Table 3

Risk factors for hand bone loss in a multivariate linear regression model

DXA-BMD hand percentage change

DXR-BMD hand percentage change

DXR-MCI percentage change


B (standard error)

P value

B (standard error)

P value

B (standard error)

P value


Disease activity score including 28 joints

0.09 (0.25)

0.73

-0.47 (0.16)

0.003

-0.47 (0.18)

0.009

Disease duration <3 years

-2.84 (0.88)

0.001

0.46 (0.55)

0.40

0.45 (0.63)

0.47

Baseline BMD (g/cm2)/MCI

-9.70 (5.01)

0.05

-3.80 (2.51)

0.13

-5.79 (2.81)

0.04

Prednisolone during 2-year follow-up (no/yes)

0.44 (0.69)

0.53

-0.03 (0.43)

0.95

-0.41 (0.49)

0.40

Ever disease-modifying antirheumatic drug user (no/yes)

-0.31 (0.90)

0.73

-0.58 (0.55)

0.30

-0.56 (0.63)

0.38

Ever antiresorptive osteoporosis treatment user (no/yes)

0.78 (0.70)

0.27

0.03 (0.42)

0.95

-0.05 (0.47)

0.91

R2

0.11

0.05

0.06


B values are unstandardized coefficients. Age, gender, rheumatoid factor and the Modified Health Questionnaire were also tested, but did not influence the results. DXA, dual-energy X-ray absorptiometry; DXR, digital X-ray radiogrammetry; BMD, bone mineral density; MCI, metacarpal cortical index.

Hoff et al. Arthritis Research & Therapy 2007 9:R81   doi:10.1186/ar2280

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