A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity
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* Corresponding author: Lina M Olsson lina.olsson@med.lu.se
Arthritis Research & Therapy 2007, 9:R98 doi:10.1186/ar2299
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Emma Ahlqvist, Malin Hultqvist, Rikard Holmdahl Arthritis Research & Therapy 2009, 11:226 (19 May 2009) This article is part of a collection on The Scientific Basis of... |
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Research
NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity Bernhard Greve, Peter Hoffmann, Reinhard Vonthein, Jürgen Kun, Bertrand Lell, Marcin P Mycko, Krysztof W Selmaj, Klaus Berger, Robert Weissert, Peter G Kremsner Malaria Journal 2008, 7:251 (11 December 2008) The authors have investigated the ratio of two neutrophil cytosolic factor 1 (NCF1) pseudogenes in patients with malaria and also in patients with multiple sclerosis. NCF1 is involved in the formation of oxygen intermediates implicated both in protection/pathogenesis of malaria as well as being a harmful factor in murine models of MS.
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