Table 4

Characteristics of women with connective tissue disease and silicone breast implants who were previously diagnosed with paraproteinemia (Group 6)
Age (years)
 Connective tissue disease
 Silicone implant
 Serum paraprotein (concentration and isotype)a



Type
 Duration (years)
 Type
 Duration (years)
 Exposure (years)
 Ruptureb
43
 UCTD/FMS
 7.0
 Silicone gel
 14.2
 17.1
 Yes
 6 g/l IgG(κ)
44
 UCTD
 12.8
 Silicone gel
 15.3
 17.7
 No
 3 g/l IgG(λ), 3 g/l IgG(λ)
46
 UCTD
 7.1
 Silicone gel
 15.1
 17.2
 Yes
 4 g/l IgG(κ), IgG(λ)
50
 UCTD
 4.0
 Silicone gel/polyurethane
 10.5
 17.4
 Yes
 5 g/l IgM(κ)
50
 UCTD
 8.0
 Silicone gel
 n/a
 19.2
 Yes
 13 g/l IgG(κ), 6 g/l IgG(κ)
52
 UCTD
 4.6
 Silicone gel
 14.1
 20.5
 Yes
 4 g/l IgG(κ)
54
 UCTD
 3.0
 Silicone gel/saline
 11.4
 14.2
 Yes
 1 g/l IgG(κ)
55
 UCTD/FMS
 5.0
 Silicone gel
 21.0
 30.0
 Yes
 7 g/l IgG(λ)
56
 UCTD
 10.4
 Silicone gel
 15.1
 23.3
 No
 9 g/l IgG(κ)
58
 UCTD
 9.3
 Silicone gel
 13.5
 18.1
 Yes
 22 g/l IgG(λ)
All: 50.8 ± 5.2
7.1 ± 3.1
14.5 ± 3.0
 19.5 ± 4.4

Subjects are listed in increasing order of age. All subjects were White. FMS, fibromyalgia syndrome; UCTD, undifferentiated connective tissue disease; n/a, not available. aWeak paraprotein bands (defined as <1 g/l) are shown without specifying their concentration; all others are shown by concentrations estimated from protein electrophoresis. bImplant rupture was suspected by signs and symptoms in eight cases and was documented at surgery in five cases.

Csako et al. Arthritis Research & Therapy 2007 9:R95   doi:10.1186/ar2295