|
Baseline measures of individual standardized cartilage biomarkers and their respective prediction of subsequent cartilage loss on magnetic resonance imaging |
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| Unadjusted OR (95% CI) |
R2 |
AUC |
P value |
Adjusted ORa (95% CI) |
|
|
|
|||||
| COMP |
6.09 (1.34, 27.67) |
0.06 |
0.60 |
0.02 |
6.35 (1.36–29.65) |
| 846 epitope |
0.93 (0.51, 1.71) |
0.001 |
0.52 |
0.82 |
0.96 (0.52, 1.78) |
| CPII |
1.19 (0.61, 2.32) |
0.002 |
0.53 |
0.62 |
1.18 (0.60, 2.32) |
| C1,2C |
0.69 (0.30, 1.59) |
0.008 |
0.55 |
0.38 |
0.72 (0.31, 1.68) |
| Col2CTX/Cr ratio |
0.99 (0.65, 1.52) |
0.000 |
0.52 |
0.97 |
0.95 (0.61, 1.47) |
| C2C |
0.39 (0.13, 1.13) |
0.03 |
0.58 |
0.08 |
0.4 (0.14, 1.17) |
|
aAdjusted for age, gender, and body mass index. AUC, area under the curve; C2C, collagenase cleavage of triple-helical type II collagen; CI, confidence interval; Col2CTx, crosslinked peptides from the C-telopeptide domain of type II collagen; COMP, Cartilage Oligomeric Matrix Protein; CPII, C-propeptide of type II collagen; OR, odds ratio. | |||||
Hunter et al. Arthritis Research & Therapy 2007 9:R108 doi:10.1186/ar2314 |
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