møller, Aage Vestergaard, Jesper Nørregaard, Lene Terslev, Mikkel Østergaard Arthritis Research & Therapy 2007, 9:R119 (14 November 2007)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Recruitment of dendritic cells and macrophages during T cell-mediated synovial inflammation
Mahin Moghaddami, Leslie G Cleland, Gorjana Radisic, Graham Mayrhofer Arthritis Research & Therapy 2007, 9:R120 (20 November 2007)
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Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study
Christelle Boileau, Nathalie Amiable, Johanne Martel-Pelletier, Hassan Fahmi, Nicolas Duval, Jean-Pierre Pelletier Arthritis Research & Therapy 2007, 9:R121 (21 November 2007)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Inorganic pyrophosphate generation by transforming growth factor-beta-1 is mainly dependent on ANK induction by Ras/Raf-1/extracellular signal-regulated kinase pathways in chondrocytes
Frederic Cailotto, Arnaud Bianchi, Sylvie Sebillaud, Narayanan Venkatesan, David Moulin, Jean-Yves Jouzeau, Patrick Netter Arthritis Research & Therapy 2007, 9:R122 (22 November 2007)
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Gait analysis in a murine model of collagen-induced arthritis
Jon Vincelette, Yifan Xu, Le-Ning Zhang, Caralee J Schaefer, Ronald Vergona, Mark E Sullivan, Thomas G Hampton, Yi-Xin Wang Arthritis Research & Therapy 2007, 9:R123 (24 November 2007)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Cross-sectional analysis of adverse outcomes in 1,029 pregnancies of Afro-Caribbean women in Trinidad with and without systemic lupus erythematosus
Mariam Molokhia, Noreen Maconochie, Alan Patrick, Pat Doyle Arthritis Research & Therapy 2007, 9:R124 (27 November 2007)
Abstract | Full text | PDF | PubMed
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Editor’s summary
An analysis of more than 1,000 pregnancies shows an increased risk of stillbirth and fetal death in women with systemic lupus erythematosus, which is not accounted for by raised antibody titres.
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The proinflammatory cytokines IL-2, IL-15 and IL-21 modulate the repertoire of mature human natural killer cell receptors
Casimir de Rham, Sylvie Ferrari-Lacraz, Sabrina Jendly, Gregory Schneiter, Jean-Michel Dayer, Jean Villard Arthritis Research & Therapy 2007, 9:R125 (3 December 2007)
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A critical appraisal of guidelines for the management of knee osteoarthritis using Appraisal of Guidelines Research and Evaluation criteria
Stéphane Poitras, Jérôme Avouac, Michel Rossignol, Bernard Avouac, Christine Cedraschi, Margareta Nordin, Chantal Rousseaux, Sylvie Rozenberg, Bernard Savarieau, Philippe Thoumie, Jean-Pierre Valat, Éric Vignon, Pascal Hilliquin Arthritis Research & Therapy 2007, 9:R126 (6 December 2007)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Guidelines for treating knee osteoarthritis were found to lack educational information and differ in treatments addressed when they were reviewed using the Appraisal of Guidelines Research and Evaluation (AGREE) criteria.
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Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition
John Bainbridge, Leigh Madden, David Essex, Michael Binks, Rajneesh Malhotra, Ewa M Paleolog Arthritis Research & Therapy 2007, 9:R127 (11 December 2007)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Apoptosis is not the major death mechanism induced by celecoxib on rheumatoid arthritis synovial fibroblasts
Rachel Audo, Véronique Deschamps, Michael Hahne, Bernard Combe, Jacques Morel Arthritis Research & Therapy 2007, 9:R128 (12 December 2007)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Cyclooxygenase inhibition lowers prostaglandin E2 release from articular cartilage and reduces apoptosis but not proteoglycan degradation following an impact load in vitro
Janet E Jeffrey, Richard M Aspden Arthritis Research & Therapy 2007, 9:R129 (20 December 2007)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Cyclooxygenase inhibition with NSAIDs alone is unlikely to slow down or prevent the development of secondary osteoarthritis, suggests an in-vitro study investigating the release of prostaglandin E2 from cartilage following impact.
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