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Baseline characteristics of study population (n = 137) |
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| Whole sample |
No cartilage loss in any plate (at follow-up) (n = 66) |
Cartilage loss in any plate (at follow-up) (n = 71) |
|
|
|
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| Age in years, mean ± SD |
67 ± 9 |
66 ± 9 |
67 ± 10 |
| Males, number (percentage) |
74 (54%) |
38 (58%) |
36 (51%) |
| Body mass index, mean (SD) |
31.43 (5.48) |
31.03 (6.08) |
31.75 (4.87) |
| Percentage with K&L grade of ≥ 2 |
73% |
67% |
80% |
| Number of plates with cartilage loss, mean (SD) |
0.99 (1.24) |
0 (0) |
1.92 (1.09) |
| Mean interval in years between baseline and follow-up scan |
2.67 |
2.68 |
2.66 |
| Levels of biomarkers, mean (SD) |
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| COMP |
12.5 (2.9) |
11.9 (2.9) |
13.0 (2.9) |
| 846 epitope |
269.3 (154.2) |
273.4 (154.6) |
265.4 (154.8) |
| CPII |
1,660.9 (598.5) |
1,635.9 (623.9) |
1,684.1 (577.3) |
| C1,2C |
0.06 (0.03) |
0.06 (0.03) |
0.06 (0.03) |
| Col2CTX/Cr ratio |
51.77 (63.53) |
45.82 (31.81) |
57.62 (83.70) |
| C2C |
53.2 (22.9) |
57.0 (28.6) |
49.7 (15.5) |
|
C2C, collagenase cleavage of triple-helical type II collagen; Col2CTx, crosslinked peptides from the C-telopeptide domain of type II collagen; COMP, cartilage oligomeric matrix protein; CPII, C-propeptide of type II collagen; K&L, Kellgren & Lawrence; SD, standard deviation. | |||
Hunter et al. Arthritis Research & Therapy 2007 9:R108 doi:10.1186/ar2314 |
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