Table 2

Characteristics of women with connective tissue disease and silicone implants in whom paraproteinemia was identified from Group 1
Age (years)
 Connective tissue disease
 Silicone implant
 Serum paraprotein (isotype)a



Type
 Duration (years)
 Type
 Duration (years)
 Exposure (years)
 Ruptureb
48
 UCTD
 15.4
 Silicone gel, saline
 17.7
 18.0
 Yes
 IgM(λ)
49
 FMS/UCTD
 15.2
 Silicone gel (chin)
 6.0
 17.7
 Yes
 IgG(κ)
53
 UCTD
 6.2
 Saline
 3.5
 3.5
 Yes
 IgG(λ)
55
 Systemic sclerosis
 12.1
 Polyurethane
 4.3
 16.1
 n/a
 IgG(κ)
60
 UCTD/FMS
 3.9
 Silicone gel
 20.1
 24.2
 Yes
 IgG(κ)
61
 Dermatomyositis
 4.2
 Silicone gel
 10.0
 10.2
 Yes
 IgG(κ)
63
 UCTD
 16.1
 Silicone gel
 n/a
 23.3
 Yes
 IgM(λ)
All: (55.6 ± 5.9)
10.4 ± 5.5
10.3 ± 7.1
 16.1 ± 7.3

Subjects are listed in increasing order of age. All subjects were White. FMS, fibromyalgia syndrome; UCTD, undifferentiated connective tissue disease; n/a, not available. aBased on protein electrophoresis, all paraprotein bands were considered weak (defined as <1 g/l). bImplant rupture was suspected by signs and symptoms in six cases and was documented at surgery in four cases.

Csako et al. Arthritis Research & Therapy 2007 9:R95   doi:10.1186/ar2295